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The RNA editome of Macaca mulatta and functional characterization of RNA editing in mitochondria

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Science Bulletin 2017年第12期62卷 820-830页

作者： Ling-Qun Ye Hui Zhao He-JiangZhou Xiao-Die Ren Lin-Lin Liu newton o.otecko Zheng-boWang Min-Min Yang Lin Zeng Xin-Tian Hu Yong-Gang Yao Ya-Ping Zhang Dong-Dong Wu State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan UniversityKunming 650091China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences Kunming 650223China Kunming College of Life Science University of Chinese Academy of Scienceskunming 650204China Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

RNA editing was first discovered in mitochondrial RNA molecular. However, whether adenosine-toinosine(A-to-I) RNA editing has functions in nuclear genes involved in mitochondria remains ***, we retrieved 707,246 A-to-I RNA editing sites in Macaca mulatta leveraging massive transcriptomes of 30 different tissues and genomes of nine tissues, together with the reported data, and found that A-to-I RNA editing occurred frequently in nuclear genes that have functions in mitochondria. The mitochondrial structure, the level of ATP production, and the expression of some key genes involved in mitochondrial function were dysregulated after knocking down the expression of ADAR1 and ADAR2, the key genes encoding the enzyme responsible for RNA editing. When investigating dynamic changes of RNA editing during brain development, an amino-acid-changing RNA editing site(I234/V) in MFN1, a mediator of mitochondrial fusion, was identified to be significantly correlated with age, and could influence the function of MFN1. When studying transcriptomes of brain disorder, we found that dysregulated RNA editing sites in autism were also enriched within genes having mitochondrial functions. These data indicated that RNA editing had a significant function in mitochondria via their influence on nuclear genes.

关键词：线粒体RNA RNA编辑酶猕猴特性编辑位点核基因体功能动态变化

Population Genomic Insights into High Altitude Adaptation in Pamirs

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Population Genomic Insights into High Altitude Adaptation in...

origin of new genes after zygotic genome activation in vertebrate

2018中国遗传学会第十次全国会员代表大会暨学术讨论会

作者： Xierzhatijiang Sulaiman Min-Sheng Peng Wei-fang Xu Jin-Xiu Li Najmudinov Tojiddin Abdulloevich Manilova Elena Afanasevna Khudoidodov Behruz Ibrohimovich Xi Chen Wei-Kang Yang Xing-Yan Yang Quan-Kuan Shen Shi-Fang Wu Yun Gao newton o.otecko Yong-Gang Yao Lu-Feng Cheng Ya-Ping Zhang Department of Pharmacology College of PharmacyXinjiang Medical University State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Shenzhen Hospital of Guangzhou University of Chinese Medicine State Key Laboratory for Conservation and Utilization of Bio-Resources Yunnan University E.N.Pavlovsky Institute of Zoology and Parasitology Academy of Sciences of Republic of Tajikistan Research Center for Ecology and Environment of Central Asia Chinese Academy of Sciences Key Laboratory of Biogeography and Bioresource in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Tajik highlanders have resided in Pamirs（altitude ＞3000 m） for thousands of years. How they adapted to the harsh conditions remains unsolved. Herein, we measured four physiological traits for two groups of Tajik highlanders: Sarikoli Tajik and Wakhi Tajik, in comparison to highland Kyrgyz. Neither hematologic nor spirometric evidence exhibit Tibetan-style adaptation in Tajik highlanders. To discern the potential genetic mechanism of high altitude adaptation in Tajik highlanders, we sequenced the whole genomes of 19 Sarikoli Tajiks, 20 Wakhi Tajiks, and 20 lowland Tajiks. The population genomic analyses reveal Tajiks as a branch of Central Asians experiencing complicated patterns of gene flows from European, South Asian, and East Asian populations. The settlement of Pamirs by the Sarikoli Tajiks is approximated to be around 3200 years ago. Selective sweep assessments, verified by coalescent simulation, identify SNRNP40, ZCCHC17, and FABP3 on chromosome 1, and KCTD13, TMEM219, and TAoK2 on chromosome 16, as the potential targets of selection in the Sarikoli Tajiks. These genes are involved in neurological development and diseases. The selective haplotypes in the Sarikoli Tajiks are standing variations with distribution in lowland populations. Luciferase reporter assays show that the selective haplotype of KCTD13 promoter and enhancer regions exhibit higher transcription activity than the nonselective haplotype. overall, our findings provide novel insight into a very recent high altitude adaptation in humans, which probably targeted nervous system by utilizing standing variations via soft sweep.

