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肿瘤化疗病人护理敏感性结局指标的构建

护理研究 2024年第4期38卷 597-603页

作者：蒋蕾周婷李莉华琳蒋妮陶静楠孙晓敏严梅关琼瑶云南省肿瘤医院(昆明医科大学第三附属医院) 云南650100

目的:构建具有科学性、专科性、适用性的肿瘤化疗病人护理敏感性结局指标。方法:以奥马哈系统和护理结局分类为理论依据,采用文献研究初步拟定条目,结合临床现状调查对所拟定条目进行扩充与修订,通过小组讨论形成肿瘤化疗病人护理敏感... 详细信息

目的:构建具有科学性、专科性、适用性的肿瘤化疗病人护理敏感性结局指标。方法:以奥马哈系统和护理结局分类为理论依据,采用文献研究初步拟定条目,结合临床现状调查对所拟定条目进行扩充与修订,通过小组讨论形成肿瘤化疗病人护理敏感性结局指标条目池。应用德尔菲专家函询法实施专家函询,确立肿瘤化疗病人护理敏感性结局指标,运用层次分析法确定各级指标的权重。结果:3轮专家函询问卷的回收率分别为100.0%、90.9%、100.0%;专家权威系数分别为0.913,0.955,0.955;3轮专家函询肯德尔协调系数(kendall’s W值)分别为0.203~0.250,0.247~0.261,0.205~0.225,均P<0.05。最终确立的肿瘤化疗病人护理敏感性结局指标包括4个一级指标、13个二级指标、43个三级指标。结论:构建的肿瘤化疗病人敏感性指标具有科学性、可靠性、权威性、专科性及实用性,各级指标的权重分配合理,可用于测量病人护理结局,为量化、评价护理措施实施效果提供参考依据。

关键词：肿瘤护理化疗护理敏感性结局指标奥马哈系统护理结局分类德尔菲法

Thermocatalytic Dehydrogenation-Enabled Arene-Alkane Couplings

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Chinese Journal of Chemistry 2023年第16期41卷 1905-1914页

作者： Feng Yu Renqing Tao Lan Gan Hao ni Qi-kai kang Guixia Liu Zheng Huang Chang-kung Chuang Institute East China Normal UniversityShanghai 200062China The State key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling RoadShanghai 200032China School of Chemistry and Material Sciences Hangzhou Institute of Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhouZhejiang 310024China

Comprehensive Summary The direct use of non-prefunctionalized arene and alkane as the starting materials to construct Caryl−Calkyl bond is an unfulfilled target and approaches to this challenge rarely surface in methodology *** methods for thermocatalytic arene-alkane couplings(AAC)occur with specific substrates and/or inconvenient ***,we report a one-pot relay bicatalysis system for AAC involving(pincer)Ir-catalyzed alkane transfer dehydrogenation and Fe(OTf)3-catalyzed olefin *** system exhibits broad scope and is particularly effective for alkylation of arenes with arylalkanes to form 1,1-diarylalkanes with high chemo-and regioselectivity,making it potentially useful for late-stage alkylation of complex *** mechanistic data provide a view into the factors controlling the ***,the strategy of dehydrogenation-enabled arene-alkane couplings has been successfully extended to a tandem catalysis by using a heterogeneous olefin hydroarylation catalyst.

关键词： Alkanes Arenes Dehydrogenative coupling Hydroarylation lridium

TRAF2和SNED1基因敲低对牛病毒性腹泻病毒复制的影响

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农业生物技术学报 2024年第9期32卷 2150-2158页

作者：刘芯怡权冉刘昱成陈俊贞倪慧莹付强史慧君新疆农业大学动物医学学院新疆草食动物新药研究与创制重点实验室省部共建绵羊遗传改良与健康养殖国家重点实验室/新疆农垦科学院畜牧兽医研究所

牛病毒性腹泻/粘膜病(bovine viral diarrhea/mucosal disease, BVD/MD)是由牛病毒性腹泻病毒(Bovine viral diarrhea virus, BVDV)引起的接触性传染病，会导致持续性感染，感染犊牛(Bos taurus)会不断向外界排出病毒。本课题组前期使用... 详细信息

