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The Land- potential Knowledge System (LandpKS): mobile apps and collaboration for optimizing climate change investments

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Ecosystem Health and Sustainability 2016年第3期2卷 31-38页

作者： Jeffrey E.Herrick Adam Beh Edmundo Barrios Ioana Bouvier Marina Coetzee David Dent Emile Elias Tomislav Hengl Jason W.Karl Hanspeter Liniger John Matuszak Jason CNeff Lilian Wangui Ndungu Michael Obersteiner Keith D.Shepherd Kevin C.Urama Rik van den Bosch nicholas p.webb U.S.Department of Agriculture-Agricultural Research Service New Mexico State UniversityJornada Experimental Range MSC 3JERBox 30003Las CrucesNew Mexico 88003-8003 USA World Agroforestry Centre United Nations AvenueGigiriP.O.Box 30677Nairobi00100Kenya U.S.Agency for International Development 3014th StreetSW SA-44(Rm 848)WashingtonD.C.20024 USA Namibia University of Science and Technology 13 Storch StreetPrivate Bag 13388WindhoekNamibia Merchants of Light Ltd Forncett EndNorfolkEngland ISRIC-World Soil information Droevendaalsesteeg 36708PB WageningenThe Netherlands Center for the development and Environment University of BernHallerstrasse 103012BernSwitzerland U.S.Department of State/OES 2201 C St.NWWashingtonD.C.20520USA Environmental Studies program University of Colorado at BoulderCampus Box 397BoulderColorado 80309 USA RCMRD SERVIR-Eastern&Southern AfricaP.O.Box 63200618 RuarakaNairobiKenya International Institute for Applied Systems Analysis Schlossplatz 1 A-2361LaxenburgAustria African Development Bank Avenue Jean-Paul II01 BP 1387Abidjan 01Côte d’Ivoire

Massive investments in climate change mitigation and adaptation are projected during coming *** of these investments will seek to modify how land is *** return on both types of investments can be increased through an understanding of land potential:the potential of the land to support primary production and ecosystem services,and its resilience.A Land-potential Knowledge System(LandpKS)is being developed and implemented to provide individual users with point-based estimates of land potential based on the integration of simple,geo-tagged user inputs with cloud-based information and *** system will rely on mobile phones for knowledge and information exchange,and use cloud computing to integrate,interpret,and access relevant knowledge and information,including local knowledge about land with similar *** system will initially provide management options based on long-term land potential,which depends on climate,to-pography,and relatively static soil properties,such as soil texture,depth,and *** mod-ules will provide more specific management information based on the status of relatively dynamic soil properties such as organic matter and nutrient content,and of *** paper includes a discus-sion of how this system can be used to help distinguish between meteorological and edaphic drought.

关键词： agriculture analytics crowdsourcing expert systems extension knowledge management land evaluation land-use planning mobile apps sustainability sustainable land management

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Digital re-analysis of lost architecture and the particular case of Lutyens＇ Liverpool Metropolitan Cathedral

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Frontiers of Architectural Research 2016年第2期5卷 265-275页

作者： nicholas webb Andre Brown School of Architecture University of Liverpool Liverpool L69 7ZN United Kingdom

Research and critique of unbuilt or destroyed works of architecture is traditionally carried out through the examination of surviving information such as drawings, models, photographs, biographies and monographs. The case study presented here demonstrates that this approach cannot always give a fuU-picture of the architect or designer＇s intentions, and may miss inconsistencies in the design and links to other precedents or antecedents in such schemes. Here, we employ strategic contemporary digital representation techniques to re-present and re-analyse the evidence available for a particular architectural project. We describe a systematic methodology, which shows that these techniques can challenge or enhance current understanding. The focus therefore is on the digital re-analysis process that has been devised. Sir Edwin Lutyens＇ unbuilt Liverpool Metropolitan Cathedral design, that would have delivered one of the largest cathedrals in the world, is used as a case study. The findings reveal new information about the cathedral by following structured lines of enquiry generated from the study of primary and secondary source data, as well as serendipitous results that occur as a potential by-product of the methodological process.

关键词： Unbuitt architecture Digitalcritique Forensic anatysis Digitat modetting

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Interactive 360°media for the dissemination of endangered world heritage sites:the ancient city of palmyra in Syria

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Built Heritage 2024年第2期8卷 103-118页

作者： Rida Dieb Ataa Alsalloum nicholas webb Faculty of Architecture Damascus UniversityDamascusSyria School of Architecture University of LiverpoolAbercromby SquareLiverpoolMerseysideL697ZNUK

Since the onset of conflict in Syria in 2011,several heritage sites have suffered partial or complete *** ancient city of palmyra,a UNESCO World Heritage Site since 1980,was placed on the List of World Heritage in Danger in 2013,alongside five other Syrian heritage *** 2015 and 2017,palmyra experienced the loss of nearly 40%of its historic buildings and *** site’s remote location and ongoing armed conflict pose additional challenges in accessing and preserving *** paper introduces an interactive online platform employing 360°media to document and disseminate information about the world heritage site of *** platform contributes to the safeguarding process of palmyra,facilitating public engagement and interaction with the *** also has potential applications for other sites in Syria and *** platform allows users to explore both archival and current information of damaged historical monuments and buildings,revealing their layered histories before and after *** interactive 360°media,similar to applications like Google Street View,the platform offers a reality-based digital *** can virtually move into different buildings or follow specific pathways within the site,accessing archival information and documentation about particular monuments and buildings along their *** project serves as a unique informational resource for decision-makers and policy planners,aiding in the understanding of the site and the development of relevant strategies and *** also proves beneficial as an educational *** collective understanding fostered by this platform is expected to positively influence post-conflict restoration and reconstruction plans,making it an invaluable asset for research and educational purposes.

