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The impacts of organizational culture and neoliberal ideology on the continued existence of incivility and bullying in healthcare institutions:A discussion paper

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International Journal of Nursing Sciences 2021年第3期8卷 361-366,I0009页

作者： Michael LaGuardia nelly D.Oelke School of Nursing The University of British ColumbiaBritish ColumbiaCanada Rural Coordination Centre of British Columbia British ColumbiaCanada

Countless research studies have demonstrated the detrimental effects of incivility and bullying in *** the abundance of proposed solutions to this issue,many healthcare leaders continue to fail in mitigating the existence of such negative behaviors in the *** attributes of perpetrators and victims have received attention,but much less research has examined the organizational and neoliberal causations of incivility and bullying in *** the largest occupational group in the health sector,nursing professionals have the greatest influence and are crucial in ending these *** discussion paper outlines the effects of incivility and bullying in healthcare and provides a critical analysis on how organizational culture and neoliberal ideology influence the pervasiveness and persistence of these negative *** analysis reveals that organizational cultures that misuse power,disregard equality,and facilitate oppression,foster the existence of incivility and bullying in the *** cultures permit perpetrators to misuse their authority to control resource allocation,ignorance to social inequalities,and the silence of ***,the neoliberal concept of deregulation,austerity,and individualism further these *** neoliberal reforms have led to underfunding of anti-bullying programs and policies,use of bullying behaviours as management strategies,and victim-blaming for profit *** cutbacks have resulted in denial and acceptance of uncivil and bullying behaviours in healthcare institutions,which endangers the rights of healthcare providers to a safe workplace *** curtail these negative behaviors,robust anti-bullying policies and programs must be strictly enforced and sustained in *** exploration on the association of organizational culture and neoliberal principles to incivility and bullying in healthcare is greatly warranted.

关键词： Austerity Bullying Health personnel Incivility Neoliberalism Organizational culture Resource allocation

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CHO-HPA-1a细胞快速检测人血小板同种(异型)抗体方法的建立

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南京大学学报（自然科学版） 2004年第5期40卷 585-591页

作者：陈平孙崇秀杨文秦朝平 nelly Kieffer 南京大学分子医学研究所医药生物技术国家重点实验室南京210093 湛江海洋大学农学院湛江524088 卢森堡大学生物与生理实验室

应用蛋白印迹(WB)、悬浮细胞免疫荧光流式细胞分析(SIFT)、单抗分析血小板抗体检测(MAIPA)以及限制性内切酶片段长度分析对新生儿血小板减少患儿母体作基因分型和血清分型比较研究。从两例新生儿血小板减少症患儿母亲的血清中检测到了抗... 详细信息

应用蛋白印迹(WB)、悬浮细胞免疫荧光流式细胞分析(SIFT)、单抗分析血小板抗体检测(MAIPA)以及限制性内切酶片段长度分析对新生儿血小板减少患儿母体作基因分型和血清分型比较研究。从两例新生儿血小板减少症患儿母亲的血清中检测到了抗β_3抗体。CHO-SIFT方法的敏感性和MAIPA分析相似。和间接免疫荧光或MAIPA分析相比,WB分析法敏感性稍低,可能是SDS使HPA-1a抗原决定簇发生了改变。以较温和条件对CHO细胞进行固定时,不但细胞表面的HPA-1a抗原表位未受影响,而且细胞的保存时间被大大的延长。这些结果表明,作为分型血小板的替代物,固定化的细胞可能更适合于一般妇幼保健门诊对大量血清样品进行筛查。研究结果表明,表达有重组β_3整合素的CHO细胞可以用来检测母体血清中的抗HPA-1a同种(异型)抗体。

关键词：人血小板抗原同种(异型)抗体流式细胞分析基因分型

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人血小板多态性抗原HPA-1a/HPA-1b在CHO细胞中的表达及功能研究

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南京大学学报（自然科学版） 2004年第5期40卷 559-565页

作者：陈平杨文孙崇秀秦朝平 nelly Kieffer 南京大学分子医学研究所医药生物技术国家重点实验室南京210093 湛江海洋大学农学院湛江524088 卢森堡大学生物与生理实验室

为了在体外研究HPA-1抗原的多态性,同时建立一种更简便灵敏的检测抗HPA-1同种(异型)抗体的方法,将含有HPA-1a和HPA-1b的DNA质粒分别转染CHO细胞(中国仓鼠卵巢细胞)并获得稳定表达β_3HPA-1a和β_3HPA-1b的细胞株。流式细胞分析结果表明,... 详细信息