关键词： High altitude adaptation Tajiks Pamirs nervous system KCTD13

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Journal of Molecular Cell Biology 2018年第2期10卷 139-146页

作者： Hai-Bo Xu Yong-Xin Li Yan Li newton o. otecko Ya-Ping Zhang Bingyu Mao Dong-Dong Wu State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China College of Life Science Anhui University Hefei China Kunming College of Life Science University of Chinese Academy of Sciences Kunming China State Key Laboratory for Conservation and Utilization of Bio-resource Yunnan University Kunming China

New genes are drivers of evolutionary innovation and phenotypic evolution. Expression of new genes in early development raises the possibility that new genes could originate and be recruited for functions in embryonic development, but this remains undocu- mented. Here, based on temporal gene expression at different developmental stages in Xenopus tropicolis, we found that young protein-coding genes were significantly enriched for expression in developmental stages occurring after the midblastula trans- ition （MBT）, and displayed a decreasing trend in abundance in the subsequent stages after MBT. To complement the finding, we demonstrate essential functional attributes of a young orphan gene, named as Fog2, in morphological development. our data indicate that new genes could originate after MBT and be recruited for functions in embryonic development, and thus provide insights for better understanding of the origin, evolution, and function of new genes.

关键词： young gene evolution zygotic genome activation new gene origin

Time to consider the potential role of alternative resistance training methods in cancer management?

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Journal of Sport and Health Science 2023年第6期12卷 715-725页

作者： Francesco Bettariga Chris Bishop Dennis R.Taaffe Daniel A.Galvão Luca Maestroni Robert U.newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4067Australia

Exercise has emerged as fundamental therapeutic medicine in the management of *** improves health-related outcomes,including quality of life,neuromuscular strength,physical function,and body composition,and it is associated with a lower risk of disease recurrence and increased ***,exercise during or post cancer treatments is safe,can ameliorate treatment-related side effects,and may enhance the effectiveness of chemotherapy and radiation *** date,traditional resistance training(RT)is the most used RT modality in exercise ***,alternative training modes,such as eccentric,cluster set,and blood flow restriction are gaining increased *** training modalities have been extensively investigated in both athletic and clinical populations(e.g.,age-related frailty,cardiovascular disease,type 2 diabetes),showing considerable benefits in terms of neuromuscular strength,hypertrophy,body composition,and physical ***,these training modes have only been partially or not at all investigated in cancer ***,this study outlines the benefits of these alternative RT methods in patients with *** evidence in cancer populations is sparse,we provide a robust rationale for the possible implementation of certain RT methods that have shown positive results in other clinical ***,we provide clinical insights for research that may guide future RT investigations in patients with cancer and suggest clear practical applications for targeted cancer populations and related benefits.

