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Clinical Trial of Measles and Rubella Combined Vaccine Produced by POLYVAC in Vietnam

Open Journal of Pediatrics 2018年第2期8卷 178-188页

作者： Nguyen Dang Hien Nguyen thuy huong ngo thu huong Pham Thi Phuong Thao Dinh Hong Duong Nguyen Xuan Dong Tomio Lee Takashi Ito Tetsuo Nakayama Center for Research and Production of Vaccines and Biologicals (POLYVAC) Hanoi Vietnam Military Academy of Medicine Hanoi Vietnam Kitasato Vaccine Plant Kitasato Daiichi Sankyo Vaccine Saitama Japan Laboratory of Viral Infection I Kitasato Institute for Life Sciences Tokyo Japan

A clinical trial of measles and rubella combined vaccine (MR: MRVAC) produced by POLYVAC was conducted in Vietnam in 2016. A total of 756 subjects were enrolled, and 504 were allocated to MRVAC and 252 to control MR vaccine groups. Paired sera were obtained in 733, and the number of subjects was 403 aged 1 - 2 years, 164 aged 2 - 18 years, and 166 aged 18 - 45 years. Antibodies against measles and rubella viruses were evaluated by EIA. Most subjects had been immunized with a single dose of Expanded Programme on Immunization (EPI) measles vaccine at 9 months of age. Only 41 of 403 subjects aged 1 - 2 years were negative for measles antibody before vaccination, and all became seroconverted. A serological response of more than a 2-fold increase against measles was noted in 214 (47%, 95% CI;42.4% - 51.6%) of 458 initially seropositive individuals immunized with MRVAC and 65 (28%, 95% CI;22.3% - 33.8%) of 234 in the control group, and geometric mean titer (GMT) after vaccination was 25.49-5.60 in MRVAC and 25.03-5.24 in control group. Seroconversion against rubella virus after immunization with MRVAC was noted in 267 (98.5%, 95% CI;97.1% - 100%) of 271 initially seronegative subjects, similar to that after immunization with control group. GMT after immunization with MRVAC was 24.88-5.11 significantly lower than that after immunization with control vaccine (25.59-5.80). Most subject ≥ 2 years of age had rubella antibody because of MR vaccination campaign and no significant serological response was observed in initially seronegatives. MRVAC was highly immunogenic and safe vaccine and the domestic production of MR vaccine would contribute to realizing the goal of eliminating measles and rubella.

关键词： Measles Vaccine Rubella Vaccine MR Combined Vaccine Elimination of Measles and Rubella

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Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： thu Nguyen Minh Pham Christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

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Luminescent and magnetic properties of multifunctional europium(Ⅲ) complex based nanocomposite

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Journal of Rare Earths 2019年第11期37卷 1237-1241页

作者： Hoang Thi Khuyen Nguyen Thanh huong Tran thu huong Pham Thi Lien Do Thi Anh thu Nguyen Thi Anh huong Wieslaw Strek Le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau CiayHanoiViet Nam Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry University of Natural SciencesHanoi National University19 Le Thanh TongHoan KiemHanoiViet Nam Institute of Low Temperature and Structure Research PASOkolna 2Wroclaw 50-422Poland Duy Tan University K7/25 Quang TrungDa DangViet Nam

The luminescent rare earth(RE)complex based multifunctional nanocomposites offer new potential applications of multimodal imaging(magnetic resonance imaging(MRI),fluorescent bioimaging,etc.)that can be associated with therapeutic *** this study,we report some results obtained with novel multifunctional Fe3O4/Si-amine/Eu(NTA)3 nanocomposites that are composed of europium(Ⅲ)complex with 1-(2-naphthoyl)-3,3,3-trifluoroacetone ligands(NTA)(Eu(NTA)3)and superparamagnetic Fe3O4 *** nanocomposites were functionalized with an amine group for biomedicine *** multifunctional Fe3O4/Si-amine/Eu(NTA)3 nanocomposites exhibit both good magnetic behavior of Fe3O4 nanoparticles as a core and strong fluorescent property of europium(Ⅲ)*** characterizations were analyzed by XRD,SEM,EDX and FTIR *** optical properties were studied in detail by UV-VIS spectra and luminescent emission *** magnetic property was estimated by *** effect of concentrations of luminescent Eu(NTA)3 complex on luminescent and magnetic properties is discussed.

