检索结果-南通市图书馆

Disrupted maturation of Prefrontal Layer 5 Neuronal Circuits in an Alzheimer’s Mouse Model of Amyloid Deposition

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2023年第6期39卷 881-892页

作者： Chang Chen Jing Wei Xiaokuang ma Baomei Xia neha.Shakir Jessica K.Zhang Le Zhang Yuehua Cui Deveroux Ferguson Shenfeng Qiu Feng Bai Department of Neurology Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing210008China Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZ85004USA

Mutations in genes encoding amyloid precursor protein(APP)and presenilins(PSs)cause familial forms of Alzheimer’s disease(AD),a neurodegenerative disorder strongly associated with *** is currently unknown whether and how AD risks affect early brain development,and to what extent subtle synaptic pathology may occur prior to overt hallmark AD *** mutant APP/PS1 over-expression mouse lines are key tools for studying the molecular mechanisms of AD *** these lines,the 5XFAD mice rapidly develop key features of AD pathology and have proven utility in studying amyloid plaque formation and amyloidβ(Aβ)-induced *** reasoned that transgenic mutant APP/PS1 over-expression in 5XFAD mice may lead to neurodevelopmental defects in early cortical neurons,and performed detailed synaptic physiological characterization of layer 5(L5)neurons from the prefrontal cortex(PFC)of 5XFAD and wild-type littermate controls.L5 PFC neurons from 5XFAD mice show early APP/Aβ***-cell patch-clamp recording at an early post-weaning age(P22–30)revealed functional impairments;although 5XFAD PFC-L5 neurons exhibited similar membrane properties,they were intrinsically less *** addition,these neurons received smaller amplitude and frequency of miniature excitatory synaptic *** functional disturbances were further corroborated by decreased dendritic spine density and spine head volumes that indicated impaired synapse *** biotinylation followed by Western blot analysis of PFC-L5 tissue revealed that 5XFAD mice showed reduced synaptic AMPA receptor subunit GluA1 and decreased synaptic NMDA receptor subunit *** with this,patch-clamp recording of the evoked L23>L5 synaptic responses revealed a reduced AMPA/NMDA receptor current ratio,and an increased level of AMPAR-lacking silent *** results suggest that transgenic mutant forms of APP/PS1 overexpression in 5XFAD mice leads to early deve

关键词： Alzheimer’s disease Mouse model Synaptic plasticity Long-term potentiation Cortical circuit Electrophysiology Learning and memory

is machine learning redefining the perovskite solar cells?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2022年第3期31卷 74-90,I0004页

作者： Nishi Parikh Meera Karamta neha.Yadav mohammad mahdi Tavakoli Daniel Prochowicz Seckin Akin Abul Kalam Soumitra Satapathi Pankaj Yadav Department of Science School of TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Electrical Engineering School of TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Telecommunication Ministry of CommunicationMumbai LSAMumbai 400072MaharashtraIndia Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMA 02139USA institute of Physical Chemistry Polish Academy of SciencesKasprzaka 44/5201-224 WarsawPoland Department of Metallurgical and materials Engineering Karamanoglu Mehmetbey University70200 KaramanTurkey Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha 61413P.O.Box 9004Saudi Arabia Department of Physics Indian Institute of Technology RoorkeeRoorkeeHaridwarUttarakhand 247667India Department of Solar Energy School of TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia

Development of novel materials with desirable properties remains at the forefront of modern scientific *** learning(ML),a branch of artificial intelligence,has recently emerged as a powerful technology in optoelectronic devices for the prediction of various properties and rational design of *** halide perovskites(MHPs)have been at the centre of attraction owing to their outstanding photophysical properties and rapid development in solar cell ***,the application of ML in the field of MHPs is also getting much attention to optimize the fabrication process and reduce the cost of ***,we comprehensively reviewed different applications of ML in the designing of both MHP absorber layers as well as complete perovskite solar cells(PSCs).At the end,the challenges of ML along with the possible future direction of research are *** believe that this review becomes an indispensable roadmap for optimizing materials composition and predicting design strategies in the field of perovskite technology in the future.

