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Procalcitonin could be a reliable marker in differential diagnosis of post-implantation syndrome and infection after percutaneous endovascular aortic repair

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Chinese Medical Journal 2014年第14期127卷 2578-2582页

作者： Xue Ling Luo Songyuan Luo Jianfang Liu Zhen Gu Mengnan Kang Huiyuan Yang Fan nie Bingrong Liu Yuan Huang Wenhui Xie nianjin He Pengcheng Dong Haojian ni zhonghan Fan Ruixin Chen Jiyan Guangdong Acad Med Sci Dept Cardiol Guangdong Prov Cardiovasc Inst Guangdong Gen Hosp Guangzhou 510080 Guangdong Peoples R China Southern Med Univ Guangzhou 510000 Guangdong Peoples R China Sun Yat Sen Univ Dept Pharmacol Zhongshan Sch Med Guangzhou 510080 Guangdong Peoples R China

Background Thoracic endovascular aortic repair （TEVAR） is an emerging treatment moaality, wnicn nas been rapidly embraced by clinicians treating thoracic aortic disease. However, the clinical manifestations of systemic inflammatory response after TEVAR as post-implantation syndrome （PIS） resemble the perioperative infection. This study aimed to evaluate changes and diagnostic value of procalcitonin （PCT） and other traditional inflammatory markers for infections after TEVAR. Methods We conducted a prospective clinical study that enrolled 162 consecutive aortic dissection cases. who underwent TEVAR in our institution between July 2011 and November 2012. The PCT, C-response protein （CRP）, erythrocyte sedimentation rate （ESR） and blood routine examination were monitored before the operation and on days 1, 2, 3 and 5 after the operation. The diagnosis of infection was confirmed by the infection control committee with reference to Hospital Acquired Infection Diagnostic Criteria Assessment, released by the Ministry of Health of the People＇s Republic of China. Results Post endovascular repair of thoracic aorta, PCT changes significantly at different time points （X^2= 13.225, P=0.021）, without significant difference between the PIS group and the control group （0.24±0.04 vs.0.26±0.10, P=0.804）. PCT values were significantly higher in the first day after TEVAR than the preoperative levels （0.18±0.03 vs. 0.11±0.02, P 〈0.001）. Compared with PIS patients, the level of PCT, CRP, White blood cell （WBC） and neutrophil （NEU） in the infection patients elevated significantly （relatively X2=6.062, P=0.048; X2=6.081, P=0.048; X2=11.030, P=0.004; X2=14.632, P=0.001）. According to the ROC analysis, the PCT levels in the first day after TEVAR （AUC=0.785, P=0.012） had better predictive values of infection than WBC, NEU CRP and ESR （AUC=0.720, P=0.040; AUC=0.715, P=0.045; AUC=0.663, P=0.274; AUC=0.502, P=0.991）. The best predictive index was the changes of PCT between preoperative and postope

关键词： aortic dissection inflammatory response infection endovascular repair procalcitonin

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Spin-glass behavior in the competing CoCrGaO_(4)cubic spinel system

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Nano Research 2025年第1期18卷 501-507页

作者： Jiyu Hu Jiangli ni Zhenfa Zi Chaocheng Liu School of Physics and Materials Engineering Hefei Normal UniversityHefei 230009China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China

Spin glasses(SGs),generally defined as disordered systems with randomized competing interactions,are widely investigated complex *** the ground states of spin glasses is crucial for understanding the nature of disordered magnets and many other physical manifestations,while also helping to solve some hard combinatorial optimization problems across multiple ***,the intrinsic cause of SG has always been elusive,especially in spinel oxide ***,we report the SG behavior observed in the cubic spinel oxides CoCrGaO_(4),and provide a comprehensive understanding of its intrinsic *** results indicate a frustrated state under multi-magnetic competition,and the features of SG are confirmed by susceptibility *** fitting parameters ofτ0,T0,and zv of isothermal remanent magnetization further reveal the relaxation behavior and strong spin ***,the varying exchange coupling under different temperatures and magnetic fields is unveiled,which should be responsible for the disordered *** studies unravel the underlying mechanism responsible for doping-induced magnetic frustration and introduce CoCrGaO_(4)as a potential platform for investigating spin glass behavior,thereby advancing fundamental research on frustrated magnetism within the spinel system.

