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Passive Smoking During the Periconceptional Period and Risk for Neural Tube Defects in Offspring—Five Counties,Shanxi Province,China,2010–2016

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China CDC weekly 2021年第37期3卷 778-782页

作者： Yali Zhang Jufen Liu Le Zhang Lei Jin nicholas D E greene Zhiwen Li Aiguo Ren Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health National Health Commission of the People’s Republic of ChinaPeking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina UCL Great Ormond Street Institute of Child Health University College LondonLondonUK.

Summary What is already known about this topic?Passive smoking during pregnancy,which is prevalent in China,has been reported to be associated with an increased risk for neural tube defects(NTDs)in five counties of Shanxi Province in northern *** is added by this report?After 4 years since the implementation of the World Health Organization(WHO)Framework Convention on Tobacco Control(FCTC)in China.

关键词： China. Shanxi Period

Development and progression of cancer cachexia:Perspectives from bench to bedside

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Sports medicine and Health Science 2020年第4期2卷 177-185页

作者： Seongkyun Lim Jacob L.Brown Tyrone A.Washington nicholas P.greene Cachexia Research Laboratory Exercise Science Research CenterDepartment of Human Health Performance and RecreationUniversity of Arkansas155 Stadium DrFayettevilleARUSA Aging and metabolism Research Program Oklahoma Medical Research Foundation825 NE 13th StOklahoma CityOKUSA Exercise muscle Biology Laboratory Exercise Science Research CenterDepartment of Human Health Performance and RecreationUniversity of Arkansas155 Stadium DrFayettevilleARUSA

Cancer cachexia(CC)is a devastating syndrome characterized by weight loss,reduced fat mass and muscle mass that affects approximately 80%of cancer patients and is responsible for 22%-30%of cancer-associated *** underlying mechanisms for the development of CC are crucial to advance therapies to treat CC and improve cancer *** is a multi-organ syndrome that results in extensive skeletal muscle and adipose tissue wasting;however,CC can impair other organs such as the liver,heart,brain,and bone as well.A considerable amount of CC research focuses on changes that occur within the muscle,but cancer-related impairments in other organ systems are ***,metabolic changes in organ systems other than muscle may contribute to ***,the purpose of this review is to address degenerative mechanisms which occur during CC from a whole-body *** the information known about metabolic changes that occur in response to cancer is necessary to develop and enhance therapies to treat *** much of the current evidences in CC are from pre-clinical models we should note the majority of the data reviewed here are from preclinical models.

关键词： muscle atrophy Tumor-bearing mouse Lewis lung carcinoma Protein turnover mitochondrial dysfunction

Orofacial Clefts in High Prevalence Area of Birth Defects—Five Counties,Shanxi Province,China,2000–2020

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China CDC weekly 2021年第37期3卷 773-777页

作者： Jufen Liu Yali Zhang Le Zhang Linlin Wang Lei Jin nicholas D E greene Zhiwen Li Aiguo Ren Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health National Health Commission of the People’s Republic of ChinaPeking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina UCL Great Ormond Street Institute of Child Health University College LondonLondonUK.

Summary What is already known on this topic?The prevalence of structural birth defects,especially neural tube defects,decreased after national folic acid(FA)supplementation *** is added by this report?The prevalence of orofacial clefts(OFCs)in five counties of Shanxi Province in northern China,including most subtypes except cleft palate,showed a downward trend in the past two *** this study,pre-perinatal prevalence increased due to earlier detection.

关键词： Shanxi defects downward

Emerging mechanisms for exercise effects on muscle wasting and anabolic resistance

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Sports medicine and Health Science 2020年第4期2卷 175-176页

作者： J.William Deaver nicholas P.greene Cachexia Research Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleARUSA muscle Biology Laboratory Department of Health and KinesiologyTexas A&M UniversityCollege StationTXUSA

Introduction At the 2018 Annual meeting of the American College of Sports medicine,presentations were given by *** ***,James ***,and James ***,at a symposium titled“Emerging mechanisms for Exercise Effects on muscle Wasting and Anabolic Resistance”.Inspired by the presentations at this symposium,the following reviews have been crafted to examine the current understanding of muscle diseases characterized by muscle wasting and anabolic resistance,particularly their identification,development,progression,and mitigation.