关键词： Multifunctional nanocomposite Luminescence Magnetic Europium(Ⅲ)complex Fe3O4 Rare earths

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An isogeometric approach for nonlocal bending and free oscillation of magneto-electro-elastic functionally graded nanobeam with elastic constraints

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1401-1423页

作者： thu huong NGUYEN THI Van Ke TRAN Quoc Hoa PHAM School of Mechanical and Automotive Engineering Hanoi University of IndustryHanoi 100000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam

This work uses isogeometric analysis(IGA),which is based on nonlocal hypothesis and higher-order shear beam hypothesis,to investigate the static bending and free oscillation of a magneto-electro-elastic functionally graded(MEE-FG)nanobeam subject to elastic boundary constraints(BCs).The magneto-electric boundary condition and the Maxwell equation are used to calculate the variation of electric and magnetic potentials along the thickness direction of the *** study is innovative since it does not use the conventional boundary ***,an elastic system of straight and torsion springs with controllable stiffness is used to support nanobeams’beginning and end positions,creating customizable *** governing equations of motion of nanobeams are established by applying Hamilton’s principle and IGA is used to determine deflections and natural frequency *** studies were performed to evaluate the convergence and accuracy of the proposed *** from this,the impact of the input parameters on the static bending and free oscillation of the MEE-FG nanobeam is examined in *** findings could be valuable for analyzing and designing innovative structures constructed of functionally graded MEE materials.

关键词： elastic boundary conditions isogeometric analysis nanobeam via nonlocal theory grading of magneto-electro-elastic functions

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Automatic Identification Fingerprint Based on Machine Learning Method

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Journal of the Operations Research Society of China 2022年第4期10卷 849-860页

作者： Long The Nguyen huong thu Nguyen Alexander Diomidovich Afanasiev Tao Van Nguyen Laboratory of Artificial Intelligence and Machine Learning Institute of Information Technology and Data ScienceIrkutsk National Research Technical UniversityIrkutskRussia Baikal School of BRICS Irkutsk National Research Technical UniversityIrkutskRussia University of Information and Communication Technology Thai Nguyen UniversityThai NguyenViet Nam

The fingerprint identification technology has been developed and applied effectively to security systems in financial transactions,personal information security,national security,and other *** this paper,we proposed the development of a fingerprint identification system based on image processing methods that clarify fingerprint contours,using machine learning methods to increase processing speed and increase the accuracy of the fingerprint identification *** identification system consists of the following main steps:improving image quality and image segmentation to identify the fingerprint area,extracting features,and matching the *** accuracy of the system reached 97.75%on the mixed high-and low-quality fingerprint database.

关键词： Fingerprint identification Feature extraction Image segmentation Wavelet transform Neural network algorithm Machine learning

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Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam

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World Journal of Gastroenterology 2024年第46期30卷 4880-4903页

作者： thuy thu Nguyen Tu Cam Ho huong Thi thu Bui Van-Khanh Tran Tue Trong Nguyen Center for Gene and Protein Research Hanoi Medical UniversityHanoi 116177Viet Nam Institute of Virology TUM School of MedicineTechnical University of MunichMunich 81675Germany Department of Biochemistry Thai Nguyen University of Medicine and PharmacyThai Nguyen 251540Viet Nam Medical Technology Department Hanoi Medical UniversityHanoi 116177Viet Nam Clinical Laboratory Hanoi Medical University HospitalHanoi 116177Viet Nam