为了在体外研究HPA-1抗原的多态性,同时建立一种更简便灵敏的检测抗HPA-1同种(异型)抗体的方法,将含有HPA-1a和HPA-1b的DNA质粒分别转染CHO细胞(中国仓鼠卵巢细胞)并获得稳定表达β_3HPA-1a和β_3HPA-1b的细胞株。流式细胞分析结果表明,CHO细胞结合抗HPAPA-1a同种(异型)抗体的能力与细胞表面β_3整合素表达量直接相关。同时,针对HPA-1a表位的单克隆抗体SZ21仅能抑制CHOβ_3HPA-1a细胞的粘附,对 CHOβ_3HPA-1b细胞却没有影响。抗HPA-1a参照血清能阻断CHOβ_3HPA-1a细胞的粘附,但对CHOβ_3HPA-1b细胞却影响甚微。结果表明,CHO细胞模型可以成功地用来表达并研究HPA-1a的多态性及其抗原特性,同时可以作为用于临床检测抗HPA-1a同种(异型)抗体的一种替代方法。

关键词：人血小板抗原 HPA 整合素同种(异型)抗体

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Effect of Soaking Temperature on Water Absorption Characteristics of Selected Ghanaian Cowpea Varieties

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Open Journal of Applied Sciences 2019年第9期9卷 736-748页

作者： Nancy nelly Idun-Acquah Ahmad Addo Ato Bart-Plange CSIR-Food Research Institute Council for Scientific and Industrial Research Accra Ghana Department of Agricultural and Biosystems Engineering Kwame Nkrumah University of Science and Technology Kumasi Ghana

The water absorption kinetics of three cowpea varieties (Asontem, Hewale and Asomdwee) was studied following the phenomenological models derived from Fick’s law of diffusion. Soaking of seeds from each cowpea variety was carried out for 10 h at four temperatures (30°C, 40°C, 50°C and 60°C). The saturation moisture content was higher for Asontem (106.9 g water/1000 g dry weight) and Hewale varieties (108.7 g water/1000 g dry weight) and lower for Asomdwee hybrid (100.7 g water/1000 g dry weight), respectively. The proposed Fick’s law of diffusion satisfactorily described the kinetics of water absorption regardless of the variety and temperature. The estimated values for water diffusion coefficient for Asontem, Hewale and Asomdwee varied from 5.12 × 10-10 m2/s to 6.64 × 10-10 m2/s, 3.96 × 10-10 m2/s to 5.12 × 10-10 m2/s, 4.93 × 10-10 m2/s to 6.08 × 10-10 m2/s, respectively. The strong influence of temperature on the water diffusion coefficient was adequately described by an Arrhenius-type equation with activation energy values for Asontem, Hewale and Asomdwee as 7.27 kJ/mol, 7.26 kJ/mol and 6.26 kJ/mol, respectively.

关键词： Cowpea Water Absorption Diffusion Coefficient Arrhenius-Type Equation Modelling

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广义Lorenz曲线的非参数统计推断

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中国科学：数学 2012年第3期42卷 235-250页

作者：杨宝莹秦更生 BELINGA-HILL nelly E. 西南交通大学数学学院成都610031 Department of Mathematics and Statistics Georgia State UniversityAtlantaGA 30303USA

本文讨论了广义Lorenz曲线的经验似然统计推断.在简单随机抽样、分层随机抽样和整群随机抽样下,本文分别定义了广义Lorenz坐标的profile经验似然比统计量,得出这些经验似然比的极限分布为带系数的自由度为1的χ2分布.对于整个Lorenz曲线... 详细信息

本文讨论了广义Lorenz曲线的经验似然统计推断.在简单随机抽样、分层随机抽样和整群随机抽样下,本文分别定义了广义Lorenz坐标的profile经验似然比统计量,得出这些经验似然比的极限分布为带系数的自由度为1的χ2分布.对于整个Lorenz曲线,基于经验似然方法类似地得出相应的极限过程.根据所得的经验似然理论,本文给出了bootstrap经验似然置信区间构造方法,并通过数据模拟,对新给出的广义Lorenz坐标的bootstrap经验似然置信区间与渐近正态置信区间以及bootstrap置信区间等进行了对比研究.对整个Lorenz曲线,基于经验似然方法对其置信域也进行了模拟研究.最后我们将所推荐的置信区间应用到实例中.

