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Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh nguyen han Yu Xingzhi Li Huiren Wang Tram Gia Bao nguyen Prakash Kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

Bifurcation Analysis of the Voltage Controlled Photosensitive Chaotic Oscillator

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Chinese Physics Letters 2013年第6期30卷 42-45页

作者： Van Ha nguyen han Jung Song Department of Nano Systems Engineering Inje UniversityGimhae 621-749Korea Center for Nano Manufacturing Inje UniversityGimhae 621-749Korea

A photosensitive chaotic oscillator which can be controlled with light illumination under various control voltage levels is *** oscillator consists of a photodiode for the light input,clock switches and capacitors for the sample and hold function,a nonlinear function that creates an adjustable chaos map,and a voltage shifter that adjusts the output voltage for *** optimizing the photodiode sub-circuit by using an available photodiode model in PC-based simulation program with integrated circuit emphasis to obtain a suitable output,the full chaotic circuit is verified with standard 0.6-μm complementary metal oxide semiconductor *** dynamics are analyzed as a function of the light intensity under different control voltage *** time series,frequency spectra,transitions in state spaces,bifurcation diagrams and the largest Lyapunov exponent are improved.

关键词： oscillator chaotic function

Inter-harmonics in multi-terminal VSC-based HVDC systems

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Journal of Modern Power Systems and Clean Energy 2016年第2期4卷 282-291页

作者： Minxiao han Phuchuy nguyen Wenli YAN School of Electrical Engineering North China Electric Power UniversityBeijing 102206China School of Mathematical&Physical Science School North China Electric Power UniversityBeijing 102206China

Multi-terminal voltage sourced converter(VSC)-based high voltage direct current (HVDC) system composes of a number of VSCs connected to an HVDC grid (or dc grid).The dc grid is often configured by cable interconnections between converter stations,thus imposing resonance issues affecting harmonic interaction in the *** on the harmonic transfer characteristics of VSC and HVDC systems,the appearance and the interaction of inter-harmonics in the multi-terminal VSC-based HVDC system are *** models are built and implemented using SimPowerSystems in *** simulation results show that,a series of inter-harmonics are produced and tend to be dominant in low-frequency *** in the dc grid,the inter-harmonic transfer can be magnified due to inter-harmonic *** complex resonance issues in the dc grid are investigated in combination with interaction through the VSC,it is beneficial to harmonic filter designs as well as other harmonic mitigation methods.

关键词： Voltage sourced converter Inter-harmonic VSC-based HVDC Multi-terminal VSC-based HVDC DC-resonance

Seamless handover between unicast and multicast multimedia streams

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 929-942页

作者： Mau-Luen THAM Chee-Onn CHOW Yi-han XU Khong Neng CHOONG Cheng suan LEE Department of Electrical Engineering Faculty of Engineering University of Malaya College of Information Science and Technology Nanjing Forestry University Wireless Communication Cluster MIMOS BerhadKuala Lumpur 57000 Malaysia Power-All Networks Jalan AmpangKuala Lumpur 50450 Malaysia

With the deployment of heterogeneous networks, mobile users are expecting ubiquitous connectivity when using applications. For bandwidth-intensive applications such as Internet Protocol Television(IPTV), multimedia contents are typically transmitted using a multicast delivery method due to its bandwidth efficiency. However, not all networks support multicasting. Multicasting alone could lead to service disruption when the users move from a multicast-capable network to a non-multicast network. In this paper, we propose a handover scheme called application layer seamless switching(ALSS) to provide smooth real-time multimedia delivery across unicast and multicast networks. ALSS adopts a soft handover to achieve seamless playback during the handover period. A real-time streaming testbed is implemented to investigate the overall handover performance, especially the overlapping period where both network interfaces are receiving audio and video packets. Both the quality of service(QoS) and objective-mapped quality of experience(QoE) metrics are measured. Experimental results show that the overlapping period takes a minimum of 56 and 4 ms for multicast-to-unicast(M2U) and unicast-to-multicast(U2M) handover, respectively. The measured peak signal-to-noise ratio(PSNR) confirms that the frame-by-frame quality of the streamed video during the handover is at least 33 dB, which is categorized as good based on ITU-T recommendations. The estimated mean opinion score(MOS) in terms of video playback smoothness is also at a satisfactory level.

