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Anti-hyperglycemic effect of the polysaccharide fraction isolated from mactra veneriformis

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Frontiers of Chemical Science and Engineering 2011年第2期5卷 238-244页

作者： Lingchong WANG Hao WU nian chang Kun ZHANG College of Pharmaceutical Science Nanjing University of Chinese MedicineNanjing 210046China Research Center of Marine Drug in Jiangsu Province Nanjing 210046China

Total macromolecule extract was obtained from the soft body of Mactra veneriformis by the coupling techniques of decoction and alcohol *** extract was deproteinized with an ion exchange column,and resulted in the purifying of the crude polysaccharide *** was found by chemical analysis that the crude polysaccharide part is composed of abundant polysacchar-ides(>95%)and few proteins(<1%).Furthermore,only one type of monosaccharide,glucose,was detected from its hydrolytes by thin-layer chromatography,indicating that the polysaccharides might be analogs of *** anti-hyperglycemia effects of the crude polysaccharide part were preliminarily investigated using several pharmacolo-gical methods in normal and diabetic *** experimental results showed that the crude polysaccharide fraction exhibited proper glycemia inhibition activity,and 300 mg/kg-weight dose has the optimal effect among all the studied *** is concluded that the crude polysaccharide fraction can be explored as a novel health product that possesses potential as an anti-hyperglycemic agent.

关键词： anti-hyperglycemia Mactra veneriformis polysaccharide monosaccharide composition oral glucose tolerance test

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改性沸石去除地下水中铁锰的研究进展

应用化工 2024年第3期53卷 694-698页

作者：张欣宇唐玉朝王坤尹翠琴伍昌年朱静坤安徽建筑大学环境污染控制与废弃物资源化利用安徽省重点实验室安徽合肥230601 合肥供水集团有限公司安徽合肥230011

根据沸石的结构特征并利用沸石进行除铁锰的动力学机理总结了影响其除铁锰性能的材料自身的因素,综述了对沸石进行改性的方法以及改性前后的对比,其中包括在合成过程中在保证沸石基本框架的前提下,对影响沸石合成的因素,即硅铝比、杂质... 详细信息

根据沸石的结构特征并利用沸石进行除铁锰的动力学机理总结了影响其除铁锰性能的材料自身的因素,综述了对沸石进行改性的方法以及改性前后的对比,其中包括在合成过程中在保证沸石基本框架的前提下,对影响沸石合成的因素,即硅铝比、杂质去除、碱度、结晶温度、晶化时间、导向剂的人为控制调节,以及进行微波、高温、涂层、化学药剂浸泡的预处理改性。为改性沸石后续研究提出参考和建议。

关键词：地下水除铁除锰合成沸石改性沸石

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EDITORIAL

电子学报 1986年第4期 2-5页

作者： Cai chang-nian, Fellow, CIE

In Ghina the field of information theory essentially covers the areas of research of IEEE IT Group members or our U. S. colleagues. The central areas are Shannon theory (including multi-user information theory), channel and source coding theory and the implementations of encoding and decoding: decision and estimation theories are prerequisite knowledges for understanding information theory, but we also consider them as

关键词： EDITORIAL

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血塞通片体外溶出行为研究

食品与药品 2024年第4期26卷 323-327页

作者：罗慧玉闫伟伟谢颖陈正源吴长年丁杰刘琪张家口市食品药品检验中心河北张家口075000

目的建立血塞通片溶出度检验方法,测定血塞通片中三七皂苷R_(1)、人参皂苷Rg_(1)、人参皂苷Re、人参皂苷Rb_(1)和人参皂苷Rd的整合溶出度。方法以小杯法进行溶出度实验,采用高效液相色谱法(HPLC)测定5种指标成分的溶出量,采用质量分... 详细信息

目的建立血塞通片溶出度检验方法,测定血塞通片中三七皂苷R_(1)、人参皂苷Rg_(1)、人参皂苷Re、人参皂苷Rb_(1)和人参皂苷Rd的整合溶出度。方法以小杯法进行溶出度实验,采用高效液相色谱法(HPLC)测定5种指标成分的溶出量,采用质量分数权重系数法进行溶出度整合。绘制溶出曲线,采用f_(2)相似因子法比较各成分溶出曲线与整合溶出曲线的相似性,对整合溶出数据进行模型拟合,计算溶出参数T_(50)、T_(d)和T_(85)。结果以水为溶出介质,转速50 r/min,60 min取样。5种指标成分溶出曲线与整合溶出度溶出曲线的f_(2)相似因子分别为64.5,61.6,79.8,60.0和68.2。溶出数据拟合模型以Weibull模型最优,溶出参数T_(50)、T_(d)和T_(85)分别为12.29 min、18.09 min和56.09 min。结论建立的溶出度检查方法准确、可行,采用质量分数权重系数法整合溶出度能较好地表征血塞通片的体外溶出行为,可为血塞通片的质量一致性评价研究及质量控制提供技术借鉴。

关键词：血塞通片溶出行为整合溶出度溶出曲线相似因子

Integrated Network Pharmacology and Antioxidant Activity?Guided Screen System to Exploring Antioxidants and Quality Markers of Shunaoxin Pills against Chronic Cerebral Ischemia

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World Journal of Traditional Chinese Medicine 2019年第1期5卷 1-8页

作者： nian-Wei chang Dan-Dan Cheng Jia-Nan Ni Ying-Ying Guo Guang-Cui Chu Unchol Kim Min Jiang Gang Bai Graduate School Tianjin University of Traditional Chinese Medicine Department of Genetic Engineering State Academy of SciencePyongyang Democratic People's Republic of Korea College of Pharmacy State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Molecular Drug Research Nankai University

