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Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta Thomas Butler Stephen Molloy Fintan John O'Hara Barbara Ryan niall breslin Sarah O'Donnell Anthony O'Connor Sinead Smith Deirdre McNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland Department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

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Diagnosing health in composite battery electrodes with explainable deep learning and partial charging data

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Energy and AI 2024年第2期16卷 256-268页

作者： Haijun Ruan niall Kirkaldy Gregory J.Offer Billy Wu Dyson School of Design Engineering Imperial College LondonSW72AZLondonUK Centre for E-Mobility and Clean Growth Research Coventry UniversityCoventryCV15FBUK Department of Mechanical Engineering Imperial College LondonSW72AZLondonUK The Faraday Institution Harwell Science and Innovation CampusOX110RADidcotUK

Lithium-ion batteries with composite anodes of graphite and silicon are increasingly being used. However, their degradation pathways are complicated due to the blended nature of the electrodes, with graphite and silicon degrading at different rates. Here, we develop a deep learning health diagnostic framework to rapidly quantify and separate the different degradation rates of graphite and silicon in composite anodes using partial charging data. The convolutional neural network (CNN), trained with synthetic data, uses experimental partial charging data to diagnose electrode-level health of tested batteries, with errors of less than 3.1% (corresponding to the loss of active material reaching ∼75%). Sensitivity analysis of the capacity-voltage curve under different degradation modes is performed to provide a physically informed voltage window for diagnostics with partial charging data. By using the gradient-weighted class activation mapping approach, we provide explainable insights into how these CNNs work;highlighting regions of the voltage-curve to which they are most sensitive. Robustness is validated by introducing noise to the data, with no significant negative impact on the diagnostic accuracy for noise levels below 10 mV, thus highlighting the potential for deep learning approaches in the diagnostics of lithium-ion battery performance under real-world conditions. The framework presented here can be generalised to other cell formats and chemistries, providing robust and explainable battery diagnostics for both conventional single material electrodes, but also the more challenging composite electrodes.

关键词： Lithium-ion battery Composite electrode Silicon Degradation diagnostic Explainable deep learning Partial charging

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Hybrid versus global thermostatting in molecular-dynamics simulation of methane-hydrate crystallisation

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Chinese Journal of Chemical Engineering 2019年第9期27卷 2180-2188页

作者： niall J.English Mohammad Reza Ghaani School of Chemical and Bioprocess Engineering University College Dublin

Molecular-dynamics(MD)simulations have been performed for the growth of a spherical methane-hydrate nano-crystallite,surrounded by a supersaturated water–methane liquid phase,using both a hybrid and globalsystem thermostatting *** was found that hybrid thermostatting led to more sluggish growth and the establishment of a radial temperature profile about the spherical hydrate crystallite,in which the growing crystal phase is at a higher temperature than the surrounding liquid phase in the interfacial region,owing to latent-heat *** addition,Onsager’s-hypothesis fluctuation–dissipation analysis of fluctuations in the number of crystal-state water molecules at the interface shows slower growth.

关键词： Molecular dynamics Clathrate hydrates Crystallisation Thermostatting Radial temperature profile Fluctuation–dissipation

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Magnetic ferrite/carbonized cotton fiber composites for improving electromagnetic absorption properties at gigahertz frequencies

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Journal of Materials Science & Technology 2021年第27期86卷 127-138页

作者： Sateesh Bandaru Narashima Murthy Ravindra Kulkarni niall J.English School of Chemical and Bioprocess Engineering University College DublinBelfieldDublin 4Ireland Scinva Chemicals and Pharmaceuticals Pvt Ltd Kumbalagodu Industrial AreaBangaloreIndia BVDU’s Poona College of Pharmacy ErandawanePuneIndia

