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中国化学前沿:英文版 2011年第4期6卷 269-279页

作者： neil Qiang SU Igor Ying ZHANg Jianming WU Xin XU State Key Laboratory of Physical Chemistry of Solid Surfaces/College for Chemistry and Chemical Engineering Xiamen UniversityXiamen361005China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials MOE Laboratory for Computational Physical ScienceDepartment of ChemistryFudan UniversityShanghai200433China

In the present work,we examined the performance of 36 density functionals,including the newly developed doubly hybrid density functional XYg3(***,***,and *** Ⅲ,***,USA,2009,106,4963),to calculate ionization energies(IEs)and electron affinities(EAs).We used the well-established g2-1 set as reference,which contains 14 atoms and 24 molecules for IE,along with 7 atoms and 18 molecules for ***3 leads to mean absolute deviations(MADs)of 0.057 and 0.080 eV for IEs and EAs,respectively,using the basis set of 6-311+g(3df,2p).In comparison with some other functionals,MADs for IEs are 0.109(B2PLYP),0.119(M06-2X),0.159(X3LYP),0.161(PBE),0.162(B3LYP),0.165(PBE0),0.173(TPSS),0.200(BLYP),and 0.215 eV(LC-BLYP).MADs for EAs are 0.090(X3LYP),0.090(B2PLYP),0.102(PBE),0.103(M06-2X),0.104(TPSS),0.105(BLYP),0.106(B3LYP),0.126(LC-BLYP),and 0.128 eV(PBE0).

关键词： ionization energy electron affinity DFT XYg3 B3LYP

Protein tolerance to standard and high protein meals in patients with liver cirrhosis

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World Journal of Hepatology 2017年第14期9卷 667-676页

作者： Octavio Campollo Dirk Sprengers gitte Dam Hendrik Vilstrup neil McIntyre Center of Studies on Alcohol and Addictions Antigüo Hospital Civil de GuadalajaraUniversidad de Gua-dalajara Department of gastroenterology and Hepatology Gasthuis Zusters Antwerpen Department of Medicine V(gastroenterology and Hepatology) Aarhus University Hospital University College Royal Free School of Medicine

To investigate the plasma amino acid response and tolerance to normal or high protein meals in patients with cirrhosis. METHODSThe plasma amino acid response to a 20 g mixed protein meal was compared in 8 biopsy-proven compensated cirrhotic patients and 6 healthy subjects. In addition the response to a high protein meal (1 g/kg body weight) was studied in 6 decompensated biopsy-proven cirrhotics in order to evaluate their protein tolerance and the likelihood of developing hepatic encephalopathy (HE) following a porto-caval shunt procedure. To test for covert HE, the “number connection test” (NCT) was done on all patients, and an electroencephalogram was recorded in patients considered to be at Child-Pugh C stage. RESULTSThe changes in plasma amino acids after a 20 g protein meal were similar in healthy subjects and in cirrhotics except for a significantly greater increase (P gher in the healthy persons and remained stable-but it decreased significantly after the meal in the cirrhotic group. After the high protein meal there was a marked increase in the levels of most amino acids, but only small changes occurred in the levels of taurine, citrulline, cysteine and *** BCAA/AAA ratio was significantly higher 180 and 240 min after the meal. Slightly elevated basal plasma ammonia levels showed no particular pattern. Overt HE was not observed in any patients. CONCLUSIONPatients with stable liver disease tolerate natural mixed meals with a standard protein content. The response to a high protein meal in decompensated cirrhotics suggests accumulation of some amino acids but it did not precipitate HE. These results support current nutritional guidelines that recommend a protein intake of 1.2-1.5 g/kg body weight/day for patients with cirrhosis.