关键词： palmyra Web platform 360°media tour Cultural heritage Archaeological preservation Heritage in conflict zones

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Neoadjuvant treatment of esophageal cancer

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World Journal of Gastroenterology 2010年第30期16卷 3793-3803页

作者： nicholas p Campbell Victoria M Villaflor Section of Hematology/Oncology Department of MedicineThe University of Chicago Pritzker School of MedicineChicagoIL 60637United States

The management of esophageal cancer has been evolving over the past 30 years. In the United States, multimodality treatment combining chemotherapy and radiotherapy (RT) prior to surgical resection has come to be accepted by many as the standard of care, although debate about its overall effect on survival still exists, and rightfully so. Despite recent improvements in detection and treatment, the overall survival of patients with esophageal cancer remains lower than most solid tumors, which highlights why further advances are so desperately needed. The aim of this article is to provide a complete review of the history of esophageal cancer treatment with the addition of chemotherapy, RT, and more recently, targeted agents to the surgical management of resectable disease.

关键词： Esophageal cancer Multimodality therapy Neoadjuvant therapy Chemotherapy Radiotherapy Targeted agents Disease management

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Shaping Taste: The Molecular Discovery of Rice Genes Improving Grain Size, Shape and Quality

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Journal of Genetics and Genomics 2015年第11期42卷 597-599页

作者： nicholas p.Harberd Department of plant Sciences University of Oxford

Modern-day human life is absolutely dependent upon the food that we derive from our crop plants. We eat grains, fruits, roots, tubers and other structures, all of which are constructed via coordinated organ growth. Whilst plant organ identity is first established in apical meristems （vegetative and floral shoot meristems and root meristems）, and in other meristematic regions, the final size and shape of organs are defined by subsequent coordination of organ expansion in longitudinal and transverse axes.

关键词： QTLs Shaping Taste The Molecular Discovery of Rice Genes Improving Grain Size Shape and Quality gene

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Immune checkpoint inhibitors in cancer therapy

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The Journal of Biomedical Research 2018年第5期32卷 317-326页

作者： Eika S.webb peng Liu Renato Baleeiro nicholas R.Lemoine Ming Yuan Yaohe Wang Center for Molecular Oncology Barts Cancer Institute Queen Mary University of London EC1M 6BQ UK Sino-British Research Centre for Molecular Oncology National Center for International Research in Cell and Gene Therapy Zhengzhou University School of Basic Medical Sciences Academy of Medical Sciences Zhengzhou UniversityZhengzhou Henan 450002 China

In recent years immune checkpoint inhibitors have garnered attention as being one of the most promising types of immunotherapy on the horizon. There has been particular focus on the immune checkpoint molecules, cytotoxic Tlymphocyte antigen-4（CTLA-4） and programmed cell death protein 1（pD-1） which have been shown to have potent immunomodulatory effects through their function as negative regulators of T cell activation. CTLA-4, through engagement with its ligands B7-1（CD80） and B7-2（CD86）, plays a pivotal role in attenuating the activation of naive and memory T cells. In contrast, pD-1 is primarily involved in modulating T cell activity in peripheral tissues via its interaction with pD-L1 and pD-L2. The discovery of these negative regulators of the immune response was crucial in the development of checkpoint inhibitors. This shifted the focus from developing therapies that targeted activation of the host immune system against cancer to checkpoint inhibitors, which aimed to mediate tumor cell destruction through the removal of coinhibitory signals blocking anti-tumor T cell responses.

关键词： checkpoint inhibitor CTLA-4 pD-1 immunotherapy cancer

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Anthropogenic Influence on Decadal Changes in Concurrent Hot and Dry Events over China around the Mid-1990s

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Advances in Atmospheric Sciences 2024年第2期41卷 233-246页

作者： Qin SU Buwen DONG Fangxing TIAN nicholas p.KLINGAMAN Yunnan Key Laboratory of Meteorological Disasters and Climate Resources in the Great Mekong Subregion Yunnan UniversityKunming 650500China Department of Atmospheric Sciences Yunnan UniversityKunming 650500China National Centre for Atmospheric Science Department of MeteorologyUniversity of ReadingReadingRG66BBUK Geofysisk Institut University of BergenBergen 5007Norway Citadel Investment Group Moor House120 London WallLondonRG66BBUK

