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FACTORS ASSOCIATED WITH QUALITY OF LIFE IN ACUTE EXACERBATION OF COPD

Journal of Shanghai Second Medical University(Foreign Language Edition) 2005年第2期17卷 116-122页

作者：曹振英 ng tze pin Department of Geriatrics Ruijin Hospital Shanghai Second Medical University Shanghai 200025 China Department of Medicine National University of Singapore Singapore 119260 Singapore

Objective To measure the QOL in patients with AECOPD and the frequency of potential risk factors, and to evaluate the association of risk factors with poor QOL in patients with AECOPD. Methods A study sample of 196 patients with moderate to severe COPD admitted for acute exacerbations to two large general hospitals were studied. The St George QOL (SGQOL) scale, socio-demographic, clinical and patient care characteristics, including depression and spirometry were ascertained in the stable state before discharge and at one-month post discharge. Results There was a high prevalence of current or ex-heavy smokers, depression and consumption of psychotropic drugs, and low prevalence of care giver support, pulmonary rehabilitation and vaccination. The mean scores for the different domains were 55.9 for Symptoms; 65.1 for Activity; 32.9 for Impact; and the mean of overall Total scores was 46.5. Multiple regression analysis showed that CMH, male, depression, previous frequent hospital readmissions and poor therapy compliance were independently related to worse Symptoms Scores. Previous frequent readmissions, depression, severe dyspnea and older age (>72 years) were related to worse Activity Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea, long COPD duration(≥5years) and severe smoking were related to worse Impact Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea and long COPD duration(≥5years) were independently related to worse Total Scores of SGQOL. Conclusion Poor QOL in patients with COPD exacerbation was associated with disease severity, psychosocial and health care factors which are modifiable.

关键词： COPD exacerbation SGQOL risk factors

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影响慢性阻塞性肺病急性加重患者生活质量的危险因素

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上海第二医科大学学报 2005年第7期25卷 722-726页

作者：曹振英 Tan Wan Cheng ng tze pin 上海第二医科大学瑞金医院老年病科上海200025 新加坡国立大学医学院新加坡国立大学医学院新加坡国立大学医学院

目的测定和评价慢性阻塞性肺病(COPD)急性加重患者的生活质量和潜在危险因素的发生率及其影响。方法研究两家大型医院因COPD急性加重入院的196个中重度COPD患者。在患者出院时和出院后1月稳定状态,测量肺功能指标、精神状态及用圣乔治... 详细信息

目的测定和评价慢性阻塞性肺病(COPD)急性加重患者的生活质量和潜在危险因素的发生率及其影响。方法研究两家大型医院因COPD急性加重入院的196个中重度COPD患者。在患者出院时和出院后1月稳定状态,测量肺功能指标、精神状态及用圣乔治呼吸问卷测定生活质量,并收集了患者的临床性状、社会性状和照料因素。结果196例患者中,吸烟、抑郁及嗜用镇痛剂、安眠药相当普遍,而完成肺康复、接种流感病毒疫苗和肺炎球菌疫苗以及看护支持却很少。生活质量的症状域均值为55.9,活动域均值为65,影响域均值为32.9,总体均值为46.5。多变量分析显示慢性黏液高分泌症、男性、抑郁、前1年多次入院和治疗依顺性差与症状域值低下独立显著相关;前1年多次入院、抑郁、严重气促和72岁以上老年与活动域值低下独立显著相关;抑郁、前1年多次入院、严重气促、病程长和重度吸烟与影响域值低下独立显著相关;抑郁、前1年多次入院、严重气促和病程长与总体数值低下独立显著相关(P<0.05)。结论COPD急性加重患者的生活质量低下与COPD严重程度、患者精神抑郁状态及照料这些可改善因素有关。

关键词：慢性阻塞性肺病急性加重生活质量危险因素

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Factors Associated with Quality of Life in Acute Exacerbation of COPD

