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Characterization and validation of a chronic retinal neovascularization rabbit model by evaluating the efficacy of anti-angiogenic and anti-inflammatory drugs

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 15-22页

作者： Sandeep Kumar John Quach nicholas cook Glenwood Gum Vatsala Naageshwaran Department of Ophthalmology Absorption Systems:a Pharmaron company7901 Vickers StSan DiegoCA 92111USA

AIM:To establish a rabbit model with chronic condition of retinal neovascularization(RNV)induced by intravitreal(IVT)injection of DL-2-aminoadipic acid(DL-AAA),a retinal glial(Mül er)cell toxin,extensive characterization of DL-AAA induced angiographic features and the suitability of the model to evaluate anti-angiogenic and anti-inflammatory therapies for ocular vascular ***:DL-AAA(80 mmol/L)was administered IVT into both eyes of Dutch Belted *** DL-AAA delivery,clinical ophthalmic examinations were performed weekly following modified Mc Donald-Shadduck Scoring *** fundus photography,fluorescein angiography(FA),and optical coherence tomography(OCT)procedures were performed every 2 or 4 wk until stable retinal vascular leakage was *** stable retinal leakage(12 wk post DL-AAA administration)was established,anti-vascular endothelial growth factor(VEGF)(bevacizumab,ranibizumab and aflibercept)and anti-inflammatory(triamcinolone,TAA)drugs were tested for their efficacy after IVT *** angiograms were scored before and after treatment following a novel grading system,developed for the DL-AAA rabbit ***:Post DL-AAA administration,eyes were presented with moderate to severe retinal/choroidal inflammation which was accompanied by intense vitreous flare and presence of inflammatory cells in the vitreous *** hemorrhage was restricted to the tips of neo-retinal *** revealed maximum retinal vascular leakage at 2 wk after DL-AAA injection and then persisted as evidenced by stable mean FA scores in weeks 8 and *** vascular angiographic and tomographic features were stable and consistent up to 36 mo among two different staggers induced for RNV at two different *** 7,mean FA scores showed that 1μg/eye of bevacizumab,ranibizumab,aflibercept and 2μg/eye of TAA suppress 65%,90%,100%and 50%retinal vascular leakage,*** 30,bevacizumab and TAA continued to show 66%and 44%su

关键词： DL-2-aminoadipic acid chronic wet agerelated macular degeneration retinal neovascularization animal model anti-vascular endothelial growth factor drugs fluorescein angiography

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音乐中的相遇:在音乐中听到相关性

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大音 2020年第1期14卷 -页

作者：尼古拉斯·库克严逸澄(译) 剑桥大学上海音乐学院

《音乐中的相遇:在音乐中听到相关性》是前剑桥大学教授尼古拉斯·库克于2016年大音论坛上发表的主旨讲座。该讲座跳出了从纯文本角度观察音乐的方式,转而挖掘社会性特质在音乐中的体现。所谓"相关性",意指参与音乐活动中牵涉的人际交互... 详细信息

《音乐中的相遇:在音乐中听到相关性》是前剑桥大学教授尼古拉斯·库克于2016年大音论坛上发表的主旨讲座。该讲座跳出了从纯文本角度观察音乐的方式,转而挖掘社会性特质在音乐中的体现。所谓"相关性",意指参与音乐活动中牵涉的人际交互,或由这种交互促进与生发的事。库克以跨文化语境为基础,通过交互性观察角度,讨论音乐在个体与群体认同构建中的作用。

关键词：相关性社会性交互认同跨文化

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Factor analysis identifies subgroups of constipation

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World Journal of Gastroenterology 2011年第11期17卷 1468-1474页

作者： Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski nicholas J Talley Ian J cook Department of Gastroenterology St.George HospitalUniversity of New South WalesKogarahNSW 2217Australia Department of Psychology Macquarie UniversityNSW 2109Australia Gastroenterology Research Unit Nepean HospitalUniversity of SydneySydneyNSW 2050Australia Department of Colorecta Surgery St.George HospitalKogarahNSW 2217Australia Gastroenterology and Hepatology Mayo ClinicJacksonvilleFL 32224United States

AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic ***:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport *** hundred of these patients had colonic transit measured *** analysis determined whether constipation-related symptoms grouped into distinct aspects of *** analysis was used to determine whether indi-vidual patients naturally group into distinct ***:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main *** all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool *** majority of patients with these characteristics also reported regular laxative ***:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated ***,clear stratification into clinically identifiable groups remains imprecise.

关键词：大便秘结因子分析识别亚群润肠通便聚类分析病理生理功能紊乱

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Predicting flows through microfluidic circuits with fluid walls

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Microsystems & Nanoengineering 2021年第6期7卷 119-127页

作者： Cyril Deroy nicholas Stovall-Kurtz Federico Nebuloni Cristian Soitu Peter R.cook Edmond J.Walsh Department of Engineering Science Osney Thermo-Fluids LaboratoryUniversity of OxfordOxford OX20ESUK Sir William Dunn School of Pathology University of OxfordOxford OX13REUK Cold Spring Harbor Laboratory Cold Spring HarborNYUSA

The aqueous phase in traditional microfluidics is usually confined by solid walls;flows through such systems are often predicted *** solid walls limit access,open systems are being developed in which the aqueous phase is partly bounded by fluid walls(interfaces with air or immiscible liquids).Such fluid walls morph during flow due to pressure gradients,so predicting flow fields remains *** recently developed a version of open microfluidics suitable for live-cell biology in which the aqueous phase is confined by an interface with an immiscible and bioinert fluorocarbon(FC40).Here,we find that common medium additives(fetal bovine serum,serum replacement)induce elastic no-slip boundaries at this interface and develop a semi-analytical model to predict flow *** experimentally validate the model’s accuracy for single conduits and fractal vascular trees and demonstrate how flow fields and shear stresses can be controlled to suit individual applications in cell biology.