Ferrite/carbon composited materials,especially the bio-derived composited materials possessing both environmental friendliness and outstanding microwave absorption performance,attract numerous attentions for solving the"electromagnetic problem"in the Gigahertz frequency *** this work,we demonstrate a bio-derived ferrite/carbon material by compositing functional carbonized cotton fibers(CCFs)and Fe_(3)O_(4)nanoparticles with optimized microwave-absorption *** adjusting the carbonization conditions systematically,the Fe_(3)O_(4)loading contents and the microwave absorption properties can be varied simultaneously-and,indeed,optimized and *** CCFs-Fe_(3)O_(4)composites exhibited a minimum reflection-loss capacity RL(d B)of-56.8 d B at 10.9 GHz with a thickness of 1.67 mm,and its effective absorption bandwidth(RL(d B)<-20 d B)was found to broaden to 7.1 *** characterizations,coupled with microstructure analyses,revealed that the enhancement in microwave absorption was triggered by the different microstructures of CCFs-Fe_(3)O_(4)composites-attributable to the different carbonization *** different conditions result in different amounts of Fe_(3)O_(4)attachment sites and lead to the enhancement of dielectric polarization at localized *** present work of bio-derived ferrite/carbon materials has important implications in understanding structure-performance relationships in dielectric-magnetic materials,and,meanwhile,could well be extended to a microwave-absorber design approach.

关键词： Electromagnetic absorption Bio-derived material Dielectric-magnetic composite Interfacial polarization

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Viscosity of food boluses affects the axial force in the esophagus

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World Journal of Gastroenterology 2011年第15期17卷 1982-1988页

作者： Flemming Gravesen niall Behan Asbjorn Drewes Hans Gregersen Mech-Sense Aalborg Hospital Hobrovej 9000 Aalborg Denmark Vysera Biomedical Ltd. BMR House Parkmore Business Park West Galway Ireland Sino-Danish Center for Education and Research Niels Jensens Vej 28000 Aarhus Denmark

AIM: To study the effect of viscosity on axial force in the esophagus during primary peristalsis using a newly validated impedance-based axial force recording technique. METHODS: A probe able to simultaneously measure both axial force and manometry was positioned above the lower esophageal sphincter. Potable tap water and three thickened fluids were used to create boluses of different viscosities. Water has a viscosity of 1 mPa·s. The three thickened fluids were made with different concentrations of Clinutren Instant thickener. The viscous fluids were in appearance comparable to pudding (2 kPa·s), yogurt (6 kPa·s) and slush ice (10 kPa·s). Six healthy volunteers swallowed 5 and 10 mL of boluses multiple times. RESULTS: The pressure amplitude did not increase with the bolus viscosity nor with the bolus volume whereas the axial force increased marginally with bolus volume (0.1 > P > 0.05). Both techniques showed that contraction duration increased with bolus viscosity (P < 0.01). Association was found between axial force and pressure but the association became weaker withincreasing viscosity. The pressure amplitude did not increase with the viscosity or bolus volume whereas the axial force increased marginally with the bolus size. CONCLUSION: This indicates a discrepancy between the physiological functions that can be recorded with axial force measurements and pressure measurements.

关键词： Axial force Manometry Esophagus Primary peristalsis Viscosity

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Digital surgery for gastroenterological diseases

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World Journal of Gastroenterology 2021年第42期27卷 7240-7246页

作者： niall Philip Hardy Ronan Ambrose Cahill UCD Centre for Precision Surgery University College DublinDublin D07 Y9AWIreland

Advances in machine learning,computer vision and artificial intelligence methods,in combination with those in processing and cloud computing capability,portend the advent of true decision support during interventions in real-time and soon perhaps in automated surgical *** capability,deployed alongside technology intraoperatively,is termed digital surgery and can be delivered without the need for high-end capital robotic *** area close to clinical usefulness right now harnesses advances in near infrared endolaparoscopy and fluorescence guidance for tissue characterisation through the use of biophysics-inspired *** represents a potential synergistic methodology for the deep learning methods currently advancing in ophthalmology,radiology,and recently gastroenterology via *** databanks of more general surgical videos are created,greater analytic insights can be derived across the operative spectrum of gastroenterological disease and operations(including instrumentation and operative step sequencing and recognition,followed over time by surgeon and instrument performance assessment)and linked to value-based ***,issues of legality,ethics and even morality need consideration,as do the limiting effects of monopolies,cartels and isolated data ***,the role of the surgeon,surgical societies and healthcare institutions in this evolving field needs active deliberation,as the default risks relegation to bystander or passive *** editorial provides insight into this accelerating field by illuminating the nearfuture and next decade evolutionary steps towards widespread clinical integration for patient and societal benefit.