关键词： resistance mechanisms muscle

用IREFINDER算法在非翻译区搜索人和小鼠的铁反应元件

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Acta Biochimica et Biophysica Sinica 2002年第6期34卷 743-747页

作者：陈新,王鲁泉,黄弋,邱平,mURGOLO nicholas J.,greene Jonathan R.,吴才宏,姜颖北京大学生命科学学院生物信息中心 Schering Plough研究所北京大学生命科学学院生物信息中心 Schering Plough研究所 Schering Plough研究所 Schering Plough研究所北京大学膜及膜的工程国家重点实验室北京大学生命科学学院生物信息中心北京100871 NJ07033 北京100871 NJ07033 NJ07033 NJ07033 北京100871 北京100871

铁反应元件 (IRE)具有的高度保守的RNA茎环结构 ,是胞质中IRE结合铁调控蛋白 (IRP)的位点。IRP与IRE的结合受细胞内铁含量的调控 ,与铁代谢有着密切的关系。许多与铁代谢有关的基因在 5′UTR或 3′UTR都存在IRE。当铁离子缺乏时 ,IRE与... 详细信息

铁反应元件 (IRE)具有的高度保守的RNA茎环结构 ,是胞质中IRE结合铁调控蛋白 (IRP)的位点。IRP与IRE的结合受细胞内铁含量的调控 ,与铁代谢有着密切的关系。许多与铁代谢有关的基因在 5′UTR或 3′UTR都存在IRE。当铁离子缺乏时 ,IRE与IRP结合 ,使核糖体的翻译进程受阻 ,抑制mRNA的翻译 ;而当铁离子浓度较高时 ,IRP就释放IRE ,促进翻译。因此 ,IRE在 5′UTR调节着翻译的起始[1] 。如果IRE位于 3′UTR ,IRE与IRP的结合可以稳定mRNA并预防其被降解。所有已知的IRE均为C1G5型 ,即环的 1号和 5号碱基位置分别是保守的C和G ;另外还存在一类体外合成的U1A5型IRE ,即环的 1号和 5号碱基位置分别是保守的U和A ,能够在体外有效地结合IRP。由于IRE与铁代谢、氧化性损伤 (oxidativestress)和衰老等过程都有密切的关系 ,因此在临床及新药研制等方面都很受重视。通过改进搜索IRE的算法 ,用计算机程序对人与鼠的mRNA非编码区(UTR)序列数据库进行全面的搜索 ,期望找出可能存在的C1G5或U1A5类型的IRE ,或包含这两种类型IRE的基因。

关键词：铁反应元件铁调控蛋白茎环结构非翻译区

Exercise during weight loss improves hepatic mitophagy

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Sports medicine and Health Science 2022年第3期4卷 183-189页

作者： megan E.Rosa-Caldwell Kaylee E.Poole Andrew Seija matthew P.Harris nicholas P.greene Joshua S.Wooten Cacheixia Research Laboratory Exercise Science Research CenterDepartment of HealthHuman Performanceand RecreationUniversity of ArkansasFayettevilleARUSA Department of Neurology Beth Israel Deaconess Medical CenterBostonMAUSA Department of Applied Health Southern Illinois University EdwardsvilleEdwardsvilleILUSA

Non-alcoholic fatty liver disease(NAFLD)has recently become a public health concern concurrent with the obesity *** work has shown aberrant mitochondrial content/quality and autophagy in models of NAFLD,whereas exercise is known to improve these *** purpose of this study was to examine the effect of different weight-loss modalities on hepatic mitochondrial content,autophagy and mitophagy in ***-eight male C57BL/6J mice were divided into 1 of 4 groups:low fat diet(LFD,10%fat,18 weeks),high fat diet(HFD,60%fat diet,18 weeks),weight-loss by diet(D,60%fat diet for 10 weeks then 10%fat diet for 8 weeks)or weight-loss by diet and physical activity(D/PA,60%fat diet for 10 weeks,then 10%fat diet plus a running wheel for 8 weeks).Immunoblot data were analyzed by one-way analysis of variance(ANOVA)with significance denoted at pmately 50%less in HFD compared to LFD.D/PA had 50%more BNIP3 compared to ***1 content was 40%higher in D and D/PA compared to ***/PARKIN levels were 40%lower in HFD,D,and D/PA compared to *** p-UbSer65 was 3-fold higher in ***3II/I ratio was 50%greater in HFD and D/PA,yet p62 protein content was 2.5 fold higher in ***-fat diet causes disruptions in markers of mitochondrial quality *** activity combined with diet were able to ameliorate these derangements and seemingly improve hepatic mitochondrial quality above control values.