BACKGROUND Human leukocyte antigen(HLA)class II molecules are cell surface receptor proteins found on antigen-presenting *** and mutations in the HLA gene can affect the immune system and the progression of hepatitis *** To study the relation between rs2856718 of HLA-DQ,rs3077,and rs9277535 of HLA-DP,hepatitis B virus(HBV)-related cirrhosis,and hepatocellular carcinoma(HCC).METHODS In this case-control study,the genotypes of these single nucleotide polymorphisms(SNPs)were screened in 315 healthy controls,471 chronic hepatitis B patients,250 patients with HBV-related liver cirrhosis,and 251 patients with HCC using TaqMan real-time *** conducted Hardy-Weinberg equilibrium and linkage disequilibrium tests on the genotype distributions of rs2856718,rs3077,and rs9277535 before hierarchical clustering analysis to build the complex interaction between the markers in each patient *** The physical distance separating these SNPs was 29816 kB with the disequilibrium(D’)values ranging from 0.07 to *** close linkage between rs3077 and rs9277535 was attributed to a distance of 21 *** D’value decreased from moderate in the healthy control group(D’=0.50,P<0.05)to weak in the hepatic disease group(D’<0.3,P<0.05).In a combination of the three variants rs2856718,rs3077,and rs9277535,the A allele decreased hepatic disease risk[A-A-A haplotype,risk ratio(RR)=0.44(0.14;1.37),P<0.05].The G allele had the opposite effect[G-A/G-G haplotype,RR=1.12(1.02;1.23),P<0.05].In liver cancer cases,the A-A-A/G haplotype increased the risk of HCC by 1.58(P<0.05).CONCLUSION Rs9277535 affects liver fibrosis progression due to HBV infection,while rs3077 is associated with a risk of HBVrelated *** link between rs2856718,rs3077,and rs9277535 and disease risk was determined using a multiclustering analysis.

关键词： Human leukocyte antigen Multi-clustering study Hepatitis B virus Hepatocellular carcinoma Cirrhosis

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A mediation system for continuous spatial queries on a unified schema using Apache Spark

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Big Earth Data 2024年第1期8卷 115-141页

作者： Thi thu Trang ngo François Pinet David Sarramia Myoung-Ah Kang UniversitéClermont Auvergne ISIMAAubièreFrance UniversitéClermont Auvergne INRAEUR TSCFClermont-FerrandFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance

Recent advances in big and streaming data systems have enabled real-time analysis of data generated by Internet of Things(IoT)systems and sensors in various *** this context,many applications require integrating data from several heterogeneous sources,either stream or static *** such as Apache Spark are able to integrate and process large datasets from different ***,these frameworks are hard to use when the data sources are heterogeneous and *** address this issue,we propose a system based on mediation techniques for integrating stream and static data *** integration process of our system consists of three main steps:configuration,query expression and query *** the configuration step,an administrator designs a mediated schema and defines mapping between the mediated schema and local data *** the query expression step,users express queries using customized SQL grammar on the mediated ***,our system rewrites the query into an optimized Spark application and submits the application to a Spark *** results are continuously returned to *** experiments show that our optimizations can improve query execution time by up to one order of magnitude,making complex streaming and spatial data analysis more accessible.

关键词： Streaming data streaming data integration mediator geospatial data continuous queries

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Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis

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Bioactive Materials 2023年第9期27卷 231-256页

作者： Akriti Nepal huong D.N.Tran Nam-Trung Nguyen Hang thu Ta Queensland Micro-and Nanotechnology Centre Griffith UniversityNathanQueensland4111Australia Australian Institute for Bioengineering and Nanotechnology University of QueenslandSt LuciaQueensland4072Australia Bioscience Discipline School of Environment and ScienceGriffith UniversityNathanQueensland4111Australia

