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Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks

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Journal of Pharmaceutical Analysis 2022年第5期12卷 743-754页

作者： nguyen Hoang anh Young Cheol Yoon Young Jin Min nguyen Phuoc Long Cheol Woon Jung Sun Jo Kim Suk Won Kim Eun Goo Lee Daijie Wang Xiao Wang Sung Won Kwon College of Pharmacy Seoul National UniversitySeoul08826Republic of Korea School of Pharmaceutical Sciences Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Biological Engineering Technology Innovation Center of Shandong Province Heze Branch of Qilu University of Technology(Shandong Academy of Sciences)HezeShandong274000China

Lipidomics coverage improvement is essential for functional lipid and pathway construction.A powerful approach to discovering organism lipidome is to combine various data acquisitions,such as full scan mass spectrometry(full MS),data-dependent acquisition(DDA),and data-independent acquisition(DIA).Caenorhabditis elegans(***)is a useful model for discovering toxic-induced metabolism,highthroughput drug screening,and a variety of human disease *** determine the lipidome of *** and investigate lipid disruption from the molecular level to the system biology level,we used integrative data *** methyl-tert-butyl ether method was used to extract L4 stage *** after exposure to triclosan(TCS),perfluorooctanoic acid,and nanopolystyrene(nPS).Full MS,DDA,and DIA integrations were performed to comprehensively profile the *** lipidome by Q-Exactive Plus *** annotated lipids were then analyzed using lipid ontology and pathway *** annotated up to 940 lipids from 20 lipid classes involved in various functions and *** biological investigations revealed that when *** were exposed to nPS,lipid droplets were disrupted,whereas plasma membrane-functionalized lipids were likely to be changed in the TCS treatment *** nPS treatment caused a significant disruption in lipid ***,glycerophospholipid,and ether class lipids were those primarily hindered by ***,toxicant exposure frequently involved numerous lipid-related pathways,including the phosphoinositide 3-kinase/protein kinase B *** conclusion,an integrative data acquisition strategy was used to characterize the *** lipidome,providing valuable biological insights into hypothesis generation and validation.

关键词： Caenorhabditis elegans Lipidomics Data-dependent acquisition Data-independent acquisition

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安庆-贵池矿集区宝树尖铜多金属矿床成因:来自岩石地球化学及年代学的约束

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岩石学报 2020年第1期36卷 184-204页

作者：汪海赵壮杨晓勇古黄玲郑荥 nguyen Tuan anh 中国科学技术大学地球和空间科学学院湖南工业大学安徽省地勘局324地质队

宝树尖铜多金属矿床位于长江中下游成矿带安庆-贵池矿集区,是一个新发现的矽卡岩型矿床。本文主要通过岩石地球化学和年代学方法来解释矿床的成因。锆石U-Pb年代学研究表明,宝树尖岩体形成于148.6±3.2Ma,是长江中下游燕山晚期的产物,... 详细信息

宝树尖铜多金属矿床位于长江中下游成矿带安庆-贵池矿集区,是一个新发现的矽卡岩型矿床。本文主要通过岩石地球化学和年代学方法来解释矿床的成因。锆石U-Pb年代学研究表明,宝树尖岩体形成于148.6±3.2Ma,是长江中下游燕山晚期的产物,为长江中下游成矿带内发现的一个较早的中酸性含矿侵入体。对于该成矿岩体及矿床的深入研究,将为区内燕山期岩浆活动及成矿提供一个不可多得的范例。岩石属于高钾钙碱性、钙碱性系列,地球化学特征显示为埃达克质岩;矿区矿石金属硫化物以方铅矿、闪锌矿、黄铜矿和黄铁矿为主,非金属矿物有透辉石、石榴石、透闪石、石英、钠长石、方解石、绿泥石和绿帘石等。矿区侵入岩主要由闪长岩和闪长玢岩组成,总体上具有高的全碱含量,低的Al2O3、TiO 2、Fe2O3^T和P2O5含量,富集大离子亲石元素(U、Rb、Sr)和高场强元素(Nb、Ta、Ti),轻稀土富集、重稀土亏损。岩石具有高的La/Yb、Sr/Y比值,低的Yb、Y含量,属于埃达克质岩。锆石稀土元素配分图显示典型的轻稀土亏损、重稀土富集。锆石Ti温度计表明岩石形成的平均温度为674.3℃。全岩Sr-Nd-Pb同位素特征表明岩石起源于俯冲洋壳的部分熔融。矿石黄铁矿δ34 S变化范围为7.6‰~9.6‰,表明成矿物质来源于岩浆热液和地层。锆石Eu异常特征和Ce^4+/Ce^3+比值表明形成岩石的岩浆具有高氧逸度,这有利于Cu、Au、Zn等成矿物质的迁移。结合区域地质背景,我们认为宝树尖矽卡岩型矿床的形成过程是:燕山期太平洋板块向中国东部俯冲,导致板片部分熔融产生埃达克质岩浆,最后经埃达克质岩浆分异形成的含矿气水热液在地壳浅部与上覆寒武系灰岩发生接触交代作用。

