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Management of infected acute necrotizing pancreatitis

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World Journal of Clinical Cases 2023年第2期11卷 482-486页

作者： efstathios T Pavlidis Theodoros e Pavlidis Second Propedeutic Department of Surgery Hippocration HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Necrotizing or severe pancreatitis represents approximately 10%-20%of acute pancreatitis.30%-40%of patients with acute necrotizing pancreatitis(ANP)will develop debris infection through translocation of intestinal microbial *** ANP constitutes a serious clinical condition and is complicated by severe sepsis with high mortality rates of up to 40%despite progress in current intensive *** timely detection of sepsis is *** Quick Sequential Organ Failure Assessment score,procalcitonin levels>1.8 ng/mL and increased lactates>2 mmol/L(>18 mg/dL),indicate the need for urgent *** escalated step-by-step management protocol starts with broad-spectrum antibiotics,percutaneous drainage or endoscopic management,and ends with surgical management if *** latter includes necrosectomy(either laparoscopic or traditional open surgery),peritoneal lavage and extensive *** management protocol increases the chance of survival to approximately 60%in patients with otherwise fatal *** treatment choice must be individualized,and the timing is critical.

关键词： Pancreas Acute abdomen Acute pancreatitis Necrotizing pancreatitis Sepsis Septic shock

我国电子商务中消费者保护的若干法律问题探析

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消费经济 2006年第1期22卷 82-84页

作者：刘益灯中南大学法学院湖南长沙410083

随着科学技术和信息产业的高速发展,电子商务作为一种新兴的商业模式正在全球范围内兴起。电子商务所产生的法律问题冲击了传统的消费者保护法律制度。为了适应电子商务迅猛发展的形势,并确保消费者对电子商务的信心,必须从保护消费者... 详细信息

随着科学技术和信息产业的高速发展,电子商务作为一种新兴的商业模式正在全球范围内兴起。电子商务所产生的法律问题冲击了传统的消费者保护法律制度。为了适应电子商务迅猛发展的形势,并确保消费者对电子商务的信心,必须从保护消费者权益的角度对电子商务消费者权益的法律保护问题进行探讨,以建立和完善我国电子商务立法。

关键词：电子商务消费者权益法律保护

阿奇霉素序贯疗法治疗小儿支原体肺炎的临床效果及安全性研究

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中国当代医药 2014年第18期21卷 58-60页

作者：汤彩娥江苏省溧阳市妇幼保健院儿科江苏溧阳213300

目的：研究分析阿奇霉素序贯疗法治疗小儿支原体肺炎的临床效果及其安全性。方法选取2011年11月~2013年11月在本院接受治疗的120例小儿支原体肺炎患儿，随机分为观察组和对照组，每组60例。观察组患儿采用阿奇霉素序贯疗法治疗，对照组... 详细信息

目的：研究分析阿奇霉素序贯疗法治疗小儿支原体肺炎的临床效果及其安全性。方法选取2011年11月~2013年11月在本院接受治疗的120例小儿支原体肺炎患儿，随机分为观察组和对照组，每组60例。观察组患儿采用阿奇霉素序贯疗法治疗，对照组单纯采用红霉素治疗，比较两组患儿的治疗效果、症状消失时间及不良反应情况。结果观察组总有效率为96.7%，显著高于对照组的78.3%，差异有统计学意义（P＜0.05）；观察组退热、咳嗽及肺部湿啰音消失时间均短于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为3.33%，低于对照组的15.00%，差异有统计学意义（P＜0.05）。结论阿奇霉素序贯疗法治疗小儿支原体肺炎临床效果显著，不良反应少，值得临床推广应用。

关键词：阿奇霉素序贯疗法小儿支原体肺炎

氨溴索不同用法辅助治疗小儿肺炎的临床效果观察

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中国当代医药 2014年第22期21卷 79-80,83页

作者：汤彩娥江苏省溧阳市妇幼保健院江苏溧阳213300

目的：探讨氨溴索辅助治疗小儿肺炎的临床应用效果。方法选取本院2010年1月∽2014年1月收治的200例小儿肺炎患者，随机分为对照组、观察A组、观察B组、观察C组，每组50例，对照组患儿采用常规治疗，观察A组患儿在常规治疗的基础上辅助... 详细信息

