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Does Anesthesiologist-Directed Sedation Afford Superior Deep Cannulation Rates and Procedural Outcomes for ERCP in the Community Setting?

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Open Journal of Gastroenterology 2016年第2期6卷 46-52页

作者： brad bowyer Kathy Geissler Robert barclay Sumeet Tewani James Frakes nicholas brown Matthew Houlihan Kunal Patel Andrew Spiel Rockford Gastroenterology Associates Rockford IL USA University of Illinois College of Medicine Rockford Rockford IL USA

Aim: To compare outcomes by sedation class in community patients undergoing index endoscopic retrograde cholangiopancreatography (ERCP). Methods: Nineteen hundred sixteen consecutive patients underwent ERCP from May 2005 to May 2011. Eight hundred thirty seven patients were excluded due to prior papillary intervention or attempted ERCP. A total of 1079 patients were included. The 981 patients who underwent gastroenterologist directed sedation (GDS) served as the control population, while the 98 patients who received anesthesiologist directed sedation (ADS) served as the case population. Medical records were analyzed for patient demographics, procedure indication, adverse events, case complexity, procedural failure and sedation failure. Case complexity was defined by the grading system proposed by the working party of the ASGE Quality Committee. Sedation failure was defined by agitation or airway compromise prompting termination of the ERCP. Reasons for procedural failure included surgically altered anatomy, luminal obstruction, and technical failure. Study endpoint was defined as successful deep cannulation of the intended target duct. Results: Demographic distribution did not differ between the GDS and the ADS groups. Cannulation success rates were similar between the two groups, with 89.85% in the GDS group, and 89.58% in the ADS group (P = 0.864). There were no statistical differences between sedation groups in procedural or respiratory adverse events. Technical failure was the predominant basis for deep cannulation failure in both groups. Agitation and airway compromise accounted for deep cannulation failure similarly in both groups. The need for reversal agents was low but similar in both groups. There was no statistical advantage in deep cannulation success rate by complexity grade in either sedation class. Conclusion: Excellent procedural outcomes and low adverse event rates were achieved using GDS, a more accessible and cost-effective method in a community-b

关键词： ERCP Community-based Medicine Conscious Sedation Anesthesiologist-Directed Sedation Gastroenterologist-Directed Sedation

获得性免疫缺陷综合征患者的寡克隆免疫球蛋白

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宁夏医科大学学报 1986年第2期 93-94页

作者： nicholas M. Papadopoulos 王湘仪

用高分辩电泳法对获得性免疫缺陷综合征(acquired immunodeficiency syadrome,AIDS)患者的血清标本作了分析。发现27例Kaposi氏肉瘤患者中的24例和15例条件致病性感染(opportu nist infection,OI)中的2例的血清,单克隆和寡克隆免疫球蛋... 详细信息

用高分辩电泳法对获得性免疫缺陷综合征(acquired immunodeficiency syadrome,AIDS)患者的血清标本作了分析。发现27例Kaposi氏肉瘤患者中的24例和15例条件致病性感染(opportu nist infection,OI)中的2例的血清,单克隆和寡克隆免疫球蛋白(oligoclonal immunoglobulins)的出现率高。单克隆蛋白带的存在与患者是否有过OI无关。这些发现说明,伴有Kaposi氏肉瘤的AIDS患者中单克隆或寡克隆b—细胞活化的发生率要高得多。从而提示,在AIDS患者的b—细胞和内皮细胞恶性或假恶性增殖当中,相似的机制可能起着作用。获得性免疫缺陷综合征(AIDS)是近来报道的一种病,它由严重的条件致病性感染(opportunistinfection,OI)、Kaposi氏肉瘤(KS)的发生,淋巴腺肿瘤和细胞免疫体系的基本功能丧失等组成。最近已经报道了这些病人多克隆b—淋巴细胞活化作用和b-细胞免疫调节异常。我们用高分辩电泳法证明了那些存在KS的AIDS患者,除了有以前报道过的多克隆b—细胞活化作用之外,单克隆或寡克隆b—细胞还有变化。

关键词：获得性免疫缺陷综合征 KS 单克隆艾滋病病毒病寡克隆 AIDS 免疫球蛋白患者

A phase 1b randomized clinical trial of CT1812 to measure Aβoligomer displacement in Alzheimer’s disease using an indwelling CSF catheter

