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In vivo anticancer activity of maesopsin 4—O— β—glucoside isolated from leaves of Artocarpus tonkinensis *** Gagnep

Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 343-348页

作者： Trinh thi Thuy Dao Duc thien Tran Quang Hung nguyen Thanh Tam nguyen thi Hoang Anh nguyen thi Nga nguyen thi cuc Le Phuong Mai Tran Van Sung Domenico V.Delfino Do thi Thao Institute of Chemistry.Vietnam Academy of Science and Technology Institute of Biotechnology Vietnam Academy of Science and Technology National Research Council Canada Measurement Science and Standards1200 Montreal RoadBuilding M-12.Ottatca.Ontario KIA OR6 Department of Medicine University of PerugiaPiazzale Gambuli.S.Andrea delle Fratte

Objective:To investigate the antitumor effect of maesopsin 4-O-β-glucoside(TAT2) isolated from the leaves of Artocarpus tonkinensis(***) *** ***:The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma(LLC) tumor-bearing ***/c mice had tumors induced by implantation with 2× 10~6 LLC cells into the subcutaneous right posterior ***-bearing mice were treated orally with a range of doses of TAT2 and a standard drug,*** were observed for tumor growth and mortality *** was collected to determine hematological and biochemical *** TAT2 was isolated from an ethanolic extract of *** *** structure was determined by MS and NMR spectroscopy,and identified as *** compound did not show acute toxicity at the highest dose tested(2 OIK) mg/kg body weight).TAT2 exhibited antitumor activity by decreasing tumor growth,increasing the survival rale,and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight(P<0.05).Conclusions:These results indicate that TAT2 possesses clear antitumor *** to its bioavailability and low toxicity,and the fact that it could be isolated in a large scale from *** leaves,the compound shows promise as a potential anticancer drug.

关键词： Artocarpus tonkinensis BALB/c Hematological parameters Lewis lung carcinoma Maesopsin 4-0-β-glucoside

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Simultaneous Quantitative Analysis of Five Components in Angelica sinensis and Angelica acutiloba Acclimatized Growing in Vietnam by High-Performance Liquid Chromatography with Photodiode Array Detector

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 6-10页

作者： thi Minh Tam Pham thi Thu cuc Le Van Thanh nguyen Viet Hung Tran Departments of Microbiology Institute of Drug Quality ControlHo Chi Minh City Departments of Instrumental Analysis Institute of Drug Quality ControlHo Chi Minh City Institute of Drug Quality Control Ho Chi Minh City Faculty of Pharmacy Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam

Background:Chinese Danggui(Angelica sinensis)and Japanese Danggui(Angelica acutiloba)are evaluated as the same in using and critical of quality control in Vietnamese *** Vietnam,Japanese Danggui were acclimatized and cultivated in several regions in recent *** the huge climatic difference between Vietnam and Japan,Japanese Danggui grows very well in ***,there are no studies to assess the overall quality of this medicinal *** and Objectives:The aim of this study is to develop a method to identify and assay simultaneously 5 component compounds of these crude herbs:chlorogenic acid,ferulic acid,scopoletin,xanthotoxin and ligustilide by high-performance liquid chromatography with photodiode array detector(HPLC-PDA).Materials and Methods:The procedure was optimized by using column Phenomenex Gemini 5μm PR C18,15 x 4,6 mm with the detection wavelength set at 321 nm for detector PDA and mobile phase was composed of(A)ACN and(B)aqueous solution 1%of acid acetic using a gradient *** were performed at 30°C with a flow rate of 1.0 mL/***:The developped method were fully validated for linearity,accuracy,recovery and met the validation requirements,proved practical applicability for the quality control of these herbs and related ***:The method was successfully applied to the quantification of five markers simultaneously from collected samples.

