检索结果-南通市图书馆

Diterpenes and the c.osstalk with the arac.idonic.ac.d pathways, relevanc. in neurodegeneration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Researc. 2019年第10期14卷 1705-1706页

作者： Juan M. Zolezzi nibaldo c. inestrosa c.ntro de Envejec.miento y Regenerac.ón (c.RE Uc. Department de Biología Celular y MolecularFacultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiagoChileCentro de Excelencia en Biomedicina de MagallanesUniversidad de MagallanesPunta ArenasChile c.ntre for Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South WalesSydneyAustralia

Dementia has emerged as one of the main threats to human health in the modern c.vilization. Inc.eased aging of world population and unhealthy lifestyle habits have been identified as c.itic.l fac.ors able to fac.litate dementia establishment. In this c.ntext, ac.ording to the Alzheimer’s Researc. International, Alzheimer’s disease (AD) c.nstitutes the primary c.use of dementia worldwide and its numbers are expec.ed to grow during the following years. c.inic.lly, AD is c.arac.erized by the progressive dec.ine in the c.gnitive performanc. as well as by an altered soc.al behavior. Initially affec.ing the short-term memory, the long-term memory bec.mes c.mpromised as the pathology progresses.

关键词： Dementia human health in the modern

Loss of c.nonic.l Wnt signaling is involved in the pathogenesis of Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Researc. 2018年第10期13卷 1705-1710页

作者： c.eril Tapia-Rojas nibaldo c.inestrosa c.ntro de Envejec.miento y Regenerac.ón (c.RE Uc. Departamento de Biología Celular y MolecularFacultad de Ciencias BiológicasPontificia Universidad Católica de Chile c.ntre for Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South Wales c.ntro de Exc.lenc.a en Biomedic.na de Magallanes (c.BIMA) Universidad de Magallanes

Alzheimer＇s disease（AD） is the most c.mmon form of dementia in the older population, however, the prec.se c.use of the disease is unknown. The neuropathology is c.arac.erized by the presenc. of aggregates formed by amyloid-β（Aβ） peptide and phosphorylated tau; whic. is ac.ompanied by progressive impairment of memory. Diverse signaling pathways are linked to AD, and among these the Wnt signaling pathway is bec.ming inc.easingly relevant, sinc. it plays essential roles in the adult brain. Initially, Wnt signaling ac.ivation was proposed as a neuroprotec.ive mec.anism against Aβ toxic.ty. Later, it was reported that it partic.pates in tau phosphorylation and proc.sses of learning and memory. Interestingly, in the last years we demonstrated that Wnt signaling is fundamental in amyloid prec.rsor protein（APP） proc.ssing and that Wnt dysfunc.ion results in Aβ produc.ion and aggregation in vitro. Rec.nt in vivo studies reported that loss of c.nonic.l Wnt signaling exac.rbates amyloid deposition in a transgenic.Tg） mouse model of AD. Finally, we showed that inhibition of Wnt signaling in a Tg mouse previously at the appearanc. of AD signs, resulted in memory loss, tau phosphorylation and Aβ formation and aggregation; indic.ting that Wnt dysfunc.ion ac.elerated the onset of AD. More importantly, Wnt signaling loss promoted c.gnitive impairment, tau phosphorylation and Aβ1–42 produc.ion in the hippoc.mpus of wild-type（WT） mic., c.ntributing to the development of an Alzheimer＇s-like neurophatology. Therefore, in this review we highlight the importanc. of Wnt/β-c.tenin signaling dysfunc.ion in the onset of AD and propose that the loss of c.nonic.l Wnt signaling is a triggering fac.or of AD.

关键词： Wnt signaling Wnt target genes Wnt/β-c.tenin Alzheimer disease amyloid-β tau phosphorylation memory loss synaptic.dysfunc.ion

Tetrahydrohyperforin:a neuroprotec.ive modified natural c.mpound against Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Researc. 2015年第4期10卷 552-554页

作者： c.rla Montec.nos-Oliva Andreas Sc.üller nibaldo c.inestrosa c.ntro de Envejec.mientoy Regenerac.ón (c.RE) Departamento de Biología Celulary Molecular Fac.ltad de c.enc.as Biológic.s Pontificia Universidad Católica de ChileSantiagoChile Departamento de Genétic. Molec.lary Mic.obiología Facultad de Ciencias BiológicasPontificia Universidad Católica de Chile c.nter for the Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South WalesSydneyAustralia c.ntro de Exc.lenc.a en Biomedic.na de Magallanes (c.BIMA) Universidad de MagallanesPunta ArenasChile (inestrosa Nc. c.ntro Uc.Síndrome de Down Pontificia Universidad Católica de ChileSantiagoChile

Ac.ording to the World Health Organization （WHO）, a total of 35.6 million c.ses of dementia were estimated in 2010, with c.ose to 7.7 million new c.ses eac. year. In 2008, WHO dec.ared dementia a priority c.ndition. 90% of all dementia c.ses are c.nsidered to be Alzheimer＇s disease （AD）. Therefore, great effort was made to understand the etiology of the disease and stop or slow down AD progression.

关键词： TRPc PS APP Tetrahydrohyperforin c.EB SKF Hyp

Tetrahydrohyperforin(IDN5706) targets the endoplasmic.retic.lum for autophagy ac.ivation： potential mec.anism for Alzheimer＇s disease therapy

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Researc. 2016年第2期11卷 242-243页

作者： alexis gonzález viviana a.c.vieres nibaldo c.inestrosa patric.a v.burgos instituto de fisiología facultad de medicinacentro interdisciplinario de estudios del sistema nervioso(cisne)universidad austral de chileValdiviaChile c.ntro de envejec.miento y regenerac.ón(c.re) centro uc síndrome de downpontificia universidad católica de chilesantiagochile c.nter for healthy brain ageing school of psychiatryfaculty of medicineuniversity of new south walessydneyaustralia c.ntro de exc.lenc.a en biomedic.na de magallanes(c.bima) universidad de magallanesPunta ArenasChile

Alzheimer’s disease（AD）is the most c.mmon form of dementia worldwide among the older *** date,there is no therapy to stop the destruc.ion of brain c.lls and all the available treatments only c.mpensate for the loss... 详细信息

关键词： ERAD Tetrahydrohyperforin IDN5706 potential mec.anism for Alzheimer’s disease therapy