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Translational Neurodegeneration 2023年第1期12卷 568-571页

作者： Kelsie M.Labarbera Yvette I.Sheline nicholas J.Izzo Carla M.Yuede Lora waybright Raymond Yurko Hannah M.Edwards woodrow D.Gardiner Kaj blennow Henrik Zetterberg Anne börjesson-Hanson Roger Morgan Charles S.Davis Robert J.Guttendorf Lon S.Schneider Steven DeKosky Harry LeVine III Michael Grundman Anthony O.Caggiano John R.Cirrito Susan M.Catalano Mary E.Hamby Cognition Therapeutics Inc. PittsburghPAUSA University of Pennsylvania PhiladelphiaUSA washington University St.LouisUSA University of Gothenburg MölndalSweden Department of Psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden Clinical Neurochemistry Laboratory Sahlgrenska University HospitalMölndalSweden Department of Neurodegenerative Disease UCL Institute of NeurologyQueen SquareLondonUK UK Dementia Research Institute at UCL LondonUK Hong Kong Center for Neurodegenerative Diseases Clear Water BayHong KongChina wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWIUSA Karolinska University Hospital StockholmSweden MedSurgPI LLCRaleighNCUSA CSD biostatistics Inc.Oro ValleyAZUSA Aclairo Pharmaceutical Development Group IncViennaVAUSA Keck School of Medicine of USC Los AngelesCAUSA McKnight brain Institute University of FloridaGainesvilleFLUSA Sanders-brown Center on Aging University of KentuckyLexingtonKYUSA Global R&D Partners LLCSan DiegoCAUSA Department of Neurosciences University of CaliforniaSan DiegoUSA

Trial Registration:May 11th,2018 *** Identifier:NCT03522129 https://clini caltr ***/ct2/show/*** therapies for Alzheimer’s disease(AD)target a wide range of mechanisms,yet promising dis-ease-modifying therapies remain a huge unmet *** evidence indicates that the oligomeric form of amyloid-beta(Aβ)is a toxic species contributing to AD through synaptic damage and neuronal toxicity[1].

关键词： Alzheimer Aβ damage

The Correlation of IFN <i>γ</i>to the Preferential Isolation of Influenza Type b over Type A Viruses in Madin Darby Canine Kidney Cells

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Open Journal of Medical Microbiology 2017年第1期7卷 12-28页

作者： Timothy byaruhanga bernard bagaya Joyce Namulondo John Timothy Kayiwa barbara Namagambo nicholas owor Irene Nabukenya barnabas bakamuntumaho Julius Julian Lutwama Department of Arbovirology Uganda Virus Research Institute Entebbe Uganda College of Health Sciences Makerere University Kampala Uganda

The isolation of influenza viruses in Madin Darby Canine Kidney (MDCK) cells has shown preferential isolation of a great percentage of Influenza b strains at the first passage than Influenza A strains. During in vitro isolation of Influenza viruses, majority of type A viruses are not confirmed as positive isolates by Hemagglutination (HA) assay despite having higher virulence and pathogenicity versus influenza b viruses. This study investigated the differences in IFN-γ and IL-10 cytokines secreted by MDCK cells upon exposure to the viruses and thus provided possible answers as to why influenza type b can easily be isolated from MDCK cells compared to influenza A. Positive influenza viruses were inoculated onto MDCK cells. IFN-γ and IL-10 cytokines stimulated by the viruses in MDCK cells were measured by indirect ELISA at 1 hour, 12 hours, 48 hours and 72 hours post inoculation (pi). A total of 46 specimens, with 23 specimens from each virus type were analyzed. IFN-γ was significantly higher at 1 hour pi in MDCK cells for influenza type A at p value of 0.024 than type b. No statistical significance was observed in means of cytokine IL-10 between influenza type A and type b. The study may show that IFN-γ is correlated to the preferential isolation of influenza type b over type A viruses. Anti-inflammatory cytokines may not necessarily be playing a role in the preferential growth of influenza type b, a less virulent type over influenza type A in MDCK cells.

