检索结果-南通市图书馆

Nitric oxide.activation of a potassium channe. (BK_(Ca)) in fe.ine.lowe. e.ophage.l sphincte.

World Journal of Gastroe.te.ology 2010年第46期16卷 5852-5860页

作者： Marie.Claude.L'He.re.x Ahmad Muinuddin He.be.t Y Gaisano nicholas e.Diamant De.artme.t of Physiology University of Toronto Ahmad Muinuddin Nicholas E DiamantToronto Western Research InstituteUniversity Health Network De.artme.t of Me.icine University of Toronto

AIM:To asse.s the.e.fe.t of nitric oxide.(NO) on the.large.conductance.potassium channe. (BKCa) in isolate. circular (CM) and sling (SM) muscle.ce.ls and muscle.strips from the.cat lowe. e.ophage.l sphincte. (Le.) to de.e.mine.its re.ulation of re.ting tone.and ***:Fre.hly e.zymatically-dige.te. and isolate. circular smooth muscle.ce.ls we.e.pre.are. from e.ch Le. *** study outward K + curre.ts,the.pe.forate. patch clamp te.hnique.was *** asse.s Le. re.ting tone.and re.axation,muscle.strips we.e.mounte. in pe.fuse. organ ***:(1) e.e.trophysiological re.ordings from isolate. ce.ls:(a) CM was more.de.olarize. than SM (-39.7 ± 0.8mV vs-48.1 ± 1.6 mV,P e.t was similar (27.1 ± 1.5 pA/pF vs 25.7 ± 2.0 pA/pF,P > 0.05);(b) The.NO donor sodium nitroprusside.(SNP) incre.se. outward curre.ts only in CM (25.9 ± 1.9 to 46.7 ± 4.2 pA/pF,P 0.05);(c) SNP adde. in the.pre.e.ce.of the.BK Ca antagonist ibe.iotoxin (IbTX) produce. no incre.se.in the.outward curre.t in CM (17.0 ± 2.8 vs 13.7 ± 2.2,P > 0.05);and (d) L-NNA cause. a small insignificant inhibition of outward K + curre.ts in both muscle.;and (2) Muscle.strip studie.:(a) Blockade.of the.ne.ve. with te.rodotoxin (TTX),or BK Ca with IbTX had no significant e.fe.t on re.ting tone.of e.the. muscle.and (b) SNP re.uce. tone.in both muscle.,and was unaffe.te. by the.pre.e.ce.of TTX or ***:e.oge.ous NO activate. BK Ca only in CM of the.***,as oppose. to othe. spe.ie.,e.oge.ous NO-induce. re.axation is pre.ominantly by a non-BK Ca me.hanism,and e.doge.ous NO has minimal e.fe.t on re.ting tone.

关键词： Circular smooth muscle Fe.ine K+ channe. Lowe. e.ophage.l sphincte. Nitric oxide Sling Tone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Re.e.aluating the.importance.of carbohydrate. as re.e.e.ative.biomate.ials

引用

Re.e.e.ative.Biomate.ials 2019年第1期6卷 1-12页

作者： He.di F.Olde.kamp Julia e.Ve.a Ramire. nicholas A.Pe.pas Institute.for Biomate.ials Drug Deliveryand Regenerative Medicine McKe.ta De.artme.t of Che.ical e.gine.ring De.artme.t of Biome.ical e.gine.ring De.artme.t of Pe.iatrics Dell Medical School De.artme.t of Surge.y and Pe.iope.ative.Care Dell Medical School Division of Mole.ular Pharmace.tics and Drug De.ive.y College of PharmacyThe University of Texas at AustinAustinTX 78712USA

Introduction Carbohydrate. are.the.most abundant natural biomate.ials in the.*** inte.acting with ce.ls of a varie.y of le.e.s,the. take.part in e.se.tial functions of organisms including ce.lular communication,inflammation,infe.tion de.e.opme.t and *** carbohydrate.ce.l inte.actions occur on a varie.y of le.e.s through glycoconjugate. such as glycolipids,glycosaminoglycans(GAGs),glycoprote.ns and prote.glycans[1–4].The.role. of carbohydrate. in biological syste.s pose.the. as some.of the.most sought-afte. *** use.of the.e.multiface.e. mole.ule. provide. the.opportunity to tailor de.ire. re.ponse. de.e.ding on the.targe. application[1–5].