关键词： Branched chain amino acids Fischer’s ratio Liver Protein Cirrhosis Tolerance Nutrition Amino acids Diet

Facile and Scalable Preparation of Fluorescent Carbon Dots for Multifunctional Applications

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Engineering 2017年第3期3卷 402-408页

作者： Dan Wang Zhiyong Wang Qiuqiang Zhan Yuan Pu Jie-xin wang neil R. Foster Liming Dai Beijing Advanced Innovation Center for Soft Matter Science and Engineering & State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Beijing 100029 China Center of Advanced Science and Engineering for Carbon (Case4Carbon) Department of Macromolecular Science and Engineering Case School of Engineering Case Western Reserve University Cleveland OH 44106 USA SCNU-ZJU Joint Research Center of Photonics South China Academy of Advanced Optoelectronics South China Normal University Guangzhou 510006 China Department of Chemical Engineering Curtin University Perth WA 6845 Australia

The synthesis of fluorescent nanomaterials has received considerable attention due to the great potential of these materials for a wide range of applications, from chemical sensing through bioimaging to optoelectron- ics. Herein, we report a facile and scalable approach to prepare fluorescent carbon dots （FCDs） via a one-pot reaction of citric acid with ethylenediamine at 150 ℃ under ambient air pressure. The resultant FCDs pos- sess an optical bandgap of 3.4 eV and exhibit strong excitation-wavelength-independent blue emission （λEm = 450 nm） under either one- or two-photon excitation. Owing to their low cytotoxicity and long fluorescence lifetime, these FCDs were successfully used as internalized fluorescent probes in human cancer cell lines （HeLa cells） for two-photon excited imaging of cells by fluorescence lifetime imaging microscopy with a high-contrast resolution. They were also homogenously mixed with commercial inks and used to draw fluo- rescent patterns on normal papers and on many other substrates （e.g., certain flexible plastic films, textiles, and clothes）. Thus, these nanomaterials are promising for use in solid-state fluorescent sensing, security labeling, and wearable optoelectronics.

关键词： Scalable Carbon dots Two-photon Fluorescence lifetime imaging Patterning

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黄芪总黄酮抗肝损伤作用初探

中国中西医结合杂志 2005年第S1期25卷 149-151页

作者：汪德清田亚平 Thomas g neil Tomlinson Brian 解放军总医院生化科北京100853 香港中文大学临床药理学部

目的研究黄芪总黄酮(total navonoids 0f Astragalus,TFA)对扑热息痛所致小鼠肝损伤的预防功效。方法观察不同剂量(0、100、300、400、500 ms/kg)扑热息痛对c57BL/6J小鼠肝脏的损伤作用,比较经1天或5天(每天2次)的TFA预处理后对扑热息痛... 详细信息

目的研究黄芪总黄酮(total navonoids 0f Astragalus,TFA)对扑热息痛所致小鼠肝损伤的预防功效。方法观察不同剂量(0、100、300、400、500 ms/kg)扑热息痛对c57BL/6J小鼠肝脏的损伤作用,比较经1天或5天(每天2次)的TFA预处理后对扑热息痛(400 mg/kg)所致肝损伤的防护作用。结果扑热息痛对小鼠肝损伤作用具有明显的量效关系。不同剂量的TFA对扑热息痛诱导小鼠肝损伤有不同程度的防护作用,其作用强度与药物浓度成正比；TFA可增加血清中SOD活性(P＜0．05)；高剂量的TFA(100mg/kg)具有降低肝组织中脂质过氧化物质的作用；此外,在相同TFA剂量下,5天组对扑热息痛诱导小鼠肝损伤的预防作用优于1天组。结论提示TFA可预防扑热息痛诱导的肝损伤,其预防作用与其使用时间有密切关系。

关键词：黄芪总黄酮扑热息痛肝损伤

Specificity of early-career general practitioners’problem formulations in patients presenting with dizziness:a cross-sectional analysis

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Family Medicine and Community Health 2021年第4期9卷 10-19,I0001,I0002页