关键词： Experimental approach Multimedia session continuity Seamless handover Unicast/multicast switching Multimedia streaming

Land subsidence prediction for a new urban mass rapid transit line in hanoi

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Underground Space 2020年第2期5卷 93-104页

作者： Pham Huy Giao Vu Thi Hue nguyen Dang han nguyen Thi Hai Anh nguyen Ngoc Minh Asian Institute of Technology BangkokThailand Institute of Foundation and Underground FECONHanoiViet Nam Sonhai JSC Viet Nam

The rapidly increasing population,urbanization,and industrialization of hanoi city in the last few decades have necessitated the urgent development of a new underground public transport infrastructure such as the urban mass rapid transit(UMRT)system that is now under ***,concerns on the possible effects of land subsidence on the to-be-constructed and operated UMRT lines must be *** of the difficulties while assessing land subsidence in hanoi is the insufficient subsidence monitoring ***,a good geotechnical characterization of the subsoil profile and proper numerical analysis can help predict groundwater pumping-induced subsidence *** UMRT line No.2 that was selected for this study is special as it runs across the old quarter downtown,located at the very heart of hanoi *** this paper,the hanoi aquifer system,groundwater extraction,and subsidence monitoring network of hanoi are reviewed *** data from 30 investigation boreholes were analyzed to characterize the subsoil profile underlying a segment of the UMRT line No.2 that consists of both elevated and underground *** soil layers were identified up to a depth of 50 m,including a compressible soft clay layer 10-15 m thick that is supposed to be most vulnerable to subsidence by groundwater *** on the long-term groundwater monitoring data,one-dimensional finite element method(FEM)consolidation analyses were carried out for three drawdown boundary conditions of 5,10,and 15 m and yielded a total subsidence of 0.15,0.35,and 0.5 m,respectively,after 25 years with 1994 as the reference *** results of this study confirmed that land subsidence in particular should be considered in the construction and maintenance of the UMRT lines in hanoi,in particular for underground sections that are founded on soft to medium clay layers.

关键词： hanoi aquifer system Groundwater pumping Land subsidence UMRT line Geotechnical characterization

Recovery of child immunization programs post COVID-19

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Asian Pacific Journal of Tropical Medicine 2021年第10期14卷 429-430页

作者： Giao Huynh han Thi Ngoc nguyen An Le Pham Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Family Medicine Training Center University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Infection Control Department University Medical Center at Ho Chi Minh CityVietnam Grant and Innovation Center University of Medicine and Pharmacy at Ho Chi Minh CityVietnam

Immunization is considered as the most effective measure to safely reducing the rate of vaccine-preventable diseases like tuberculosis,hepatitis B,diphtheria,tetanus,pertussis,polio,measles,etc.,and reducing infant mo... 详细信息

关键词： vaccine mortality diseases

Antidiabetic and antioxidant activities of red seaweed Laurencia dendroidea

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Asian Pacific Journal of Tropical Biomedicine 2019年第12期9卷 501-509页

作者： The han nguyen Thi Huyen nguyen Van Minh nguyen Thi Lan Phuong nguyen Thi Van Anh Tran Anh Duy Do Sang Moo Kim Faculty of Food Technology Nha Trang University02 Nguyen Dinh Chieu StreetNha Trang CityKhanh HoaVietnam Quality Control Department Institute of Vaccines and Medical BiologicalsNha Trang CityKhanh HoaVietnam Faculty of Pharmacy University of Medicine and Pharmacy of Ho Chi Minh City41 Dinh Tien Hoang StreetHo Chi Minh CityVietnam Research Department of Marine Conservation Research Institute for Marine Fisheries224 Le Lai StreetHai Phong CityVietnam Department of Marine Food Science and Technology Gangneung-Wonju National University7 Jukheon-gilGangneung 25457Republic of Korea