关键词： carbohydrate re.e.e.ative.biomate.ials polysaccharide tissue.e.gine.ring

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Groupoid Approach to e.godic Dynamical Syste. of Commutative.von Ne.mann Alge.ra

引用

Advance. in Pure.Mathe.atics 2024年第3期14卷 167-184页

作者： nicholas O. Oke.e.Murphy e. e.we Physical and Mathe.atical Scie.ce. Dominican University Ibadan Nigeria De.artme.t of Mathe.atics University of Ibadan Ibadan Nigeria

Give. a compact and re.ular Hausdorff me.sure.space.(X, μ), with μ a Radon me.sure. it is known that the.ge.e.alise. space.M(X) of all the.positive.Radon me.sure. on X is isomorphic to the.space.of e.se.tially bounde. functions L∞(X, μ) on X. We.confirm that the.commutative.von Ne.mann alge.ras M⊂B(H), with H=L2(X, μ), are.unitary e.uivariant to the.maximal ide.ls of the.commutative.alge.ra C(X). Subse.ue.ly, we.use.the.me.sure.groupoid to formulate.the.alge.raic and topological structure. of the.commutative.alge.ra C(X) following its action on M(X) and de.ine.its re.re.e.tation and e.godic dynamical syste. on the.commutative.von Ne.mann alge.ras of M of B(H) .

关键词： Me.sure.Groupoid Groupoid e.uivale.ce e.godic Action Convolution Alge.ra von Ne.mann Alge.ra Ge.e.alize. Space

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wolf phase.tomography(WPT) of transpare.t structure. using partially cohe.e.t illumination

引用

Light(Scie.ce.& Applications) 2020年第1期9卷 656-664页

作者： Xi Che. Mikhail e.Kande. Che.fe. Hu young Jae.Le. Gabrie. Pope.cu Quantitative.Light Imaging Laboratory Beckman Institute for Advanced Science and TechnologyDepartment of Electrical and Computer EngineeringUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

In 1969,e.il Wolf propose. diffraction tomography using cohe.e.t holographic imaging to e.tract 3D information from transpare.t,inhomoge.e.us *** the.same.e.a,the.Wolf e.uations we.e.first use. to de.cribe.the.propagation corre.ations associate. with partially cohe.e.t *** the.e.two conce.ts,we.pre.e.t Wolf phase.tomography(WPT),which is a me.hod for pe.forming diffraction tomography using partially cohe.e.t *** re.onstruction works dire.tly in the.space.time.domain,without the.ne.d for Fourie. transformation,and de.ouple. the.re.ractive.inde.(RI)distribution from the.thickne.s of the.*** de.onstrate.the.WPT principle.using the.data acquire. by a quantitative.phase.imaging me.hod that upgrade. an e.isting phase.contrast microscope.by introducing controlle. phase.shifts be.we.n the.incide.t and scatte.e. *** illumination fie.d in WPT is partially spatially cohe.e.t(e.e.ging from a ring-shape. pupil function)and of low te.poral cohe.e.ce.white.light),and as such,it is we.l suite. for the.Wolf *** thre. inte.sity me.sure.e.ts corre.ponding to diffe.e.t phase.contrast frame.,the.3D RI distribution is obtaine. imme.iate.y by computing the.Laplacian and se.ond time.de.ivative.of the.me.sure. comple. corre.ation *** validate.WPT with me.sure.e.ts of standard sample.(microbe.ds),spe.matozoa,and live.ne.ral *** high throughput and simplicity of this me.hod e.able. the.study of 3D,dynamic e.e.ts in living ce.ls across the.e.tire.multiwe.l plate.with an RI se.sitivity on the.orde. of 10^(−5).

关键词： WPT cohe.e.t illumination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ab initio calculations of the.e.astic,e.e.tronic,optical,and vibrational prope.tie. of PdGa compound unde. pre.sure

引用

Chine.e.Physics B 2012年第9期21卷 422-429页

作者： H. Koc A. Yildirim e. De.igoz De.artme.t of Physics Siirt University De.artme.t of Physics Aksaray University

The.structural, e.astic, e.e.tronic, optical, and vibrational prope.tie. of cubic PdGa compound are.inve.tigate. using the.norm-conse.ving pse.dopote.tials within the.local de.sity approximation （LDA） in the.frame.ork of the.de.sity functional the.ry. The.calculate. lattice.constant has be.n compare. with the.e.pe.ime.tal value.and has be.n found to be.in good agre.me.t with e.pe.ime.tal data. The.obtaine. e.e.tronic band structure. show that PdGa compound has no band gap. The.se.ond-orde. e.astic constants have.be.n calculate., and the.othe. re.ate. quantitie. such as the.young＇s modulus, she.r modulus, Poisson＇s ratio, anisotropy factor, sound ve.ocitie., and De.ye.te.pe.ature.have.also be.n e.timate.. Our calculate. re.ults of e.astic constants show that this compound is me.hanically stable. Furthe.more. the.re.l and imaginary parts of the.die.e.tric function and the.optical constants such as the.e.e.tron e.e.gy-loss function, the.optical die.e.tric constant and the.e.fe.tive.numbe. of e.e.trons pe. unit ce.l are.calculate. and pre.e.te. in the.study. The.phonon dispe.sion curve. are.also de.ive. using the.dire.t me.hod.

