Anti-hyperglycemic effect of the polysaccharide fraction isolated from mactra veneriformis
Anti-hyperglycemic effect of the polysaccharide fraction isolated from mactra veneriformis作者机构：College of Pharmaceutical ScienceNanjing University of Chinese MedicineNanjing 210046China Research Center of Marine Drug in Jiangsu ProvinceNanjing 210046China
出 版 物：《Frontiers of Chemical Science and Engineering》 (化学科学与工程前沿（英文版）)
年 卷 期：2011年第5卷第2期
页 面：238-244页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 0817[工学-化学工程与技术] 08[工学] 070303[理学-有机化学] 0703[理学-化学]
基 金：supported by the National Natural Science Foundation of China(Grant No.30900293) the R&D Special Fund for Public Welfare Industry from State Ocean Administration of China(No.200709005)
主 题：anti-hyperglycemia Mactra veneriformis polysaccharide monosaccharide composition oral glucose tolerance test
摘 要：Total macromolecule extract was obtained from the soft body of Mactra veneriformis by the coupling techniques of decoction and alcohol *** extract was deproteinized with an ion exchange column,and resulted in the purifying of the crude polysaccharide *** was found by chemical analysis that the crude polysaccharide part is composed of abundant polysacchar-ides(95%)and few proteins(1%).Furthermore,only one type of monosaccharide,glucose,was detected from its hydrolytes by thin-layer chromatography,indicating that the polysaccharides might be analogs of *** anti-hyperglycemia effects of the crude polysaccharide part were preliminarily investigated using several pharmacolo-gical methods in normal and diabetic *** experimental results showed that the crude polysaccharide fraction exhibited proper glycemia inhibition activity,and 300 mg/kg-weight dose has the optimal effect among all the studied *** is concluded that the crude polysaccharide fraction can be explored as a novel health product that possesses potential as an anti-hyperglycemic agent.
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