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Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma

World Journal of Clinical Oncology 2019年第3期10卷 149-160页

作者： Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji bert H O'neil Anne Noonan Robert Tudor Ray Lee Division of Hematology and Oncology Perlmutter Cancer CenterNew York University School of Medicine Department of Radiology at New York University School of Medicine Division of Hematology and Oncology Columbia University Medical Center Division of Hematology and Oncology Indiana University Division of Hematology and Oncology Ohio State University Medical Center Roche Pharmaceutical Company Roche and Teclison Pharmaceutical Company

bACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in *** To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to *** In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of *** Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased *** study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes

关键词： Hepatocellular carcinoma Hypoxia-inducible factor 1α RO7070179,Superresponder Dynamic contrast-enhanced-magnetic resonance imaging

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Handbook of proteolytic enzymes

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1998年

作者： ed. by Alan J. barrett neil D. Rawlings J. Fred Woessner

本书演示了生物化学实验中仪器设备的正确使用、实验装置的科学搭建和规范操作等实验环节。全书精选了12个实验,内容涵盖糖、脂、蛋白质、核酸和酶等领域。

ISBN: (纸本)0120793709

关键词： Proteolytic enzymes

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威士忌、朗姆、冲浪裤和广告

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中国广告 2015年第9期 42-43页

作者：林朗 Join Chuck Porter Andrew Keller neil Riddell 不详 CP+b公司

App开发商,规章破坏者、技术工还是人类学家？在戛纳创意节的研讨会上,CP＋b广告公司宣称他们是一个新兴公司（Start-up）,正如他们在官方主页所写的那样：“我们不是广告人,请叫我们文化玩家!”大约在6年前,面对行业中新经济实体的不... 详细信息

App开发商,规章破坏者、技术工还是人类学家？在戛纳创意节的研讨会上,CP＋b广告公司宣称他们是一个新兴公司（Start-up）,正如他们在官方主页所写的那样：“我们不是广告人,请叫我们文化玩家!”大约在6年前,面对行业中新经济实体的不断涌现,CP＋b创建了一支特别的团队,它致力于发展和销售其公司自己拥有的品牌。今天,CP＋b的最新制品已经成为其公司所有业务中最具意义和发展性的一部分。

关键词：戛纳新兴公司技术工创意者破坏者人员流动性 Keller 内户波旁 boris

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Evaluating the probability of silent circulation of polio in small populations using the silent circulation statistic

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Infectious Disease Modelling 2019年第1期4卷 239-250页

作者： Celeste Vallejo Carl A.b.Pearson James Koopman Thomas J.Hladish Mathematical biosciences Institute The Ohio State UniversityJennings Hall 3rd Floor1735 Neil Ave.ColumbusOH 43210United States Department of Infectious Disease Epidemiology&Centre for Mathematical Modelling of Infectious Disease London School of Hygiene&Tropical MedicineUnited Kingdom South African Centre for Epidemiological Modeling and Analysis Stellenbosch UniversitySouth Africa Very Good Research&Development LLCUnited States Department of Epidemiology University of Michigan1415 Washington HeightsAnn ArborMI 48109United States Emerging Pathogens Institute University of FloridaP.O.Box 1000092055 Mowry RoadGainesvilleFL 32610United States Department of biology University of Florida220 Bartram HallP.O.Box 118525GainesvilleFL 32611United States

As polio-endemic countries move towards elimination,infrequent first infections and incomplete surveillance make it difficult to determine when the virus has been eliminated from the *** and Dietz[American Journal of Epidemiology,143,8(1996)]proposed a model to estimate the probability of silent polio circulation depending upon when the last paralytic case was *** the same kind of stochastic model they did,we additionally model waning polio immunity in the context of isolated,small,and unvaccinated *** compare using the Eichner and Dietz assumption of an initial case at the start of the simulation to a more accurate determination that observes the first *** former estimates a higher probability of silent circulation in small populations,but this effect diminishes with increasing model *** also show that stopping the simulation after a specific time estimates a lower probability of silent circulation than when all replicates are run to extinction,though this has limited impact on small *** extensions to the Eichner and Dietz work improve the basis for decisions concerning the probability of silent *** model realism will be needed for accurate silent circulation risk assessment.

关键词： Silent circulation Silent circulation statistic Polio

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未来的放疗质子和离子治疗有广阔的前景

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英国医学杂志中文版 2005年第4期8卷 202-203页

作者： bleddyn Jones neil burnet 王淑莲（译）余子豪（校） Department of Clinical Oncology Queen Elizabeth University Hospital Birmingham B45 8TB University of Cambridge Department of Oncology Oncology Centre Addenbrookes Hospital Cambridge CB2 2QQ 不详

带电粒子束(Charged particle beams,CPb),包括由回旋加速器和同步加速器产生的质子和碳离子,是放疗领域的重要进展1,wl.与常规X线相比,带电粒子束在肿瘤区有极好的剂量分布,正常组织剂量减少.因此,带电粒子束有望提高肿瘤的治疗效果,... 详细信息

带电粒子束(Charged particle beams,CPb),包括由回旋加速器和同步加速器产生的质子和碳离子,是放疗领域的重要进展1,wl.与常规X线相比,带电粒子束在肿瘤区有极好的剂量分布,正常组织剂量减少.因此,带电粒子束有望提高肿瘤的治疗效果,同时改善患者的生活质量.

关键词：放射治疗带电粒子束回旋加速器同步加速器质子离子

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Morphology,molecular phylogeny and azaspiracid profile of Azadimium poporum(Dinophyceae) from the Gulf of Mexico

Morphology,molecular phylogeny and azaspiracid profile of Az...

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福建省海洋学会2016年学术年会

作者： Zhaohe Luo bernd Krock Kenneth neil Mertens Andrea Michelle Price Robert Eugene Turner Nancy N.Rabalais Haifeng Gu College of Science and technology Jinan University Third institute of Oceanography SOA Alfred Wegener institute for Potar and Marine Research Research Unit for Palaeontology Ghent University Department Gengraphy McGiill University Deparfment of Oceanography and Coastal Science Louisiana State University

Azadinium poporum produces a variety of azaspiracids and consists of several ribotypes,but information on its biogeography is limited.A strain of A poponim(GM29) was incubated from a Gulf of Mexico sediment *** GM29 was characterized by a plate pattern of po,cp,x,4′,3a,6″,6C,5S,6′″,2″″,a distinct ventral pore at the junction of po and the first two apical plates,and a lack of an antapical spine,thus fitting the original description of A *** genus Azadinium has not been reported in waters of the United States of America before this *** phylogeny,based on large subunit ribosomal DNA(LSU rDNA) and internal transcribed spacer(ITS) sequences,reveals that strain GM29 is nested within the well-resolved A poponim complex,but forms a sister clade either to ribotype b(ITS) or ribotype C(LSU).It is,therefore,designated as a new ribotype,termed as ribotype *** and ITS sequences similarity among different ribotypes of A poponim ranges from 95.4%to 98.2%.and from97.1%to 99.2%respectively,suggesting that the LSU fragment is a better candidate for molecular *** profiles were analyzed using LC-MS/MSand demonstrate that strain GM29 produces predominantly AZA-2 with an amount of 45 fg/*** results suggest that A popomm has a wide distribution and highlights the risk potential of azaspiracid intoxication in the United States.

关键词： AZA-2 AZA-2 phosphate biogeography LC-MS/MS LSU rDNA Ribotype D

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