关键词： machine learning Metal halide perovskites Perovskite solar cell Lead free perovskites

impact of increased renewables on natural gas markets in eastern United States

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2017年第3期5卷 424-438页

作者： neha.NANDAKUmaR Anuradha M.ANNASWAMY institute for Data Systemsand SocietyMassachusetts Institute of TechnologyCambridgeMAUSA Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

This paper explores the market structures of natural gas and electricity as well as the interdependence of natural gas prices and bids with increasing reliance on natural gas as the penetration of renewable energy resources increases in order to complement their intermittencies. in particular, the paper will attempt to answer the following two questions: What could the generation mix look like in 2030 with a renewable-rich generation landscape and how could this impact gas prices? How do gasfired generator(GFG) generation volatility, their prices,and their bids for gas change between 2015 and 2030 with increased penetration of renewables? in order to answer these questions, computational models are derived using forecasting and regression analysis tools and an auction model.

关键词： Natural gas markets Gas-fired generators Regression analysis Optimal auction model Volatility Gas prices

Geothermobarometry of Askaoun Pluton in Ouzellarh-Sirwa Promontory (Central Anti-Atlas;Morocco)

在线全文

学校读者我要写书评

暂无评论

Open Journal of Geology 2012年第3期2卷 136-147页

作者： Abdeslam Toummite moha ikenne El Hassane Beraaouz Applied Geology and Environmental Geology Laboratory Faculty of Sciences Ibn Zohr University Agadir Morocco

Rocks of the late Neoproterozoic Askaoun pluton (558 ± 2 ma) located in the Ouzellarh-Sirwa promontory (Anti-Atlas) include magmatic microgranular enclaves (MMEs) ranging from rounded to ovoid in shape, dark and fine grained and generally 5 to 10 cm in size, some reaching a size of 50 cm. They are composed of microdiorite, quartz microdiorite and micromonzodiorite, whereas the felsic host rocks comprise mainly quartz-diorite and amphibole-biotite granodiorite based on mineralogical compositions. The mineral assemblage is similar to those described in their hosting granitoids but with different proportions. in this study composition of minerals is used to describe the nature of the magma and estimate the pressure, temperature and oxygen fugacity at which Askaoun pluton is emplaced. Based on chemistry of biotite Askaoun pluton formed from calc-alkaline magma. Compositions of plagioclase (An5 - An29);hornblende (Mg ≠= 0.59 - 0.65) and biotite (Mg ≠= 0.49 - 0.55) of MMEs are slightly distinct or similar to those of host rocks (An7-40;hbl Mg ≠= 0.64 - 0.69;Bi Mg ≠= 0.49 - 0.50) which suggest partial to complete equilibration during mafic-felsic magma interaction. The coexisting hornblende and plagioclase (hornblende-plagioclase thermometry), Al content in hornblende (aluminum-in-hornblende barometry) and the assemblage titanite-magnetite-quartz were used to constrain the P, T and fO2 during the crystallization of the parent magmas. The Askaoun pluton was emplaced at temperature ca. 504°C - 633°C and at pressure ca. 0.9 - 4.66 ± 0.6 Kbars (average depth = 6.5 km) from a highly oxidized magma (log fO2 = ?24.8 to ?19.2).

关键词： Askaoun Pluton MMEs Hornblende Thermobarometry Ouzellargh-Sirwa Promontory Anti-Atlas Morocco

Whole-blood sorting,enrichment and in situ immunolabeling of cellular subsets using acoustic microstreaming

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2018年第1期4卷 457-465页

作者： neha.Garg Trisha M.Westerhof Vick Liu Robin Liu Edward L.Nelson Abraham P.Lee Henry Samueli School of Engineering Department of Biomedical EngineeringUniversity of California IrvineIrvineCAUSA School of Medicine Department of MedicineDivision of Hematology/OncologyUniversity of CaliforniaIrvineIrvineCAUSA massachusetts institute of Technology CambridgeMAUSA Hochuen Medical Technology Co. LtdArcadiaCAUSA Chao Family Comprehensive Cancer Center Cancer Research InstituteUniversity of CaliforniaIrvineIrvineCAUSA Ayala School of Biological Sciences Department of Molecular Biology&BiochemistryUniversity of CaliforniaIrvineIrvineCAUSA Department of Mechanical and Aerospace Engineering University of CaliforniaIrvineIrvineCAUSA Center for Advanced Design and manufacturing of integrated Microfluidics University of CaliforniaIrvineIrvineCAUSA