关键词： Digital surgery Artificial intelligence Gastrointestinal disease Biophysics Deep learning Fluorescence-guided surgery

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Quality of life issues in men undergoing androgen deprivation therapy： a review

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Asian Journal of Andrology 2012年第2期14卷 226-231页

作者： Rowan G Casey niall M Corcoran S Larry Goldenberg University of British Columbia Department of Urologic Sciences Vancouver General HospitalVancouverBC V5Z 1M9Canada

Androgen deprivation therapy （ADT） has been an essential treatment option for treating prostate cancer （PCa）. The role for hormonal treatment initially was restricted to men with metastatic and inoperable, locally advanced disease. Now it has been extended to neoadjuvant or adjuvant therapy for surgery and radiotherapy, for biochemical relapse after surgery or radiation, and even as primary therapy for non-metastatic disease. Fifty percent of PCa patients treated will receive ADT at some point. There is growing concern about the adverse effects and costs associated with more widespread ADT use. The adverse effects on quality of life （QoL）, including physical, social and psychological well-being when men are androgen-deprived, may be considerable. This review examines the QoL issues in the following areas： body feminisation, sexual changes, relationship changes, cognitive and affective symptoms, fatigue, sleep disturbance, depression and physical effects. Further suggestions for therapeutic approaches to reduce these alterations are suFuzested.

关键词： androgen deprivation therapy men prostate cancer quality of life

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Computing the Smallest Eigenvalue of Large Ill-Conditioned Hankel Matrices

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Communications in Computational Physics 2015年第6期18卷 104-124页

作者： niall Emmart Yang Chen Charles C.Weems College of Information and Computer Science University of MassachusettsAmherstMA 01002USA Department of Mathematics University of MacaoMacaoChina

This paper presents a parallel algorithm for finding the smallest eigenvalue of a family of Hankel matrices that are *** matrices arise in random matrix theory and require the use of extremely high precision ***,we find that a group of commonly-used approaches that are designed for high efficiency are actually less efficient than a direct approach for this class of *** then develop a parallel implementation of the algorithm that takes into account the unusually high cost of individual arithmetic *** approach combines message passing and shared memory,achieving near-perfect scalability and high tolerance for network *** are thus able to find solutions for much larger matrices than previously possible,with the potential for extending this work to systems with greater levels of *** contributions of this work are in three areas:determination that a direct algorithm based on the secant method is more effective when extreme fixed-point precision is required than are the algorithms more typically used in parallel floating-point computations;the particular mix of optimizations required for extreme precision large matrix operations on a modern multi-core cluster,and the numerical results themselves.

关键词： Parallel eigensolver Hankel matrices extremely ill-conditioned matrices

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Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions

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World Journal of Gastroenterology 2014年第27期20卷 8859-8866页

作者： niall P Hyland Eamonn MM Quigley Elizabeth Brint Alimentary Pharmabiotic Centre University College Cork 30 Cork Ireland Department of Pharmacology and Therapeutics University College Cork 30 Cork Ireland Houston Methodist Hospital Houston TX 77030 United States Department of Pathology University College Cork 30 Cork Ireland

Irritable bowel syndrome(IBS) is a common, sometimes debilitating, gastrointestinal disorder worldwide. While altered gut motility and sensation, as well as aberrant brain perception of visceral events, are thought to contribute to the genesis of symptoms in IBS, a search for an underlying aetiology has, to date, proven unsuccessful. Recently, attention has been focused on the microbiota as a possible factor in the pathogenesis of IBS. Prompted by a number of clinical observations, such as the recognition of the de novo development of IBS following enteric infections, as well as descriptions of changes in colonic bacterial populations in IBS and supported by clinical responses to interventions, such as antibiotics and probiotics, that modify the microbiota, various approaches have been taken to investigating the microbiota-host response in IBS, as well as in animal models thereof. From such studies a considerable body of evidence has accumulated to indicate the activation or upregulation of both factors involved in bacterial engagement with the host as well host defence mechanisms against bacteria. Alterations in gut barrier function, occurring in response, or in parallel, to changes in the microbiota, have also been widely described and can be seen to play a pivotal role in generating and sustaining host immune responses both within and beyond the gut. In this manner a plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS, can be generated.

关键词： Microbiota Irritable bowel syndrome Tolllike receptor Epithelial barrier Gut-brain axis

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In the shadow of the bomb

In the shadow of the bomb

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作者： niall Heffernan.

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