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Sports Medicine and Health Science 2019年第1期1卷 49-58页

作者： I-Ling Yeh naveen elangovan Rebecca Feczer Sanaz Khosravani Arash Mahnan Jürgen Konczak Human Sensorimotor Control Laboratory School of KinesiologyUniversity of MinnesotaMinneapolisUSA Department in Occupational Therapy Singapore Institute of TechnologySingapore Program in Rehabilitation Science University of MinnesotaMinneapolisUSA Department of Otolaryngology Harvard University Medical SchoolCambridgeUSA

High vibration transfer from a tennis racquet to the player may cause discomfort,and is hypothesized to influence performance and the onset of muscle *** study examined a racquet with a novel vibration damping technology(VDT)designed to mitigate frame *** vibration,post-impact vibration transfer to the player,arm electromyographic activity and tennis performance were compared to a non-VDT *** young adult,competitive tennis players hit forehands and serves until near exhaustion on two days;using one of the two racquets each ***-axial accelerometers mounted to racquet shaft,hand and forearm recorded vibration *** electromyography recorded activity of five arm *** comparison to the non-VDT racquet,the VDT design showed:1)A significantly lower mean normalised acceleration signal energy at the racquet during unfatigued play(-40%)and at near exhaustion(-34%),which corresponded to a 20–25%lower signal energy at the hand.2)Reduced signs of arm muscle fatigue at near exhaustion,which was most pronounced in biceps and wrist extensors.3)Players hit 11%more forehands and placed 40%more hits in the target area at near ***:VDT effectively reduces racquet *** evidence indicates that it may delay muscle fatigue,which was associated with increased ball placement accuracy.

关键词： Acceleration Biomechanics Electromyography Human Kinematics

Hatha yoga training improves standing balance but not gait in Parkinson's disease

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Sports Medicine and Health Science 2020年第2期2卷 80-88页

作者： naveen elangovan Corjena Cheung Arash Mahnan Jean F.Wyman Paul Tuite Jürgen Konczak Human Sensorimotor Control Laboratory School of KinesiologyUniversity of MinnesotaMinneapolisMNUSA Center for Clinical Movement Science University of MinnesotaMinneapolisMNUSA School of Nursing University of MinnesotaMinneapolisMNUSA Department of Neurology University of Minnesota HealthMinneapolisMNUSA Department of Health Hong Kong Adventist CollegeHong KongChina

Background and purpose:Complementary therapies,such as yoga,have been proposed to address gait and balance problems in Parkinson's disease(PD).However,the effects of yoga on gait and static balance have not been studied systematically in people with PD(PWP).Here we evaluated the effects of a 12-week long Hatha yoga intervention on biomechanical parameters of gait and posture in ***:We employed a pilot randomized controlled trial design with two groups of mild-to-moderate PWP(immediate treatment,waitlist control;N?10 each;Mean Hoehn and Yahr score=2 for each group).Baseline Unified Parkinson's Disease Rating Scale(UPDRS)motor scores,and gait and postural kinematics including postural sway path length,cadence,walking speed,and turning time were *** immediate treatment group received a 60-min Hatha yoga training twice a week for 12 weeks,while the waitlisted control group received no *** 12 weeks,gait and postural kinematics were assessed(post-test for treatment group and second-baseline for waitlist group).Then,the waitlist group received the same yoga training and was evaluated ***:After Hatha yoga training,UPDRS motor scores improved with an 8-point mean decrease which is considered as a moderate clinically important change for mild-moderate *** path length during stance decreased significantly(mean reduction:-34.4%).No significant between-group differences or improvements in gait kinematics were ***:This study showed that a 12-week Hatha yoga training can improve static balance in *** found no evidence that it systematically improves gait performance in PWP.

关键词： Hatha yoga Parkinson's disease Posture Gait

Commentary on:“Assessing proprioception:A critical review of methods”by Han et al.

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Journal of Sport and Health Science 2016年第1期5卷 91-92页

作者： Carmen Krewer Ann Van de Winckel naveen elangovan Joshua E.Aman Jürgen Konczak Human Sensorimotor Control Laboratory University of Minnesota Minneapolis MN 55455 USA Schon Klinik BadAibling BadAibling 83043 Germany Program in Physical Therapy University of Minnesota Minneapolis MN 55455 USA

In recent years,the assessment of proprioceptive function has received increased attention in clinical and motor skill *** is not surprising given the growing body of scientific evidence on the importance of proprioceptive information for controlling nearly all facets of human movement;from standing to performing highly skilled movement patterns

关键词： surprising skill performing discrimination validity Commentary on by Han et al selecting reproduction modality

Cool white light and tunable multicolor emission from Tb^(3+)/Dy^(3+)co-activated glasses under different excitations for WLEDs

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Journal of Rare Earths 2024年第1期42卷 46-56,I0002页