牛病毒性腹泻/粘膜病(bovine viral diarrhea/mucosal disease, BVD/MD)是由牛病毒性腹泻病毒(Bovine viral diarrhea virus, BVDV)引起的接触性传染病，会导致持续性感染，感染犊牛(Bos taurus)会不断向外界排出病毒。本课题组前期使用RNA-蛋白质相互作用检测(RNA-protein interaction detection,RaPID)技术，筛选出了与BVDV互作的肿瘤坏死因子受体相关因子2 (tumor necrosis factor receptor associated factor 2, TRAF2)和Sushi、nidogen和EGF样结构域1 (Sushi, nidogen and EGF like domains 1,SNED1)基因。为了确定TRAF2和SNED1基因对BVDV复制的影响，本研究利用小干扰RNA (small interfering RNA, siRNA)技术敲低牛肾细胞(madin-darby bovine kidney cells, MDBk)中TRAF2和SNED1基因，通过qPCR检测TRAF2和SNED1基因的敲低效率和BVDV感染TRAF2和SNED1敲低细胞的BVDV 5'UTR RNA水平变化；使用免疫荧光染色法检测BVDV复制的中间产物双链RNA (double stranded RNA, dsRNA)的积累变化；通过荧光倒置显微镜观察致细胞病变效应(cytopathic effect, CPE)，使用karber法计算子代病毒滴度变化。结果表明，TRAF2和SNED1的mRNA水平显著性降低(PkD和SNED1 kD);BVDV感染对照组(NC) 36 h开始出现明显的空斑、脱落、死亡等CPE现象，TRAF2 kD细胞和SNED1 kD细胞的CPE现象减弱；与对照组(NC)相比，在BVDV感染TRAF2 kD和SNED1 kD细胞后，BVDV 5'UTR RNA水平在24、36和48 h显著下降(PkD和SNED1 kD细胞中36和48 h绿色荧光强度明显降低；BVDV感染TRAF2 kD和SNED1 kD细胞后48 h子代病毒滴度极显著降低(P<0.01)。以上结果表明，敲低TRAF2和SNED1会抑制BVDV复制，本研究为揭示BVDV致病机制提供重要依据。

关键词：牛病毒性腹泻病毒(BVDV) 小干扰RNA (siRNA)技术肿瘤坏死因子受体相关因子2 (TRAF2) Sushi、nidogen和EGF样结构域1 (SNED1)

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基于改进下垂的多逆变器并联控制策略

电力电容器与无功补偿 2024年第2期45卷 169-176页

作者：罗军杰粟时平倪亮李志轩苏乾坤长沙理工大学电气与信息工程学院长沙410114

针对微电网孤岛运行时,传统解耦式下垂控制策略由于未能考虑线路阻抗的影响,多逆变器并联运行时存在无功功率分配不均、环流等问题,论文提出一种基于自适应电压补偿的改进下垂控制策略。文中首先针对因线路阻抗不同所带来的电压跌落问题... 详细信息

针对微电网孤岛运行时,传统解耦式下垂控制策略由于未能考虑线路阻抗的影响,多逆变器并联运行时存在无功功率分配不均、环流等问题,论文提出一种基于自适应电压补偿的改进下垂控制策略。文中首先针对因线路阻抗不同所带来的电压跌落问题,增加了线路压降补偿环节,在此基础上,考虑逆变器出口处电压与母线电压的一致性,改进了下垂控制式,并利用低带宽通信技术获取各逆变器输出功率信息,引入自适应电压补偿环节,提高了逆变器间无功功率的均分精度。最后,基于Matlab平台搭建文章所提控制策略的仿真模型,仿真结果验证了所提控制策略的正确性与有效性。

关键词：微电网下垂控制线路阻抗功率均分电压补偿

Temperature dependence on the electrical and physical performance of InAs/AlSb heterojunction and high electron mobility transistors

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Chinese Physics B 2018年第9期27卷 489-494页

作者： Jing Zhang Hongliang Lv Haiqiao ni Zhichuan niu Yuming Zhang School of Microelectronics Xidian University and Key Laboratory of Wide Band-Gap Semiconductor Materials and DevicesXi＇an 710071China State key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

In this report, the effect of temperature on the In As/Al Sb heterojunction and high-electron-mobility transistors（HEMTs） with a gate length of 2 μm are discussed comprehensively. The results indicate that device performance is greatly improved at cryogenic temperatures. It is also observed that the device performance at 90 k is significantly improved with 27% lower gate leakage current, 12% higher maximum drain current, and 22.5% higher peak transconductance compared to 300 k. The temperature dependence of mobility and the two-dimensional electron gas concentration in the In As/Al Sb heterojunction for the temperature range 90 k-300 k is also investigated. The electron mobility at 90 k（42560 cm2/V·s）is 2.5 times higher than its value at 300 k（16911 cm^2/V·s） because of the weaker lattice vibration and the impurity ionization at cryogenic temperatures, which corresponds to a reduced scattering rate and higher mobility. We also noted that the two-dimensional electron gas concentration decreases slightly from 1.99 × 10^（12） cm^（-2） at 300 k to 1.7 × 10^（12） cm^（-2） at 90 k with a decrease in temperature due to the lower ionization at cryogenic temperature and the nearly constant ？Ec.