关键词： spin glass(SG) magnetic frustration magnetic competition spinel ferrites

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牛生长激素cDNA的分子克隆

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生物工程学报 1988年第1期 20-25页

作者：宋德秀倪彬晖戴宗汉史瀛仙中国科学院发育生物学研究所

我们克隆了与牛生长激素 Poly（A）+RNA 互补的 DNA（cDNA）。首先从小牛垂体中提纯总的 Poly（A）+RNA,用 AMV 逆转录酶合成单链 cDNA,以单链 cDNA 为模板合成双链cDNA,用多聚 G 及多聚 C 谱尾法将双链 cDNA 克隆到 pBR322质粒的 Pst ... 详细信息

我们克隆了与牛生长激素 Poly（A）+RNA 互补的 DNA（cDNA）。首先从小牛垂体中提纯总的 Poly（A）+RNA,用 AMV 逆转录酶合成单链 cDNA,以单链 cDNA 为模板合成双链cDNA,用多聚 G 及多聚 C 谱尾法将双链 cDNA 克隆到 pBR322质粒的 Pst I位点上,构建成牛垂体 Poly（A）+RNA 的 cDNA 文库。以牛生长激素基因为探针,筛选出7个阳性菌落,经电冰鉴定有两个菌落（1号和2号）含有大于500bp 的插入片段。1号克隆经酶切图谱、Southern blot 杂交及序列分析证实含有牛生长激素的编码序列。

关键词：牛生长激素克隆限制性酶图谱

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紫杉醇洗脱球囊治疗冠状动脉原发病变的安全性和可行性

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中华心血管病杂志 2018年第1期46卷 39-43页

作者：倪忠涵黄文晖刘媛陈竹君李捷杨峻青何鹏程周颖玲陈纪言罗建方广东省心血管病研究所广东省冠心病防治研究重点实验室广东省医学科学院广东省人民医院心内科广州510080

目的探讨紫杉醇洗脱球囊治疗冠状动脉原发病变的安全性和可行性.方法纳入2015年4月至2016年11月在广东省人民医院使用紫杉醇洗脱球囊治疗的冠状动脉原发病变患者76例（共80处原发病变,接受预处理后残余狭窄＜30％,且未发生限制冠状动... 详细信息

目的探讨紫杉醇洗脱球囊治疗冠状动脉原发病变的安全性和可行性.方法纳入2015年4月至2016年11月在广东省人民医院使用紫杉醇洗脱球囊治疗的冠状动脉原发病变患者76例（共80处原发病变,接受预处理后残余狭窄＜30％,且未发生限制冠状动脉血流的夹层）.回顾性分析患者的基线资料、介入治疗情况和即刻效果,并进行临床随访,主要终点是心原性死亡、再发心肌梗死和靶病变血运重建.结果（1）患者年龄（63.3±10.3）岁,急性冠状动脉综合征患者占68.4％（52/76）,合并糖尿病者占36.8％（28/76）,合并至少1项出血高危因素者占64.5％（49/76）.（2）以紫杉醇洗脱球囊处理的冠状动脉原发病变长度为（17.4±7.6）mm,狭窄程度为（88.1±8.2）％,51.2％（41/80）的病变参考血管直径≥2.75 mm,分叉病变占67.5％（54/80）.（3）53.7％（43/80）的冠状动脉病变使用嵌入式球囊进行预处理.紫杉醇洗脱球囊长度为（22.3±5.5）mm,直径为（2.74±0.52）mm,术后残余狭窄为（12.3±10.3）％.技术成功率为88.8％（71/80）,补救性支架置入率为5.0％（4/80）.（4）术后随访时间中位数为12（6,25）个月,主要终点事件发生率为3.9％（3/76）,其中心原性死亡2例（再发心肌梗死导致死亡1例,合并重度二尖瓣关闭不全患者发生急性心力衰竭导致死亡1例）,靶病变血运重建1例.结论使用紫杉醇涂层球囊治疗预处理后残余狭窄＜30％且无限制血流夹层的冠状动脉原发病变安全、可行.