关键词：经验似然广义 Lorenz曲线置信区间

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Mother to Child Transmission of HIV after Option B+ in Low Income Environment

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Open Journal of Obstetrics and Gynecology 2018年第12期8卷 1163-1175页

作者： Mve Koh Valère Kamgaing nelly Nda Mefo Foumane Pascal Faculty of Medicine and Biomedical Sciences of University of Yaoundé I Yaoundé Cameroon University Teaching Hospital of Yaoundé Yaoundé Cameroon Chantal Biya International Reference Center for Research on Prevention and Management of HIV Yaounde Cameroon Faculty of Medicine and Pharmaceutical Sciences of the University of Douala Douala Cameroon General Hospital of Douala Douala Cameroon Gynecological Obstetrics and Pediatric Hospital Yaoundé Yaoundé Cameroon

Background: In Cameroon, the prevalence of HIV in pregnant women was 7.8% in 2012, and they were 8500 HIV positive newborns in 2013. Option B+ is the first highly active antiretroviral therapy (HAART) preventive protocol. The objective was to evaluate the rate of HIV transmission on children born from mothers who were on Option B+ during pregnancy, in three university teaching hospitals of the University of Yaoundé I. Methods: It was a retrospective, cross-sectional study over a period of four years (2013-2017). We included HIV positive mothers not on previous antiretroviral treatment and who received a single tablet daily of combined tenofovir (300 mg) + Lamivudine (300 mg) + Efavirenz (600 mg) started at any time during pregnancy. Newborn received nevirapine syrup according to WHO option B+ protocol. Results: 179 women were included. The average age was 33.5 ± 2.92 years, all ages were represented. Blood donation was the most frequent HIV positive screening opportunity, voluntary testing rate was 29% (29/179), and adherence rate was 98.9%. Few male partners were involved (58/179). Premature deliveries and low birth weight were rare (5/179;10/179)), the indication of mode of delivery was strictly obstetrical, newborn feeding choice didn’t affect the transmission outcome, and the mother to child transmission rate was 2.2% (4/179). Conclusion: Option B+ could achieve the lowest mother to child transmission ever in Cameroon and should be generalized in high endemicity low resources settings.

关键词： Option B+ University of Yaoundé I Cross Sectional

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A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles

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Nano Research 2016年第2期9卷 537-548页

作者： Sara Capolla nelly Mezzaroba Sonia Zorzet Claudio Tripodo Ramiro Mendoza-Maldonado Marilena Granzotto Francesca Vita Ruben Spretz Gustavo Larsen Sandra Noriega Eduardo Mansilla Michele Dal Bo Valter Gattei Gabriele Pozzato Luis Nunez Paolo Macor Department of Life Sciences University of Trieste 34127 Trieste Italy Department of Human Pathology University of Palermo 90133 Sicilia Italy Molecular Oncology Unit National Laboratory Consorzio Interuniversitatio per le Biotecnologie (CIB) 34012 Trieste Italy Dipartimento Universitario Clinico di Scienze mediche Chirurgiche e della Salute University of Trieste 34149 Trieste Italy LNK Chemsolutions LLC Lincoln NE 68521 USA Bio-Target Inc. Chicago IL 60637 USA Centro Unico Coordinador de Ablacion e Implante Provincia de Buenos Aires (C.U.CA.I.B.A.) Ministry of Health La Plata Buenos AiresArgentina Clinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico Istituto di Ricerca e Cura a Carattere Scientifico(I.R.C.C.S.) 33081 Aviano Italy Callerio Foundation Onlus Institutes of Biological Researches 34127 Trieste Italy

Current approaches for the treatment of chronic lymphocytic leukemia （CLL） have greatly improved the prognosis for survival, but some patients remain refractive to these therapeutic regimens. Hence, in addition to reducing the long-term side- effects of therapeutics for all leukemia patients, there is an urgent need for novel therapeutic strategies for difficult-to-treat leukemia cases. Due to the cytotoxicity of drugs, the major challenge currently is to deliver the therapeutic agents to neoplastic cells while preserving the viability of non-malignant ceils. In this study, we propose a therapeutic approach in which high doses of hydroxychloroquine and chlorambucil were loaded into biodegradable polymeric nanopartides coated with an anti-CD20 *** first demonstrated the ability of the nanoparticles to target and internalize in tumor B-cells. Moreover, these nanoparticles could kill not only p53-mutated]deleted leukemia cells expressing a low amount of CD20, but also circulating primary ceils isolated from chronic lymphocytic leukemia patients. The safety of these nanoparticles was also demonstrated in healthy mice, and their therapeutic effects were shown in a new model of aggressive leukemia. These results showed that anti-CD20 nanoparticles containing hydroxychloroquine and chlorambucil can be effective in controlling aggressive leukemia and provided a rationale for adopting this approach for the treatment of other B-cell disorders.