作者： Jocelyn Ledger Amanda Tapley Christopher Levi Andrew Davey Mieke van Driel Elizabeth g Holliday Jean Ball Alison Fielding neil Spike Kristen Fitzgerald Parker Magin The University of Newcastle School of Medicine and Public Health CallaghanNew South WalesAustralia NSW&ACT Research and Evaluation Unit GP SynergyRegional Training OrganisationNewcastleNew South WalesAustralia The Sydney Partnership for Health EducationResearch and Enterprise(SPHERE)SydneyNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Primary Care Clinical Unit The University of Queensland Faculty of MedicineBrisbaneQueenslandAustralia Clinical Research Design and Statistical Support Unit(CReDITSS) The University of Newcastle Hunter Medical Research InstituteNew LambtonNew South WalesAustralia Eastern Victoria general Practice Training Regional Training OrganisationHawthornVictoriaAustralia Department of general Practice and Primary Health Care The University of MelbourneMelbourneVictoriaAustralia general Practice Training Tasmania Regional Training OrganisationHobartTasmaniaAustralia University of Tasmania School of Medicine HobartTasmaniaAustralia

Objectives Dizziness is a common and challenging clinical presentation in general *** to determine specific aetiologies can lead to significant morbidity and *** aimed to establish frequency and associations of general practitioner(gP)trainees’(registrars’)specific vertigo provisional diagnoses and their non-specific symptomatic problem *** A cross-sectional analysis of Registrar Clinical Encounters in Training(ReCEnT)cohort study data between 2010 and *** is an ongoing,prospective cohort study of registrars in general practice training in *** collection occurs once every 6 months midtraining term(for three terms)and entails recording details of 60 consecutive clinical consultations on hardcopy case report *** outcome factor was whether dizziness-related or vertigo-related presentations resulted in a specific vertigo provisional diagnosis versus a non-specific symptomatic problem *** with patient,practice,registrar and consultation independent variables were assessed by univariate and multivariable logistic *** Australian general practice training *** training is regionalised and delivered by regional training providers(RTPs)(2010-2015)and regional training organisations(RTOs)(2016-2018)across Australia(from five states and one territory).Participants All general practice registrars enrolled with participating RTPs or RTOs undertaking gP training *** 2333 registrars(96%response rate)recorded 1734 new problems related to dizziness or *** these,546(31.5%)involved a specific vertigo diagnosis and 1188(68.5%)a non-specific symptom *** associated with a non-specific symptom diagnosis on multivariable analysis were lower socioeconomic status of the practice location(OR 0.94 for each decile of disadvantage,95%CIs 0.90 to 0.98)and longer consultation duration(OR 1.02,95%CIs 1.00 to 1.04).A specific vertigo diagnosis was associated wit

关键词： diagnosis formulation sectional

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黄芪总黄酮对动脉粥样硬化早期形成的影响

中国药理学通报 2003年第6期19卷 637-640页

作者：汪德清丁保国 Tomas g neil 田亚平王成彬 Tomlinson Brian 解放军总医院北京100853 香港中文大学临床药理学部

目的探讨黄芪总黄酮(TFA)对高脂饲料诱导家兔动脉粥样硬化(AS)的防护作用。方法 60只新西兰白兔被随机分为5组,分别给正常饲料(对照组,n=10)、高脂饲料(造模组,n=10)、高脂饲料加维生素E 400 IU·d^(-1)(VitE组,n=10)、高脂饲料加TFA 6... 详细信息

目的探讨黄芪总黄酮(TFA)对高脂饲料诱导家兔动脉粥样硬化(AS)的防护作用。方法 60只新西兰白兔被随机分为5组,分别给正常饲料(对照组,n=10)、高脂饲料(造模组,n=10)、高脂饲料加维生素E 400 IU·d^(-1)(VitE组,n=10)、高脂饲料加TFA 60 mg·d^(-1)(TFA 1组,n=15)和高脂饲料加TFA 120 mg·d^(-1)(TFA 2组,n=15)处理12 wk,动态监测(0、8和12 wk)血脂的变化,实验结束前,所有动物用CO_2处死,分别检测主动脉弓的病理变化和胆固醇的含量。结果实验数据表明所有接受高脂饲料的动物血浆中的总胆固醇、甘油三脂、主动脉弓的粥样硬化斑块面积、胆固醇含量和动脉壁内膜与中膜平均厚度比值均高于正常饲料组。TFA能降低血浆总胆固醇(Pg·d^(-1))能分别降低43.1％和63.0％的AS斑块面积;维生素E可降低动脉壁中的胆固醇沉积和动脉壁内膜与中膜比率(P<0.05),减低43.7％的AS斑块面积。在本实验中TFA和维生素E对甘油三脂代谢无影响。结论 TFA对高脂饲料诱导家兔AS形成有一定的防护作用。

