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Warm temperature compromises JA-regulated basal resistance to enhance Magnaporthe oryzae infection in rice

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Molecular Plant 2022年第4期15卷 723-739页

作者： Jiehua Qiu Junhui Xie Ya Chen Zhenan Shen Huanbin Shi naweed i.naqvi Qian Qian Yan Liang Yanjun Kou State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 311400China Temasek Life Sciences Laboratory and Department of Biological Sciences1 Research LinkNational University of SingaporeSingapore 117604Singapore College of Agriculture and Biotechnology Zhejiang UniversityHangzhou 310058China

Changes in global temperatures profoundly affect the occurrence of plant *** is well known that rice blast can easily become epidemic in relatively warm ***,the molecular mechanism remains *** this study,we show that enhanced blast development at a warm temperature(22C)compared with the normal growth temperature(28C)is rice *** transcriptome analysis revealed that jasmonic acid(JA)biosynthesis and signaling genes in rice could be effectively induced by Magnaporthe oryzae at 28C but not at 22*** analyses of the osaoc1 and osmyc2 mutants,OsCOi1 RNAi lines,and OsMYC2-OE plants further demonstrated that compromised *** JA biosynthesis and signaling lead to enhanced blast susceptibility at the warm *** with these results,we found that exogenous application of methyl jasmonate served as an effective strategy for improving blast resistance under the warm environmental ***,decreased activation of JA signaling resulted in the downregulated expression of some key basal resistance genes at 22C when compared with 28*** these affected genes,OsCEBiP(chitin elicitorbinding protein precursor)was found to be directly regulated by OsMYB22 and its interacting protein OsMYC2,a key component of JA signaling,and this contributed to temperature-modulated blast *** together,these results suggest that warm temperature compromises basal resistance in rice and enhances *** infection by reducing JA biosynthesis and signaling,providing potential new strategies for managing rice blast disease under warm climate conditions.

关键词： temperature-modulated resistance rice blast jasmonic acid CEBiP MYB22 plant immunity

Tangeretin inhibits fungal ferroptosis to suppress rice blast

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Journal of integrative Plant Biology 2021年第12期63卷 2136-2149页

作者： Meiling Liang Huijuan Ye Qing Shen Xianya Jiang Guobing Cui Wenxiang Gu Lian-Hui Zhang naweed i.naqvi Yi Zhen Deng State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Province Key Laboratory of Microbial Signals and Disease ControlIntegrative Microbiology Research CenterSouth China Agricultural UniversityGuangzhou 510642China Zhaoqing Food inspection institute Zhaoqing 526000China Temasek Life Sciences Laboratory Singapore 117604Singapore Yangjiang institute of Agricultural Sciences Yangjiang 529500China Department of Applied Chemistry College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642China Department of Biological Sciences National University of SingaporeSingapore 117558Singapore

Flavonoids are polyphenolic secondary metabolites that function as signaling molecules,allopathic compounds,phytoalexins,detoxifying agents and antimicrobial defensive compounds in *** caused by the fungus Magnaporthe oryzae is a serious disease affecting rice *** this study,we revealed that a natural flavonoid,tangeretin,substantially delays the formation of *** appressoria and blocks the development of blast lesions on rice *** data suggest that tangeretin has antioxidant activity that interferes with conidial cell death/ferroptosis,which is critical for *** *** showed a ferroptosis inhibition efficacy comparable to the well-established ***,overexpression of the NADPH oxidases NOX1 or NOX2 significantly decreased sensitivity toward tangeretin treatment,suggesting Nox-mediated lipid peroxidation as a possible target for tangeretin in regulating redox signaling and ferroptosis in *** nursery and field tests showed that application of tangeretin can effectively mitigate overall disease symptoms and prevent leaf *** study reveals the plant-derived fungal ferroptosis inhibitor tangeretin as a potential and novel antifungal agrochemical for the sustainable prevention of the devastating blast disease in important cereal crops.

关键词： antifungal agrochemical antioxidant appressorium autophagy cell death ferroptosis lipid peroxidation NOX rice blast tangeretin

Polycomb Repressive Complex 2-Mediated H3K27 Trimethylation is Required for Pathogenicity in Magnaporthe oryzae

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Rice science 2022年第4期29卷 363-374页

作者： WU Zhongling QiU Jiehua SHi Huanbin LiN Chuyu YUE Jiangnan LiU Zhiquan XiE Wei naweed inaqvi KOU Yanjun TAO Zeng Ministry of Agriculture and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and insects Institute of BiotechnologyZhejiang UniversityHangzhou 310058China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 311400China Temasek Life Sciences Laboratory and Department of Biological Sciences 1 Research LinkNational University of SingaporeSingapore 117604Singapore

