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Effect of Pre-treatment of α-Ketoglutarate on Cyanide-induced Toxicity and Alterations in Various Physiological Variables in Rodents

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Biomedical and Environmental Sciences 2007年第1期20卷 56-63页

作者： RAJKUMAR TULSAWANI deo KUMAR R.BHATTACHARYA Division of Pharmacology and Toxicology Defence Research and Development Establishment Jhansi Road Gwalior 474 002 M.P. India

Objective To investigate the effects of pre-treatment of α-ketoglutarate （α-KG） on cyanide-induced lethality and changes in various physiological parameters in rodents. Methods The LD50 of potassium cyanide （KCN） given orally （po）, intraperitoneally （ip）, subcutaneously （sc） or intravenously （iv） was determined in male mice, in the presence or absence α-KG given po, ip or iv. α-KG was administered 10, 20 or 40 min prior to KCN at 0.50, 1.0 or 2.0 g/kg by po or ip route, and at 0.10, 0.20 or 0.40 g/kg by iv route. Protection index （PI） was calculated as the ratio of LD50 of KCN in the presence of α-KG （protected animals） and LD50 of KCN in the absence of α-KG （unprotected animals）. In a separate experiment, several physiological variables viz. mean arterial pressure （MAP）, heart rate （HR）, respiratory rate （RR）, neuromuscular transmission （NMT） and rectal temperature （RT） were measured in anesthetized female rats pre-treated （-10 rain） with po （2.0 g/kg） or iv （0.125 g/kg） α-KG and then administered sub-lethal （0.75 LD50） or lethal （2.0, 4.0 or 8.0 LD50） doses of KCN （po）. Results PI of 4.52, 6.40 and 7.60 at -10 min, 3.20, 5.40 and 6.40 at -20 min, and 1.40, 3.20 and 5.40 at -40 min of po administration with α-KG was observed for 0.50, 1.0 and 2.0 g/kg doses, respectively, against KCN given by po route. When KCN was given ip, a PI of 3.38, 4.79 and 5.70 was observed for 0.50, 1.0 and 2.0 g/kg α-KG given ip （-10 min）, respectively. A lower PI of 3.37, 2.83 and 2.38 was observed when KCN given sc was challenged by 2.0 g/kg α-KG given ip at -10, -20 or -40 min, respectively. Similarly, a PI of 3.37, 2.83 and 2.0 was noted when KCN given sc was antagonized by 2.0 g/kg α-KG given po at -10, -20 or -40 rain, respectively. No appreciable protection was observed when lower doses of α-KG （ip or po） challenged KCN given by sc route. Pre-treatment of iv or po administration of α-KG did not afford any protection against KCN given po or iv route. Oral treatment of 0.75 LD50 KCN

关键词： Cyanide Toxicity Physiological variables Protection α-Ketoglutarate

Effect of photoperiod on slow and fast developing individuals in aphidophagous ladybirds, Menochilus sexmaculatus and Propylea dissecta （Coleoptera： Coccinellidae）

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Insect Science 2016年第1期23卷 117-133页

作者： neha Singh Geetanjali Mishra Omkar Ladybird Research Laboratory Department of Zoology University of Lucknow Lucknow 226007 India

The effects of environmental parameters on insect development have been studied extensively. But the reasons for 2 differential developmental rates within same cohort under varying environmental factors have not been explored. For the purpose, in this study the existence and stability of slow and fast development under 5 photoperiods （i.e., 8L： 16D, 10L ： 14D, 12L ： 12D, 14L ： 10D and 16L ： 8D; light and dark hours per day） and its effect on body mass and reproductive attributes in 2 aphidophagous ladybirds, Menochilus sexmaculatus （Fabricius） and Propylea dissecta （Mulsant） was examined on Aphis craccivora Koch at 27 4- 1 ~C temperature. A clear bimodal （2 peaks, where the first peak represented the fast developing and the 2nd peak slow developing individuals） pattern of distribution at each photoperiod was found. The proportion of slow and fast developing individuals in a cohort differed with photoperiods. The slow developing individuals were more in numbers at 8L ： 16D, in equal numbers at 14L ： 10D and in less numbers at 16L： 8D, indicating that the variation in emergence was owing to exogenous cues influenced differential rates of mortality. Slow developing individuals had female biased sex ratio, higher longevity and lower body mass than fast developing individuals. Fast developing females laid higher numbers of eggs with higher egg viability than slow developing females. Study of such variations in development at different photoperiods is helpful to understand its role in the development of insects particularly ladybirds and permits the selection of fast developing bioagents for their use in biocontrol of pest species.