Analyzing undiluted whole human blood is a challenge due to its complex composition of hematopoietic cellular populations,nucleic acids,metabolites,and *** present a novel multi-functional microfluidic acoustic streaming platform that enables sorting,enrichment and in situ identification of cellular subsets from whole *** single device platform,based on lateral cavity acoustic transducers(LCAT),enables(1)the sorting of undiluted donor whole blood into its cellular subsets(platelets,RBCs,and WBCs),(2)the enrichment and retrieval of breast cancer cells(MCF-7)spiked in donor whole blood at rare cell relevant concentrations(10 mL^(−1)),and(3)on-chip immunofluorescent labeling for the detection of specific target cellular populations by their known marker expression *** approach thus demonstrates a compact system that integrates upstream sample processing with downstream separation/enrichment,to carry out multi-parametric cell analysis for blood-based diagnosis and liquid biopsy blood sampling.

关键词： cell sorting cell enrichment in situ labeling lateral cavity acoustic transducers microstreaming whole blood

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

RHiC能区反物质和奇特粒子态研究

中国科学：物理学、力学、天文学 2019年第10期49卷 6-17页

作者：陈金辉马余刚张正桥 SAHA neha 复旦大学现代物理研究所核物理与离子束应用教育部重点实验室上海200433 中国科学院上海应用物理研究所上海201800

本文介绍了我们在相对论重离子对撞机上进行反物质奇特粒子态研究上的新进展.主要包括:通过反质子-反质子动量关联函数研究,提取出反质子间相互作用的有效力程和散射长度等关键物理参数,在实验上实现反物质间相互作用力的首次测量,结果... 详细信息

本文介绍了我们在相对论重离子对撞机上进行反物质奇特粒子态研究上的新进展.主要包括:通过反质子-反质子动量关联函数研究,提取出反质子间相互作用的有效力程和散射长度等关键物理参数,在实验上实现反物质间相互作用力的首次测量,结果表明反质子之间存在较强的吸引力,足够克服反质子-反质子之间的排斥力,结合成反物质原子核;通过质子-Ω及其反粒子对动量关联函数测量,在实验上寻找多奇异性双重子态,实验结果表明质子与Ω超子之间存在强的吸引,约为27 MeV,远大于氘核的结合能.

关键词：相对论重离子对撞机大型强子对撞机反物质原子核超子双重子态

Targeting MUC1-C suppresses BCL2A1 in triple-negativebreast cancer

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2018年第1期3卷 212-219页

作者： masayuki Hiraki Takahiro maeda neha.Mehrotra Caining Jin maroof Alam Audrey Bouillez Tsuyoshi Hata Ashujit Tagde Amy Keating Surender Kharbanda Harpal Singh Donald Kufe Dana-Farber Cancer institute Harvard Medical SchoolBostonMAUSA Center for Biomedical Indian Institute of TechnologyDelhiIndia Departments of Biology and Biological Engineering Massachusetts Institute of TechnologyCambridgeMAUSA Department of Gastrointestinal Surgery Graduate School of MedicineOsaka UniversitySuitaOsaka 565-0871Japan

B-cell lymphoma 2-related protein A1(BCL2A1)is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs;however,there are presently no agents that target *** MUC1-C oncoprotein is aberrantly expressed in triple-negative breast cancer(TNBC)cells,induces the epithelial–mesenchymal transition(EMT)and promotes anti-cancer drug *** present study demonstrates that targeting MUC1-C genetically and pharmacologically in TNBC cells results in the downregulation of BCL2A1 *** results show that MUC1-C activates the BCL2A1 gene by an NF-κB p65-mediated mechanism,linking this pathway with the induction of *** MCL-1 anti-apoptotic protein is also of importance for the survival of TNBC cells and is an attractive target for drug *** found that inhibiting MCL-1 with the highly specific MS1 peptide results in the activation of the MUC1-C→NF-κB→BCL2A1 *** addition,selection of TNBC cells for resistance to ABT-737,which inhibits BCL-2,BCL-xL and BCL-W but not MCL-1 or BCL2A1,is associated with the upregulation of MUC1-C and BCL2A1 *** MUC1-C in ABT-737-resistant TNBC cells suppresses BCL2A1 and induces death,which is of potential therapeutic *** findings indicate that MUC1-C is a target for the treatment of TNBCs unresponsive to agents that inhibit anti-apoptotic members of the BCL-2 family.