关键词：动脉粥样硬化黄芪总黄酮维生素E

Structural characteristics,anticoagulant and antithrombotic mechanism of a novel polysaccharide from Rosa Chinensis Flos

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Food Science and Human Wellness 2023年第2期12卷 407-415页

作者： Xiaofeng Zhang Zhenhua Liang geoffrey Ivan neil Waterhouse Shengjun Jiang Dongxiao Sun-Waterhouse Jinmei Wang Changyang Ma Wenyi Kang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceKaifeng 475004China School of Chemical Sciences University of AucklandAuckland 1142New Zealand Kaifeng Key Laboratory of Functional Components in Health Food Kaifeng 475004China

This is the first report on a polysaccharide(RCJ2-Ib)isolated from Rosa Chinensis ***2-Ib was obtained through the extraction with water,precipitation with ethanol,separation with DEAE-52 column and purification with DEAE-Sepharose Fast Flow column and Sephadex g100 ***,FT-IR and NMR analyses revealed that RCJ2-Ib(3.3 k Da)was a 1,4-linked polymannuronic acid containing substantialβ-Danomers *** anticoagulant effect of RCJ2-Ib evaluated by using rabbit ear venous blood and an acute blood stasis rat model showed that RCJ2-Ib had obvious anticoagulant activity in regulating endogenous and exogenous coagulation pathways and reducing serum thromboxane B2 and *** addition,RCJ2-Ib could also increase the number of Lactobacillus and Escherichia *** a result,RCJ2-Ib has the potential to inhibit thrombosis and maintain the intestinal environment.

关键词： Rosa Chinensis Flos Polysaccharide isolation Antithrombotic activity Intestinal flora

2型糖尿病患者大脑中动脉狭窄的危险因素分析

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中华神经科杂志 2004年第2期37卷 135-138页

作者：林健雯 g.neil Thomas 黄如训方燕南黄家星香港中文大学威尔斯亲王医院内科及药物治疗学系中山大学附属第一医院神经科

目的　探讨 2型糖尿病患者大脑中动脉 (MCA)狭窄的危险因素。方法　对 2 2 0 2例 2型糖尿病患者用经颅多普勒 (TCD)筛选 ,MCA狭窄者为病例组 ,其余为对照组 ,行年龄、性别、糖尿病病程的频率配对后分析MCA狭窄的危险因素。结果　MCA狭... 详细信息

目的　探讨 2型糖尿病患者大脑中动脉 (MCA)狭窄的危险因素。方法　对 2 2 0 2例 2型糖尿病患者用经颅多普勒 (TCD)筛选 ,MCA狭窄者为病例组 ,其余为对照组 ,行年龄、性别、糖尿病病程的频率配对后分析MCA狭窄的危险因素。结果　MCA狭窄组与对照组在高血压 (76 8%与5 3 4 % )、抗高血压治疗 (5 1 5 %与 2 6 6 % )、收缩压 [14 7与 138mmHg(1mmHg =0 133kPa) ]、舒张压(81与 84mmHg)、血糖 (8 1与 8 7mmol/L)、白蛋白尿 (4 1 1%与 30 1% )、尿的白蛋白肌酐比 (ACR)(5 9与 3 5mg/mmol)、低密度脂蛋白 (LDL) (3 8与 3 6mmol/L)的分布差异存在显著意义。Logistic回归发现年龄、高血压、LDL 胆固醇是MCA狭窄的独立危险因素。结论　年龄增长、高血压、LDL 胆固醇高是MCA狭窄的危险因素。

