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Neurotoxicity and transcriptome changes in embryonic zebrafish induced by halobenzoquinone exposure

Journal of Environmental Sciences 2022年第7期34卷 129-140页

作者： Xue Yang Chang Wang Lihua Yang Qi Zheng Qiongyu Liu nicholas J.P.Wawryk Xing-Fang Li Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances School of Environment and HealthJianghan UniversityWuhan 430056China Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAlbertaT6G 2G3Canada South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center Guangdong Provincial Key Laboratory of Marine Resources and Coastal EngineeringSchool of Marine SciencesSun Yat-Sen UniversityZhuhai 519082China

Halobenzoquinones(HBQs) are emerging disinfection byproducts(DBPs) with a widespread presence in drinking water that exhibit much higher cytotoxicity than regulated DBPs. However, the developmental neurotoxicity of HBQs has not been studied in vivo. In this work, we studied the neurotoxicity of HBQs on zebrafish embryos, after exposure to varying concentrations(0-8 μmol/L) of three HBQs, 2,5-dichloro-1,4-benzoquinone(2,5-DCBQ), 2,6-dichloro-1,4-benzoquinone(2,6-DCBQ), and 2,5-dibromo-1,4-benzoquinone(2,5-DBBQ) for 4 to 120 hr post fertilization(hpf). HBQ exposure significantly decreased the locomotor activity of larvae, accompanied by significant reduction of neurotransmitters(dopamine and γ-aminobutyric acid) and acetylcholinesterase activity. Furthermore, the expression of genes involved in neuronal morphogenesis( gfap, α1-tubulin, mbp, and syn-2 α) were downregulated by 4.4-, 5.2-, 3.0-, and 4.5-fold in the 5 μmol/L 2,5-DCBQ group and 2.0-, 1.6-, 2.1-, and 2.3-fold in the 5 μmol/L 2,5-DBBQ group, respectively. Transcriptomic analysis revealed that HBQ exposure affected the signaling pathways of neural development. This study demonstrates the significant neurotoxicity of HBQs in embryonic zebrafish and provides molecular evidence for understanding the potential mechanisms of HBQ neurotoxicity.

关键词： Disinfection byproducts Halobenzoquinone Neurotoxicity Zebrafish embryos

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Macroencapsulation Devices for Cell Therapy

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Engineering 2022年第6期8卷 53-70页

作者： Wei Liu Yanfang Wang Jinqiang Wang Olivia LLanier Marissa EWechsler nicholas A.Peppas Zhen Gu Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Biomedical Engineering The University of Texas at AustinAustinTX 78712USA Department of Biomedical Engineering and Chemical Engineering The University of Texas at San AntonioSan AntonioTX 78249USA Division of Molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at AustinAustinTX 78712USA Zhejiang Laboratory of Systems and Precision Medicine Zhejiang University Medical CenterHangzhou 311121China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Macroencapsulation has been widely used in cell therapy due to its capability to provide immune-privileged sites for implanted allogeneic or xenogeneic *** also serves to provide mechanical and physiochemical support for maintaining cell expansion and promoting therapeutic *** devices such as membrane-controlled release systems,hydrogels,micronee-dle(MN)array patches,and three-dimensional(3D)stents have shown promising in-lab and preclinical results in the maintenance of long-term cell survival and the strengthening of treatment *** studies focus on expanding the applications of these devices to new cell-based areas such as chimeric antigen receptor(CAR)-T cell delivery,cardiovascular disease therapy,and the exploration of new materials,construction methods,and working principles to augment treatment efficacy and prolong therapy ***,we survey innovative platforms and approaches,as well as translation outcomes,for advancing the performance and applications of macrodevices for cell-based therapies.A discussion and critique regarding future opportunities and challenges is also provided.