目的：探讨氨溴索辅助治疗小儿肺炎的临床应用效果。方法选取本院2010年1月∽2014年1月收治的200例小儿肺炎患者，随机分为对照组、观察A组、观察B组、观察C组，每组50例，对照组患儿采用常规治疗，观察A组患儿在常规治疗的基础上辅助采用氨溴索雾化进行治疗，观察B组患儿在常规治疗基础上辅助采用氨溴索静脉滴注进行治疗，观察C组患儿在常规治疗基础上行氨溴索静脉滴注＋雾化进行治疗。观察4组的治疗效果。结果观察A组治愈37例（74%），观察B组治愈36例（72%），观察C组治愈42例（84%），对照组治愈26例（52%），观察组3组的治愈率明显高于对照组（P〈0.05）；观察C组的总有效率明显高于观察A组、观察B组（P〈0.05）。观察组3组患儿的体温恢复正常时间、咳嗽咳痰时间、肺部体征消失时间及住院时间均明显短于对照组，差异有统计学意义（P〈0.05）；观察A组和观察B组间差异无统计学意义（P〉0.05），观察C组与观察A组、观察B组比较，差异有统计学意义（P〈0.05）。结论利用氨溴索辅助治疗小儿肺炎能有效改善患儿的临床症状，缩短患儿住院时间，其中，采用氨溴索静脉滴注＋雾化治疗的方式能进一步缩短治疗时间，减轻患儿痛苦，治疗效果更加明显，值得临床推广应用。

关键词：氨溴索小儿肺炎治疗效果

阿芬太尼和艾司洛尔对气管插管时循环和儿茶酚胺反应的影响

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中华麻醉学杂志 1999年第3期19卷 146-148页

作者：龚志毅 J.C.Yang K.F.ng T.S.Siu 罗爱伦中国医学科学院香港大学麻醉系

目的　比较阿芬太尼和艾司洛尔对气管插管时循环及儿茶酚胺反应的影响。方法　 35例病人随机分为 3组 ,A组为对照组 ,B组为艾司洛尔组 ,C组为阿芬太尼组。插管前 B、C组分别给予2 mg/ kg艾司洛尔、30μg/ kg阿芬太尼。静注硫喷妥钠和维... 详细信息

目的　比较阿芬太尼和艾司洛尔对气管插管时循环及儿茶酚胺反应的影响。方法　 35例病人随机分为 3组 ,A组为对照组 ,B组为艾司洛尔组 ,C组为阿芬太尼组。插管前 B、C组分别给予2 mg/ kg艾司洛尔、30μg/ kg阿芬太尼。静注硫喷妥钠和维库溴铵诱导插管。结果　插管后 3分 ,阿芬太尼组收缩压显著降低 (Pe)增加 ,均高于其基础值 (Pe水平无明显改变 ,肾上腺素水平较基础值降低 (P<0 .0 1)。结论　艾司洛尔 2 mg/ kg可在一定程度上缓解插管时的循环反应。阿芬太尼 30μg/ kg能完全抑制插管时的循环及儿茶酚胺反应。

关键词：气管内插管术阿芬太尼艾司洛尔血液动力学

The novel male meiosis recombination regulator coordinates the progression of meiosis prophase Ⅰ

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Journal of Genetics and Genomics 2020年第8期47卷 449-464页

作者： Miao Li Haiwei Feng Zexiong Lin Jiahuan Zheng Dongteng Liu Rui Guo Junshi Li Raymond H.W.Li ernest H.Y.ng Michael S.Y.Huen P.Jeremy Wang William S.B.Yeung Kui Liu Shenzhen Key Laboratory of Fertility Regulation Center of Assisted Reproduction and EmbryologyThe University of Hong Kong-Shenzhen HospitalShenzhen518000China Department of Obstetrics and Gynecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China Department of Biomedical Sciences University of Pennsylvania School of Veterinary MedicinePhiladelphiaPA19104USA School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China