关键词： Chlorogenic acid Danggui ferulic acid ligustilide scopoletin xanthotoxin

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Isolation and Identification of Two Flavonoid Compounds from Acclimatized Angelica acutiloba Kitagawa Growing in Vietnam

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 413-416页

作者： thi Minh Tam Pham thi Thu cuc Le Viet Hung Tran Van Thanh nguyen Department of Microbiology Institute of Drug Quality ControlDepartment of Analytical Chemistry and Quality ControlUniversity of Medicine and PharmacyHo Chi Minh CityVietnam Department of Analytical Chemistry and Quality Control Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam Department of Microbiology Institute of Drug Quality ControlHo Chi Minh CityVietnam

Traditional Vietnamese Medicine has its own development based on the local endemic herbs,but it also inherits from Traditional Chinese Medicine using Chinese herbal *** the history of cultural exchange between two countries,the adoption of Chinese Danggui,Angelica sinensis(Oliv.)Diels.,has been made by Vietnamese traditional medicine practitioners for a long ***,the acclimatization has never been *** Danggui,or Angelica acutiloba Kitagawa,is recently being acclimatized and cultivated in several Vietnamese *** the huge climate change between the two countries,the herb adapted exquisitely well to the humid tropical ***,so far,there are no studies that have evaluated the effect of acclimatization on the overall quality of this medicinal *** aim of our study is screening secondary metabolites of this acclimatized herb for new natural compound(s),if *** analysis of flavonoid fraction from this herb led to the identification of two known compounds which previously have not been isolated from this species *** detection showed that the herb has reacted to the new environment.

关键词： Abiotic stress Angelica acutiloba danggui isoquercitrin rutin

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Two-Stage Production Planning Under Stochastic Demand:Case Study of Fertilizer Manufacturing

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Computers, Materials & Continua 2022年第1期70卷 1195-1207页

作者： Chia-Nan Wang Shao-Dong Syu Chien-Chang Chou Viet Tinh nguyen Dang Van Thuy cuc Department of Industrial Engineering and Management National Kaohsiung University of Science and TechnologyKaohsiung80778Taiwan Sunline NP Telecommunications Co.Ltd Kaohsiung80778Taiwan Department of Shipping Technology National Kaohsiung University of Science and TechnologyKaohsiung80778Taiwan Faculty of Commerce Van Lang UniversityHo Chi Minh City70000Vietnam Faculty of Industrial Engineering and Management International UniversityHo Chi Minh City70000Vietnam

Agriculture is a key facilitator of economic prosperity and nourishes the huge global *** achieve sustainable agriculture,several factors should be considered,such as increasing nutrient and water efficiency and/or improving soil health and *** fertilizer is one of the fastest and easiest ways to improve the quality of nutrients inland and increase the effectiveness of crop *** supplies most of the necessary nutrients for plants,and it is estimated that at least 30%-50%of crop yields is attributable to commercial fertilizer nutrient *** is always a major concern in achieving sustainable and efficient *** reasonable and customized fertilizerswill require a significant increase in the number of formulae,involving increasing costs and the accurate forecasting of the right time to apply the suitable *** alternative solution is given by two-stage production planning under stochastic demand,which divides a planning schedule into two *** primary stage has non-existing demand information,the inputs of which are the proportion of raw materials needed for producing fertilizer products,the cost for purchasing materials,and the production *** total quantity of purchased material and produced products to be used in the blending process must be defined to meet as small as possible a paid *** the second stage,demand appears under multiple scenarios and their respective *** stage will provide a solution for each occurring scenario to achieve the best *** two-stage approach is presented in this paper,the mathematical model of which is based on linear integer *** the diversity of fertilizer types,themathematicalmodel can advise manufacturers about which products will generate as much as profit as ***,two objectives are taken into ***,the paper’s thesis focuses on minimizing overall system costs,e.g.,including inventory cost,pur

关键词： Two-stage stochastic programming demand uncertainty planning blending fertilizer

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Application of Marker Assisted Backcrossing to Introgress the Submergence Tolerance QTL <i>SUB</i>1 into the Vietnam Elite Rice Variety-AS996

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American Journal of Plant Sciences 2012年第4期3卷 528-536页

作者： Luu M. cuc Luu T. N. Huyen Pham T. M. Hien Vu T. T. Hang nguyen Q. Dam Pham T. Mui Vu D. Quang Abdelbagi M. Ismail Le H. Ham Agricultural Genetics Institute Tu Liem Vietnam Cuu Long River Delta Rice Research Institute Tan Thanh Vietnam International Rice Research Institute Metro Manila Philippine