关键词： temperature mobility two-dimensional electron gas InAs/AlSb HEMT

Studies on Insoluble Species of Gd(Ⅲ)in Human Blood Plasma by Computer Simulation

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Chemical Research in Chinese Universities 2001年第4期17卷 352-355页

作者： WANG Yue LU Xing ZHANG Hai-yuan YANG kui-yueniU Chun-ji ni Jia-zuan key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022

The insoluble species of Gd ( Ⅲ ) in human blood plasma were investigated by computer simulation. The distribution of the Gd(Ⅲ ) species was obtained. It was found that most of the Gd( Ⅲ ) ions were bound to phosphate to form precipitate GdPO4 at the concentration of 1. 000 10-7 mol/L and when the concentration of the Gd (Ⅲ ) increased to 3. 750 X 10-4 mol/L, in excess of the concentration of phosphate, the Gd ( Ⅲ ) ions were bound to carbonate to form another kind of precipitate, Gd2(CO3)3.

关键词： Speciation Gadolinium ( Ⅲ ) Computer simulation

Integration of a Nonlinear Vibration Absorber and Levitation Magnetoelectric Energy Harvester for Whole-Spacecraft Systems

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Acta Mechanica Solida Sinica 2019年第3期32卷 298-309页

作者： Ye-Wei Zhang Zhi-Wei Fang Shi-Lei Wang Zhi-Yu ni Jian Zang Bo Fang College of Aerospace Engineering Shenyang Aerospace University Shenyang 110136 China Shanghai Prime Machinery Company Limited Shanghai 200072 China

This paper presents a new device integrating a nonlinear vibration absorber with a levitation magnetoelectric energy harvester for whole-spacecraft systems. This device effectively reduces vibration and has a stronger energy harvesting capability than the existing systems. It harvests energy from a wide frequency range and has a high output voltage. The harvested energy is determined by magnetic field strength, excitation frequency, and resistive load. The change in the magnetic field strength has the least impact on the output voltage. The vibration reduction effects and harvested energy of the system are analyzed with an approximate analytical method that combines the harmonic balance approach and the pseudo-arclength continuation algorithm. The results of the Runge-kutta method are nearly consistent with those of the approximate analytical method. Moreover, the effects of the excitation frequency, resistive load, and parameters of the nonlinear energy sink on the system vibration response and energy harvesting are analyzed.

关键词： Levitation magnetoelectric energy harvester Whole spacecraft Nonlinear energy sink Vibration reduction

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夹桩基条件下双线隧道盾构施工沉降特性研究

甘肃科学学报 2024年第5期36卷 1-8页

作者：王武超范磊倪嵩波魏继红乐慧琳中建安装集团有限公司江苏南京210023 河海大学地球科学与工程学院江苏南京210098

盾构法具有适用范围广、施工速度快、施工质量好等优点。为探究双线隧道盾构施工引起的地表沉降对隧道间既有桩基变形的影响特征,以无锡地铁某区间隧道盾构开挖工程为依托,采用有限元法构建数值计算模型,对比了双线异步掘进(方案1)、右... 详细信息

盾构法具有适用范围广、施工速度快、施工质量好等优点。为探究双线隧道盾构施工引起的地表沉降对隧道间既有桩基变形的影响特征,以无锡地铁某区间隧道盾构开挖工程为依托,采用有限元法构建数值计算模型,对比了双线异步掘进(方案1)、右线隧道先施工(方案2)和左线隧道先施工(方案3)3种盾构施工方案的地面沉降和桩基变形,通过现场监测数据与模拟计算数据的对比分析,验证所建立数值模型的合理性。结果表明:方案1具有最小的地表沉降和桩基变形,方案2地表沉降和桩基变形最大,方案3的地表沉降和桩基变形比方案2小。研究结果可为类似拟建和在建盾构隧道工程提供理论指导与参考。

关键词：隧道盾构施工桩基础地表沉降数值模拟现场监测

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Preparation of CuInSe_2 thin films by four-step process

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International Journal of Minerals,Metallurgy and Materials 2009年第4期16卷 439-443页

作者： Yan-lai Wang Hong-bo nie Pei-ran ni Yi-min Wang Shi-ju Guo School of Materials Science and Technology University of Science and Technology Beijing Beijing 100083 China Wuxi ASIC Micro Electronics Co. Ltd. Wuxi 214028 China

A simple process for the deposition of CulnSe2 thin films was described. The CulnSe2 compound was prepared by selenization of Cu-In alloy precursors, which were electrodeposited at a constant current. The selenized precursors were compacted and then annealed. The films were characterized by X-ray diffractometry （XRD）, scanning electron microscopy （SEM） and energy dispersive spectroscopy （EDS）. The results indicate that single-phase CulnSe2 is formed at 250℃ and its crystallinity of this phase is improved as the annealing temperature rises. The losses of In occur in selenization process. The dense CulnSe2 film with comparatively smooth surface can be obtained by compaction under the pressure of 200 MPa.

关键词： CulnSe2 electrodeposition selenization compaction