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Assessment and Analysis of Rockfall-Caused Tree Injuries in a Turkish Fir Stand:A Case Study from Kastamonu-Turkey

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Journal of Mountain Science 2012年第2期9卷 137-146页

作者： Abdurrahim AYDIN nesibe KSE nal AKKEMK Hüseyin YURTSEVEN Düzceüniversity Faculty of ForestryKonuralp Campus Faculty of Forestry Department of Forest BotanyIstanbul University Faculty of Forestry Department of Surveying and PhotogrammetryIstanbul University

Rockfalls can cause serious damage to people,property,facilities and transportation ***,rockfalls are major hazards in mountain areas with negative impacts on individual trees and forested *** conducted a study of rockfall events on 117 mapped(91% of total trees in the stand with>1.3 m in height and>5 cm diameter at breast height)Turkish fir trees(Abies bornmuelleriana Mattf.)in a stand within the Kayaarkasi-Topular Village,Inebolu district, Kastamonu province of *** study site of 0.35 Ha is located on the transition zone of frequently passing rockfall fragments(～40 cm in diameter) generally causing healable *** of trees and injuries were recorded and analysed as to injury number,height and *** correlation analysis were used to investigate the relationships between:a)diameter at breast height and number of injuries per tree,b)diameter at breast height and total injury size,c)the number of injuries and total injury size and d)the number of injuries per tree and distance from the source of the rockfall *** indicate that the average height of injury,average number of injuries and average injury area to be 81.3 cm(STDEV:49.8),7.46(STDEV:4.4)and 628.6 cm2 (STDEV:678.2),*** total 84% of all injuries were recorded within 160°sector at the upslope side of trees and callus tissue that had closed wounds was observed in 79.1% of all injuries. Furthermore 14.5% of injured trees had callus tissue in the process of closing wounds while 6.4% of injuries had not formed any callus *** most common injury types were bark and wood injuries. Bivariate correlation analysis indicated strong relationships between diameter at breast height and the number of injuries(rs=0.524),injury number and total injury area(rs=0.653)and distance from rockfall area and injury numbers relations(rs=-0.518).A weaker relationship was found between diameter at breast height and total injury area(rs=0.363).These results

关键词： Tree injuries Rockfall Past event assessment Turkish fir Turkey

Boric acid reduces axonal and myelin damage in experimental sciatic nerve injury

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Neural Regeneration Research 2016年第10期11卷 1660-1665页

作者： Zahir Kizilay Haydar Ali Erken nesibe Kahraman Cetin Serdar Aktas Burcin lrem Abas Ali Yilmaz Department of Neurosurgery Faculty of Medicine Adnan Menderes University Aydin Turkey Department of Physiology Faculty of Medicine Balikesir University BalikesirTurkey Department of Pathology Faculty of Medicine Adnan Menderes University Aydin Turkey Department of Pharmacology and Toxicology Faculty of Medicine Adnan Menderes University Aydin Turkey Department of Clinical Biochemistry Faculty of Medicine Adnan Menderes University AydinTurkey

The aim of this study was to investigate the effects of boric acid in experimental acute sciatic nerve injury. Twenty-eight adult male rats were randomly divided into four equal groups （n = 7）： control （C）, boric acid （BA）, sciatic nerve injury （I） , and sciatic nerve injury ＋ boric acid treatment （BAI）. Sciatic nerve injury was generated using a Yasargil aneurysm clip in the groups I and BAI. Boric acid was given four times at 100 mg/kg to rats in the groups BA and BAI after injury （by gavage at 0, 24, 48 and 72 hours） but no injury was made in the group BA. In vivo electrophysiological tests were performed at the end of the day 4 and sciatic nerve tissue samples were taken for histopathological examination. The amplitude of compound action potential, the nerve conduction velocity and the number of axons were significantly lower and the myelin structure was found to be broken in group I compared with those in groups C and BA. However, the amplitude of the compound action potential, the nerve conduction velocity and the number of axons were significantly greater in group BAI than in group I. Moreover, myelin injury was significantly milder and the intensity of nuclear factor kappa B immunostaining was significantly weaker in group BAI than in group I. The results of this study show that administration of boric acid at 100 mg/kg after sciatic nerve injury in rats markedly reduces myelin and axonal injury and improves the electrophysiological function of injured sciatic nerve possibly through alleviating oxidative stress reactions.

