Quality of life issues in men undergoing androgen deprivation therapy： a review

作     者：Rowan G Casey Niall M Corcoran S Larry Goldenberg 

作者机构：University of British Columbia Department of Urologic SciencesVancouver General HospitalVancouverBC V5Z 1M9Canada 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2012年第14卷第2期

页      面：226-231页

核心收录：

学科分类：090603[农学-临床兽医学] 02[经济学] 0201[经济学-理论经济学] 1002[医学-临床医学] 020105[经济学-世界经济] 09[农学] 0906[农学-兽医学] 

主　　题：androgen deprivation therapy men prostate cancer quality of life 

摘      要：Androgen deprivation therapy （ADT） has been an essential treatment option for treating prostate cancer （PCa）. The role for hormonal treatment initially was restricted to men with metastatic and inoperable, locally advanced disease. Now it has been extended to neoadjuvant or adjuvant therapy for surgery and radiotherapy, for biochemical relapse after surgery or radiation, and even as primary therapy for non-metastatic disease. Fifty percent of PCa patients treated will receive ADT at some point. There is growing concern about the adverse effects and costs associated with more widespread ADT use. The adverse effects on quality of life （QoL）, including physical, social and psychological well-being when men are androgen-deprived, may be considerable. This review examines the QoL issues in the following areas： body feminisation, sexual changes, relationship changes, cognitive and affective symptoms, fatigue, sleep disturbance, depression and physical effects. Further suggestions for therapeutic approaches to reduce these alterations are suFuzested.