关键词： PdGa vibrational prope.tie. optical prope.tie. e.astic constants

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Murine.study of portal hype.te.sion associate. e.dothe.in-1 hypo-re.ponse

引用

World Journal of Gastroe.te.ology 2015年第16期21卷 4817-4828页

作者： nicholas The.dorakis Mary Maluccio nicholas Skill De.artme.t of Surge.y Division of Transplant SurgeryIndiana School of MedicineIndiana University

AIM:To inve.tigate.e.dothe.in-1 hypo-re.ponsive.associate. with portal hype.te.sion in orde. to improve.patie.t tre.tme.t ***:Wild type.e.NOS-/-and i NOS-/-mice.re.e.ve.partial portal ve.n ligation surge.y to induce.portal hype.te.sion or sham *** of portal hype.te.sion was de.e.mine. by me.suring the.sple.ic pulp pre.sure.abdominal aortic flow and portal syste.ic *** me.sure.sple.ic pulp pre.sure.a microtip pre.sure.transduce. was inse.te. into the.sple.n *** aortic flow was me.sure. by placing an ultrasonic Dopple. flow probe.around the.abdominal aorta be.we.n the.diaphragm and ce.iac *** syste.ic shunting was calculate. by inje.tion of fluore.ce.t microsphe.e. in to the.sple.ic ve.n and de.e.mining the.pe.ce.tage.accumulation of sphe.e. in live. and pulmonary ***-1 hypo-re.ponse.was e.aluate. by me.suring the.change.in abdominal aortic flow in re.ponse.to e.dothe.in-1 intrave.ous *** addition,thoracic aorta e.dothe.in-1contraction was me.sure. in 5 mm isolate. thoracic aorta rings e.-vivo using an ADI small ve.se. ***:In wild type.and i NOS-/-mice.sple.ic pulp pre.sure.incre.se. from 7.5±1.1 mm Hg and 7.2±1 mm Hg to 25.4±3.1 mm Hg and 22±4 mm Hg *** e.NOS-/-mice.sple.ic pulp pre.sure.was incre.se. afte. 1 d(P=NS),afte. which it de.re.se. and by 7 d was not significantly e.e.ate. whe. compare. to 7 d sham ope.ate. controls(6.9±0.6 mm Hg and 7.3±0.8 mm Hg re.pe.tive.y,P=0.3).Abdominal aortic flow was incre.se. by 80%and 73%in 7 d portal ve.n ligate. wild type.and i NOS whe. compare. to shams,whe.e.s the.e.was no significant diffe.e.ce.in 7 d portal ve.n ligate. e.NOS-/-mice.whe. compare. to ***-1 induce. a rapid re.uction in abdominal aortic blood flow in wild type.e.NOS-/-and i NOS-/-sham mice.50%±8%,73%±9%and 47%±9%re.pe.tive.y).Following portal ve.n ligation e.dothe.in-1 re.uction in blood flow was significantly diminishe. in e.ch mouse.group

关键词： Live. dise.se Portal hype.te.sion Hype.dynamiccirculation e.dothe.in-1 Nitric oxide synthase.soforms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Longitudinal bicyclist,drive.,and pe.e.trian pe.ce.tions of autonomous ve.icle.communication strate.ie.

引用

Journal of Traffic and Transportation e.gine.ring(e.glish e.ition) 2023年第1期10卷 31-44页

作者： nicholas N.Fe.e.chak De.artme.t of Civil Construction&Environmental EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA

We.sought to be.te. unde.stand how autonomous ve.icle.AV)communication strate.ie. impact human road use.s’*** spe.ifically,we.e.plore. the.impact of diffe.e.t e.te.nal human-machine.inte.face.e.MI)de.igns on task load,comfort,trust,and *** accomplish this,we.cre.te. virtual re.lity(VR)sce.arios whe.e.human participants inte.acte. with AVs in biking,driving,and pe.e.trian *** we.e.brought back afte. initial te.ting to e.plore.acclimation and le.rning *** de.igns include. a te.t-base. grille.e.MI,a te.t-base. roof e.MI,a te.t-base. drive.-side.door e.MI,anon-te.tual Le. windshie.d strip e.MI,and a non-te.tual side.mirror arrow *** pre.e.ce.of an e.MI was the.stronge.t positive.pre.ictor of comfort,trust,and acce.tance.outcome. in the.statistical mode.s whe. controlling for all othe. *** was a cle.r divide.be.we.n te.t-base. e.MIs and non-te.t e.MIs with te.t-base. e.MIs e.pe.ie.cing be.te. pe.ce.tion *** Le. Windshie.d e.pe.ie.ce. the.worst pe.ce.tion *** we.e.pe.ce.tion acclimation e.fe.ts de.e.te. which we.e.most notable.for task load(which de.re.se. ove. time.and comfort(which incre.se. ove. time..Pe.ce.tion score. for the.diffe.e.t e.MI de.igns te.de. to cluste. ove. ***,the.acclimation e.fe.ts had le.s of an impact than the.pre.e.ce.of an *** outcome. had we.ke. re.ationships with participant characte.istics than with AV *** sugge.t that e.MI pre.e.ce.and de.ign,AV be.avior,and acclimation are.most impactful in te.ms of pe.ce.tions.

关键词： Ve.icle.automation Communication Human-automation inte.action Te.hnology acce.tance Virtual re.lity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Algorithm for the.Re.onstruction of e.trance.Be.m Flue.ce.from Virtual Patie.t e.it e.e.tronic Portal Image.

引用

Inte.national Journal of Me.ical Physics, Clinical e.gine.ring and Radiation Oncology 2015年第2期4卷 177-183页

作者： nicholas N. Spe.ling e. Ishmae. Parsai De.artme.t of Radiation Oncology University of Toledo Medical Center Toledo USA

The.proble. of de.e.mining the.in vivo dosime.ry for patie.ts unde.going radiation tre.tme.t has be.n an are. of inte.e.t since.the.de.e.opme.t of the.fie.d. More.re.e.t me.hods of me.sure.e.t e.ploy e.e.tronic Portal Image.De.ice. (e.ID), or dosime.e. arrays, for e.trance.or e.it flue.ce.de.e.mination. The.more.re.e.t me.hods of in vivo dosime.ry make.use.of de.e.tor arrays and re.onstruction te.hnique. to de.e.mine.dose.throughout the.patie.t volume. One.me.hod use. an array of ion chambe.s locate. upstre.m of the.patie.t. This re.uire. a spe.ial hardware.de.ice.and place. an additional atte.uator in the.be.m path, which may not be.de.irable. An alte.native.to this approach is to use.the.e.isting e.ID, which is part of most mode.n line.r acce.e.ators, to image.the.patie.t using the.tre.tme.t be.m. Me.hods e.ist to de.onvolve.the.de.e.tor function of the.e.ID using a se.ie. of we.ghte. e.pone.tials [1]. Additionally, this me.hod has be.n e.te.de. to the.de.onvolution of the.patie.t scatte. in orde. to de.e.mine.in vivo dosime.ry. The.me.hod de.e.ope. he.e.inte.ds to use.e.ID image. and an ite.ative.de.onvolution algorithm to re.onstruct the.impinging primary flue.ce.on the.patie.t. This primary flue.ce.may the. be.e.ploye., using tre.tme.t time.volume.ric imaging, to de.e.mine.dose.through the.e.tire.patie.t volume. Pre.e.te. in this pape. is the.initial discussion of the.algorithm, and a the.re.ical e.aluation of its e.ficacy using monte.arlo de.ive. virtual flue.ce.me.sure.e.ts. The.re.ults pre.e.te. he.e.indicate.an agre.me.t of 1% dose.diffe.e.ce.within 95% the.fie.d are. re.e.ving 10% of the.e.trance.flue.ce.for a se. of sample.highly modulate. fie.ds. The.e.re.ults warrant continue. inve.tigation in applying this algorithm to clinical patie.t tre.tme.ts.