Objective:To investigate antidiabetic and antioxidant activities of the extract and fractions from Vietnamese red seaweed Laurencia ***:The seaweed Laurencia dendroidea was extracted by using microwave-assisted extraction method in 80%*** seaweed extract was then fractionated using different solvents(n-hexane,chloroform,ethyl acetate,butanol and water).These obtained fractions were evaluated forα-glucosidase inhibitory and antioxidant *** activities were tested using DPPH,nitric oxide radical scavenging and metal chelating *** enzyme inhibition mode was determined using Lineweaver-Burk *** acidic and thermal stabilities,the ethyl acetate fraction was treated at pH 2.0 and 100℃,*** residual inhibitory activity of the fraction was calculated based on the initial inhibitory *** in vivo antidiabetic activity,mice were divided into four groups,including normal control,diabetic control,diabetic mice treated with ethyl acetate fraction and diabetic mice treated with *** glucose level of treated mice during acute and prolonged treatments was *** evaluate the toxicity of the ethyl acetate fraction,the body weight changes and activities of liver function enzymes(aspartate transaminase,alanine transaminase and gammaglutamyl transferase)were carried ***:The extract of Laurencia dendroidea showed strongα-glucosidase inhibitory and DPPH radical scavenging *** concentrations affected bothα-glucosidase inhibitory and antioxidant activities.A 80%aqueous methanol was the suitable solvent for extraction of enzyme inhibitors and *** solvent fractions,ethyl acetate fraction had the highest inhibitory activities againstα-glucosidase with a mixed type of inhibition and the strongest antioxidant activities,and was stable under acidic and thermal *** ethyl acetate fraction treated diabetic mice significantly reduced blood glucose level compare

关键词： α-Glucosidase inhibitor Antidiabetic Antioxidant Red seaweeds Vietnam

The future of COVID-19 vaccination rates for children

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Asian Pacific Journal of Tropical Medicine 2022年第9期15卷 381-382页

作者： Giao Huynh Kimberly H.nguyen han Thi Ngoc nguyen Tuan Diep Tran Pham Le An Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Public Health and Community Medicine Tufts University School of MedicineBostonMAUSA Infection Control Department University Medical Center Ho Chi Minh CityHo Chi Minh CityVietnam Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Family Medicine Training Center University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam

The COVID-19 pandemic has been ongoing for over two years since the first case was reported in the end of January *** has successfully controlled the pandemic through its vaccination campaign,targeted messages and applications of various public health interventions including social distancing,quarantining,masking,and hand washing,which have made some significant achievements in reducing hospitalizations and deaths[1].

关键词： vaccination targeted COV

COVID-19 vaccination intention among healthcare workers in Vietnam

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Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 159-164页

作者： Giao Huynh Thien Thuan Tran han Thi Ngoc nguyen Le An Pham Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Infection Control Department University Medical Center Ho Chi Minh CityHo Chi Minh CityVietnam Family Medicine Training Center University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam

Objective:To assess the acceptance of coronavirus disease(COVID-19)vaccine among healthcare workers at two general hospitals in Vietnam when it is ***:A cross-sectional study was conducted using a convenience sampling from January to February 2021 among 410 healthcare workers at two general hospitals in Vietnam via a selfadministered questionnaire.A multivariable regression analysis was performed to determine predictors of vaccine acceptance including the demographic factors,COVID-19 knowledge,and vaccine beliefs based on the domains of Health Belief ***:Among 410 healthcare workers,76.10%showed vaccination *** of acceptance were determined that the group reporting as“vaccine acceptance”was more likely to be positive towards the perceived susceptibility and severity of COVID-19(OR 2.45;95%CI 1.48-4.06,P<0.05),perceived benefits of vaccination,and cues to action(OR 4.36;95%CI 2.35-8.09,and OR 5.49;95%CI 2.84-10.61,respectively,all P<0.001),but less likely to have the perceived barriers to vaccination(OR 0.19;95%CI 0.09-0.38;P<0.001)compared with the no acceptance ***,people who had a good knowledge regarding the severity of illness were 3.37 times more likely to have identified as vaccine acceptance(OR 3.37;95%CI 1.04-10.86,P<0.05).The demographic factors were also associated with willingness to receive the vaccine,with participants who were staff and received COVID-19 information from relatives were less likely to accept the vaccine over those who were doctors and not receiving information from relatives(OR 0.36;95%CI 0.13-0.96,and OR 0.37;95%CI 0.17-0.78,respectively,all P<0.05).Conclusions:A rate of willingness to get vaccinated against COVID-19 was relatively high with discrepancies between occupation,receiving information from relatives,knowledge toward the severity of illness,and the elements of Health Belief *** findings will provide information for the management authorities to develop relevant interv

关键词： Acceptance COVID-19 Healthcare workers Intention SARS-CoV-2 Vaccination