关键词：宝树尖多金属矿床安庆贵池矿集区埃达克岩锆石U-Pb定年 Sr-Nd-Pb同位素俯冲洋壳长江中下游

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The global COVID-19 vaccine surplus:tackling expiring stockpiles

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Infectious Diseases of Poverty 2023年第2期12卷 106-111页

作者： nguyen Khoi Quan nguyen Le My anh Andrew W.Taylor-Robinson College of Health Sciences VinUniversityGia Lam DistrictHanoi100000Vietnam Faculty of Medicine Imperial College LondonLondonSW72AZUK Center for Global Health Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA19104USA

Background A global surplus of coronavirus disease 2019(COVID-19)vaccines exists as a result of difficulties in aligning the demand and supply for vaccine manufacturing and *** leaders have accelerated vaccine development,approval,production and distribution as a pragmatic approach to addressing the immediate public health challenges of the first two and a half years of the *** body The currently predominant,highly transmissible Omicron variant of severe acute respiratory syndrome coronavirus 2 has brought us closer to the threshold required to achieve herd immunity by greatly increasing rates of natural ***,in parallel with rising vaccination levels in industrialized nations,this indirectly reduces the need for mass vaccine *** concerns that contribute to low vaccination rates which persist in several other countries,particularly of the Global South,are vaccine hesitancy and unequal access to *** uncertainty fueled by fake news,misinformation,unfounded lay opinions and conspiracy theories has inevitably led to an erosion of public trust in *** To address the current mismatch between supply and demand of COVID-19 vaccines,there should be a focus on three principles:decelerating vaccine production,increasing distribution across communities,and optimizing cost-effectiveness of distribution *** down and switching from large-scale production to effectively‘made to order’is a feasible option,which should be commensurate with management *** and evidence-based data should be widely and freely disseminated to the public through multimedia channels to mitigate miscommunication and conspiracy *** of soon-to-expire stockpiles should be prioritized not only to enhance booster dose rollouts in adults but to expand immunization campaigns to children(especially those aged 5–11 years),subject to national *** research should ideally aim to de

关键词： COVID-19 SARS-CoV-2 Omicron Vaccination Immunization Vaccine surplus Vaccine hesitancy Vaccine reluctance Vaccine inequity

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Morphology of the ^(13)CO(3–2) millimetre emission across the gas disc surrounding the triple protostar GG Tau A using ALMA observations

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Research in Astronomy and Astrophysics 2018年第3期18卷 63-76页

作者： nguyen Thi Phuong Pham Ngoc Diep Anne Dutrey Edwige Chapillon Pierre Darriulat Stéphane Guilloteau Do Thi Hoai Pham Tuyet Nhung Ya-Wen Tang nguyen Thi Thao Pham Tuan-anh Department of Astrophysics Vietnam National Space CenterVietnam Academy of Science and Technology Graduate University of Science and Technology Vietnam Academy of Science and Technology Laboratoire d’Astrophysique de Bordeaux Université de Bordeaux IRAM F-38406 Saint Martin d’Hères Cedex Academia Sinica Institute of Astronomy and Astrophysics

Observations by the Atacama Large Millimetre/sub-millimetre Array of the dust continuum and ^13 CO（3–2） millimetre emissions of the triple stellar system GG Tau A are analysed,giving evidence for a rotating gas disc and a concentric and coplanar dust ring. The present work complements an earlier analysis（Tang et al.） by exploring detailed properties of the gas disc. A 95% confidence level upper limit of 0.24＂（34 au） is placed on the disc scale height at a distance of 1＂（140 au） from the central stars. Evidence for Keplerian rotation of the gas disc is presented,with the rotation velocity reaching-3.1 km s^-1 at 1＂ from the central stars,and a 99% confidence level upper limit of 9% is placed on relative contribution from a possible in-fall velocity. Variations of the intensity across the disc area are studied in detail and confirm the presence of a hot spot in the south-eastern quadrant. However several other significant intensity variations,in particular a depression in the northern direction,are also revealed. Variations of the intensity are found to be positively correlated to variations of the line width. Possible contributions to the measured line width are reviewed,suggesting an increase of the disc temperature and opacity with decreasing distance from the stars.