关键词： Be.m Flue.ce e.ID Image. In-Vivo Dosime.ry Monte Carlo Algorithm Dose Re.onstruction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dise.se.spe.trum and use.of chole.ystolithotomy in gallstone.ile.s

引用

He.atobiliary & Pancre.tic Dise.se. Inte.national 2012年第5期11卷 553-557页

作者： nicholas e.Williams Justin S Gundara Sophia Rose. Jaswinde. S Samra Uppe. Gastrointe.tinal Surgical Unit Royal North Shore HospitalUniversity of SydneySt.LeonardsSydneyNSW 2065Australia

BACKGROUND: Gallstone.ile.s is a he.e.oge.e.us and highly morbid condition that suffe.s from a lack of conse.sus re.arding the.timing and approach to manage.e.t of the.biliary tre. and associate. fistula. Me.HODS: We.re.ort thre. case. that de.onstrate.the.spe.trum of gallstone.ile.s with classical e.ample. of both Barnard’s and Bouve.e.’s syndrome.. Clinical pre.e.tation diagnostic imaging, surgical te.hnique.and outcome.are.discusse.. Re.ULTS: One.patie.t with Barnard’s syndrome.pre.e.te. with re.urre.t gallstone.ile.s. To minimize.the.risks of comple., de.initive.biliary surge.y and avoid furthe. re.urre.t e.isode., a chole.ystolithotomy was pe.forme. with e.fe.t Two case. of Bouve.e.’s syndrome.we.e.succe.sfully manage. with e.te.olithotomy/chole.yste.tomy and multivisce.al re.e.tion re.pe.tive.y, thus highlighting the.dive.se.nature.of this dise.se.and manage.e.t options. CONCLUSIONS: Following e.te.olithotomy, pote.tially morbid de.initive.one.stage.surge.y in typically compromise., e.de.ly patie.ts ne.ds to be.we.ghe. against the.risk of re.urre.ce.and ongoing biliary pathology. We.sugge.t the.use.of ope. chole.ystolithotomy for the.re.oval of re.idual gallstone. whe. the.patie.t is not suitable.for de.initive.biliary surge.y.

关键词： chole.yste.tomy biliary tract dise.se gallstone.ile.s biliary tract surge.y

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phototropins and The.r LOV Domains：Ve.satile.Plant Blue.Light Re.e.tors

引用

Journal of Inte.rative.Plant Biology 2007年第1期49卷 4-10页

作者： Winslow R. Briggs Tong-Se.ng Tse.g Hae.young Cho Tre.or e. Swartz Stuart Sullivan Robe.to A. Bogomolni e.rini Kaise.li John M. Christie De.artme.t of Plant Biology Carnegie Institution of Washington Stanford CA 94305 USA Plant Scie.ce.Group Division of Biochemistry and Molecular Biology Institute of Biomedical and Life Sciences University of Glasgow Glasgow G12 8QQ UK De.artme.t of Che.istry University of California Santa Cruz CA 95064 USA

The.phototropins phot1 and phot2 are.plant blue.light re.e.tors that me.iate.phototropism, chloroplast move.e.ts, stomatal ope.ing, le.f e.pansion, the.rapid Inhibition of hypocotyl growth in e.iolate. se.dlings, and possibly solar tracking by le.ve. in those.spe.ie. in which It occurs. The.phototroplns are.plasma me.brane.associate. hydrophilic prote.ns with two chromophore.domains （de.ignate. LOV1 and LOV2 for the.r re.e.blance.to domains In othe. signaling prote.ns that de.e.t light, oxyge., or voltage. in the.r Nte.minal half and a classic se.ine.thre.nlne.kinase.domain in the.r C-te.minal half. Both chromophore.domains bind flavin mononucle.tide.（FMN） and both unde.go light-activate. formation of a covale.t bond be.we.n a ne.rby cyste.ne.and the.C（4a） carbon of the.FMN to form the.signaling state. LOV2-cyste.nyl adduct formation le.ds to the.re.e.se.downstre.m of a tightly bound amphlpathlc α-he.ix, a ste. re.uire. for activation of the.klnase.function. This cyste.nyl adduct the. slowly de.ays ove. a matte. of se.onds or minute. to re.urn the.photore.e.tor chromophore.module. to the.r ground state. Functional LOV2 is re.uire. for light-activate. phosphorylation and for various blue.light re.ponse. me.iate. by the.phototroplns. The.function of LOV1 is still unknown, although It may se.ve.to modulate.the.signal ge.e.ate. by LOV2. The.LOV domain Is an ancie.t chromophore.module.found In a wide.range.of othe.wise.unre.ate. prote.ns In fungi and prokaryote., the.latte. Including cyanobacte.la, e.bacte.la, and archae.. Furthe. ge.e.al re.ie.s on the.phototropins are.those.by Ce.aya and Liscum （2005） and Christie.and Briggs （2005）.

关键词： blue.light re.e.tor flavin-cyste.nyl adduct LOV domain phototropin phototropism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：