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上海第二医科大学学报 2005年第12期25卷 1266-1266页

作者： CAO Zhen-ying Tan Wan Cheng ng tze pin Department of Geriatrics Ruijin Hospital Shanghai Second Medical University Shanghai 200025 China Department of Medicine National University of Singapore Singapore 119260 Singapore

Objective To measure the QOLin patients with AECOPD and the frequency of potential risk factors, and to evaluate the as-sociation of risk factors with poor QOL in patients with AECOPD. Methods A study sample of 196 patients with moderate to severeCOPD admitted for acute exacerbations to two large general hospitals were studied. The St George QOL (SGQOL) scale, socio-demo-graphic, clinical and patient care characteristics, including depression and spirometry were ascertained in the stable state before dischargeand at one-month post discharge. Results There was a high prevalence of current or ex-heavy smokers, depression and consumption ofpsychotropic drugs, and lowprevalence of care giver support, pulmonary rehabilitation and vaccination. The mean scores for the differentdomains were 55.9 for Symptoms; 65.1 for Activity; 32.9 for Impact; and the mean of overall Total scores was 46.5. Multiple regressionanalysis showed that CMH, male, depression, previous frequent hospital readmissions and poor therapy compliance were independentlyrelated to worse Symptoms Scores. Previous frequent readmissions, depression, severe dyspnea and older age ( >72 years) were relatedto worse Activity Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea, long COPD duration(≥5years) andsevere smoking were related to worse Impact Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea and longCOPD duration(≥5years) were independently related to worse Total Scores of SGQOL. Conclusion Poor QOL in patients with COPDexacerbation was associated with disease severity, psychosocial and health care factors which are modifiable.

关键词：呼吸系统疾病生活质量预后病理机制

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慢性阻塞性肺疾病急性加重患者频繁再入院与其危险因素

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中国临床保健杂志 2005年第1期8卷 14-16页

作者：曹振英 Tan Wan Cheng ng tze pin 上海第二医科大学附属瑞金医院老年病科 200025 新加坡国立大学医学院

目的　评价慢性阻塞性肺疾病 (COPD)患者急性加重频繁入院的危险因素。方法　调查两家大型医院因COPD急性加重入院的 196名中重度COPD患者。在患者出院时和出院后一个月稳定状态 ,收集患者的临床性状、社会性状、日常护理因素和过去一... 详细信息

目的　评价慢性阻塞性肺疾病 (COPD)患者急性加重频繁入院的危险因素。方法　调查两家大型医院因COPD急性加重入院的 196名中重度COPD患者。在患者出院时和出院后一个月稳定状态 ,收集患者的临床性状、社会性状、日常护理因素和过去一年中急性加重入院的频率 ,测定肺功能指标及精神状态。结果　 196例COPD患者中 ,72 %过去一年中有一次以上再入院 ,4 8%有 2次以上 ,8%有超过 10次再入院。单变量分析显示男性、病程长、嗜用镇痛剂和安眠药、第 1秒用力呼气容量占预计值的百分比 (FEV1% ) <4 5 %、缺乏肺康复训练和严重气促与频繁再入院有显著相关性 (P <0 .0 5 )。多变量分析显示病程长 (OR =2 .6 0 )、FEV1% <4 5 % (OR =2 .0 3)、严重气促 (OR =2 .5 0 )和男性 (OR =3.13)与COPD急性加重再入院有独立显著相关性 (P <0 .0 5 )。结论　COPD急性加重频繁再入院与COPD严重程度。

关键词：肺疾病慢性阻塞性病人再入院危险因素

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Novel rapid tissue lysis method to evaluate cancer proteins: Correlation between elevated Bcl-X_L expression and colorectal cancer cell proliferation

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World Journal of Gastroenterology 2005年第33期11卷 5162-5168页