关键词： nerve regeneration peripheral nerve injury sciatic nerve boric acid nerve conduction velocity axon myelin electrophysiology neural regeneration

The Efficacy of Tocilizumab for Takayasu Arteritis: Review of the Literatures

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第4期5卷 118-125页

作者： nesibe Karahan Yesil Hatice Sahin Metin Isik Ziyaeddin Aktop Ismail Dogan Ali Erdem Baki Department of Rheumatology Ankara Research and Education HospitalAnkaraTurkey Division of Rheumatology Department of Internal MedicineFaculty of MedicineBülent Ecevit UniversityZonguldakTurkey Division of Rheumatology Department of Internal MedicineFaculty of MedicineMevlana UniversityKonyaTurkey Department of Cardiology Bülent Ecevit UniversityZonguldakTurkey Division of Rheumatology Department of Internal MedicineÇorum Hitit UniversityÇorumTurkey Department of Physical Medicine and Rheabilitation Bülent Ecevit UniversityZonguldakTurkey

Takayasu arteritis is a large vessel vasculitis of the young women with giant cells and granuloma formation. The diagnosis and management of the disease are really not so easy because of the insidious onset and the difficulties in assessment of disease activity. Nearly 60% of the patients are corticosteroid resistant or dependent and relapses are very frequent during taper of the dose [1]. The novel biologic agents as Anti-TNF, Rutiximab and Tocilizumab provide acceptable response rates with low toxicity. Herein, we reviewed the efficacy of Tocilizumab in Takayasu arteritis.

关键词： Takayasu Arteritis Tocilizumab Corticosteroid

Rational Usage of Disease Modifying Anti-Rheumatic Drugs with the Guidance of EULAR and ACR Suggestions

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第4期5卷 104-112页

作者： Zuhal Ornek Metin Isik nesibe Karahan Yesil Ismail Dogan Hatice Sahin Ali Erdem Baki Department of Pediatrics Faculty of MedicineBülent Ecevit UniversityZonguldakTurkey Division of Rheumatology Department of Internal MedicineFaculty of MedicineBülent Ecevit UniversityZonguldakTurkey Department of Rheumatology Ankara Education and Research HospitalAnkaraTurkey Division of Rheumatology Department of Internal MedicineFaculty of MedicineCorum Hitit UniversityCorumTurkey Department of Internal Medicine Faculty of MedicineBülent Ecevit UniversityZonguldakTurkey Department of Physical Medicine and Rheabilitation Faculty of MedicineBülent Ecevit UniversityZonguldakTurkey

Disease modifying anti-rheumatic agents are the cornerstone in management of Rheumatoid Arthritis and when used correctly they are life-saving. As the number of the agents increases, detailed guidelines become more and more important for clinicians to set safe and effective regimens. Herein, we combined the EULAR and ACR recommendations for clinicians and also pointed some important facts peculiar to our country.

关键词： DMARD Rational EULAR ACR

Biologic Agents in Behcet’s Disease:Our Experience and Review of the Literature

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第4期5卷 97-103页

作者： nesibe Karahan Yesil Hatice Sahin Hatice Isik Zuhal Irnek Serpil Yazgan Adem Tok Yunus Emre Yandi Metin Isik Ismail Dogan Department of Rheumatology Ankara Research and Education Hospital Ankara Turkey Department of Internal Medicine Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Department of Obstetrics and Gynecology Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Department of Pediatric Disaease Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Department of Ophtalmology Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Department of Urology Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Division of Biochemistry Department of Medical Services and Techniques Health Sciences Vocational School Bülent Ecevit University Zonguldak Turkey Division of Rheumatology Department of Internal Medicine Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Division of Rheumatology Department of Internal Medicine Faculty of Medicine Hitit University &Ccedilorum Turkey

Behcet’s disease (BD) is a large vessel vasculitis with a wide range of clinical manifestations. Some of these manifestation may be life threatening and rapid suppression of the inflammation with effective immunosuppressive agent is crucial. There are traditional drugs with different response rates and all have efficacy on different manifestations of the disease. The most frightening manifestations of the disease are ocular, neurologic, intestinal and vascular types of involvement. Besides benign and easily treated manifestations there are also refractory cases with complicated involvement. The novel biologic agents have been used for these resistant patients and favorable response rates have been reported. In this review, we have shared our experience with biologic agents in BD and also reviewed the literature for the efficacy and safety for these novel agents for refractory patients.