Polycomb repressive complex 2(PRC2)contributes to catalyze the methylation of histone H3 at lysine 27 and plays vital roles in transcriptional silencing and growth development in various *** Magnaporthe oryzae,histone H3K27 is found to associate with altered transcription of in planta induced ***,it is still unknown whether and how H3K27me3 modification is involved in pathogenicity to rice and stress *** this study,we found that core subunits of PRC2,Kmt6-Suz12-Eed,were required for fungal pathogenicity to rice in ***6-Suz12-Eed localized in the nuclei and was necessary for the establishment of H3K27me3 *** ChiP-seq analysis,9.0%of genome regions enriched with H3K27me3 occupancy,which corresponded to 1033 genes in ***,deletion of Kmt6,Suz12 or Eed altered genome-wide transcriptional expression,while the de-repression genes in theΔkmt6 strain were highly associated with H3K27me3 ***,plenty of genes which encode effectors and secreted enzymes,secondary metabolite synthesis genes,and cell wall stress-responsive genes were directly occupied with H3K27me3 modification and de-repression in theΔkmt6 *** results elaborately explained how PRC2 was required for pathogenicity,which is closely related to effector modulated host immunity and host environment adaption.

关键词： rice blast H3K27me3 transcriptional regulation pathogenicity Polycomb repressive complex 2

Liver Characterization of a Cohort of Alpha-1 Antitrypsin Deficiency Patients with and without Lung Disease

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Journal of Clinical and Translational Hepatology 2024年第10期12卷 845-856页

作者： naweed Mohammad Regina Oshins Tongjun Gu Virginia Clark Jorge Lascano Naziheh Assarzadegan George Marek Mark Brantly Nazli Khodayari Division of Pulmonary Critical Care and Sleep MedicineCollege of MedicineUniversity of FloridaGainesvilleFLUSA interdisciplinary Center for Biotechnology Research Bioinformatics CoreUniversity of FloridaGainesvilleFLUSA Division of Gastroenterology Hepatology and NutritionCollege of MedicineUniversity of FloridaGainesvilleFLUSA Division of Pathology Immunologyand Laboratory MedicineCollege of MedicineUniversity of FloridaGainesvilleFLUSA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA

Background and Aims:Alpha-1 antitrypsin deficiency(AATD)is a genetic disorder characterized by the misfolding and accumulation of the mutant variant of alpha-1 antitrypsin(AAT)within hepatocytes,which limits its access to the circulation and exposes the lungs to protease-mediated tissue *** results in progressive liver disease secondary to AAT polymerization and accumulation,and chronic obstructive pulmonary disease(COPD)due to deficient levels of AAT within the *** goal was to characterize the unique effects of COPD secondary to AATD on liver disease and gene ***:A subcohort of AATD individuals with COPD(n=33)and AATD individuals without COPD(n=14)were evaluated in this study from our previously reported cross-sectional *** used immunohistochemistry to assess the AATD liver phenotype,and RNA sequencing to explore liver *** observed a distinct transcriptomic profile in liver tissues from AATD individuals with COPD compared to those ***:A total of 339 genes were differentially *** pathways related to fibrosis,extracellular matrix remodeling,collagen deposition,hepatocellular damage,and inflammation were significantly upregulated in the livers of AATD individuals with *** analysis also revealed higher levels of fibrosis and hepatocellular damage in these ***:Our data supports a relationship between the development of COPD and liver disease in AATD and introduces genes and pathways that may play a role in AATD liver disease when COPD is *** believe addressing lung impairment and airway inflammation may be an approach to managing AATD-related liver disease.

关键词： Alpha-1 antitrypsin deficiency Chronic obstructive pulmonary disease Liver fibrosis Liver biopsy Liver histology Transcriptomics

Multifocal papillary thyroid cancer in Graves’ disease: A case report

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World Journal of Clinical Cases 2023年第35期11卷 8379-8384页

作者： naweed Alzaman Department of internal Medicine Taibah University College of MedicineTayba 42353Al-Madinah al-MunawwarahSaudi Arabia

BACKGROUND Thyroid cancer is not commonly observed in patients with Graves’disease(GD).The presence of thyroid nodules in GD is not ***,a link bet-ween these two entities has been ***,we report the case of a patient with GD and thyroid cancer in Saudi Arabia,which has not been reported previously in our *** SUMMARY A 26-year-old male patient with GD,receiving carbimazole for 2 years,presented to our *** hyperthyroidism was controlled clinically and *** clinical examination,he was found to have a left-sided thyroid ***-sound revealed a 2.6 cm hypoechoic nodule with high *** was then referred for fine needle aspiration which showed that the nodule was highly suspicious for *** patient underwent total thyroidectomy and was diagnosed with multifocal classical micropapillary thyroid *** thyroid-ectomy he received radioactive iodine ablation along with levothyroxine replace-ment *** Careful preoperative assessment and thyroid gland ultrasound might assist in screening and diagnosing thyroid cancer in patients with GD.