关键词： protoplanetary disks - stars low-mass - stars individual (GG Tau A)

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Picture-Neutrosophic Trusted Safe Semi-Supervised Fuzzy Clustering for Noisy Data

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Computer Systems Science & Engineering 2023年第8期46卷 1981-1997页

作者： Pham Huy Thong Florentin Smarandache phung The Huan Tran Manh Tuan Tran Thi Ngan Vu Duc Thai nguyen Long Giang Le Hoang Son Graduate University of Science and Technology Vietnam Academy of Science and TechnologyHanoi100000Vietnam Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi100000Vietnam VNU Information Technology Institute Vietnam National UniversityHanoi100000Vietnam Department of Mathematics University of New MexicoGallup87301New MexicoUSA University of Information and Communication Technology Thai Nguyen UniversityThai Nguyen250000Vietnam Faculty of Computer Science and Engineering Thuyloi UniversityHanoi100000Vietnam

Clustering is a crucial method for deciphering data structure and producing new *** to its significance in revealing fundamental connections between the human brain and events,it is essential to utilize clustering for cognitive *** with noisy data caused by inaccurate synthesis from several sources or misleading data production processes is one of the most intriguing clustering *** data can lead to incorrect object recognition and *** research aims to innovate a novel clustering approach,named Picture-Neutrosophic Trusted Safe Semi-Supervised Fuzzy Clustering(PNTS3FCM),to solve the clustering problem with noisy data using neutral and refusal degrees in the definition of Picture Fuzzy Set(PFS)and Neutrosophic Set(NS).Our contribution is to propose a new optimization model with four essential components:clustering,outlier removal,safe semi-supervised fuzzy clustering and partitioning with labeled and unlabeled *** effectiveness and flexibility of the proposed technique are estimated and compared with the state-of-art methods,standard Picture fuzzy clustering(FC-PFS)and Confidence-weighted safe semi-supervised clustering(CS3FCM)on benchmark UCI *** experimental results show that our method is better at least 10/15 datasets than the compared methods in terms of clustering quality and computational time.

关键词： Safe semi-supervised fuzzy clustering picture fuzzy set neutrosophic set data partition with noises fuzzy clustering

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The Effect of Different Levels of Sesame Oil on Productive Performance, Egg Yolk and Blood Serum Lipid Profile in Laying Hens

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Open Journal of Animal Sciences 2016年第1期6卷 85-93页

作者： nguyen Duy Hoan Mai anh Khoa Faculty of Animal Husbandry—Veterinary Thai Nguyen University of Agriculture and Forestry Thai Nguyen City Vietnam

Addition of sesame oil into layer diets has been proved to enrich the proportion of polyunsatu-rated fatty acids in animal’s products. In this study, the effects of different levels of sesame oil in the diets on the performance, egg yolk and blood serum lipid profile of Isa Brown laying hens were investigated. A total of 96 layers were assigned into 4 groups to receive either 1 of 4 different diets contained 0.0%, 1.5%, 3.0% and 4.5% sesame oil, respectively. Sample of 12 eggs obtained from each groups were assessed for egg quality. The egg yolk fatty acid profile was determined with gas chromatography. Results revealed that the higher levels of sesame oil in the diet decreased egg production, egg weight, and egg yolk color except feed conversion ratio. In addition, supplementation of sesame oil increased the flow index of the eggs and the Haugh unite. The egg yolk lipid profile was not significantly different in the sesame oil fed groups, whereas, compare to control, it decreased the level of cholesterol. The blood serum lipid profile decreased in the sesame oil groups compare to control group. Meanwhile, monoacildigliserol also decreased in the sesame addition groups. In parallel with increasing levels of sesame oil, monounsaturated fatty acid (oleic acid) in the egg yolks significantly increased compared to the control (37.00%, 42.89%, 42.20% and 43.48%, respectively). It can be implied that sesame oil supplementation into the laying hens diet is necessary to produce monounsaturated fatty acid (MUFA) enriched eggs.

关键词： Sesame Oil Egg Yolk Lipid Profile Performance Laying Hens

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Stability Criteria of Solutions for Stochastic Set Differential Equations

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Applied Mathematics 2012年第4期3卷 354-359页

作者： Ho Vu nguyen Ngoc phung Ngo Van Hoa nguyen Dinh Phu Faculty of Basic Education University of Banking HCM City Vietnam Faculty of Mathematics and Computer Science Vietnam National University HCM City Vietnam

The existence and uniqueness results on solutions of set stochastic differential equation were studied in [1]. In this paper, we present the stability criteria for solutions of stochastic set differential equation.

