Thermocatalytic Dehydrogenation-Enabled Arene-Alkane Couplings
作者机构：Chang-Kung Chuang InstituteEast China Normal UniversityShanghai 200062China The State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling RoadShanghai 200032China School of Chemistry and Material SciencesHangzhou Institute of Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhouZhejiang 310024China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2023年第41卷第16期
页 面：1905-1914页
核心收录：
学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术]
基 金：the National Key R&D Program of China(2021YFA1501700) the National Natural Science Foundation of China(21825109,21821002,22072178,22293013)
主 题：Alkanes Arenes Dehydrogenative coupling Hydroarylation lridium
摘 要：Comprehensive Summary The direct use of non-prefunctionalized arene and alkane as the starting materials to construct Caryl−Calkyl bond is an unfulfilled target and approaches to this challenge rarely surface in methodology *** methods for thermocatalytic arene-alkane couplings(AAC)occur with specific substrates and/or inconvenient ***,we report a one-pot relay bicatalysis system for AAC involving(pincer)Ir-catalyzed alkane transfer dehydrogenation and Fe(OTf)3-catalyzed olefin *** system exhibits broad scope and is particularly effective for alkylation of arenes with arylalkanes to form 1,1-diarylalkanes with high chemo-and regioselectivity,making it potentially useful for late-stage alkylation of complex *** mechanistic data provide a view into the factors controlling the ***,the strategy of dehydrogenation-enabled arene-alkane couplings has been successfully extended to a tandem catalysis by using a heterogeneous olefin hydroarylation catalyst.
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