关键词： Coccinellidae developmental duration Menochilus sexmaculatus photoperiod Propylea dissecta slow : fast emergence

A review on current status of municipal solid waste management in India

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Journal of Environmental Sciences 2015年第11期27卷 206-217页

作者： neha Gupta Krishna Kumar Yadav Vinit Kumar Institute of Environment and Development Studies Bundelkhand University

Municipal solid waste management is a major environmental issue in India. Due to rapid increase in urbanization, industrialization and population, the generation rate of municipal solid waste in Indian cities and towns is also increased. Mismanagement of municipal solid waste can cause adverse environmental impacts, public health risk and other socio-economic problem. This paper presents an overview of current status of solid waste management in India which can help the competent authorities responsible for municipal solid waste management and researchers to prepare more efficient plans.

关键词： Municipal solid waste Characteristic Management India Disposal

Influence of pyrolysis temperature on rice straw biochar properties and corresponding effects on dynamic changes in bispyribac-sodium adsorption and leaching behavior in soil

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Pedosphere 2023年第3期33卷 463-478页

作者： Pervinder KAUR neha SHARMA Khushwinder KAUR Department of Agronomy Punjab Agricultural UniversityLudhianaPunjab 141004(India) Department of Chemistry Punjab Agricultural UniversityLudhianaPunjab 141004(India) Department of Chemistry Panjab UniversityChandigarh 160014(India)

Bispyribac-sodium is a weakly acidic herbicide with high water solubility and is thus a potential source of groundwater *** the risk inherent to the use of this herbicide,this study assessed the impacts of rice straw(RS)and biochar amendments on the adsorption and leaching behavior of bispyribac-sodium in *** were produced from RS at different pyrolysis temperatures and characterized using various spectral *** straw had a surface area of 3.996×10^(4)m^(2)kg^(-1),which increased under pyrolysis;biochars prepared at 350 and 550℃(RS350 and RS550)in a closed furnace with limited oxygen supply had a surface area of 5.763×10^(4)and 6.890×10^(4)m^(2)kg^(-1),respectively,and biochar prepared by purging the pyroformer with N2(RSC)had the highest surface area of 12.173×10^(4)m^(2)kg^(-1).After amendment with RS and biochar,soil Freundlich adsorption capacity(KF ads)increased to varying extents in the order RSC>RS350>RS550,from 2.89×10^(3)to 29.57×10^(3)mg^(1-1)/nkg^(-1)L1/n,compared to1.55×10^(3)mg^(1-1)/nkg^(-1)L1/nin unamended *** variability in KF ads of bispyribac-sodium amongst the RS-and biochar-amended soils was dependent on the surface area of the *** desorption of bispyribac-sodium decreased in the RS-and biochar-amended soils and varied from90.45%to 95.20%in unamended soils and from 60.95%to 89.50%in amended *** adsorption and desorption of bispyribac-sodium varied significantly depending on its concentration and the type and application rate of soil *** leaching risk evaluation indices,viz.,modified leach index(***),leach index(LEACH),groundwater ubiquity score(GUS),Hornsby index(HI),leaching index(LIN),and pesticide leaching potential(PLP)index,were used to assess the susceptibility of groundwater to herbicide *** reduce the repetitive effects of common parameters in each index,a new index was developed by employing principal component analysis(PCA)to condense their infor

关键词： desorption Freundlich model groundwater contamination leaching potential leaching risk evaluation index pesticide soil amendment Temkin isotherm

Modified grey wolf optimised adaptive super-twisting sliding mode control of rotary inverted pendulum system

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Journal of Control and Decision 2023年第2期10卷 270-279页

作者： neha Gupta Lillie Dewan Department of Electrical Engineering National Institute of TechnologyKurukshetraIndia

This paper proposes a modified grey wolf optimiser-based adaptive super-twisting sliding mode control algorithm for the trajectory tracking and balancing of the rotary inverted pendulum *** super-twisting sliding mode algorithm severely alleviates the chattering present in the classical sliding mode *** provides robustness against model uncertainties and external disturbances with the knowledge of the upper bounds of the uncertainties and *** gains of the super-twisting sliding mode algorithm are selected through adaptive *** of the adaption law are tuned using a modified grey wolf optimisation algorithm,a meta-heuristic optimisation *** stability analysis is carried out to analyse the overall control system *** performance of the proposed control algorithm is compared with two other sliding mode control strategies present in the literature,therein showing better performance of the proposed control scheme.