关键词： Graves’disease Thyroid cancer Thyroid nodules Ultrasound Multifocal Case report

Mild closed head traumatic brain injury-induced changes in monoamine neurotransmitters in the trigeminal subnuclei of a rat model:mechanisms underlying orofacial allodynias and headache

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Neural Regeneration Research 2017年第6期12卷 981-986页

作者： Golam Mustafa Jiamei Hou Rachel Nelson Shigeharu Tsuda Mansura Jahan naweed S.Mohammad Joseph V.Watts Floyd J.Thompson Prodip Bose Brain Rehabilitation Research Center of Excellence Malcom Randall VA Medical Center North Florida/South Georgia Veterans Health System Department of Physiological Sciences College of Veterinary Medicine University of Florida Department of Neuroscience McKnight Brain Institute College of Medicine University of Florida Department of Neurology McKnight Brain Institute College of Medicine University of Florida

Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by non-painful stimulation. These allodynias, tested using thermal hyperalgesia, correlated with changes in several known pain signaling receptors and molecules along the trigeminal pain pathway, especially in the trigeminal nucleus caudalis. This study focused to extend our previous work to investigate the changes in monoamine neurotransmitter immunoreactivity changes in spinal trigeminal nucleus oralis, pars interpolaris and nucleus tractus solitaries following mild to moderate closed head traumatic brain injury, which are related to tactile allodynia, touch-pressure sensitivity, and visceral pain. Our results exhibited significant alterations in the excitatory monoamine, serotonin, in spinal trigeminal nucleus oralis and pars interpolaris which usually modulate tactile and mechanical sensitivity in addition to the thermal sensitivity. Moreover, we also detected a robust alteration in the expression of serotonin, and inhibitory molecule norepinephrine in the nucleus tractus solitaries, which might indicate the possibility of an alteration in visceral pain, and existence of other morbidities related to solitary nucleus dysfunction in this rodent model of mild to moderate closed head traumatic brain injury. Collectively, widespread changes in monoamine neurotransmitter may be related to orofacial allodynhias and headache after traumatic brain injury.

关键词： traumatic trigeminal headache alteration visceral nucleus underlying moderate stimulation possibility

Clinical high-risk criteria of psychosis in 8–17-year-old community subjects and inpatients not suspected of developing psychosis

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World Journal of Psychiatry 2022年第3期12卷 425-449页

作者： Frauke Schultze-Lutter Petra Walger Maurizia Franscini Nina Traber-Walker naweed Osman Helene Walger Benno G Schimmelmann Rahel Flückiger Chantal Michel Department of Psychiatry and Psychotherapy Medical FacultyHeinrich-Heine UniversityDüsseldorf 40629North-Rhine WestphaliaGermany Department of Psychology Faculty of PsychologyAirlangga UniversitySurabaya 60286Indonesia University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of BernBern 3000Switzerland Department of Child and Adolescent Psychiatry and Psychotherapy University of ZürichZürich 8032Germany Department of Psychiatry and Psychotherapy Ludwig-Maximilian-UniversityMunich 80336BavariaGermany University Hospital of Child and Adolescent Psychiatry University Hospital Hamburg-EppendorfHamburg 20246Germany

BACKGROUND in children and adolescents compared to adults,clinical high-risk of psychosis(CHR)criteria and symptoms are more prevalent but less psychosis-predictive and less clinically *** on high rates of non-converters to psychosis,especially in children and adolescents,it was suggested that CHR criteria were:(1)Pluripotential;(2)A transdiagnostic risk factor;and(3)Simply a severity marker of mental disorders rather than specifically *** any of these three alternative explanatory models were true,their prevalence should differ between persons with and without mental disorders,and their severity should be associated with functional impairment as a measure of *** To compare the prevalence and severity of CHR criteria/symptoms in children and adolescents of the community and *** in the mainly cross-sectional examinations,8–17-year-old community subjects(n=233)randomly chosen from the population register of the Swiss Canton Bern,and inpatients(n=306)with primary diagnosis of attention-deficit/hyperactivity disorder(n=86),eating disorder(n=97),anxiety including obsessive–compulsive disorder(n=94),or autism spectrum disorder(n=29),not clinically suspected to develop psychosis,were examined for CHR symptoms/*** items of the Structured interview for Psychosis-Risk Syndromes(SiPS)were used to assess the symptomatic ultra-high-risk criteria,and the Schizophrenia Proneness instrument,Child and Youth version(SPi-CY)was used to assess the 14 basic symptoms relevant to basic symptom *** examined group differences in frequency and severity of CHR symptoms/criteria usingχ^(2) tests and nonparametric tests with Cramer’s V and Rosenthal’s r as effect sizes,and their association with functioning using correlation *** The 7.3%prevalence rate of CHR criteria in community subjects did not differ significantly from the 9.5%rate in *** and severity of CHR criteria never differed bet

