Treatment of hepatitis C in children and adolescents:how far have we reached?
作者机构：Department of Gastroenterology and Hepatobiliary SciencesIMS and SUM HospitalSOA UniversityBhubaneswarIndia Department of PediatricsSri Manakula Vinayagar Medical College and HospitalPuducherryIndia Department of PediatricsCommand Hospital-Southern CommandPune411040India
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2023年第19卷第2期
页 面：107-119页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：Children Directly acting antivirals Hepatitis C
摘 要：Background Hepatitis C virus(HCV)infection is a global public health problem and also generates a significant case load in children and *** the introduction of directly acting antivirals(DAA),the treatment and care of HCV-infected patients have progressed *** available treatment options in children are limited,and this review aims to provide an overview of treatment of HCV infection in children and adolescents with the current available DAA *** sources This comprehensive review was undertaken after searching the PubMed/Medline and Embase databases for the available up-to-date literature on pediatric HCV infection and treatment using hepatitis C virus infection/HCV,directly acting antivirals/DAA,natural history,treatment,pediatrics,children,and adolescents as *** Combination therapies with highly effective DAA regimes,such as sofosbuvir/ledipasvir,sofosbuvir/velpatasvir,glecaprevir/pibrentasvir,sofosbuvir/daclatasvir,sofosbuvir/ribavirin and others,are available for use in *** of the DAA regimens have either received or are pending to receive regulatory approval by different medical/drug agencies for use in children and ***-genotypic regimens are also available in children and adolescents,and these regimens can be used while skipping genotype *** The literature on different DAA regimens for use in children shows that these regimens have higher cure rates with minimal side effects and shorter duration of therapy.
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