Meiosis is a specialized cell division for producing haploid gametes in sexually reproducing *** this study,we have independently identified a novel meiosis protein male meiosis recombination regulator(MAMeRR)/4930432 K21 Rik and showed that it is indispensable for meiosis prophase I progression in male *** super-resolution structured illumination microscopy,we found that MAMeRR functions at the same double-strand breaks as the replication protein A and meiosis-specific with OB domains/spermatogenesis associated 22 *** generated a Mamerr-deficient mouse model by deleting exons 3 e6 and found that most of Mamerrà/àspermatocytes were arrested at pachynema and failed to progress to diplonema,although they exhibited almost intact synapsis and progression to the pachytene stage along with XY body *** mechanistic studies revealed that the recruitment of DMC1/RAD51 and heat shock factor 2 ebinding protein in Mamerrà/àspermatocytes was only mildly impaired with a partial reduction in double-strand break repair,whereas a substantial reduction in ubiquitination on the autosomal axes and on the XY body appeared as a major phenotype in Mamerrà/à*** propose that MAMeRR may participate in meiotic prophase I progression by regulating the ubiquitination of key meiotic proteins on autosomes and XY chromosomes,and in the absence of MAMeRR,the repressed ubiquitination of key meiotic proteins leads to pachytene arrest and cell death.

关键词： Meiosis 4930432K21Rik Recombination Ubiquitination

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T辅助细胞在疫苗研制中的作用(英文)

热带医学杂志 2002年第3期2卷 207-214页

作者： Waiyan Candy ng 冯明钊香港中文大学生物系

发展感染性疾病疫苗之关键挑战在于利用确定的抗原以刺激产生能引起保护作用的合适的免疫反应。肽类疫苗的运用得到了极大的关注 ,其意义在于 ,已知不同的多表位构成单一结构以诱导出所希望的免疫反应所表现出的灵活性。这一般比利用减... 详细信息

发展感染性疾病疫苗之关键挑战在于利用确定的抗原以刺激产生能引起保护作用的合适的免疫反应。肽类疫苗的运用得到了极大的关注 ,其意义在于 ,已知不同的多表位构成单一结构以诱导出所希望的免疫反应所表现出的灵活性。这一般比利用减毒的活疫苗要安全并且相对而言比制造亚单位疫苗要容易。然而 ,多肽疫苗的发展面临巨大挑战。这一方法在诱导遗传背景复杂的人群免疫反应方面受到限制 ,这与主要组织相溶性复合物 (MHC)多态性有关。因同样的理由 ,肽类免疫应答常因缺乏适当的辅助T淋巴细胞 (HTL)而引导出不充分的细胞毒素T淋巴细胞 (CTL)和抗体反应。另一个运用线性肽链结构的可能缺点是 :为了引导出合适抗体反应 ,表面免疫球蛋白受体簇对于激活静息的B细胞就成为必须因素。由MHC多肽性引起的问题可由运用不加区别的T细胞表位来解决。从麻疹病毒F蛋白 (氨基酸 2 88到 30 2 )中得到的不加区别的T细胞表位和鼠的确定结合在多种MHC分子上的辅助T细胞表位 (V1eB ,aa 191- 2 0 9)已被定性并且被用于能极大激发免疫应答的结构中 ,以克服单一限制型免疫应答的缺陷。合成的 ,非自然PanDR表位 (PADRe)具有退化的结合几种通常HLA DR的能力 ,能以绝对效价和抗体反应质量两种形式来增强激发短肽链的免疫应答。另外 ,?

关键词： T细胞表位疫苗 PADRZ,MHCⅡ 免疫反应灵活性辅助T淋巴细胞细胞毒素T淋巴细胞肽类

Oral everolimus inhibits intimal proliferation in injured carotid artery in rats

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Chinese Medical Journal 2013年第10期126卷 1906-1912页

作者： WAng Xiao-fang SHeN De-liang ZHAO Xiao-yan N1ng Hong-jie Feng Ri-sheng ZHAng Jin-ying Department of Cardiology First Affiliated Hospital College ofMedicine Zhengzhou University Zhengzhou Henan 450052 China