关键词： 2型糖尿病大脑中动脉 MCA 危险因素非胰岛素依赖型脑动脉疾病

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智造一场新的数字革命

Effect of L-carnitine supplementation during in vitro maturation and in vitro culture on oocyte quality and embryonic development rate of bovines

丛书名：上海市大学生科技创业基金会译丛

2016年

作者： neil gershenfeld

本书以尼尔·格申斐尔德教授在推动全球第一间“数制”工坊（FabLab，2001年在波士顿建立）的过程中的经历与观察为主，介绍了令他印象深刻的作品，并结合各地FabLab的筹建发展情况，提出了诸如“发展中国家更需要高科技”、“孩子‘做... 详细信息

ISBN: (数字)9787560864655

ISBN: (纸本)9787560864655

本书以尼尔·格申斐尔德教授在推动全球第一间“数制”工坊（FabLab，2001年在波士顿建立）的过程中的经历与观察为主，介绍了令他印象深刻的作品，并结合各地FabLab的筹建发展情况，提出了诸如“发展中国家更需要高科技”、“孩子‘做中学’的惊人效率”等观点，这给予了后人很大的指导作用。

关键词：智能制造系统制造工业研究

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Asian pacific Journal of Reproduction 2019年第6期8卷 289-296页

作者： Diego F.Carrillo-gonzález Nélida Rodríguez-Osorio Charles R.Long neil A.Vásquez-Araque Juan g.Maldonado-Estrada One Health and Veterinary Innovative Research and Development group School of Veterinary MedicineUniversity of Antioquia050034 MedellinColombia Faculty of Agricultural Sciences School of ZootechnicsUniversidad de SucreColombia genomics and Bioinformatics Lab Department of Biological SciencesUniversity of the Republic of UruguaySalto CampusUruguay Department of Veterinary Physiology and Pharmacology College of Veterinary MedicineTexas A&M UniversityCollege StationTexas 77843-4466USA grupo de investigación Biotecnología Animal Facultad de CienciasUniversidad Nacional de ColombiaSede MedellínMedellínColombia

Objective:To assess the effect of L-carnitine supplementation during in vitro oocyte maturation and in vitro culture process of bovine ***:L-carnitine(3.8 mM)was added to maturation medium and the effect was assessed in the quality(Experiment 1)and in the cleavage and 4-cells stage(Experiment 2).Besides,the effect of L-carnitine addition on maturation medium(3.8 mM)and culture medium(1.5 mM)on embryo rate production was *** Experiment 1,bovine oocytes from abattoir were randomly separated into two groups(the control group and L-carnitine group)forin vitro *** oocytes were examined for cumulus cells expansion as an indicator of maturation,and the content of the mitochondrial activity,the presence of lipid droplets,the reduced glutathione,and the reactive oxygen species were measured by using specific *** Experiment 2,oocytes were matured as performed in Experiment 1,afterward fertilized and cultured until day 3,and cleavage rate and 4-cells stage rate were *** Experiment 3,in vitro maturation and fertilization were done as performed in Experiment 2,but at day 3 of culture,each group of embryos was separated into two new groups,and L-carnitine(1.5 mM)was added in culture media until day *** cleavage and embryo development rate were determined on the basis with the oocytes put on *** rate was calculated from cleaved ***:The cumulus expansion rate at gradeⅢand mitochondrial activity were significantly higher in the L-carnitine group in comparison with the control group(P0.05).In addition,cleavage and the proportion of embryo development and hatching rate were similar for all groups(P>0.05).Conclusions:L-carnitine as a supplement in culture media improves the cumulus expansion and increases the mitochondrial activity during in vitro maturation process but has no apparent effect on the cleavage and development of bovine *** investigations of L-carnitine addition on in vit

关键词： Antioxidants Culture supplement Embryo development Lipid droplets Maturation Mitochondria