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discovering the universe 5th ed.

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Discovering the universe

2000年

作者： Comins neil F.

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Barron’s 巴朗AP化学第8版

The status of marine release programs (aquaculture-based enhancement) in north America, Europe, Oceania and south-east Asia and comparisons with those in China and Japan

丛书名：出国留学书系·SAT、AP备考书系

2016年

作者：（美）叶斯柏森（neil d.Jesperson）克里根（Pamela K.Kerrigan）

本书是巴朗教育集团AP化学考试权威指导用书，内容丰富，讲解清晰，结构严谨。本书是第8版，共包括9套测试题，其中3套是诊断测试题，3套是全真测试题，2套是Cd附赠的测试题，还有一套是在线测试题。所有的测试题均与学习目标紧密相关... 详细信息

ISBN: (纸本)9787510054013

本书是巴朗教育集团AP化学考试权威指导用书，内容丰富，讲解清晰，结构严谨。本书是第8版，共包括9套测试题，其中3套是诊断测试题，3套是全真测试题，2套是Cd附赠的测试题，还有一套是在线测试题。所有的测试题均与学习目标紧密相关。书中专家给出了得到考试高分的实用性的建议，对于指导考生取得好成绩十分有效。

关键词：中学化学课

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The status of marine release programs (aquaculture-based enh...

Si/Ga埃尼碳硅酸盐的合成与表征（英文）

第二届现代化海洋牧场国际学术研讨会、中国水产学会渔业资源与环境专业委员会2018年学术年会

作者： neil R.Loneragan Clara Obregón Matt d.Taylor James R.Tweedley Zhongxin Wu Yimin Ye Centre for Sustainable Aquatic Ecosystems Harry Butler Institute and School of Veterinary and Life Sciences Murdoch University Asia Research Centre School of Business and Management Murdoch University New South Wales department of Primary Industries Port Stephens Fisheries Research Institute dalian Ocean University Fisheries and Aquaculture department FAO

A systematic literature review of over 500 documents on marine release programs published since 2000 was done to evaluate the current state of aquaculture based enhancement(ABE = restocking,stock enhancement and sea ranching) for commercial and recreational(= leisure) fisheries in North America,Europe,Oceania and southern *** have been made with reviews and government information on ABE in China and Japan,where large-scale continuous(> 300 billion released individuals from 2004 to 2015) have been practised for over three *** broad categories of release programs were identified:(1) Enhancement to increase commercial yield and value;(2) Restocking to increase the spawning population of a commercial or recreational fishery;(3) restocking species for conservation;(4) Sea ranching – creating or maintaining a fishery by releasing individuals and harvesting them before they mature;and(5) releasing individuals to increase knowledge of the species and ABE system *** ***,crustaceans,molluscs and echinoderms were the focus of most publications in North America,Europe,Oceania and south *** on teleosts and crustaceans was most numerous in all regions(> 60%),except south Asia(～ 24%),where molluscs(41%),echinoderms(35%) and crustaceans(20.6%) were the dominant taxa in *** has implemented a large government initiative to promote research,investment and best practices in freshwater and marine releases,with a focus in marine waters largely on invertebrates,particularly penaeid prawns(～80% of releases in 2015).In other regions considered in the review,releases have been of a much smaller scale(millions of released individuals each year) and the focus of releases has been largely on species of recreational significance such as penaeid prawns(Penaeus plebejus,Metapenaeus dalli),and Mulloway(Agryrosomus japonicas) in Australia and Red drum(Sciaenops ocellatus) and Snook(Centropomus undecimalis) in the United States.

关键词： Europe Oceania and south-east Asia and comparisons with those in China and Japan The status of marine release programs aquaculture-based enhancement in north America

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催化学报 2015年第6期36卷 813-819页

作者： Giuseppe Bellussi Angela Carati Stefania Guidetti Caterina Rizzo Roberto Millini Stefano Zanardi Erica Montanari Wallace O'neil Parker Jr. Michela Bellettato Eni s.p.a. Development Operations & Technology Downstream R&D

Phenylene-gallosilicates were prepared with the same crystalline structure as their aluminum analogues. The new Ga-Eni Carbon Silicates(Ga-ECS) phases were investigated by X-ray diffraction, scanning electron microscopy, nuclear magnetic resonance and thermogravimetric analysis, which demonstrated that gallium isomorphously replaced aluminum in the framework of the organic-inorganic hybrids similar to the case of classical zeolites. Hybrid ECS materials were obtained with different types of bridged silsesquioxane precursors that maintained the aluminum-silicate nature of the inorganic moiety. This work confirms a new level of crystal chemistry versatility for this class of materials, and demonstrates the possibility to tailor also the inorganic part of the framework by changing the nature of the trivalent heteroatom.

