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Greasy hair against obesity

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Signal Transduction and Targeted Therapy 2022年第1期7卷 11-12页

作者： Sandra nickel Bruno Christ Department of General Visceral and Vascular SurgeryJena University Hospital07740 JenaGermany Cell Transplantation/Molecular Hepatology Lab Department of VisceralTransplantThoracic and Vascular SurgeryUniversity of Leipzig Medical Center04103 LeipzigGermany

In their article,Choa et *** the perspective to loose fat by in creasing seboge *** a T cell-depe ndent mechanism,they suggest that stimulation of sebum production by thymic stromal lymphopeietin(TSLP)"pulls"lipids out of the adipose tissue.^(1) The World Population Review(***/)ranks obesity rates to one third of the global *** co-morbidities comprise diabetes type 2,ischemic stroke and cardiovascular complications render this epidemic disease the number 1 cause of deaths worldwide(***/).

关键词： obesity al stimulation

Electrochemical Realization of 3D Interconnected MoS_(3)/PPy Nanowire frameworks as Sulfur-Equivalent Cathode Materials for Li-S Batteries

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Energy & Environmental Materials 2024年第2期7卷 9-17页

作者： Hongtao Yu Andreas Siebert Shilin Mei Raul Garcia-Diez Roberto f.lix Ting Quan Yaolin Xu Johannes frisch Regan G.Wilks Marcus Bär Chun Pei Yan Lu Department for Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und Energie GmbH(HZB)Hahn-Meitner Platz 114109 BerlinGermany Guangdong Province Key Laboratory of Durability for Marine Civil Engineering School of Civil EngineeringShenzhen UniversityShenzhenGuangdong 518060China Department of Interface Design HZBAlbert-Einstein-Str.1512489 BerlinGermany Energy Materials In-Situ Laboratory Berlin(EMIL) Albert-Einstein-Str.1512489 BerlinGermany Helmholtz-Institute Erlangen-Nürnberg for Renewable Energy(HI ERN) Albert-Einstein-Str.1512489 BerlinGermany Department of Chemistry and Pharmacy Friedrich-Alexander-Universität Erlangen-NürnbergEgerlandstr.391058Erlangen Germany Institute of Chemistry University of Potsdam14467Potsdam Germany

The development of freestanding and binder-free electrode is an effective approach to perform the inherent capacity of active materials and promote the mechanism study by minimizing the interference from ***,we construct a freestanding cathode composed of MoS_(3)/PPy nanowires(NWs)deposited on porous nickel foam(Nf)(MoS_(3)/PPy/Nf)through electrochemical methods,which can work efficiently as sulfur-equivalent cathode material for Li-S *** structural stability of the MoS_(3)/PPy/Nf cathode is greatly enhanced due to its significant tolerance to the volume expansion of MoS_(3)during the lithiation process,which we ascribe to the flexible 3D framework of PPy NWs,leading to superior cycling performance compared to the bulk-MoS_(3)/Nf *** the interference of binder and carbon additives,the evolution of the chemical and electronic structure of Mo and S species during the discharge/charge was studied by X-ray absorption near-edge spectroscopy(XANES).The formation of lithium polysulfides was excluded as the driving cathode reaction mechanism,suggesting the great potential of MoS_(3)as a promising sulfur-equivalent cathode material to evade the shuttle effect for Li-S *** present study successfully demonstrates the importance of structural design of freestanding electrode enhancing the cycling performances and revealing the corresponding mechanisms.

关键词： 3D-Network electrochemical lithium-sulfur battery MoS_(3) PPy

formation and Microstructural Characterization of Silicon-modified Aluminide Coating on nickel-based Superalloy IN738LC

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材料热处理学报 2004年第05B期25卷 657-660页

作者： f. Shahriari f. Ashrafizadeh A. Monshi Materials engineering department Isfahan University of Technology Isfahan IranMaterials engineering department Isfahan University of Technology Isfahan IranMaterials engineering department Isfahan University of Technology Isfahan Iran

In this investigation, aluminide coatings used to protect industrial components at high temperature and corrosive environments were modified with silicon addition and the microstructural features and formation mechanism were evaluated. The coating on the nickel-based superalloy IN738LC was carried out by a two stage process including siliconizing at first and aluminizing thereafter. Pack cementation siliconizing performed at 950C for 2, 4 and 6 hours in several powder mixtures of Si, A12O3 and NHiCl, then aluminum was diffused into the surface of the specimens by an industrial aluminizing process. The modified coatings were characterized by means of standard metallography, scanning electron microscopy, energy dispersive spectroscopy and X-ray diffraction methods. The results show that Si in the coatings mainly presents in the form of secondary phases including Cr3Si, Mo5Si3 and Nii6Ti6Si7, well distributed within the NiAl matrix. The advantages of this two stage modified coating is discussed.