关键词： chronic lymphocytic leukemia immune targeted nanoparticles treatment xenograft model

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Simultaneous Determination of Four Estrogens in Compost Based on Ultrasonic Solvent Extraction, Solid-Phase Extraction Clean-Up and Analysis by UHPLC-MS/MS

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American Journal of Analytical Chemistry 2016年第5期7卷 434-445页

作者： Miguel Ángel López Zavala Blanca nelly Flores Arriaga Naoyuki Funamizu Water Center forLatin America and the Caribbean Tecnológico de Monterrey Col. Tecnológico Monterrey Mexico Department of Environmental Engineering Graduate School of Engineering Hokkaido University Sapporo Japan

A rapid, cost effective and reliable analytical method was developed and validated for the simultaneous determination of four estrogens (17 β-estradiol, 17 α-ethinylestradiol, estrone, and estriol) in compost samples from the biodegradation of biological infectious hazardous wastes. Ultrasonic solvent extraction, using methanol as extraction solvent, coupled with SPE clean-up, using cartridges HLB 60 mg - 6 ml Supelco® and acetonitrile for reconstitution of eluents, was used for the simultaneous extraction of the four estrogens. Mean recoveries in the range of 98% - 107% were obtained. All compounds were separated in a single gradient run by UHPLC KinetexTM 2.6 μm XB-C18 100 ÅLC (50 × 4.6 mm) column. Analytes were detected via multiple reaction monitoring (MRM) using an AB SCIEX API-5000TM triple quadrupole (Applied Biosystems/MDS SCIEX) with electrospray ionization in negative mode. Isocratic mobile phase of Water:ACN (50:50) resulted to be the optimum. Limits of detection and quantification were on the order of 0.66 ng·g-1 and 2 ng·g-1 for all the estrogens. These limits were lower than most of the values reported in the literature for similar matrices. Suitable level of linearity, good repeatability and reproducibility with coefficients of variation is lower than 11.7%, 6.8% and 8.3%, respectively.

关键词： Compost Estrogens Solid-Phase Extraction Clean-Up UHPLC-MS/MS Ultrasonic Solvent Extraction

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Propolis in Dogs: Clinical Experiences and Perspectives (A Brief Review)

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Open Journal of Veterinary Medicine 2015年第1期5卷 11-17页

作者： nelly Tovar Betancourt Lucila García-Contreras Tonatiuh Alejandro Cruz Sánchez Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Cuautitlán Izcalli México Department of Pharmaceutical Sciences The University of Oklahoma Health Sciences Center Oklahoma City USA

In light of the scarcity of novel therapeutic agents that are effective, the pharmaceutical industry has found a newer source of therapeutic compounds in natural products and herbal medicine to address the current health problems in humans and animals. What is particularly promising about these agents is that they produce fewer side effects and are more cost effective than synthetic compounds. This means greater availability of these treatments particularly for less developed countries who can’t afford expensive treatments. The reduced side effects also mean greater patient tolerance and increased compliance thereby yielding maximal therapeutic effect without negatively impacting on quality of life. Among the natural products more frequently employed nowadays is propolis, a resin that is routinely collected by bees (Apis mellifera). Propolis contains flavonoids, caffeic acid esters and diterpenic acids, which provide the bactericidal, antiviral and antifungal properties to this product. The use of propolis to address a variety of conditions in small animal species is beginning to play an important role in the currently available treatments. Its use appears to be an effective treatment with no side effects at low cost. This paper reviews the different applications of this compound to treat diseases in dogs.

关键词： Dog Propolis Uses Treatments Perspectives

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GDF-9 Stimulates Human Granulosa Cell Proliferation through Inhibition of the Cyclin-Dependent Kinase Inhibitors p15INK4b and p16INK4a

GDF-9 Stimulates Human Granulosa Cell Proliferation through ...

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第一届中华医学会生殖医学分会、中国动物学会生殖生物学分会联合年会

作者： nelly Auersperg Peter C.K.Leung Dept. Obstetrics and Gynecology University of British Columbia Vancouver B.C. Canada.

During follicular development, granulosa cell proliferation and differentiation are dependent on both endocrine factors and intra-ovarian paracrine factors. Among the latter, the members of the TGF-β superfamily are prominent, especially growth differentiation factor -9 (GDF-9). GDF-9 has been shown to promote ovarian follicle growth and granulosa cell proliferation in rodents and bovine both in vivo and in vitro. In this study, with primary cultures of human granulosa-luteal cells and a SV-40 Tag-immortalized

关键词： GDF-9 Stimulates Human Granulosa Cell Proliferation through Inhibition of the Cyclin-Dependent Kinase Inhibitors p15 Cyclin and p16 INK4a INK4b

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