The frequency and duration of observed concurrent hot and dry events(HDEs) over China during the growing season(April–September) exhibit significant decadal changes across the mid-1990s. These changes are characterized by increases in HDE frequency and duration over most of China, with relatively large increases over southeastern China(SEC), northern China(NC), and northeastern China(NEC). The frequency of HDEs averaged over China in the present day(pD,1994–2011) is double that in the early period(Ep, 1964–81);the duration of HDEs increases by 60%. Climate experiments with the Met Office Unified Model(MetUM-GOML2) are used to estimate the contributions of anthropogenic forcing to HDE decadal changes over China. Anthropogenic forcing changes can explain 60%–70% of the observed decadal changes,suggesting an important anthropogenic influence on HDE changes over China across the mid-1990s. Single-forcing experiments indicate that the increase in greenhouse gas(GHG) concentrations dominates the simulated decadal changes,increasing the frequency and duration of HDEs throughout China. The change in anthropogenic aerosol(AA) emissions significantly decreases the frequency and duration of HDEs over SEC and NC, but the magnitude of the decrease is much smaller than the increase induced by GHGs. The changes in HDEs in response to anthropogenic forcing are mainly due to the response of climatological mean surface air temperatures. The contributions from changes in variability and changes in climatological mean soil moisture and evapotranspiration are relatively small. The physical processes associated with the response of HDEs to GHG and AA changes are also revealed.

关键词： concurrent hot and dry events decadal variation greenhouse gases aerosol emissions

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On Northern Hemisphere Wave patterns Associated with Winter Rainfall Events in China

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Advances in Atmospheric Sciences 2018年第8期35卷 125-138页

作者： Claudia Christine STEpHAN Yan Ho NG nicholas p. KLINGAMAN National Centre for Atmospheric Science - Climate Department of Meteorology University of Reading Reading RG6 6BB United Kingdom Department of Meteorology University of Reading Reading RG6 6BB United Kingdom

During extended winter （November-April）, 43% of the intraseasonal rainfall variability in China is explained by three spatial patterns of temporally coherent rainfall, These patterns were identified with empirical orthogonal teleconnection （EOT） analysis of observed 1982-2007 pentad rainfall anomalies and connected to midlatitude disturbances. However, ex- amination of individual strong EOT events shows that there is substantial inter-event variability in their dynamical evolution, which implies that precursor patterns found in regressions cannot serve as useful predictors. To understand the physical nature and origins of the extratropical precursors, the EOT technique is applied to six simulations of the Met Office Unified Model at horizontal resolutions of 200-40 km, with and without air-sea coupling. All simulations reproduce the observed precursor patterns in regressions, indicating robust underlying dynamical processes. Further investigation into the dynamics associated with observed patterns shows that Rossby wave dynamics can explain the large inter-event variability. The results suggest that the appaxently slowly evolving or quasi-stationaxy waves in regression analysis are a statistical amalgamation of more rapidly propagating waves with a variety of origins and properties.

关键词： rainfall in China spring flooding Rossby wave dynamics EOT analysis predictability teleconnections

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A polarizing situation： Taking an in-plane perspective for next-generation near-field studies

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Frontiers of physics 2016年第2期11卷 1-17页

作者： p. James Schuck Wel Bao nicholas J. Borys Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Department of Materials Science and Engineering University of California Berkeley CA 94720-1760 USA

By enabling the probing of light-matter interactions at the functionally relevant length scales of most materials, near-field optical imaging and spectroscopy accesses information that is unobtainable with other methods. The advent of apertureless techniques, which exploit the ultralocalized and enhanced near-fields created by sharp metallic tips or plasmonic nanoparticles, has resulted in rapid adoption of near-field approaches for studying novel materials and phenomena, with spatial resolution approaching sub-molecular levels. However, these approaches are generally limited by the dominant out-of-plane polarization response of apertureless tips, restricting the exploration and discovery of many material properties. This has led to recent design and fabrication breakthroughs in near-field tips engineered specifically for enhancing in-plane interactions with near-field light components. This mini-review provides a perspective on recent progress and emerging directions aimed at utilizing and controlling in-plane optical polarization, highlighting key application spaces where in-plane near-field tip responses have enabled recent advancements in the understanding and development of new nanostructured materials and devices.

关键词： near-field optical microscopy nano-optics TERS plasmonics optical antenna 2D materials

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Green Revolution DELLAs: From translational reinitiation to future sustainable agriculture

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Molecular plant 2021年第4期14卷 547-549页

作者： Qian Liu Kun Wu nicholas p.Harberd Xiangdong Fu State Key Laboratory of plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Department of plant Sciences University of OxfordSouth Parks RoadOxford 0X13RBUK College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

The Green Revolution(GR)of the 1960s saw spectacular increases in cereal crop yields,enabled by widespread adoption of high-yielding semi-dwarf varieties and increased fertilizer ***-dwarfism is caused by mutant wheat Reduced height-1(Rht-1)and rice semi-dwarf1(sd1)alleles,respectively,which confer increased harvest index(grain to straw ratio)and reduced yield loss from“lodging”(flattening of crops by wind or rain).However,despite their obvious global food security benefits,the underlying mechanisms via which GR dwarfing alleles actually work remained *** began to change with the molecular discovery of Rht1(peng et al.,1999).

关键词： dwarf crops cereal

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