作者： Wei-Shone Chen Hong-Yi Chang Jui-Ting Chang Jacqueline Ming Liu Chung-pin Li Li-Li Chen Huei-Ling Chang Chia-Chi Chen tze-Sing Huang National Cancer Research Center National Health Research InstitutesTaipei Taiwan China Division of Colon and Rectal Surgery Department of Surgery Taipei Veterans General Hospital and National Yang-Ming University School of Medicine Taipei Taiwan China Division of Gastroenterology Department of Medicine Taipei Veterans General Hospital and National Yang-Ming University School of Medicine Taipei Taiwan China

AIM： We optimized a rapid and efficient tissue lysis method using the MagNA Lyser （Roche, Germany）. Using this novel method combined with immunoblot analysis, we investigated the correlation between abnormal Bcl-XL expression and clinicopathological characteristics in colorectal cancer. METHODS： Tissue samples from Sprague-Dawley rats were tested to determine optimal lysis conditions for use with MagNA Lyser. We next used the new method to extract tissue proteins from the tumor tissue of a colorectal cancer patient. The availability of extractable tissue proteins for proteomic study was demonstrated by two-dimensional （2D） gel electrophoresis and subsequent matrix-assisted laser desorption/ionization time-of-flight （MALDI-TOF） mass spectrometry. In addition, we prepared tissue lysates from paired tumor tissues and adjacent nontumor tissues of 50 colorectal carcinoma patients. Ensuing immunoblot analyses were performed to detect the level of Bcl-X, expression. RESULTS： The optimal sample sizes processed were found to be around 200 mg, with oscillation frequency of 6 500 r/rain for 80 s. Test of the first human tissue lysate confirmed that the MagNA Lyser method was adequate for protein extraction and subsequent identification by current proteomic protocols. The method was also applicable to immunoblot analysis. Thirty of 50 （60%） colorectal patients exhibited higher level of Bcl-XL expression in their tumor tissues. Raised level of Bcl-XL expression correlated with patients＇ gender and tumor cell proliferation index （P= 0.037 and P〈0.001, respectively）, but was independent of clinicopathological characteristics and overall survival. CONCLUSION： We report a novel tissue lysis method applicable to proteomic and immunoblot analyses, which can facilitate the discovery and detection of cancer protein alterations.

关键词： Tissue lysis MagNA Lyser Bcl-X, Colorectalcancer

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病原体感染对老年人心身功能和认知能力的影响及炎症因子的介导作用

病原体感染对老年人心身功能和认知能力的影响及炎症因子的介导作...

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第二十四届全国心理学学术会议

作者：鲁燕霞吴大兴 Anis Larbi tze pin ng 潘芳山东大学基础医学院医学心理学与伦理学系中南大学湘雅二医院医学心理中心 Biology of Ageing Laboratory Singapore Immunology Network (SIgN)Agency for ScienceTechnology and Research (A*STAR) Geriatrics Division Department of MedicineResearch Center on AgingUniversity of Sherbrooke Gerontology Research Programme Department of Psychological MedicineNational University Health SystemYong Loo Lin School of MedicineNational University of Singapore

背景:长期以来,科学界一直假设病毒等病原体感染与老化和心理健康之间存在密切联系,但相关实证证据仍非常有限,其生物学机制也尚不清楚。相关研究在现代尤其是新冠肺炎对老年人和全球身心健康造成严重影响的今天具有重要意义。方法:在... 详细信息