关键词：显微结构 IN738LC 镍超级合金扩散渗碳处理生长机制

Not yet IDEAL?-evidence and learning curves of minimally invasive pancreaticoduodenectomy

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 812-814页

作者： f.lix nickel Caelán Max Haney Beat-Peter Müller-Stich Thilo Hackert Department of General Visceraland Transplantation SurgeryHeidelberg UniversityHospital HeidelbergHeidelbergGermany

In response to“What’s the next step in evaluating laparoscopic pancreaticoduodenectomy?”(http://***/article/view/29682/25710)by fernando Burdío,Luís Grand and Ignasi *** and foremost,we would like to express our sincere condolences on the passing of Professor Ignasi *** were deeply saddened to hear of this and wish his family,friends and colleagues strength in these difficult times of grieving.

关键词： IDEAL learning Grand

Strongyloides stercoralis prevalence and diagnostics in Vientiane, Lao People’s Democratic Republic

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Infectious Diseases of Poverty 2020年第5期9卷 118-119页

作者： Somaphone Chankongsin Rahel Wampfler Marie-Therese Ruf Peter Odermatt Hanspeter Marti Beatrice nickel Valy Keoluangkhot Andreas Neumayr 不详 University of Basel BaselSwitzerland Department of Medicine Swiss Tropical and Public Health InstituteBaselSwitzerland

Background:Despite the high prevalence of strongyloidiasis in the Laotian population,Laotian hospitals still lack diagnostic capacity to appropriately diagnose Strongyloides stercoralis *** cross-sectional hospital-based study was conducted to assess the prevalence of Strongyloides stercoralis infection among hospitalized patients treated at Mahosot Hospital,the primary reference hospital of Lao People’s Democratic Republic(Lao PDR),and to validate feasible methods for diagnosing *** infection at hospital’s ***:Between September and December 2018,stool samples of 104 inpatients were investigated for *** infection by wet smear,Baermann technique,Koga Agar plate culture(KAPC),and real-time detection polymerase chain reaction(RTD-PCR)at the Infectious Diseases Ward of the Mahosot Hospital in *** sensitivity,the specificity,the negative predictive value(NPV)of each diagnostic test,as well as their combination(s)was calculated using a composite reference standard(CRS).The correlation of the different test methods was assessed by chi-square or fisher’s exact ***’s kappa coefficient was used to assess the diagnostic agreement of the different test ***:The overall prevalence of *** infections among the study population was 33.4%.The cumulative infection prevalence statistically significantly increased from the lowest age group of 40 years and below(22.4%),to the medium(40.0%)and to the oldest age group of 61 year and above(72.7%)(P=0.003).The cumulative infection prevalence of CRS was considerably higher in male(40.4%)compared to female patients(28.1%),but not statistically different(P=0.184).The diagnostic sensitivity of Baermann technique,KAPC,RTD-PCR,and the combination of Baermann technique and KAPC were 60.0,60.0,74.3,and 77.1%,*** 13 patients(37.1%)of the total 35 *** patients diagnosed with any technique had a simultaneously positive diagnostic test with Baer

关键词： Strongyloides stercoralis Strongyloidiasis Wet smear Baermann method Koga agar plate culture Real time detection PCR

Robotic pancreaticoduodenectomy after the learning curve-a new hope

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 489-491页

作者： Philip C.Müller Beat P.Müller-Stich Thilo Hackert f.lix nickel Swiss HPB and Transplantation Center Department of Surgery and TransplantationUniversity Hospital ZurichZurichSwitzerland Department of General Visceral and Transplantation SurgeryHeidelberg University HospitalHeidelbergGermany

first,we would like to congratulate Liu et *** their successful multicenter study including 1,032 patients undergoing robotic pancreaticoduodenectomy(RPD)and 1,154 open pancreaticoduodenectomy(OPD)in seven high volume centers in China over an 8 year period(1).To ensure the best possible outcomes of both techniques,RPD was performed by five surgeons from three centers after overcoming the individual learning curve that was defined as having performed>40 *** the other hand,OPD was performed by 9 surgeons from 6 centers after reaching the individual learning curve,defined as an experience of>60 OPD.

关键词： centers learning after

Mechanical characterization of rose bengal and green light crosslinked collagen scaffolds for regenerative medicine

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Regenerative Biomaterials 2021年第6期8卷 185-198页

作者： Joy Braun Stefanie Eckes Michelle fiona Kilb Dirk fischer Claudia Eßbach Pol Maria Rommens Philipp Drees Katja Schmitz Daniela nickel Ulrike Ritz Department of Orthopedics and Traumatology BiomaTiCSUniversity Medical CenterJohannes Gutenberg UniversityLangenbeckstraße 1Mainz 55131Germany Clemens-Schopf-Institute of Organic Chemistry and Biochemistry Technical University of DarmstadtAlarich-Weiss-Straße 4Darmstadt 64287Germany Berufsakademie Sachsen—Staatliche Studienakademie Glauchau University of Cooperative EducationKopernikusstraße 51Glauchau 08371Germany