Objective: The main objective of the study is to screen the quality markers(Q-markers) for relieving oxidative stress damage and against chronic cerebral ischemia in Shunaoxin pills(SNX). Methods: The benefit effect of SNX was evaluated by a rat chronic cerebral ischemia model. The main ingredients of SNX were identified by ultra-performance liquid chromatography-quadrupole time-of-flight, whereas its core targets and pathways around antioxidative stress were predicted by Pharm Mapper and kyoto encyclopedia of genes and genomes(KEGG) analysis. Moreover, the antioxidants were screened by high-performance liquid chromatography with postcolumn derivatization system and then representative ingredients were verified by cell experiments. Results: SNX could increase expression of catalase and superoxide dismutase(SOD) as well as antagonize oxidative damage in the brain. The effects may be related to three types of antioxidant pathways, including nitrogen metabolism, arachidonic acid metabolism, and the cyclic guanosine monophosphate-dependent protein kinase(c GMP-PKG) signaling pathway by multiple active components regulate targets. Among them, ferulic acid and ligustilide were shown the key scavenging ability for reactive oxygen free radicals and significantly increased the contents of nitric oxide(NO), NO synthase, and SOD as well as decreased malonaldehyde. Conclusion: The oxidation resistances of biological and chemical processes in SNX to protect against cerebral oxidative stress injury were preliminary revealed by an integrated network pharmacology and antioxidant activity-guided screen system. Ferulic acid and ligustilide played a major antioxidant role that could be used as Q-markers to control the quality of SNX.

关键词： Antioxidant chronic cerebral ischemia network pharmacology Q-markers Shunaoxin pills

Relationship between Perceived Health Status and Health Practices in the General Adult Population in Japan

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Open Journal of Preventive Medicine 2015年第6期5卷 280-290页

作者： Yukari Noguchi Kimiyo Ueda Kumiko Fukumoto Koichi Harada Atsushi Ueda chang-nian Wei Department of Health Sciences Graduate School of Medical Sciences Kyushu University Fukuoka Japan Faculty of Life Sciences Kumamoto University Kumamoto Japan Kyushu University of Nursing and Social Welfare Tomio Tamana Kumamoto Japan Department of Medical Technology Faculty of Health Science Kumamoto Health Science University Kumamoto Japan

The objective of this study was to explore the relationship of perceived health status and Breslow’s seven health Practices(7 - 8 hours of sleep per night, maintaining a healthy weight, moderate or no alcohol intake, regular physical activity, no eating between meals, eating breakfast, and having never smoked cigarettes) in adult residents in Kumamoto Prefecture Japan. We used 2011 data from the “Health Japan 21” program in Kumamoto Prefecture, a study consisting of 2519 adults aged from 20 - 74 years. Data for the study were gathered by questionnaire. The questionnaire was divided into following sections: perceived health status, seven health practices, life satisfaction, depression, social network, and demographic variables. We found that those groups engaged in more than four health practices had higher scores for perceived health status than those groups with less than four. Using Pearson’s correlation coefficient, positive correlations were found between perceived health status and health practices (r = 0.229, p – 0.058, p – 0.093, p– 0.109, p < 0.001). Furthermore, we clarified the differences in perceived health status by age and gender. The data from multiple regression analysis show an association between level of perceived health status and life satisfaction, the seven health practices, employment, age, depression, and social network. Our findings demonstrate a relationship between perceived health status and the seven health practices, and can be used to encourage healthier practices to enhance perceived health status and life satisfaction in community health care work.

关键词： Perceived Health Status Health Practices Japanese Population

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基于AI的网络关键词广告系统研究

微电子学与计算机 2008年第6期25卷 26-29,33页

作者：张昌年北京科技大学

为了提高网络关键词广告系统中关键词和其对应的广告内容匹配的准确率,提出了基于人工智能的决策模型.该模型采用改进的关联决策算法,使得系统不但提高了准确率,而且还解决了自我学习问题.在处理新的实例的过程中,它能够学习新的实例的... 详细信息

为了提高网络关键词广告系统中关键词和其对应的广告内容匹配的准确率,提出了基于人工智能的决策模型.该模型采用改进的关联决策算法,使得系统不但提高了准确率,而且还解决了自我学习问题.在处理新的实例的过程中,它能够学习新的实例的变化趋势并更新自己,有效地处理了未来复杂变化所带来的问题,从而提高系统整体性能.

关键词：决策模型人工智能关联决策算法自我学习

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基于神经网络和遗传算法的智能控制方法

微计算机信息 2008年第19期24卷 273-274,277页

作者：张昌年北京科技大学信息工程学院

根据油品调合的特点,应用人工神经网络(Neural Network,NN)对油品在线优化调合系统进行建模,并采用量化正交遗传算法(Orthogonal Genetic Algorithm with Quantization,OGA/Q)对神经网络模型进行学习。提出了用于油品在线优化调合系统... 详细信息

根据油品调合的特点,应用人工神经网络(Neural Network,NN)对油品在线优化调合系统进行建模,并采用量化正交遗传算法(Orthogonal Genetic Algorithm with Quantization,OGA/Q)对神经网络模型进行学习。提出了用于油品在线优化调合系统的人工神经网络适宜的拓扑结构,给出了量化正交遗传算法优化的具体执行过程,实现了系统的主要功能,该系统已经广泛地应用于生产实践中。

关键词：神经网络在线优化油品调合量化正交遗传算法

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日照港矿石码头工程特大型沉箱的出运与存放

港工技术 2005年第4期42卷 41-42,53页

作者：赵昌年日照港(集团)有限公司山东日照276826

通过日照港大型矿石码头工程建设,分析探讨特大型沉箱出运与存放新工艺。

关键词：日照港矿石码头特大型沉箱出运存放