关键词： Drug delivery Cell encapsulation Cell therapy Cell transplantation Biomedical devices

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Determining the earliest growth stage to detect the presence of endophytes in tall fescue and perennial ryegrass seedlings using molecular markers

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Grassland Research 2023年第2期2卷 106-111页

作者： Kendall Lee nicholas Hill Chloe Dela Cerna Ali Missaoui Institute of Plant Breeding Genetics and GenomicsUniversity of GeorgiaAthensGeorgiaUSA Department of Crop and Soil Sciences University of GeorgiaAthensGeorgiaUSA

Background:Tall fescue(Festuca arundinacea[Schreb.],Lolium arundinaceum[Schreb.]Darbysh)and perennial ryegrass(Lolium perenne)are important cool-season forage and amenity grasses that have a mutualistic association with an endophytic *** confer insect and drought resistance to plants but can produce mammalian *** endophytes that do not produce mammalian toxins have been introduced to elite cultivars for commercial *** companies need to maintain adequate levels of novel endophytes within the elite forage *** detection is performed using immunochemical and molecular techniques because of their speed and *** detection in seedlings is essential to evaluate the viability of the endophyte within seed ***:This research aimed to identify the earliest growth stage in which immunochemical and molecular methods can detect viable endophyte in seedlings of tall fescue cultivars BarOptima(e34),Texoma MaxQII(584),and Jesup MaxQ(542),as well as the perennial ryegrass cultivar Remington(NEA2).Results:Immunochemical testing detected endophytes in seedlings 14 days after germination(DAG),but the detection rate increased until 42 DAG in some cultivars *** molecular marker Tef1exon detected endophytes at a lower rate than the immunochemical method at 28–42 ***,there was insufficient DNA to detect endophytes in 14 DAG seedlings using ***:We conclude that the most accurate detection of viable endophytes in seedlings was 42 DAG,at which sufficient and consistent endophyte colonization occurred.

关键词： endophyte immunoblot assay molecular markers perennial ryegrass tall fescue

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Facial fillers:Relevant anatomy,injection techniques,and complications

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第3期9卷 227-235页

作者： nicholas W.Clark Debbie R.Pan Dane M.Barrett Duke University Department of Head and Neck Surgery and Communication Sciences DurhamNorth CarolinaUSA

Objective:The aim of this review article is to discuss the currently available facial fillers,their differences and indications,relevant anatomy,injection techniques,and avoidance and management of *** Sources:Clinical experience and scientific ***:Reversal of facial aging via filler injection has been around since the late 1800s with the initial use of detrimental ***,many safe and effective products exist and can be tailored to the individual patient’’s desired *** the evolution of both products and injection techniques,the rate of complications with facial filler use is ***,providers offering facial filler injections should have detailed knowledge of facial anatomy,including facial planes and soft tissue *** injection techniques *** techniques should be used,depending on the anatomic *** should also know how to avoid and manage complications.

关键词： cosmetic facial filler injection plastic surgery

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Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading:A mechanistic study

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Bioactive Materials 2023年第1期19卷 406-417页

作者： Roxane Bonithon Colin Lupton Marta Roldo Joseph nicholas Dunlop Gordon William Blunn Frank Witte Gianluca Tozzi Zeiss Global Centre School of Mechanical and Design EngineeringUniversity of PortsmouthAnglesea RoadPO13DJPortsmouthUnited Kingdom School of Pharmacy and Biomedical Sciences University of PortsmouthWhite Swan RoadPO12DTPortsmouthUnited Kingdom School of the Environment Geography&GeosciencesUniversity of PortsmouthBurnaby RoadPO13QLPortsmouthUnited Kingdom Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitätsmedizin BerlinAßmannshauser Straße 4-614197BerlinGermany Biotrics Bioimplants AG Ullsteinstr.10812109BerlinGermany

The successful application of magnesium(Mg)alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical *** study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating Hanks’Balanced Salt Solution(HBSS)with and without in situ cyclic compression(30 N/1 Hz).The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume *** in situ cyclic compression induced acceleration of the corrosion rate,probably due to local disruption of the coating layer where fatigue microcracks were formed,no critical failures in the overall scaffold were observed,indicating that the mechanical integrity of the Mg scaffolds was *** changes,due to the accumulation of corrosion debris between the scaffold fibres,resulted in a significant increase(p<0.05)in the material volume fraction from 0.52±0.07 to 0.47±0.03 after 14 days of ***,despite an increase in fibre material loss,the accumulated corrosion products appear to have led to an increase in Young’s modulus after 14 days as well as lower third principal strain(εp3)accumulation(-91000±6361μεand-60093±2414μεafter 2 and 14 days,respectively).Therefore,this innovative Mg scaffold design and composition provide a bone replacement,capable of sustaining mechanical loads in situ during the postoperative phase allowing new bone formation to be initially supported as the scaffold resorbs.