关键词： Interferon Gamma Influenza A Influenza b Isolation

Tung Tree(Vernicia fordii) Genome Provides A Resource for Understanding Genome Evolution and Improved Oil Production

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Genomics, Proteomics & bioinformatics 2019年第6期17卷 558-575页

作者： Lin Zhang Meilan Liu Hongxu Long wei Dong Asher Pasha Eddi Esteban wenying Li Xiaoming Yang Ze Li Aixia Song Duo Ran Guang Zhao Yanling Zeng Hao Chen Ming Zou Jingjing Li Fan Liang Meili Xie Jiang Hu Depeng wang Heping Cao nicholas J.Provart Liangsheng Zhang Xiaofeng Tan Key Laboratory of Cultivation and Protection for Non-wood Forest Trees Ministry of EducationCentral South University of Forestry and TechnologyChangsha 410004China Key Lab of Non-wood Forest Products of State Forestry Administration College of ForestryCentral South University of Forestry and TechnologyChangsha 410004China Department of Cell and Systems biology/Centre for the Analysis of Genome Evolution and Function University of TorontoTorontoOntario M5S 3B2Canada State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Fujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyFujian Agriculture and Forestry UniversityFuzhou 350002China College of Forestry Nanjing Forestry UniversityNanjing 210037China Nextomics biosciences Co. Wuhan 430073China Oil Crop Research Institute Chinese Academy of Agricultural SciencesWuhan 430062China US Department of Agriculture Agricultural Research ServiceSouthern Regional Research CenterNew OrleansLA 70124USA

Tung tree(Vernicia fordii) is an economically important woody oil plant that produces tung oil rich in eleostearic acid. Here, we report a high-quality chromosome-scale genome sequence of tung tree. The genome sequence was assembled by combining Illumina short reads, Pacific biosciences single-molecule real-time long reads, and Hi-C sequencing data. The size of tung tree genome is 1.12 Gb, with 28,422 predicted genes and over 73% repeat sequences. The V. fordii underwent an ancient genome triplication event shared by core eudicots but no further wholegenome duplication in the subsequent ca. 34.55 million years of evolutionary history of the tung tree lineage. Insertion time analysis revealed that repeat-driven genome expansion might have arisen as a result of long-standing long terminal repeat retrotransposon bursts and lack of efficient DNA deletion mechanisms. The genome harbors 88 resistance genes encoding nucleotide-binding sites;17 of these genes may be involved in early-infection stage of Fusarium wilt resistance. Further, 651 oil-related genes were identified, 88 of which are predicted to be directly involved in tung oil biosynthesis. Relatively few phosphoenolpyruvate carboxykinase genes, and synergistic effects between transcription factors and oil biosynthesis-related genes might contribute to the high oil content of tung seed. The tung tree genome constitutes a valuable resource for understanding genome evolution, as well as for molecular breeding and genetic improvements for oil production.

关键词： Tung tree genome Tung oil Genome evolution Electronic fluorescent pictographic browser Oil biosynthesis

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Genomic,transcriptomic,and epigenomic analysis of a medicinal snake,bungarus multicinctus,to provides insights into the origin of Elapidae neurotoxins

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Acta Pharmaceutica Sinica b 2023年第5期13卷 2234-2249页

作者： Jiang Xu Shuai Guo Xianmei Yin Mingqian Li He Su Xuejiao Liao Qiushi Li Liang Le Shiyu Chen baosheng Liao Haoyu Hu Juan Lei Yingjie Zhu Xiaohui Qiu Lu Luo Jun Chen Ruiyang Cheng Zhenzhan Chang Han Zhang nicholas Chieh wu Yiming Guo Dianyun Hou Jin Pei Jihai Gao Yan Hua Zhihai Huang Shilin Chen Institute of Herbgenomics State Key Laboratory of Southwest Chinese Medicine ResourcesPharmacy CollegeChengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and western Medicine of Zhejiang Province Zhejiang Academy of Traditional Chinese MedicineTongde Hospital of Zhejiang ProvinceHangzhou 310012China Guangdong Provincial Hospital of Chinese Medicine(the Second Clinical Medical College of Guangzhou University of Chinese Medicine Guangdong Provincial Hospital of Traditional Chinese Medicine)Guangzhou 510006China Pharmacy College Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pathology Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA beijing Engineering Research Center of Pediatric Surgery Engineering and Transformation CenterBeijing Children's HospitalNational Center for Children's HealthCapital Medical UniversityBeijing 100045China School of basic Medical Sciences Peking UniversityBeijing 100191China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 300193China School of Life and Environmental Sciences the University of SydneyNSW2006Australia University of Pittsburgh Kenneth P.Dietrich School of Arts and SciencesPittsburghPA 15260USA Agricultural College Henan University of Science and TechnologyLuoyang 471000China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China