Background everolimus, a derivative of sirolimus, is a potent immunosuppressant that has important anti-proliferative properties. In the present study, we demonstrated the inhibiting neointimal hyperplasia in injured carotid arteries in rats by using two different doses of everolimus administrated via the oral route for a long time. Methods A rat model of carotid artery injury was established by balloon inflation. eighty rats were randomly divided into the sham-operated group （n=20）, injury group （n=20）, low dosage of everolimus group （n=20）, and high dosage of everolimus group （n=20）. The low close of everolimus （1.5 mg/kg） was given one day before injuring the carotid artery by balloon, followed by 0.75 mg/kg per day for 28 days via intragastric gavage. High dose everolimus （2.5 mg/kg） was given one day before injuring the carotid artery by balloon, followed by 1 mg/kg per day for 28 days. expression of eukaryotic translation initiation factor 4e （elF-4e） and phosphorylation of ribosomal proteinS6 kinase 1 （P70S6K） were determined by reverse transcription-polymerase chain reaction and Western blotting analysis. Results In the injured carotid artery, neointimal hyperplasia was normally observed four weeks after injury. everolimus inhibited neointimal hyperplasia after balloon injury in a dose dependent manner. At the same time, the study demonstrated that everolimus reduced the expression of P-P70S6K, elF-4e, transforming growth factor （TGF）-131 and of proliferating cell nuclear antigen （PCNA）. Conclusions everolimus significantly inhibited neointimal hyperplasia of the injured carotid artery. The effect depended on dosaqe and was associated with the reduction of phosphorylation of P70S6K and the elF-4e expression level.

关键词： everolimus ribosomal protein S6 kinase 1, eukaryotic translation initiation factor 4e

Chemical Constituents in e-Cigarette Liquids and Aerosols

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Journal of environmental Protection 2020年第9期11卷 664-681页

作者： Mohd Naeem Mohd Naeem Sharifah Mazrah Sayed Mohamed Zain Catrina ng Mohd Fairulnizal Md. Noh Nutrition Metabolism and Cardiovascular Research Centre Institute for Medical Research (IMR) National Institutes of Health Ministry of Health Malaysia (MOH) Shah Alam Selangor Malaysia environmental Health Research Centre Institute for Medical Research (IMR) National Institutes of Health Ministry of Health Malaysia (MOH) Shah Alam Selangor Malaysia Perkin elmer Sdn Bhd Petaling Jaya Selangor Malaysia

electronic cigarettes (e-cigarettes, eC) form an aerosol from the heating element and liquid-containing cartridge. The heating element aerosolizes the refill solutions (e-liquids) when the power source of e-cigarette is pressed. e-liquids consist of combinations of propylene glycol, glycerine, nicotine and flavouring ingredients. Puffing activates the battery-operated heating element in the atomizer and will produce smoke that is similar to conventional cigarette (CC). This study evaluated the chemical composition of e-liquid and aerosol samples available in Malaysia. We analyzed the volatile organic compounds in e-liquids and the aerosols samples from eC using gas chromatography mass spectrometer. Seventy-two eC e-liquids were analyzed through different flavours from more than 60 brands. Samples consisted of 32 nicotine-free (0 mg) and 40 nicotine-containing refill solutions (3 - 12 mg). Overall, 116 compounds were identified from eC e-liquids. On the other hand, 275 compounds were identified from their resultant aerosol samples. There were 42 compounds found in both e-liquids and aerosols. Seven compounds were only found in e-liquids and 38 compounds were only found in aerosols. Propylene glycol was found in all of the e-liquid and aerosol samples. Glycerin was found in 99% of the e-liquid and 100% of aerosol samples. At least 60% of the eC e-liquids and the resultant aerosol contain piperidine, butanoic acid ethyl ester and nicotine. It was also found that at least 9 out of 35 nicotine free labeled e-liquids contain nicotine. Some of these compounds were known to be detrimental to health and were detected in aerosol although they were not present in e-liquids. While some of the compounds are flavouring ingredients, it is necessary to evaluate its long-term effects on eC users.

关键词： e-Cigarette Volatile Organic Compounds Aerosols e-Liquids Constituents