关键词：硅酸盐扫描电子显微镜 Si 合成表征 GA 碳 X射线衍射

Mechanism of the Rpn13-induced activation of Uch37

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Protein & Cell 2014年第8期5卷 616-630页

作者： Lianying Jiao Songying Ouyang neil Shaw Gaojie Song Yingang Feng Fengfeng Niu Weicheng Qiu Hongtao Zhu Li-Wei Hung Xiaobing Zuo V. Eleonora Shtykova Ping Zhu Yu-Hui dong Ruxiang Xu Zhi-Jie Liu National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China iHuman Institute ShanghaiTech University Shanghai 201210 China Shandong Provincial Key Laboratory ofEnergy-Genetics Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of Sciences Qingdao 266101 China Physics division 'Los Alamos National Laboratory Los Alamos NM 87545 USA X-ray Science division Argonne National Laboratory 9700 South Cass Avenue Argonne IL 60439 USA Institute of Crystallography~ Russian Academy of Sciences 59 Leninsky Pr. 117333 Moscow Russian Federation Center for Multi-disciplinary Research Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049China department of Nerosurgery The Military General Hospital of Beijing PLA Beijing 100700 China

Uch37 is a de-ubiquitinating enzyme that is activated by Rpn13 and involved in the proteasomal degradation of proteins. The full-length Uch37 was shown to exhibit low iso-peptidase activity and is thought to be auto-inhibited. Structural comparisons revealed that within a homo- dimer of Uch37, each of the catalytic domains was blocking the other＇s ubiquitin （Ub）-binding site. This blockage likely prevented Ub from entering the active site of Uch37 and might form the basis of auto-inhibition. To understand the mode of auto-inhibition clearly and shed light on the activation mechanism of Uch37 by Rpn13, we investigated the Uch37-Rpn13 complex using a combi- nation of mutagenesis, biochemical, NMR, and small- angle X-ray scattering （SAXS） techniques. Our results also proved that Uch37 oligomerized in solution and had very low activity against the fluorogenic substrate ubi- quitin-7-amino-4-methylcoumarin （Ub-AMC） of de-ubiq- uitinating enzymes. Uch37AHb＇Hc＇KEKE, a truncation removal of the C-terminal extension region （residues 256- 329） converted oligomeric Uch37 into a monomeric form that exhibited iso-peptidase activity comparable to that of a truncation-containing the Uch37 catalytic domain only. We also demonstrated that Rpn13C （Rpn13 residues 270- 407） could disrupt the oligomerization of Uch37 by sequestering Uch37 and forming a Uch37-Rpn13 com- plex. Uch37 was activated in such a complex, exhibiting 12-fold-higher activity than Uch37 alone. Time-resolved SAXS （TR-SAXS） and FRET experiments supported the proposed mode of auto-inhibition and the activation mechanism of Uch37 by Rpn13. Rpn13 activated Uch37 by forming a 1：1 stoichiometric complex in which the active site of Uch37 was accessible to Ub.

关键词： Uch37-Rpn13 complex de-ubiquitination,SAXS analysis oligomerization iso-peptidase

Radiomics analysis with three-dimensional and two-dimensional segmentation to predict survival outcomes in pancreatic cancer

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World Journal of Radiology 2023年第11期15卷 304-314页

作者： Mohammed Saleh Mayur Virarkar Hagar S Mahmoud Vincenzo K Wong Carlos Ignacio Gonzalez Baerga Miti parikh Sherif B Elsherif Priya R Bhosale department of diagnostic Radiology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States department of diagnostic Radiology The University of Florida College of MedicineJacksonvilleFL 32209United States Keck School of Medicine University of South CaliforniaLos AngelesCA 90033United States

BACKGROUNd Radiomics can assess prognostic factors in several types of tumors,but considering its prognostic ability in pancreatic cancer has been *** To evaluate the performance of two different radiomics software in assessing survival outcomes in pancreatic cancer *** We retrospectively reviewed pretreatment contrast-enhanced dual-energy computed tomography images from 48 patients with biopsy-confirmed pancreatic ductal adenocarcinoma who later underwent neoadjuvant chemoradiation and *** were segmented using TexRad software for 2-dimensional(2d)analysis and MIM software for 3d analysis,followed by radiomic feature *** proportional hazard modeling correlated texture features with overall survival(OS)and progression-free survival(PFS).Cox regression was used to detect differences in OS related to pretreatment tumor size and residual tumor following *** Wilcoxon test was used to show the relationship between tumor volume and the percent of residual ***-Meier analysis was used to compare survival in patients with different tumor densities in Hounsfield units for both 2d and 3d *** 3d analysis showed that higher mean tumor density[hazard ratio(HR)=0.971,P=0.041)]and higher median tumor density(HR=0.970,P=0.037)correlated with better OS.2d analysis showed that higher mean tumor density(HR=0.963,P=0.014)and higher mean positive pixels(HR=0.962,P=0.014)correlated with better OS;higher skewness(HR=3.067,P=0.008)and higher kurtosis(HR=1.176,P=0.029)correlated with worse *** entropy correlated with better PFS(HR=0.056,P=0.036).Models determined that patients with increased tumor size greater than 1.35 cm were likely to have a higher percentage of residual tumors of over 10%.CONCLUSION Several radiomics features can be used as prognostic tools for pancreatic ***,results vary between 2d and 3d *** tumor density was the only variable that could reliably predict OS,irrespective