关键词： Behcet’s Disease Novel Biologic Agents Refractory Patients

Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution

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Plant Communications 2023年第3期4卷 80-98页

作者： Salih Kafkas Xiaokai Ma Xingtan Zhang Hayat Topc¸u Rafael Navajas-Pérez Ching Man Wai Haibao Tang Xuming Xu Mortaza Khodaeiaminjan Murat Güney Aibibula Paizila Harun Karcı Xiaodan Zhang Jing Lin Han Lin Roberto de la Herrán Carmelo Ruiz Rejón Jerson Alexander García-Zea Francisca Robles Coral del Val Muñoz Agnes Hotz-Wagenblatt Xiangjia Jack Min HakanÖzkan Elmira Ziya Motalebipour Hatice Gozel Nergiz C¸oban nesibe Ebru Kafkas Andrej Kilian HuaXing Huang Xuanrui Lv Kunpeng Liu Qilin Hu Ewelina Jacygrad William Palmer Richard Michelmore Ray Ming Department of Horticulture Faculty of AgricultureUniversity of C¸ukurovaAdana 01330Turkey Center for Genomics and Biotechnology Haixia Institute of Science and TechnologySchool of Future TechnologyFujian Agriculture and Forestry UniversityFuzhouChina Key Laboratory of Orchid Conservation and Utilization of National Forestry and Grassland Administration Fujian Agriculture and Forestry UniversityFuzhouChina Departamento de Genética Facultad de CienciasCampus de Fuentenueva s/n18071 GranadaSpain Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems College of the Environment and EcologyXiamen UniversityXiamen 361102China Department of Computer Science University of GranadaGranadaSpain Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI Institute) 18014 GranadaSpain German Cancer Research Center Omics IT and Data Management Core FacilityHeidelbergGermany Department of Biological Sciences Youngstown State UniversityYoungstownOH 44555USA Department of Field Crops Faculty of AgricultureUniversity of C¸ukurovaAdana 01330Turkey Pistachio Research Institute SxahinbeyGaziantep 27060Turkey Diversity Arrays Technology University of CanberraCanberraACTAustralia Genome Center University of California Davis451 Health Sciences DriveDavisCA 95616USA

Pistachio is a nut crop domesticated in the Fertile Crescent and a dioecious species with ZW sex *** sequenced the genomes of Pistacia vera cultivar(cv.)Siirt,the female parent,and *** ***,the male *** chromosome-level reference genomes of pistachio were generated,and Z and W chromosomes were *** ZW chromosomes originated from an autosome following the first inversion,which occurred approximately 8.18 *** inversion events in the W chromosome led to the formation of a 12.7-Mb(22.8%of the W chromosome)non-recombining *** W-specific sequences contain several genes of interest that may have played a pivotal role in sex determination and contributed to the initiation and evolution of a ZW sex chromosome system in *** W-specific genes,including defA,defA-like,DYT1,two PTEN1,and two tandem duplications of six VPS13A paralogs,are strong candidates for sex determination or *** history analysis of resequenced genomes suggest that cultivated pistachio underwent severe domestication bottlenecks approximately 7640 years ago,dating the domestication event close to the archeological record of pistachio domestication in *** identified 390,211,and 290 potential selective sweeps in 3 cultivar subgroups that underlie agronomic traits such as nut development and quality,grafting success,flowering time shift,and drought *** findings have improved our understanding of the genomic basis of sex determination/differentiation and horticulturally important traits and will accelerate the improvement of pistachio cultivars and rootstocks.

关键词： Pistacia vera pistachio sequencing reference genome sex chromosome domestication