The many-banded krait,bungarus multicinctus,has been recorded as the animal resource of JinQianbaiHuaShe in the Chinese *** of its venoms classified chief phyla of modern animal ***,the evolutionary origin and diversification of its neurotoxins as well as biosynthesis of its active compounds remain largely unknown due to the lack of its high-quality ***,we present the 1.58 Gbp genome of *** assembled into 18 chromosomes with contig/scaffold N50 of 7.53 Mbp/149.8 *** bungarotoxin-coding genes were clustered within genome by family and found to be associated with ancient local *** truncation of glycosylphosphatidylinositol anchor in the 3'-terminal of a LY6E paralog released modern three-finger toxins(3FTxs)from membrane tethering before the Colubroidea *** expansion and mutations diversified and recruited these *** the cobra/krait divergence,the modern unit-b ofβ-bungarotoxin emerged with an extra cysteine residue.A subsequent point substitution in unit-A enabled theβ-bungarotoxin covalent *** *** gene expression,chromatin topological organization,and histone modification characteristics were featured by transcriptome,proteome,chromatin conformation capture sequencing,and *** results highlighted that venom production was under a sophisticated *** findings provide new insights into snake neurotoxin research,meanwhile will facilitate antivenom development,toxin-driven drug discovery and the quality control of JinQianbaiHuaShe.

关键词： Medicinal snake Neurotoxin origin Antivenoms Gene regulation Chromatin

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信仰的本能

作者： (美)尼古拉斯·韦德(nicholas wade)

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尼采的锤子

基于地基高分辨率太阳吸收光谱观测大气中硝酸的时空分布

作者： (英)尼古拉斯·费恩(nicholas Fearn)

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光学学报 2020年第2期40卷 17-27页

作者：章惠芳王薇刘诚单昌功胡启后孙友文 nicholas Jones 安徽大学物质科学与信息技术研究院安徽合肥230601 中国科学院合肥物质科学研究院安徽光学精密机械研究所环境光学与技术重点实验室安徽合肥230031 中国科学技术大学地球和空间科学学院安徽合肥230026 University of wollongong School of ChemistryAustraliaNew South WalesWollongong 2522

利用高分辨率傅里叶变换红外光谱(FTIR)技术探测合肥地区大气硝酸(HNO3)的浓度,基于最优估算法由中红外太阳吸收光谱反演出HNO3的垂直廓线和柱总量。获得了2017年大气HNO3的垂直廓线和柱总量的时间序列,分析了HNO3的季节变化、浓度探测... 详细信息

利用高分辨率傅里叶变换红外光谱(FTIR)技术探测合肥地区大气硝酸(HNO3)的浓度,基于最优估算法由中红外太阳吸收光谱反演出HNO3的垂直廓线和柱总量。获得了2017年大气HNO3的垂直廓线和柱总量的时间序列,分析了HNO3的季节变化、浓度探测敏感性高度、反演平均核和自由度等特征。不同季节大气HNO3的垂直廓线表明,HNO3在20~30km的大气平流层浓度较高,在对流层浓度较低。HNO3的柱浓度显示出明显的季节变化,春季出现最大值,冬季出现最小值,季节变化幅值为9.82×10^15 molecule/cm2。为了对地基FTIR的观测进行比对,选取Aura MLS卫星数据产品与地基测量数据进行比对。比对结果表明,地基遥感观测与卫星数据显示出的季节变化一致;尽管卫星偏柱量整体小于地基遥感的柱总量,但两者的相关系数为0.83,表明两者具有较好的一致性。地基观测结果验证了地基FTIR技术观测大气中HNO3时空分布的可靠性和准确性。

关键词：大气光学傅里叶变换红外光谱技术硝酸垂直廓线柱浓度

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