关键词： Autophagy High-fat diet mitochondria Hepatic metabolism

Neither autophagy nor exercise training mode affect exercise-induced beneficial adaptations in high fat-fed mice

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Sports medicine and Health Science 2020年第1期2卷 44-53页

作者： megan E.Rosa-Caldwell Lisa T.Jansen Seongkyun Lim Kirsten R.Dunlap Wesley S.Haynie Tyrone A.Washington nicholas P.greene Integrative muscle metabolism Laboratory Exercise Science Research CenterDepartment of Human Health Performance and RecreationUniversity of ArkansasUSA Exercise muscle Biology Laboratory Exercise Science Research CenterDepartment of Human Health Performance and RecreationUniversity of ArkansasUSA

Exercise mitigates obesity-associated pathologies;however,there is controversy regarding optimal exercise ***,is known to decrease during obesity and is an important moderator for exercise ***:To investigate individual and combined effects of different exercise interventions and autophagy inhibition on exercise adaptations during ***:C57BL/6J mice initiated 45%high fat diet at 8 weeks of *** 6 weeks of diet,animals were divided into moderate(mOD)or high intensity interval training interventions(HIIT),animals were further divided into autophagy inhibition or vehicle conditions(n=10/group).Animals exercised and autophagy was inhibited 3X/week by NSC185058 injections,thereby blocking autophagosome *** continued for 4 ***:High fat diet impaired glucose handling~17%;exercise interventions normalized glucoregulation to prehigh fat diet levels,without differences between any *** fat diet induced~25%decrease in aerobic capacity,which returned to baseline after exercise interventions,with no differences between any *** effects of autophagy inhibition were ***:HIIT and mOD training confer similar health-related adaptations.

关键词： Insulin resistance Exercise capacity Glucose tolerance Obesity

The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration

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Sports medicine and Health Science 2021年第4期3卷 212-217页

作者： J.William Deaver Eleanor R.Schrems Lemuel A.Brown Wesley A.Haynie Richard A.Perry Jr. megan E.Rosa-Caldwell michelle A.Tedrowe nicholas P.greene Tyrone A.Washington Exercise muscle Biology Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA Cachexia Research Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA

Diet-induced obesity has previously been shown to occur with the concomitant rise in the expression of proin-flammatory cytokines and increases in collagen *** it has been known that the regenerative process of skeletal muscle is altered in obese mice following an acute muscle injury,we sought to examine differences in the expression of various markers of extracellular matrix remodeling and *** laboratory has previously reported an impaired inflammatory and protein synthetic signaling in these mice that may contribute negatively to the muscle regenerative *** expand upon this previous investigation,tissues from these animals un-derwent further analysis to determine the extent of changes to the regenerative response within the extracellular matrix,including transcriptional changes in CollagenⅠ,CollagenⅢ,and ***,we show that the expression of CollagenⅢ:Ⅰis significantly increased at 3-days post-injury in obese injured animals compared to lean injured animals(p=0.0338),and by 28-days the obese injured animals exhibit a significantly lower CollagenⅢ:Ⅰthan their lean injured counterparts(p=0.0035).We demonstrate an impaired response to an acute muscle injury in obese mice when compared with lean ***,further studies are required to elucidate translational consequences of these changes,as well as to determine any causative mechanisms that may be driving this effect.

关键词： Diet induced obesity Extracellular matrix remodeling Skeletal muscle

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肌醇预防妊娠期糖尿病的meta分析

中国生育健康杂志 2023年第4期34卷 381-387页

作者：纳继根陈慧婷李楠 nicholas D.E.greene 李智文北京大学生育健康研究所/国家卫生健康委员会生育健康重点实验室 100191 北京大学公共卫生学院流行病与卫生统计学系英国伦敦大学学院儿童健康研究所新生婴儿出生缺陷研究中心

肌醇是一种天然存在的营养物质,广泛存在于谷物、玉米、豆类和肉类中。研究发现,肌醇可能作为一种潜在有益的补充剂用于预防妊娠期糖尿病(GDm)发生,孕期服用肌肉肌醇可以显著降低GDm的发生率,并可改善糖耐量异常,增强胰岛素敏感性,减少... 详细信息

肌醇是一种天然存在的营养物质,广泛存在于谷物、玉米、豆类和肉类中。研究发现,肌醇可能作为一种潜在有益的补充剂用于预防妊娠期糖尿病(GDm)发生,孕期服用肌肉肌醇可以显著降低GDm的发生率,并可改善糖耐量异常,增强胰岛素敏感性,减少早产、巨大儿和妊娠期高血压的发生。近年来,国内外关于孕期口服肌醇预防GDm的随机对照试验(RCT)研究逐渐增多,但取得的临床效果存在一定的争议。本文系统性地回顾了9项有关肌醇预防GDm的RCT进行meta分析,以期评价孕期口服肌醇预防GDm的临床效果。

关键词：妊娠期糖尿病(GDm) 肌醇 meta分析随机对照试验