Mother to Child Transmission of HIV after Option B+ in Low Income Environment
Mother to Child Transmission of HIV after Option B+ in Low Income Environment作者机构：Faculty of Medicine and Biomedical Sciences of University of Yaoundé I Yaoundé Cameroon University Teaching Hospital of Yaoundé Yaoundé Cameroon Chantal Biya International Reference Center for Research on Prevention and Management of HIV Yaounde Cameroon Faculty of Medicine and Pharmaceutical Sciences of the University of Douala Douala Cameroon General Hospital of Douala Douala Cameroon Gynecological Obstetrics and Pediatric Hospital Yaoundé Yaoundé Cameroon
出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)
年 卷 期：2018年第8卷第12期
页 面：1163-1175页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Option B+ University of Yaoundé I Cross Sectional
摘 要：Background: In Cameroon, the prevalence of HIV in pregnant women was 7.8% in 2012, and they were 8500 HIV positive newborns in 2013. Option B+ is the first highly active antiretroviral therapy (HAART) preventive protocol. The objective was to evaluate the rate of HIV transmission on children born from mothers who were on Option B+ during pregnancy, in three university teaching hospitals of the University of Yaoundé I. Methods: It was a retrospective, cross-sectional study over a period of four years (2013-2017). We included HIV positive mothers not on previous antiretroviral treatment and who received a single tablet daily of combined tenofovir (300 mg) + Lamivudine (300 mg) + Efavirenz (600 mg) started at any time during pregnancy. Newborn received nevirapine syrup according to WHO option B+ protocol. Results: 179 women were included. The average age was 33.5 ± 2.92 years, all ages were represented. Blood donation was the most frequent HIV positive screening opportunity, voluntary testing rate was 29% (29/179), and adherence rate was 98.9%. Few male partners were involved (58/179). Premature deliveries and low birth weight were rare (5/179;10/179)), the indication of mode of delivery was strictly obstetrical, newborn feeding choice didn’t affect the transmission outcome, and the mother to child transmission rate was 2.2% (4/179). Conclusion: Option B+ could achieve the lowest mother to child transmission ever in Cameroon and should be generalized in high endemicity low resources settings.
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