Collagen is one of the most important biomaterials for tissue engineering *** its excellent biocompatibility,it shows the non-negligible disadvantage of poor mechanical *** crosslinking with rose bengal and green light(RGX)is an appropriate method to improve this *** development of collagen laminates is helpful for further adjustment of the mechanical properties as well as the controlled release of incorporated *** this study,we investigate the impact of crosslinking and layering of two different collagen scaffolds on the swelling behavior andmechanical behavior inmicro tensile tests to obtain information on its wearing comfort(stiffness,strength and ductility).The mechanical stability of the collagen material after degradation due to cell contact is examined using thickness *** is no linear increase or decrease due to layering homologous ***,a decrease in elongation at break,Young’s modulus and ultimate tensile strength are measured when the untreated monolayer is compared to the crosslinked ***,we can detect a connection between stability and cell *** results show that with variation in number and type of layers,collagen scaffolds with tailored mechanical properties can be *** a multi-layered structure enables the release of biomolecules into inner or outer layers for biomedical applications.

关键词： collagen type I collagen laminates rose bengal and green light crosslinking thickness analysis micro tensile testing cell-collagen interactions

Addition of heparin binding sites strongly increases the bone forming capabilities of BMP9 in vivo

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Bioactive Materials 2023年第11期29卷 241-250页

作者： Claudia Siverino Shorouk fahmy-Garcia Viktoria Niklaus Nicole Kops Laura Dolcini Massimiliano Maraglino Misciagna Yanto Ridwan Eric farrell Gerjo JVMvan Osch Joachim nickel Department of Tissue Engineering and Regenerative Medicine University Hospital WuerzburgWuerzburgGermany Department of Orthopaedics and Sports Medicine Erasmus MCUniversity Medical CenterRotterdamthe Netherlands Department of Internal Medicine Erasmus MCUniversity Medical CenterRotterdamthe Netherlands Department of Oral and Maxillofacial Surgery Erasmus MCUniversity Medical CenterRotterdamthe Netherlands fin-Ceramica faenza SpA Via Granarolo 177/348018FaenzaItaly AMIE Core facility Erasmus University Medical CenterRotterdamthe Netherlands Department of Otorhinolaryngology Head and Neck SurgeryErasmus MCUniversity Medical CenterRotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritime and Materials EngineeringDelft University of TechnologyDelftthe Netherlands fraunhofer ISC Translational Center RTWuerzburgGermany

Bone Morphogenetic proteins(BMPs)like BMP2 and BMP7 have shown great potential in the treatment of severe bone *** recent in vitro studies,BMP9 revealed the highest osteogenic potential compared to other BMPs,possibly due to its unique signaling pathways that differs from other osteogenic ***,in vivo the bone forming capacity of BMP9-adsorbed scaffolds is not superior to BMP2 or *** silico analysis of the BMP9 protein sequence revealed that BMP9,in contrast to other osteogenic BMPs such as BMP2,completely lacks so-called heparin binding motifs that enable extracellular matrix(ECM)interactions which in general might be essential for the BMPs’osteogenic ***,we genetically engineered a new BMP9 variant by adding BMP2-derived heparin binding motifs to the N-terminal segment of BMP9′s mature *** resulting protein(BMP9 HB)showed higher heparin binding affinity than BMP2,similar osteogenic activity in vitro and comparable binding affinities to BMPR-II and ALK1 compared to ***,remarkable differences were observed when BMP9 HB was adsorbed to collagen scaffolds and implanted subcutaneously in the dorsum of rats,showing a consistent and significant increase in bone volume and density compared to BMP2 and *** at 10-fold lower BMP9 HB doses bone tissue formation was *** innovative approach of significantly enhancing the osteogenic properties of BMP9 simply by addition of ECM binding motifs,could constitute a valuable replacement to the commonly used *** possibility to use lower protein doses demonstrates BMP9 HB’s high translational potential.

关键词： Bone morphogenetic protein 9(BMP9) Heparin binding sites Bone regeneration Subcutaneous animal model

NUMERICAL STUDY Of THE NOTCH EffECT ON THE CREEP BEHAVIOR AND LIfE Of nickel-BASE SINGLE CRYSTAL SUPERALLOYS

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 487-492页

作者： Q.M.Yu Z.f.Yue Department of Engineering Mechanics Northwestern Polytechnical University Xi'an 710072 ChinaDepartment of Engineering Mechanics Northwestern Polytechnical University Xi'an 710072 China

Numerical calculations of creep damage development and life behavior of circular notched specimens of nickel-base single crystal had been performed. The creep stress distributions depend on the specimen geometry. for a small notch radius, von Mises stress has an especial distribution. The damage distribution is greatly influenced by the notch depth, notch radius as well as notch type. The creep crack initiation place is different for each notched specimen. The characteristics of notch strengthening and notch weakening depend on the notch radius and notch type. for the same notch type, the creep rupture lives decrease with the decreasing of notch radius. A creep life model has been presented for the multiaxial stress states based on the crystallographic slip system theory.

关键词： creep damage life model notched specimen nickel-base single crystal superalloys