关键词： Rotary inverted pendulum super-twisting sliding mode control adaptive control grey wolf optimisation Lyapunov stability

Biodegradation analysis of pendimethalin by Planococcus citreus strain PD6 using FTIR and further in silico characterization for dehydrogenase as potential regulatory enzyme of degradation pathway

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 719-729页

作者： neha Trivedi Ashutosh Dubey Department of Biochemistry College of Basic Science and HumanitiesGovind Ballabh Pant University of Agriculture and TechnologyPantnagar 263145UttarakhandIndia

Degradation of pendimethalin by microorganisms is an approach seeking more attention *** study aims to isolate a new strain of Planococcus,which is capable of degrading pendimethalin from the soil in rice *** of this coccus bacterium was done by phylogenetic analysis of 16S rRNA gene *** PD6 was found to grow potentially on pendimethalin supplemented minimal salt medium and degraded 50 mg L^(-1) pendimethalin in monosubstrate *** transform infrared(FTIR)spectroscopy was performed to check degradation of pendimethalin by Planococcus,which was demonstrated by changing chemical bonding and stretching *** study was further extended to predict possible first enzyme of pendimethalin-degradation *** docking was performed to check efficient binding of dehydrogenase with *** strain of Planococcus degraded pendimethalin with relatively high efficiency in minimal salt media and is presented as another possible bacterium other than species of Bacillus and Pseudomonas which are already demonstrated as potential in vitro pendimethalin-degrading ***,docking reveals that dehydrogenases having more chance to prove as first regulatory enzyme of pendimethalin-degradation pathway.

关键词： soil strain potential

Treatment of hepatitis C in children and adolescents:how far have we reached?

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World Journal of Pediatrics 2023年第2期19卷 107-119页

作者： Vybhav Venkatesh Keerthivasan Seetharaman neha Anushree Department of Gastroenterology and Hepatobiliary Sciences IMS and SUM HospitalSOA UniversityBhubaneswarIndia Department of Pediatrics Sri Manakula Vinayagar Medical College and HospitalPuducherryIndia Department of Pediatrics Command Hospital-Southern CommandPune411040India

Background Hepatitis C virus(HCV)infection is a global public health problem and also generates a significant case load in children and *** the introduction of directly acting antivirals(DAA),the treatment and care of HCV-infected patients have progressed *** available treatment options in children are limited,and this review aims to provide an overview of treatment of HCV infection in children and adolescents with the current available DAA *** sources This comprehensive review was undertaken after searching the PubMed/Medline and Embase databases for the available up-to-date literature on pediatric HCV infection and treatment using hepatitis C virus infection/HCV,directly acting antivirals/DAA,natural history,treatment,pediatrics,children,and adolescents as *** Combination therapies with highly effective DAA regimes,such as sofosbuvir/ledipasvir,sofosbuvir/velpatasvir,glecaprevir/pibrentasvir,sofosbuvir/daclatasvir,sofosbuvir/ribavirin and others,are available for use in *** of the DAA regimens have either received or are pending to receive regulatory approval by different medical/drug agencies for use in children and ***-genotypic regimens are also available in children and adolescents,and these regimens can be used while skipping genotype *** The literature on different DAA regimens for use in children shows that these regimens have higher cure rates with minimal side effects and shorter duration of therapy.

关键词： Children Directly acting antivirals Hepatitis C

Impact of increased renewables on natural gas markets in eastern United States

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Journal of Modern Power Systems and Clean Energy 2017年第3期5卷 424-438页

作者： neha NANDAKUMAR Anuradha M.ANNASWAMY Institute for Data Systemsand SocietyMassachusetts Institute of TechnologyCambridgeMAUSA Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

This paper explores the market structures of natural gas and electricity as well as the interdependence of natural gas prices and bids with increasing reliance on natural gas as the penetration of renewable energy resources increases in order to complement their intermittencies. In particular, the paper will attempt to answer the following two questions: What could the generation mix look like in 2030 with a renewable-rich generation landscape and how could this impact gas prices? How do gasfired generator(GFG) generation volatility, their prices,and their bids for gas change between 2015 and 2030 with increased penetration of renewables? In order to answer these questions, computational models are derived using forecasting and regression analysis tools and an auction model.

关键词： Natural gas markets Gas-fired generators Regression analysis Optimal auction model Volatility Gas prices

Nanodiamonds with powerful ability for drug delivery and biomedical applications:Recent updates on in vivo study and patents

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Journal of Pharmaceutical Analysis 2020年第1期10卷 1-12页

作者： Swati Chauhan neha Jain Upendra Nagaich Department of Pharmaceutics Amity Institute of PharmacyAmity UniversityNoidaU.P.India

Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical *** are known as the most‘captivating’crystals attributed to their chemical inertness and unique properties posing them useful for variety of applications in biomedical ***,it becomes increasingly important to find,ascertain and circumvent the negative aspects associated with *** modification or functionalization with biological molecules plays a significant role in managing the toxic behavior since nanodiamonds have tailorable surface *** take advantage of nanodiamond potential in drug delivery,focus has to be laid on its purity,surface chemistry and other considerations which may directly or indirectly affect drug adsorption on nanodiamond and drug release in biological *** review emphasizes on the basic properties,synthesis techniques,surface modification techniques,toxicity issues and biomedical applications of *** the development of nanodiamonds as an effective dosage form,researchers are still engaged in the in-depth study of nanodiamonds and their effect on life interfaces.

关键词： Nanomedicine Biochemical application Diamondoids Surface functionalization Drug targeting