关键词： Stochastic Set Differential Equation Stability Exponential Stability

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Optimal Scheduling of Multiple Rail Cranes in Rail Stations with Interference Crane Areas

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Intelligent Automation & Soft Computing 2024年第1期39卷 15-31页

作者： nguyen Vu anh Duy nguyen Le Thai nguyen Huu Tho Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City700000Vietnam

In this paper,we consider a multi-crane scheduling problem in rail stations because their operations directly influence the throughput of the rail *** particular,the job is not only assigned to cranes but also the job sequencing is implemented for each crane to minimize the makespan of cranes.A dual cycle of cranes is used to minimize the number of working cycles of *** rail crane scheduling problems in this study are based on the movement of *** consider not only the gantry moves,but also the trolley moves as well as the rehandle cases are also included.A mathematical model of multi-crane scheduling is *** traditional and parallel simulated annealing(SA)are adapted to determine the optimal scheduling *** examples are conducted to evaluate the applicability of the proposed *** of the proposed parallel SA is done by comparing it to existing previous *** of numerical computation highlighted that the parallel SA algorithm outperformed the SA and gave better solutions than other considered algorithms.

关键词： Multi-crane scheduling logistics containers makespan rail stations

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BTEX pollution caused by motorcycles in the megacity of HoChiMinh

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Journal of Environmental Sciences 2013年第2期25卷 348-356页

作者： Tran Thi Ngoc Lan Pham anh Minh University of Science Vietnam National University227 Nguyen Van CuHoChiMinh 70000Vietnam

Monitoring of benzene, toluene and xylenes （BTEX） was conducted along with traffic counts at 17 roadside sites in urban areas of HoChiMinh. Toluene was the most abundant substance, followed by p,m-xylenes, benzene, o-xylene and ethylbenzene. The maximum observed hour-average benzene concentration was 254 μg/m3 . Motorcycles contributed to 91% of the traffic fleet. High correlations among BTEX species, between BTEX concentrations and the volume of on-road motorcycles, and between inter-species ratios in air and in gasoline indicate the motorcycle-exhaust origin of BTEX species. Daily concentrations of benzene, toluene, ethylbenzene, p,m-xylenes and o-xylene were 56, 121, 21, 64 and 23 μg/m 3 , respectively. p,m-xylenes possess the highest ozone formation potential among the BTEX family.

关键词： air pollution benzene BTEX HoChiMinh motorcycle exhaust

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20-Hydroxyecdysone from Dacrycarpus imbricatus bark inhibits the proliferation of acute myeloid leukemia cells

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 151-153页

作者： Trinh Thi Thuy nguyen Thanh Tam nguyen Thi Hoang anh Dang Viet Hau Dinh Thi Phong Le Quoc Thang Sabrina Adorisio Tran Van Sung Domenico V Delfino Institute of Chemistry Vietnam Academy of Science and Technology Vietnam National Museum of Nature Vietnam Academy of Science and Technology Hue University’s College of Educations Section of Pharmacology Department of MedicineUniversity of Perugia

Objective:To investigate the anti-proliferative effects of 20-hydroxyecdysone isolated from the bark of Dacrycarpus imbricatus(Blume) de ***:Column chromatography was used for isolation of compounds from plant *** structure of the isolated compound was identified by mass spectrometry and nuclear magnetic resonance techniques,including HSQC,HMBC,NOE-difference *** isolated compound was tested for its anti-proliferative activity in acute myeloid leukemia(AML) and OCI-AML ***:Compound 1 was isolated from the ethyl acetate fraction of Dacrycarpus imbricatus barks by column *** chemical structure was identified as 20-hydroxyecdysone(20HE),a cholestane-type ecdysteroid,by a combination of mass spectrometry and nuclear magnetic resonance spectrometric *** goal was to test the anti-proliferative activity of 20 HE using the OCI-AML cell line.20 HE significantly decreased OCI cell number at a concentration of 1 mg/mL,whereas lower concentrations were ***,this decrease was due to partial blockage of the G_1/S phase of the cell cycle,with a reduction of cells in the G_2M phase,not due to increased ***:This indicates that 20 HE significantly decreases the number of cells in the G_1/S phase of the cell cycle in human AML *** is the first time that the anti-proliferative activity of 20 HE against a human tumor cell line has been reported.

关键词： Dacrycarpus imbricatus Ecdysteroid 20-hydroxyecdysone Proliferation Acute myeloid leukemia

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