关键词： walls flows flow

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Acute Toxicity of Ammonia and its Effects on the Haemolymph Osmolality,Ionic Composistion,Ammonia-N And pH Levels of Early Juvenile Mud Crabs,Scylla serrata

Acute Toxicity of Ammonia and its Effects on the Haemolymph ...

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中国甲壳动物学会第十一届年会暨学术研讨会

作者： nicholas Romano Tropical Crustacean Aquaculture Research Group School of Marine and Tropical Biology James cook University

＜正＞Over the past decade,the farming of mud crab,Scylla serrata,is expanding rapidly throughout the Indo-Pacific *** is well known that ammonia levels are one of the most limiting factors on a closed aquaculture sys...

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中国需要建设基于网络的迁徙鸟类监测和保护系统

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Science Bulletin 2021年第10期66卷 955-957页

作者：司亚丽徐菲魏洁张琳 nicholas Murray 杨锐马克平宫鹏 Ministry of Education Field Research Station for East Asian Migratory Birds Department of Earth System Science Tsinghua UniversityBeijing 100086China Institute of Environmental Sciences Leiden UniversityLeiden 2311 CTthe Netherlands College of Science and Engineering James Cook UniversityTownsville 4811Australia Institute for National Parks Tsinghua UniversityBeijing 100086China Institute of Botany Chinese Academy of SciencesBeijing 100093China

The East Asian-Australasian Flyway (EAAF) is the most threatened flyway worldwide, encompassing the greatest number of threatened migratory bird species of all flyways on Earth [1]. This is largely attributed to pronounced human-bird conflicts in Asia,leading to elevated rates of habitat loss, degradation, and illegal hunting [2,3].

关键词： habitat 迁徙鸟类 attributed

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Prevention of heart disease in women: Considerable challenges remain

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Open Journal of Nursing 2012年第3期2卷 176-180页

作者： Melissa Sherrod nicholas McIntire Sherrod Mandy Tate Spitzer Dennis Cheek cook Children’s Healthcare System Fort Worth USA Harris College of Nursing Texas Christian University Fort Worth USA

Although awareness of cardiovascular disease (CVD) as the leading cause of death among U.S. women has improved over the past decade, factors such as obesity, untreated hypertension, diabetes and the lack of access to healthcare services prevent healthcare providers from making additional gains in the fight against heart disease. Due to demographic changes in the U.S., healthcare providers are beginning to acknowledge the challenge of providing quality care to a diverse population. Root causes of health care disparities include variations and lack of provider understanding of health beliefs, cultural values and preferences, and patients’ inability to communicate symptoms in multiple languages. Barriers related to the patient, care provider and the healthcare system are discussed as well as ideas that will help address the challenges we face going forward.

关键词： Cardiovascular Disease Risk Factors AHA Guidelines Prevention Women

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Effect of Tropical Algae as Additives on Rumen <i>in Vitro</i>Gas Production and Fermentation Characteristics

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American Journal of Plant Sciences 2013年第12期4卷 34-43页

作者： Baptiste Dubois Nigel W. Tomkins Robert D. Kinley Mei Bai Scott Seymour nicholas A. Paul Rocky de Nys AgroParisTech 16 rue Claude Bernard Paris France CSIRO Livestock Industries Australian Tropical Sciences Innovation Pre- cinct James Cook Drive James Cook University Townsville Australia School of Marine and Tropical Biology James Cook Uni- versity Townsville Australia

Algae have become an area of intensive research in many fields of study. Areas of application are becoming increasingly diverse with the advent of technologies particularly in the mass production of algae biomass. Algae contain complex bioactive compounds and these are gaining importance in emerging technologies with nutritional and environmental applications. In this study, a preliminary investigation evaluated 15 species of algae from the major categories of marine and fresh water algae for their potential as inclusions in ruminant diets for management of greenhouse gas emissions. It was hypothesized that algae would positively affect rumen fermentation and gas production while reducing methane production. The hypothesis was tested using an Ankom automated gas monitoring system and rumen fluid from Bos indicus steers fed tropical forage diets. The results were variable between algae species with some showing a significant reduction in total gas and methane production, with others increasing gas and fermentation. The red and brown algae stand out as having potential for greenhouse gas mitigation with the brown alga Cystoseira having the most prominent effect. The effects observed on fermentation may be manipulated through dosage management and beneficial effects could be potentially maximized by preparing combinations of algal supplements. It has been demonstrated in this study that algae have the potential to assist in rumen fermentation management for improved gas production, and greenhouse gas abatement.

关键词： Algae Enteric Gas Macroalgae Methane Rumen Seaweed

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