关键词：冠状动脉疾病治疗结果紫杉醇洗脱球囊

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge Yin Tingting Fu Jing Liu Yuji Du Jiahui Kong Rongrong Chang Jian ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

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Selective laser melted high ni content Tini alloy with superior superelasticity and hardwearing

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Journal of Materials Science & Technology 2022年第21期116卷 246-257页

作者： Hui Shen Qingquan Zhang Ying Yang Yang Ren Yanbao Guo Yafeng Yang zhonghan Li Zhiwei Xiong Xiangguang Kong Zhihui Zhang Fangmin Guo Lishan Cui Shijie Hao State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China The Key Laboratory of Bionic Engineering(Ministry of Education)and the College of Biological and Agricultural Engineering Jilin UniversityChangchun 130025China Department of Physics City University of Hong KongKowloonHong KongChina College of Mechanical and Transportation Engineering China University of PetroleumBeijing 102249China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Tini alloys with high content ni(52-55 at.%)are perfectly suitable for preparing wear-and corrosionresistant parts that service on the space station,spacecraft,and submarine,because of their superior superelasticity,high strength,and ***,the fabrication of complicated ni-rich Tini parts by the traditional machining method often faces problems of poor precision,low efficiency,and high *** this work,we succeed in preparing an excellent Ti_(47)ni_(53) alloy by selective laser melting(SLM),and thus,open a new way for the efficient and precise formation of complicated ni-rich Tini parts with superelasticity and *** optimized processing window for compact parts without defects is *** elaborately fabricated Ti_(47)ni_(53) alloy exhibited a breaking strain of 11%,a breaking stress of 2.0 GPa,a superelastic strain of 9%,and a better hardwearing than that of casting and quenched Ti_(47)ni_(53) ***,the microstructure,phase transformation,and deformation,as well as their influence mechanisms are investigated by in situ transmission electron microscope(TEM)and high-energy X-ray diffraction(HE-XRD).The results obtained are of significance for both fundamental research and technological applications of SLM-fabricated high ni content Tini alloys.

关键词： Selective laser melting High ni content Tini Superelasticity Wear In situ high-energy X-ray diffraction Microstructure

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Homogenous coating of Li^(+)conductive Li_(5)AlO_(4)on single-crystalline nonstoichiometric Li_(1.04)ni_(0.92)Al_(0.04)O_(2)for rechargeable lithium-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 651-659,I0014页

作者： Guoyu Ding Shizhou Wang Jinhan Li Ziyan Wu Jiayu Chen Jiayong Du Xinhui Huang Kuiming Liu Yudong Zhang zhonghan Wu Yiyang Peng Qiancheng Zhao Meng Yu Fangyi Cheng Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Engineering Research Center of High-efficiency Energy Storage(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Advanced Chemical Power Sources Nankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Cobalt-free,nickel-rich Lini_(1-x)Al_(x)O_(2)(x≤0.1)is an attractive cathode material because of high energy density and low cost but suffers from severe structural degradation and poor rate *** this study,we propose a molten salt-assisted synthesis in combination with a Li-refeeding induced aluminum segregation strategy to prepare Li_(5)AlO_(4)-coated single-crystalline slightly Li-rich Li_(1.04)ni_(0.92)Al_(0.04)O_(2).The symbiotic formation of Li_(5)AlO_(4)from reaction between molten lithium hydroxide and doped aluminum in the bulk ensures a high lattice matching between the ni-rich oxide and the homogenous conductive Li_(5)AlO_(4)that permits high Li^(+)*** from mitigated undesirable side reactions and phase evolution,the Li_(5)AlO_(4)-coated single-crystalline Li_(1.04)ni_(0.92)Al_(0.04)O_(2)delivers a high specific capacity of220.2 mA h g^(-1)at 0.1 C and considerable rate capability(182.5 mA h g^(-1)at 10 C).Besides,superior capacity retention of 90.8%is obtained at 1/3 C after 100 cycles in a 498.1 mA h pouch full ***,the particulate morphology of Li_(1.04)ni_(0.92)Al_(0.04)O_(2)remains intact after cycling at a cutoff voltage of 4.3 V,whereas slightly Li-deficient Li_(0.98)ni_(0.97)Al_(0.05)O_(2)features intragranular cracks and irreversible lattice *** results highlight the value of molten salt-assisted synthesis and Li-refeeding induced elemental segregation strategy to upgrade ni-based layered oxide cathode materials for advanced Li-ion batteries.

关键词： Aluminum segregation Surface coating Nonstoichiometric oxides Molten synthesis Cathode materials

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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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