In traumatized patients, the primary cause of mortality is uncontrollable continuous bleeding and unexpected intraoperative bleeding which is likely to increase the risk of complications and surgical failure. High expansion sponges are effective clinical practice for the treatment of wound bleeding (irregular/deep/narrow) that are caused by capillaries, veins and even arterioles as they possess a high liquid absorption ratio so can absorb blood platelets easily in comparison with traditional haemostasis treatments, which involve compression, ligation, or electrical coagulation etc. When in contact with blood, haemostatic sponges can cause platelet adhesion, aggregation, and thrombosis, preventing blood from flowing out from wounds, triggering the release of coagulation factors, causing the blood to form a stable polymerized fibre protein, forming blood clots, and achieving the goal of wound bleeding control. Haemostatic sponges are found in a variety of shapes and sizes. The aim of this review is to facilitate an overview of recent research around haemostatic sponge materials, products, and technology. This paper reviews the synthesis, properties, and characteristics of haemostatic sponges, together with the haemostasis mechanisms of haemostatic sponges (composite materials), such as chitosan, cellulose, gelatin, starch, graphene oxide, hyaluronic acid, alginate, polyethylene glycol, silk fibroin, synthetic polymers silver nanoparticles, zinc oxide nanoparticles, mesoporous silica nanoparticles, and silica nanoparticles. Also, this paper reviews commercial sponges and their properties. In addition to this, we discuss various in-vitro/in-vivo approaches for the evaluation of the effect of sponges on haemostasis .

关键词： Haemostatic sponge Characteristics Mechanism Haemostasis Nanoparticles

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Fabrication and characterization of YVO_4:Eu^(3+) nanomaterials by the microwave technique

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Journal of Rare Earths 2011年第12期29卷 1137-1141页

作者： Tran thu huong Vu Duc Tu Tran Kim Anh Le Thi Vinh Le Quoc Minh Institute of Materials Science Vietnamese Academy of Science and Technology University of Engineering and Technology National University Hanoi Departments of Chemistry Hanoi University of Mining and Geology

Fabrication and characterization of YVO4：Eu^3＋ nanophosphors prepared by microwave （MW） irradiation assisted soft template synthesis were reported. The effects of synthesis conditions such as different powers of MW irradiation, pH values and concentration of reac- tion materials on properties of nanophosphor were also investigated to obtain the controllable size, morphology and high luminescence efficiency. Morphology, crystalline structure, and optical properties were characterized by field emission scanning electron microscopy （FE-SEM）, X-ray diffraction （XRD） and fluorescence spectroscopy, respectively. The results showed that YVOa：Eu^3＋ nanophosphors were obtained by using diethyleneglycol （DEG） as soft template, with pH values in the range of 4 to 12, upon microwave irradiation from 300 to 900 W, at temperature of 80 ℃. The high fluorescent YVOa：Eu^3＋ nanocrystals obtained with size from 15 nm down to 8 nm are more effective to develop an ultrahigh sensitive fluorescent label for biomolecule, cell and tissue.

关键词： microwave synthesis method DEG soft template YVO4:Eu^3+ nanophosphor luminescence rare earths

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Nonlocal isogeometric analysis for bidirectional functionally graded porous curved microbeams with arbitrary boundary conditions

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Acta Mechanica Sinica 2024年第8期40卷 194-218页

作者： thu-huong Nguyen Thi Van Ke Tran Van-Minh Phung Van Hai Trinh Quoc Hoa Pham Faculty of Mechanical Engineering Hanoi University of IndustryHanoi100000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi100000Vietnam Institute of Vehicle and Energy Engineering Le Quy Don Technical UniversityHanoi100000Vietnam Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City700000Vietnam

This research aims to analyze the static bending and free vibration behaviors of bidirectional functionally graded porous(BFGP)curved microbeams with elastic boundary conditions resting on a Pasternak’s elastic foundation in a hygro-thermal *** analysis based on non-uniform rational B-splines,first-order shear deformation theory,nonlocal elasticity theory combined with the modified strain gradient theories,modified Timoshenko beam theory are formulated to depict bending and shear deformations of BFGP curved ***,because using the modified Timoshenko beam theory,this study removes the requirement for a shear correction factor and describes shear stress by zero at the upper and lower cross-sectional sites of the BFGP curved *** from traditional boundary conditions,where the beginning and end positions of a curved beam are connected by an elastic system of straight and torsion *** allows for greater flexibility in controlling the stiffness of the springs to obtain arbitrary *** assess the accuracy and convergence of the proposed approach,validation numerical examples were conducted in the various examples.

关键词： Bidirectional functionally graded porous material Elastic boundary condition Isogeometric analysis Curved microbeams Nonlocal elasticity theory Modified strain gradient theory

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