Tetrahydrohyperforin(IDN5706) targets the endoplasmic reticulum for autophagy activation： potential mechanism for Alzheimer＇s disease therapy

作     者：alexis gonzález viviana a.cavieres nibaldo c.inestrosa patricia v.burgos 

作者机构：instituto de fisiologíafacultad de medicinacentro interdisciplinario de estudios del sistema nervioso(cisne)universidad austral de chileValdiviaChile centro de envejecimiento y regeneración(care)centro uc síndrome de downpontificia universidad católica de chilesantiagochile center for healthy brain ageingschool of psychiatryfaculty of medicineuniversity of new south walessydneyaustralia centro de excelencia en biomedicina de magallanes(cebima)universidad de magallanesPunta ArenasChile 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第2期

页      面：242-243页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：supported by FONDECYT-1130929(PB)and PB-Conicyt(No 12/2007)to NCI supported by CONICYT#21110746,MECESUPAUS1203 and DIDUACh D#201303 supported by CONICYT#21151194 fellowship 

主　　题：ERAD Tetrahydrohyperforin IDN5706 potential mechanism for Alzheimer’s disease therapy 

摘      要：Alzheimer’s disease（AD）is the most common form of dementia worldwide among the older *** date,there is no therapy to stop the destruction of brain cells and all the available treatments only compensate for the loss of synaptic transmission,thus resulting in marginal benefits to patients.