背景:长期以来,科学界一直假设病毒等病原体感染与老化和心理健康之间存在密切联系,但相关实证证据仍非常有限,其生物学机制也尚不清楚。相关研究在现代尤其是新冠肺炎对老年人和全球身心健康造成严重影响的今天具有重要意义。方法:在一项纵向追踪研究中,我们收集了884名老年人(平均年龄:67.9±8.1岁)基线水平、3-4年追踪和6-8年追踪时的病原体感染(CMV、HSV 1、HSV 2、HHV-6、EBV、VZV、RSV、Dengue、Chikungunya、***和Plasmodium)和步速、活动能力(performance-oriented mobility assessment (POMA))、认知功能(Mini-Mental State Examination (MMSE))、抑郁(Geriatric Depression Scale (GDS))与心理健康(Mental Component Score (MCS) of 12-Item Short Form Survey (SF-12))数据,并考察了炎性细胞因子(CRP、TNF-α、IL-6、MIP-1α、sTNF-RI、sTNF-RII、C3a和MCP-2)的可能介导作用。结果:在控制年龄、性别、种族、受教育水平、婚姻状况、独居和吸烟状况的差异后,高病原体负荷(7+累积感染)的老年人相比较低病原体负荷(1-5累积感染)具有较慢的步速、较低的POMA和MMSE得分、更高的脆弱指数(frailty index (FI)),以及显著增多的抑郁症状和较差的心理健康状况。病原体暴露与老化、抑郁和心理健康的关联至少部分可以通过炎症标志物来解释。结论:总之,终生病原体负担和特定感染与老年人的功能性老化、抑郁和心理健康受损密切相关,这一效应可能通过炎症和免疫以及其他生物学因素起作用,应引起足够重视。

关键词：病原体感染心身功能认知能力炎症因子

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Usage of complementary and alternative medicine in older adults: prevalence, subtypes and associated factors;a cross-sectional observation

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Aging Communications 2022年第1期4卷 6-11页

作者： Mehdy Ghaeminia Lei Feng tze-pin ng Liang Feng Hwee-Ling Koh Chay-Hoon Tan Department of Pharmacology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Psychological Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Pharmacy Faculty of ScienceNational University of SingaporeSingapore

Background:The usage of complementary and alternative medicine(CAM)is common in many healthcare settings ***,the factors associated with CAM usage in older adults and its relation with mood and cognitive function is *** used a cross-sectional study to explore the 12-month prevalence of usage of CAM among older adults in Singapore and its associated factors including mental health ***:Using a door-to-door census and questionnaire survey,community dwellers aged 60 or above were voluntarily recruited in the Singapore Longitudinal Aging *** information,usage of CAM in past 12 months,life-style,cognitive and depressive status using Mini-Mental Status Examination and Geriatric Depression Scale were collated from each ***:Out of 4985 participants,2692(54%)used some types of *** most common type of CAM was herbal medicine,followed by Qigong and *** usage of CAM was higher in Chinese females and those with higher educational *** a history of chronic diseases was associated with higher prevalence of CAM *** of CAM was also correlated with higher physical and social *** correlation was observed between cognitive or depressive status and the use of ***:These results show a high prevalence of CAM usage among older adults in Singapore,which should be considered by medical practitioners treating this age ***,despite higher prevalence of suffering from multiple chronic diseases,the lack of association of CAM usage with poorer performance in mood and cognitive assessments suggests a protective role against depression and cognitive decline for CAM practices.

关键词： complementary alternative medicine prevalence depression cognition elderly

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漳州八宝印泥的前世今生及其可持续发展

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漳州职业技术学院学报 2013年第4期15卷 58-62页

作者：周榜师漆琍娜金爱萍漳州职业技术学院福建漳州363000

八宝印泥是名扬中外的"漳州三宝"之一,与漳州水仙花和片仔癀齐名,是漳州经济文化产业中的一朵奇葩。作为一个历时数百年多年的特色产业,它的发展已日见成熟。从文化产业兴衰的角度来分析八宝印泥的前世今生,并就其可持续发展进行理论和... 详细信息

八宝印泥是名扬中外的"漳州三宝"之一,与漳州水仙花和片仔癀齐名,是漳州经济文化产业中的一朵奇葩。作为一个历时数百年多年的特色产业,它的发展已日见成熟。从文化产业兴衰的角度来分析八宝印泥的前世今生,并就其可持续发展进行理论和实证分析。

关键词：漳州八宝印泥特色产业发展

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