关键词： Blood flow restriction Cluster set Eccentric training Resistance trainingTagedAPTARAEnd

Suppressive effects of exercise-conditioned serum on cancer cells:A narrative review of the influence of exercise mode,volume,and intensity

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Journal of Sport and Health Science 2024年第4期13卷 484-498,F0003页

作者： Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Chris Bishop Jin-Soo Kim Robert U.newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this *** has emerged as fundamental therapeutic medicine in the management of cancer,associated with a lower risk of recur-rence and increased *** avenues of research demonstrate reduction in growth,proliferation,and increased apoptosis of cancer cells,including breast,prostate,colorectal,and lung cancer,when cultured by serum collected after exercise in vitro(i.e.,the cultivation of cancer cell lines in an experimental setting,which simpliﬁes the biological system and provides mechanistic insight into cell responses).The underlying mechanisms of exercise-induced cancer suppressive effects may be attributed to the alteration in circulating factors,such as skeletal muscle-induced cytokines(i.e.,myokines)and ***,exercise-induced tumor suppressive effects and detailed information about training interventions are not well investigated,constraining more precise application of exercise medicine within clinical *** date,it remains unclear what role different training modes(i.e.,resistance and aerobic training)as well as volume and intensity have on exercise-condi-tioned serum and its effects on cancer ***,the available evidence is that a single bout of aerobic training at moderate to vigorous intensity has cancer suppressive effects,while for chronic training interventions,exercise volume appears to be an inﬂuential candidate driving cancer inhibitory effects regardless of training *** for future research investigating training modes,volume and intensity are provided to further our understanding of the effects of exercise-conditioned serum on cancer cells.

关键词： Cancer cells High intensity interval training Moderate intensity continuous training Resistance training Myokines

An antiferromagnetic {Mn_8} ring supported by planar multidentate ligands

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Science China Chemistry 2012年第6期55卷 973-977页

作者： newton Graham N. SHIGA Takuya oSHIo Hiroki Graduate School of Pure and Applied Sciences Department of Chemistry University of Tsukuba Tennodai 1-1-1 Tsukuba 305-8571 Japan

Complexation of the planar multidentate ligand 3,5-bis-（2-hydroxyphenyl）pyrazole （H3L） with manganese chloride leads to the formation of the polynuclear complex [MnIHsL4oa（Meo）a（MeoH）8] （1）. 1 has an octanuclear macrocyclic core in which the MnnI ions are bridged by four L molecules to form a ring type structure. Antiferromagnetic interactions were shown to be op- erative between metal centers.

关键词： manganese magnetism antiferromagnetic ring complex planar ligands

An antiferromagnetic {Mn8} ring supported by planar multidentate ligands

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中国科学:化学 2012年第6期42卷 903-904页

作者： newton Graham N. SHIGA Takuya oSHIo Hiroki Graduate School of Pure and Applied Sciences Department of Chemistry University of Tsukuba Tennodai 1-1-1 Tsukuba 305-8571 Japan

Complexation of the planar multidentate ligand 3,5-bis-(2-hydroxyphenyl)pyrazole (H3L) with manganese chloride leads to the formation of the polynuclear complex [MnⅢ8L4o4(Meo)4(MeoH)8] (1). 1 has an octanuclear macrocyclic core in which the MnⅢ ions are bridged by four L molecules to form a ring type structure. Antiferromagnetic interactions were shown to be operative between metal centers.

关键词： manganese magnetism antiferromagnetic ring complex planar ligands

Biochar insights from laboratory incubations monitoring o_(2) consumption and Co_(2) production

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Biochar 2019年第3期1卷 249-258页

作者： Risely Ferraz Almeida Kurt A.Spokas Daniel de Bortoli Teixeira newton La Scala Junior University of Sao Paulo-USP PiracicabaBrazil United States Department of Agriculture-Agricultural Research Service St.PaulMNUSA University of Marília-Unimar MaríliaBrazil Universidade Estadual Paulista-UNESP JaboticabalBrazil