关键词： Magnesium alloys Bone regeneration In vitro corrosion X-ray computed tomography(XCT) Digital volume correlation(DVC)

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Percutaneous coronary intervention in octogenarians:10-year experience from a primary percutaneous coronary intervention centre with off-site cardiothoracic support

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Journal of Geriatric Cardiology 2022年第3期19卷 189-197页

作者： Joanna Abramik Amardeep Dastidar Nestoras Kontogiannis Victoria North Gopendu Patri nicholas Weight Tushar Raina George Kassimis Cheltenham General Hospital Gloucestershire Hospitals NHS Foundation TrustCheltenhamUnited Kingdom Bristol Heart Institute University Hospitals NHS Foundation TrustBristolUnited Kingdom Second Department of Cardiology Hippokration HospitalMedical SchoolAristotle University of ThessalonikiThessalonikiGreece

OBJECTIVE To examine the trends in patient characteristics and clinical outcomes over a ten-year period and to analyse the predictors of mortality in octogenarians undergoing percutaneous coronary intervention(PCI)in our *** A total of 782 consecutive octogenarians(aged 80 and above)were identified from a prospectively collected PCI database within our non-surgical,medium volume centre between 1st January 2007 and 31st December *** represented 10.9%of all PCI procedures performed in our centre during this *** evaluated the demographic and procedural character-istics of the cohort with respect to clinical outcomes(all-cause in-hospital and 1-year mortality,in-hospital complication rates,duration of hospital admission,coronary disease angiographic complexity and major co-morbidities).The cohort was further stratified into three chronological tertiles(January 2007 to July 2012,261 cases;August 2012 to May 2015,261 cases;June 2015 to December 2016,260 cases)to assess for differences over *** of mortality were identified through a multivariate re-gression *** The number of octogenarians undergoing PCI increased nearly ten-fold over the studied *** this,there were no significant differences in clinical outcomes or patient characteristics,except for the increased use of trans-radial vascular access[11.9%in first tertile vs.73.2%in third tertile(P<0.0001)].The all-cause in-hospital(5.8%vs.4.6%vs.3.8%,P=0.578)and 1-year mortality(12.4%vs.12.5%vs.14.4%,P=0.746)remained constant in all three tertiles *** independent predict-ors of mortality were identified-increasing age[HR=1.12(1.03−1.22),P=0.008],cardiogenic shock[HR=16.40(4.04-66.65),P<0.0001],severe left ventricular impairment[HR=3.52(1.69−7.33),P=0.001],peripheral vascular disease[HR=2.73(1.22−6.13),P=0.015],diabetes[HR=2.59(1.30−5.17),P=0.007]and low creatinine clearance[HR=0.98(0.96−1.00),P=0.031].CONCLUSION This contemporary observational study pro

关键词： coronary mortality cardio

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Feeding the world: impacts of elevated [CO_(2)] on nutrient content of greenhouse grown fruit crops and options for future yield gains

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Horticulture Research 2023年第4期10卷 83-100页

作者： nicholas H.Doddrell Tracy Lawson Christine A.Raines Carol Wagstaff Andrew J.Simkin NIAB New RoadEast MallingKentME196BJ UK Department of Food and Nutritional Sciences University of ReadingWhiteknightsReadingBerkshire RG66DZUK School of Life Sciences University of EssexColchester CO44SQUK School of Biosciences University of KentCanterburyUnited Kingdom CT27NJUK

Several long-term studies have provided strong support demonstrating that growing crops under elevated[CO_(2)]can increase photosynthesis and result in an increase in yield,flavour and nutritional content(including but not limited to Vitamins C,E and pro-vitamin A).In the case of tomato,increases in yield by as much as 80%are observed when plants are cultivated at 1000 ppm[CO_(2)],which is consistent with current commercial greenhouse productionmethods in the tomato fruit *** results provide a clear demonstration of the potential for elevating[CO_(2)]for improving yield and quality in greenhouse *** major focus of this review is to bring together 50 years of observations evaluating the impact of elevated[CO_(2)]on fruit yield and fruit nutritional *** the final section,we consider the need to engineer improvements to photosynthesis and nitrogen assimilation to allow plants to take greater advantage of elevated CO_(2) growth conditions.