关键词： Radiomics Pancreas Cancer Segmentation

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腹裂复位术是否需全身麻醉:一项比较性分析

世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 59-60页

作者： Cauchi J. parikh d.H. Samuel M. Gornall P. 王经纬 department of Paediatric Surgery Birmingham Children's Hospital NHS Trust Steel House Lane B4 6NH BirminghamUnited Kingdom

Background: Outcome after gastroschisis repair without general anesthesia is controversial, and published conclusions are variable with no comparative studies. Aim: The aim of this study was to present a comparative study evaluating outcome after gastroschisis repair with and without general ***: An ambispective nonrandomized study of a cohort of 51 neonates born with gastroschisis between July 1998 and december 2003 was performed. Twenty-four neonates (group1) had conventional reduction under general anesthesia, and 27(group 2) cotside minimal intervention reductions were without general anesthesia. Results: Groups were comparable regarding gestational age, birth weight, and quality of eviscerated bowel. Statistical significance (P d 2 with regard to age at reduction of gastroschisis(5.6 ±2.5 vs 3 ±1 hours) and time taken for completion of gastroschisis reduction (58.1 ±15 vs 49 ±14 minutes). No statistical significance (P > 0.05) was seen with respect to start of feeds (10.4 ±3.6 vs 10.9 ±4.1 days), duration of total parenteral nutrition (21.5 ±7.3 vs 22.4 ±6.8 days), and total hospital(stay 29 ±10 vs 30 ±13 days). Admission to the intensive care unit was required in 92%in group 1 for 1 to 6 days vs 7%in group 2 for 3 to 6 days. There was 1 death in group 1(4%). Total hospital cost in group 1 was ￡12,283 ±￡2438 vs￡6208 ±￡2120 in group 2 (P = 0.013). Conclusions: Neonates with gastroschisis, whose bowel was reduced without general anesthesia, have similar outcomes to those whose bowel was reduced under general anesthesia. Both approaches appear to be safe and effective, but reduction without general anesthesia was cost-effective.

关键词：复位术比较性研究腹裂切除量重症监护完全胃肠外营养队列研究显著性差异

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黄芪总黄酮对动脉粥样硬化早期形成的影响

中国药理学通报 2003年第6期19卷 637-640页

作者：汪德清丁保国 Tomas G neil 田亚平王成彬 Tomlinson Brian 解放军总医院北京100853 香港中文大学临床药理学部

目的探讨黄芪总黄酮(TFA)对高脂饲料诱导家兔动脉粥样硬化(AS)的防护作用。方法 60只新西兰白兔被随机分为5组,分别给正常饲料(对照组,n=10)、高脂饲料(造模组,n=10)、高脂饲料加维生素E 400 IU·d^(-1)(VitE组,n=10)、高脂饲料加TFA 6... 详细信息

目的探讨黄芪总黄酮(TFA)对高脂饲料诱导家兔动脉粥样硬化(AS)的防护作用。方法 60只新西兰白兔被随机分为5组,分别给正常饲料(对照组,n=10)、高脂饲料(造模组,n=10)、高脂饲料加维生素E 400 IU·d^(-1)(VitE组,n=10)、高脂饲料加TFA 60 mg·d^(-1)(TFA 1组,n=15)和高脂饲料加TFA 120 mg·d^(-1)(TFA 2组,n=15)处理12 wk,动态监测(0、8和12 wk)血脂的变化,实验结束前,所有动物用CO_2处死,分别检测主动脉弓的病理变化和胆固醇的含量。结果实验数据表明所有接受高脂饲料的动物血浆中的总胆固醇、甘油三脂、主动脉弓的粥样硬化斑块面积、胆固醇含量和动脉壁内膜与中膜平均厚度比值均高于正常饲料组。TFA能降低血浆总胆固醇(Pd^(-1))能分别降低43.1％和63.0％的AS斑块面积;维生素E可降低动脉壁中的胆固醇沉积和动脉壁内膜与中膜比率(P<0.05),减低43.7％的AS斑块面积。在本实验中TFA和维生素E对甘油三脂代谢无影响。结论 TFA对高脂饲料诱导家兔AS形成有一定的防护作用。

关键词：动脉粥样硬化黄芪总黄酮维生素E