Biochar has been touted as a long-term carbon sequestration ***,there are no studies evaluating biochar’s effect on oxygen(o_(2))consumption as a measure of the microbial respiration response to *** gain insight into this aspect,we evaluated o_(2) consumption rates to test the hypothesis that biochar is an efficient agent for carbon dioxide(Co_(2))sequestration in *** different biochar types and one activated charcoal were incubated alone and associated with three different soils for approximately 2 months in laboratory *** concentration of Co_(2) and o_(2) was periodically *** data presented here confirm that the Co_(2) production following biochar’s addition to soils results in a process that is correlated to oxygen ***,this overall stimulation is not clearly related to biochar *** carbon resulted in the highest statistically significant stimulation of activity,despite it possessing the lowest quantity of volatile carbon and mineral nutrient *** into consideration our results,we conclude that using biochar does achieve total carbon ***,the amount of available soil organic carbon following soil incorporation appears to be reduced following biochar addition and its long-term implication on this mineralizable soil organic carbon pool does deserve more research attention.

关键词： Biochar activation Charcoal Co_(2)sequestration Co_(2)sorption

Chronic exposure to high-density polyethylene microplastic through feeding alters the nutrient metabolism of juvenile yellow perch (Perca flavescens)

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Animal Nutrition 2022年第2期9卷 143-158页

作者： Xing Lu Dong-Fang Deng Fei Huang Fabio Casu Emma Kraco Ryan J.newton Merry Zohn Swee J.Teh Aaron M.Watson Brian Shepherd Ying Ma Mahmound A.o.Dawood Lorena M.Rios Mendoza School of Freshwater Sciences University of WisconsinMilwaukeeWI 53204USA South Carolina Department of Natural Resources CharlestonSC 29412USA USDA/ARS/School of Freshwater Sciences University of WisconsinMilwaukeeWI 53204USA School of Veterinary Medicine Department of AnatomyPhysiologyand Cell BiologyUniversity of CaliforniaDavisCA 95616USA Department of Natural Sciences Marine Resources Research InstituteUniversity of WisconsinSuperiorWI 54880USA Yangtze River Fisheries Research Institute Chinese Academy of Fishery SciencesWuhanChina Fisheries College Jimei UniversityXiamenChina. Faculty of Agriculture Kafrelsheikh UniversityKafr El-SheikhEgypt.

Microplastics are emergent contaminants threatening aquatic organisms including aquacultured *** study investigated the effects of high-density polyethylene(HDPE,100 to 125 mm)on yellow perch(Perca flavescens)based on integrative evaluation including growth performance,nutritional status,nutrient metabolism,fish health,and gut microbial *** test diets(0,1,2,4,or 8 g HDPE/100 g diet)containing 41%protein and 10.5%lipid were fed to juvenile perch(average body weight,25.9±0.2 g;n=15)at a feeding rate of 1.5%to 2.0%body weight *** feeding trial was conducted in a flow-through water system for 9 wk with 3 tanks per treatment and 15 yellow perch per *** mortality or HDPE accumulation in the fish was found in any *** gain and condition factor of fish were not significantly impacted by HDPE(P>0.05).Compared to the control group,fish fed the 8%HDPE diet had significantly decreased levels of protein and ash(Ponse to the increasing levels of HDPE exposure,the hepatosomatic index value,hepatocyte size,and liver glycogen level were increased,but lipid content was reduced in the liver *** to the control treatment,fish fed the 8%HDPE diet had significant accumulations of total bile acids and different metabolism pathways such as bile acid biosynthesis,pyruvate metabolism,and carnitine *** enterocyte necrosis was documented in the foregut of fish fed the 2%or 8%HDPE diet;and significant cell sloughing was observed in the midgut and hindgut of fish fed the 8%HDPE *** fed the 2%HDPE diet harbored different microbiota communities compared to the control *** study demonstrates that HDPE ranging from 100 to 125 mm in feed can be evacuated by yellow perch with no impact on ***,dietary exposure to HDPE decreased whole fish nutrition quality,altered nutrient metabolism and the intestinal histopathology as well as microbiota community of yellow *** results indicate that extende

关键词： Dietary exposure Intestinal microbiota Liver metabolomics Microplastics Nutrient composition Yellow perch