关键词： crops greenhouse content

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A failure criterion for shale considering the anisotropy and hydration based on the shear slide failure model

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International Journal of Mining Science and Technology 2023年第4期33卷 447-462页

作者： Qiangui Zhang Bowei Yao Xiangyu Fan Yong Li nicholas Fantuzzi Tianshou Ma Yufei Chen Feitao Zeng Xing Li Lizhi Wang Petroleum Engineering School Southwest Petroleum UniversityChengdu 610500China Department of Civil Geological and Mining EngineeringÉcole Polytechnique de MontréalMontreal H3T 1J4Canada State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400030China Department of Civil ChemicalEnvironmental and Materials EngineeringUniversity of BolognaBologna 40136Italy Department of Civil and Mineral Engineering University of TorontoToronto M5S 1A4Canada

A failure criterion fully considering the anisotropy and hydration of shale is essential for shale formation stability ***,a novel failure criterion for hydration shale is developed by using Jaeger’s shear failure criterion to describe the anisotropy and using the shear strength reduction caused by clay minerals hydration to evaluate the *** failure criterion is defined with four parameters in Jaeger’s shear failure criterion(S_(1),S_(2),a andφ),three hydration parameters(k,ω_(sh)andσ_(s))and two material size parameters(d and l0).The physical meanings and determining procedures of these parameters are *** accuracy and applicability of this failure criterion are examined using the published experimental data,showing a cohesive agreement between the predicted values and the testing results,R^(2)=0.916 and AAREP(average absolute relative error percentage)of 9.260%.The error(|D_(p)|)is then discussed considering the effects ofβ(angle between bedding plane versus axial loading),moisture content and confining pressure,presenting that|Dp|increases whenβis closer to 30°,and|D_(p)|decreases with decreasing moisture content and with increasing confining ***,|D_(p)|is demonstrated as being sensitive to S1and being steady with decrease in the data set whenβis 0°,30°,45°and 90°.

关键词： Shale Failure criterion Mechanical strength Shear slide failure Anisotropy Hydration

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PROJECT MANAGEMENT:RECENT DEVELOPMENTS AND RESEARCH OPPORTUNITIES

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Journal of Systems Science and Systems Engineering 2012年第2期21卷 129-143页

作者： nicholas G.HALL Department of Management Sciences Fisher College of Business The Ohio State UniversityUSA

This paper studies the business process known as project management. This process has exhibited a remarkable growth in business interest over the last 15 years, as demonstrated by a 1000% increase in membership in the Project Management Institute since 1996. This growth is largely attributable to the emergence of many new diverse business applications that can be successfully managed as projects. The new applications for project management include IT implementations, research and development, new product and service development, corporate change management, and software development. The characteristics of modem projects are typically very different from those of traditional projects such as construction and engineering, which necessitates the development of new project management techniques. We discuss these recent practical developments. The history of project management methodology is reviewed, from CPM and PERT to the influential modem directions of critical chain project management and agile methods. We identify one important application area for future methodological change as new product and service development. A list of specific research topics within project management is discussed. The conclusions suggest the existence of significant research opportunities within project management.

关键词： Project management overview recent practical developments opportunities for research

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The formation of massif anorthosite:Petrology in reverse

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Geoscience Frontiers 2013年第2期4卷 195-198页

作者： nicholas Arndt ISTerre Universite Joseph Fourier:UMR5275CNRS1381 rue de la Piscine38400 St Martin d'HeresFrance

Massif anorthosites form when basaltic magma differentiates in crustal magma chambers to form lowdensity plagioclase and a residual liquid whose density was greater than that of enclosing crustal rocks. The plagioclase and minor pyroxene crystallized in-situ on the floor of the magma chamber to produce the anorthosite complex,and the residual liquid migrated downwards,eventually to solidify as dense Fe-rich cumulates some of which were removed to the *** movements were facilitated by high temperatures in Proterozoic continental crust,thus explaining the restriction of large anorthosite massifs to this period in Earth history.

关键词： Anorthosite Petrology Proterozoic

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