关键词： Psychotic disorders Risk assessment Minors Community inpatients Psychosocial functioning

七氟醚抑制突触后胆碱能突触传递而不影响短时程增强

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国外医学（麻醉学与复苏分册） 2005年第3期26卷 189-192,i001页

作者： Hiroaki Naruo Shin Onizuka David Prince Mayumi Takasaki naweed i.Syed 方波王俊科 Research Associate Department of Anesthesiology Miyazali Medical College Research Associate Cellular and Molecular Neurobiology Research Group Faculty of Medicine University of Calgary Graduate Student Cellular and Molecular Neurobiology Research Group Faculty of Medicine University of Calgary Professor Department of Anesthesiology Miyazali Medical College Professor Cellular and Molecular Neurobiology Research GroupFaculty of Medicine University of Calgary 中国医科大学第一临床学院麻醉科

背景:目前人们已了解全身麻醉对兴奋性和抑制性突触的作用.但全身麻醉影响突触可塑性,从而影响学习和记忆的机制在细胞水平上尚不清晰.本研究选取体细胞-体细胞之间一致的突触后神经元,验证临床浓度的七氟醚是否影响胆碱能突触传递的短... 详细信息

背景:目前人们已了解全身麻醉对兴奋性和抑制性突触的作用.但全身麻醉影响突触可塑性,从而影响学习和记忆的机制在细胞水平上尚不清晰.本研究选取体细胞-体细胞之间一致的突触后神经元,验证临床浓度的七氟醚是否影响胆碱能突触传递的短时程增强。

关键词：胆碱能突触传递突触后七氟醚时程全身麻醉突触可塑性学习和记忆细胞水平体细胞抑制性兴奋性神经元

The Use of Standardized Reporting and Time-in-Range in the Management of Diabetes: A Consensus Report

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international Journal of Clinical Medicine 2021年第8期12卷 316-327页

作者： Saud Al Sifri Adnan Alshaikh Bassam Bin-Abbas Eman Sheshah Fahad Al Sabaan Mohammed Al-Dawish Mohammed Al-Dubayee naweed Al-Zaman Raed A. Al-Dahash Saad Alzahrani Emad R. issak Endocrinology and Diabetes Department Alhada and Taif Armed Forces Hospitals Taif Saudi Arabia Pediatrics Department King Abdulaziz Medical City—Ministry of National Guard Health Affairs King Khalid National Guard Hospital Jeddah Saudi Arabia Pediatrics Department King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia Endocrinology Department King Salman hospital Riyadh Saudi Arabia Endocrinology Department Security forces hospital program Riyadh Saudi Arabia Endocrinology Department Prince Sultan Military Medical City (PSMMC) Riyadh Saudi Arabia Pediatrics Department Ministry of National Guard Health Affairs-Riyadh Riyadh Saudi Arabia Endocrinology Department Taibah University Madina Saudi Arabia internal Medicine Department King Abdulaziz Medical City—National Guard Riyadh Saudi Arabia Endocrinology Department Medical Director OEMC King Fahad Medical City Riyadh Saudi Arabia internal Medicine Department Faculty of Medicine Ain-Shams University Cairo Egypt

introduction: The exhaustion of healthcare resources due to the rising prevalence in Saudi Arabia mandates the search for each method that can help in better control of diabetes. Methods: The gathered task force gath-ered to develop an explicit, evidence-based consensus for the use of time-in-range targets as guidance for better glycemic control while using continuous glucose monitoring (CGM). This article has the recommenda-tions of this expert panel. Results: HbA1c and self-monitoring blood glu-cose (SMBG) are not enough to detect blood glucose (BG) fluctuations on a daily basis. The incorporation of technology like FreeStyle Libre with its applications like Libre View is now used in many institutes in Saudi Ara-bia. This system is comprehensive and has all the standardized metrics needed. However, training and support are always needed. Barriers and challenges include the awareness & experience of the technology, the time barrier, the patients’ barriers, the technical barriers, and of course, the availability barrier. All the barriers and challenges should be dealt with by designing new training programs. Conclusion: The expert panel recom-mended using CGMs technology in people with type 1 diabetes (T1DM) children and adults, type 2 diabetes (T2DM) on multiple insulin injections, gestational diabetes (GDM) who need further glycemic control, and those at high risk for hypoglycemia. in addition, we recommend using them for a short period for those who require intensive BG control or during acute illness or stress. in addition, Ambulatory Glucose Profile (AGP) could be used as an educational tool for any individuals with DM to study the im-pact of certain elements of lifestyle modifications on their immediate BG level.

关键词： Diabetes Time in Range Glycemic Control HbA1c