The result of the study contributes to enhancing and sustaining future livelihoods and food security in Vietnam vis-a-vis climate change. An innovative strategy based on marker-assisted backcrossing (MABC) was used to transform popular rice variety AS996 into the one can tolerate submergence while maintaining its original characteristics preferred by farmers and consumers. The submergence tolerance QTL SUB1 counts for up to 70% of the submergence tolerant and provides a marked improvement of submergence tolerance in all genetic backgrounds and environments tested so far. Parental diversity was carried out with 460 markers. Of which, 53 polymorphic markers were used for assessment on BC1F1, BC2F1 and BC3F1 generations. The best BC1F1 plant was P422 with highest recipient allele was 87.5%, while the additional chosen plants were P412, P428, P215 and P39 (81% - 84%). All these plants were used to develop BC2F1 generation. The six BC2F1 plants were used to develop BC3F1 and BC2F2 were the plants number P422-11 and P422-14 having 93.75% recipient alleles and P422-12, P422-3, P39-17, P39-25 having 92.25% recipient alleles. Total of 445 BC3F1 plants were confirmed the introgresion of SUB1 using ART5 and SC3. After three generations of backcrossing, application of MABC resulted in the best BC3F1 individual P422-14-177 with 100% of recipient alleles based on the number of 53 markers used with only the introgression size of SUB1 was 0.3Mb between ART5 and SC3. Phenotyping was carried out on BC3F1 and BC2F2 of the selected lines. The survival ratio of these selected lines and IR64SUB1 were the same. It convinced the successfully introgress SUB1 into AS996 rice variety. The breeding line BC4F1 having 100% genetic background of donor variety is ready for develop new submergence tolerant rice variety ASS996-SUB1 to cope with climate change.

关键词： AS996-SUB1 Climate Change Marker-Assisted Backcrossing (MABC) Rice Submergence

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1965年11月23日的日环食

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天文学报 1962年第1期 53-60页

作者：阮王茂松刘宝琳越南民主共和国气象局中国科学院紫金山天文台

越南最近所能看到的日食是1965年11月23日的日环食,这一次日环食经过越南境内的路线作者曾进行了计算.上次计算是利用纽康(***)的日食表,用它算得的日食路线只是近似的数值.现在利用更精确的数据进一步做精密而详细的计算.计算太阳月亮... 详细信息

越南最近所能看到的日食是1965年11月23日的日环食,这一次日环食经过越南境内的路线作者曾进行了计算.上次计算是利用纽康(***)的日食表,用它算得的日食路线只是近似的数值.现在利用更精确的数据进一步做精密而详细的计算.计算太阳月亮坐标是根据纽康的太阳表和布朗的月亮表.布朗为了使计算得的月亮位置能与观测到的位置更好地符合,在月亮表中加入了经验项

关键词：历书时坐标太阳天文时恒星月亮地平视差天文学报

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越南Vedana餐厅

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现代装饰 2021年第4期 58-63页

作者： nguyen Tat Dat nguyen Due Trung Tu Minh Dong nguyen Tan Thang Hiroyuki Oki 范嘉苑

该项目坐落于越南菊芳国家公园(cuc Phuong)的边界上,四周绿树成荫,植被丰富。Vedana餐厅是Vedana度假村整体规划的一部分,而这两个项目均由武重义建筑事务所(VTN Architects)负责设计。度假村共包含能容纳1350人的135栋别墅、5家公寓...

该项目坐落于越南菊芳国家公园(cuc Phuong)的边界上,四周绿树成荫,植被丰富。Vedana餐厅是Vedana度假村整体规划的一部分,而这两个项目均由武重义建筑事务所(VTN Architects)负责设计。度假村共包含能容纳1350人的135栋别墅、5家公寓酒店以及8间单层别墅。Vedana餐厅作为园区中的重要构成,位于度假村中央。除了为客人们提供全天候的用餐空间以外,Vedana餐厅还可以作为婚庆或大型活动的举办场地使用。项目由三重圆形屋顶构成,建筑面积达1050平方米。顶部由两个层叠的环形屋顶以及顶部的圆形拱顶组成,每层屋顶之间都设有采光带。餐厅的最大半径为18米,而建筑结构几乎达16米,是武重义建筑事务所(VTN Architects)迄今为止最高的竹结构建筑项目。阶形屋顶的设计灵感来源于越南传统建筑,由36个模块化框架构成。虽然餐厅仅有一层,

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