Genomic,transcriptomic,and epigenomic analysis of a medicinal snake,Bungarus multicinctus,to provides insights into the origin of Elapidae neurotoxins
作者机构：Institute of HerbgenomicsState Key Laboratory of Southwest Chinese Medicine ResourcesPharmacy CollegeChengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang ProvinceZhejiang Academy of Traditional Chinese MedicineTongde Hospital of Zhejiang ProvinceHangzhou 310012China Guangdong Provincial Hospital of Chinese Medicine(the Second Clinical Medical College of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of Traditional Chinese Medicine)Guangzhou 510006China Pharmacy CollegeShandong University of Traditional Chinese MedicineJinan 250355China Department of PathologyMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Beijing Engineering Research Center of Pediatric SurgeryEngineering and Transformation CenterBeijing Children's HospitalNational Center for Children's HealthCapital Medical UniversityBeijing 100045China School of Basic Medical SciencesPeking UniversityBeijing 100191China School of Chinese Materia MedicaTianjin University of Traditional Chinese MedicineTianjin 300193China School of Life and Environmental Sciencesthe University of SydneyNSW2006Australia University of PittsburghKenneth P.Dietrich School of Arts and SciencesPittsburghPA 15260USA Agricultural CollegeHenan University of Science and TechnologyLuoyang 471000China Guangdong Provincial Key Laboratory of SilvicultureProtection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China
出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)
年 卷 期：2023年第13卷第5期
页 面：2234-2249页
核心收录：
学科分类：100703[医学-生药学] 1007[医学-药学(可授医学、理学学位)] 10[医学]
基 金：the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ13-YQ-047,ZXKT22006,China) quality standard system construction for the whole industry chain of Chinese medicine from Guangdong Provincial Drug Administration of China(002009/2019KT1261/2020ZDB25) the National Major Science and Technology Projects(2019ZX09201005,China) the Open Research Fund of Chengdu University of Traditional Chinese Medicino state Key Laboratory scluthwestern Chinese Medicine Resources(2022ZYXK2011006,China) the National Key R&D Program of China(2019YFC1711100)
主 题：Medicinal snake Neurotoxin origin Antivenoms Gene regulation Chromatin
摘 要：The many-banded krait,Bungarus multicinctus,has been recorded as the animal resource of JinQianBaiHuaShe in the Chinese *** of its venoms classified chief phyla of modern animal ***,the evolutionary origin and diversification of its neurotoxins as well as biosynthesis of its active compounds remain largely unknown due to the lack of its high-quality ***,we present the 1.58 Gbp genome of *** assembled into 18 chromosomes with contig/scaffold N50 of 7.53 Mbp/149.8 *** bungarotoxin-coding genes were clustered within genome by family and found to be associated with ancient local *** truncation of glycosylphosphatidylinositol anchor in the 3 -terminal of a LY6E paralog released modern three-finger toxins(3FTxs)from membrane tethering before the Colubroidea *** expansion and mutations diversified and recruited these *** the cobra/krait divergence,the modern unit-B ofβ-bungarotoxin emerged with an extra cysteine residue.A subsequent point substitution in unit-A enabled theβ-bungarotoxin covalent *** *** gene expression,chromatin topological organization,and histone modification characteristics were featured by transcriptome,proteome,chromatin conformation capture sequencing,and *** results highlighted that venom production was under a sophisticated *** findings provide new insights into snake neurotoxin research,meanwhile will facilitate antivenom development,toxin-driven drug discovery and the quality control of JinQianBaiHuaShe.
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