关键词： BCL2 MUC1 drugs treatment

Association of latitude and altitude with adverse outcomes in patients with COViD-19: The ViRUS registry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Critical Care Medicine 2022年第2期11卷 102-111页

作者： Aysun Tekin Shahraz Qamar Romil Singh Vikas Bansal mayank Sharma Allison M Lemahieu Andrew C Hanson Phillip J Schulte marija Bogojevic neha.Deo Simon Zec Diana J Valencia Morales Katherine A Belden Smith F Heavner margit Kaufman Sreekanth Cheruku Valerie C Danesh Valerie M Banner-Goodspeed Catherine A St Hill Amy B Christie Syed A Khan Lynn Retford Karen Boman Vishakha KKumar John C O'Horo Juan Pablo Domecq Allan J Walkey Ognjen Gajic Rahul Kashyap Salim Surani TheSociety of Critical Care Medicine(SCCM)Discovery Viral infection and Respiratory illness Universal Study(ViRUS):COViD-Registry investigator Group Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research Education Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmonary and Critical Care Medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinical Trials and Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix School of Medicine Mayo ClinicRochesterMN 55905United States Division of infectious Diseases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma Health GreenvilleSC 29605United States Englewood Health EnglewoodNJ 07631United States Divisions of Cardiothoracic Anesthesiology and Critical Care Medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States Center for Applied Health Research Baylor Scott and White HealthDallasTX 75246United States Department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina Health MinneapolisMN 55407United States Department of Critical Care Atrium Health NavicentMaconGA 31201United States Division of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critical Care Medicine Mount ProspectIL 60056United States Division of infectious Diseases Mayo ClinicRochesterMN 55905United States Division of Nephrology and Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmonary Center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Department of Pulmonary and Critical Care Medicine Texas A&M UniversityBryanTX 77807United States 不详

BACKGROUND The coronavirus disease 2019(COViD-19)course may be affected by environmental *** studies previously suggested a link between climatological factors and COViD-19 fatality ***,individual-level impact of these factors has not been thoroughly evaluated *** To study the association of climatological factors related to patient location with unfavorable outcomes in *** in this observational analysis of the Society of Critical Care Medicine Discovery Viral infection and Respiratory illness Universal Study:COViD-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital *** for baseline parameters and admission date,multivariable regression modeling was *** estimating equations were used to fit the *** Twenty-two thousand one hundred eight patients from over 20 countries were *** median age was 62(interquartile range:49-74)years,and 54%of the included patients were *** median age increased with increasing latitude as well as the frequency of ***,the percentage of comorbidities was lower in elevated *** within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 *** the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality wi

关键词： 28 d mortality Altitude COViD-19 Hospital-free days Latitude Outcomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

自然正交函数方法在强震预测中应用

地震地磁观测与研究 2023年第S1期44卷 71-75页

作者：罗国富马禾青杨明芝丁风和宁夏回族自治区地震局银川750001

1研究背景许多著名学者一致认为自然正交函数方法是预测、评估和检验大规模数据中短期和长期变化的最先进工具(Dawson,2016;Chao,2019;neha.et al,2021)。然而自然正交函数方法最先应用在大气、气候和气象预测上(马开玉等,1993),近年来... 详细信息

1研究背景许多著名学者一致认为自然正交函数方法是预测、评估和检验大规模数据中短期和长期变化的最先进工具(Dawson,2016;Chao,2019;neha.et al,2021)。然而自然正交函数方法最先应用在大气、气候和气象预测上(马开玉等,1993),近年来该方法逐渐应用在强震预测研究中。在中国,采用正交函数方法计算强震前的能量场(杨明芝,2004)、应变场(杨明芝,2017;罗国富,2023)和频次场(罗国富,2023),提取场的时间和空间异常信息,分析与强震的关系。在日本、印度以及欧美国家,采用经验正交函数方法计算强震前后的变形场(Chang,2011;Chao,2019;neha.et al,2021),分析强震的同震变形,给出三维变形的运动方向。

关键词：自然正交函数地震应变场地震频次场时空异常强震预测