作者： L.Vijayalakshmi K.naveen Kumar Jong Dae Baek Department of Automotive Engineering Yeungnam UniversityGyeongsanGyeongbuk38541Republic of Korea Department of Mechanical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

A set of co-doped(Tb^(3+)/Dy^(3+))lithium zinc borate(LZB)glasses were developed by melt *** structural evaluation was performed for synthesized glassy *** Dy^(3+)and Tb^(3+)individually doped glasses exhibit intense yellow and green luminescence bands at 575 nm(^(4)F_(9/2)→^(6)H_(13/2))and543 nm(^(5)D_(4)→^(7)F_(5)),*** sensitization effect of Dy^(3+)on Tb^(3+)was analyzed by increasing the Tb^(3+)content with respect to the optimum Dy^(3+)content(0.5 mol%)in Dy^(3+)/Tb^(3+).The spectral overlay of Dy^(3+)luminescence and Tb^(3+)absorption profiles,Dy^(3+)/Tb^(3+)PL spectra under different excitations 352,362,376,and 385 nm,shortening decay lifetimes of Dy^(3+)in Dy^(3+)/Tb^(3+)co-activated glasses,energy transfer(ET)parameters,chromaticity coordinates and their corresponding correlated temperatures all help to explain ET from Dy^(3+)to Tb^(3+).At 385 nm of Dy^(3+)excitation,the optimized co-activated(0.5Dy^(3+)+1.0Tb^(3+)):LZB glass displays cool white light *** non-radiative ET from Dy^(3+)to Tb^(3+)is dominated by electric dipole-dipole interaction and its ET efficiency was calculated to be 63%.At the same time,reverse ET from Tb^(3+)to Dy^(3+)was also *** shift in color coordinates from dominant yellow to greenish-yellow,green and white light emission suggests that Dy^(3+)/Tb^(3+)coactivated LZB glasses can be a potential candidate for UV converted multicolor and white light emitting devices.

关键词： Rare earths Photoluminescence Energy transfer Spectral overlap Decay lifetime Multicolor emitting LEDs

Evidence-based orthobiologic practice:Current evidence review and future directions

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World Journal of Orthopedics 2024年第10期15卷 908-917页

作者： Madhan Jeyaraman naveen Jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Sathish Muthu Department of Orthopedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Research Methods Orthopedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopedic Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Orthopedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia

The field of orthopedic and regenerative medicine is rapidly evolving with the increasing utilization of *** biologically derived therapies,inc-luding platelet-rich plasma,mesenchymal stem cells,bone marrow aspirate con-centrate,stromal vascular fraction(SVF),and autologous chondrocyte implanta-tion,are gaining traction for their potential to enhance the body's natural healing *** offer a promising alternative to traditional surgical interventions for musculoskeletal injuries and degenerative *** evidence su-ggests significant benefits of orthobiologics in treating conditions like osteoarth-ritis,tendon injuries,and spinal disorders,yet inconsistencies in treatment pro-tocols and outcomes *** global market for orthobiologics is projected to grow substantially,driven by advancements in biologic therapies such as adipose-derived stem cells and SVF,and the demand for minimally invasive *** their promise,regulatory and ethical challenges,as well as the need for high-quality,standardized research,remain significant *** dire-ctions in the field include advancements in delivery systems,personalized medi-cine approaches,and the exploration of novel sources like induced pluripotent stem cells,aiming for more targeted and effective *** efforts are crucial to overcoming these challenges and ensuring the safe and effective application of orthobiologics in clinical practice.

关键词： Orthobiologics Platelet-rich plasma Stem cells Musculoskeletal regeneration Regenerative medicine Evidence-based medicine

Understanding and controlling the variables for stromal vascular fraction therapy

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World Journal of Stem Cells 2024年第8期16卷 784-798页

作者： naveen Jeyaraman Sandeep Shrivastava VR Ravi Arulkumar Nallakumarasamy Aditya Pundkar Madhan Jeyaraman Department of Orthopaedics Datta Meghe Institute of Higher Education and ResearchWardha 442004MaharashtraIndia Regenerative Medicine Mother Cell Regenerative CentreTiruchirappalli 620017Tamil NaduIndia Department of Orthopaedics Jawaharlal Nehru Medical CollegeDatta Meghe Institute of Higher Education and ResearchWardha 442004MaharashtraIndia Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia

In regenerative medicine,the isolation of mesenchymal stromal cells(MSCs)from the adipose tissue’s stromal vascular fraction(SVF)is a critical area of *** review meticulously examines the isolation process of MSCs,starting with the extraction of adipose *** choice of liposuction technique,anatomical site,and immediate processing are essential to maintain cell *** delve into the intricacies of enzymatic digestion,emphasizing the fine-tuning of enzyme concentrations to maximize cell yield while preventing *** review then outlines the filtration and centrifugation techniques necessary for isolating a purified SVF,alongside cell viability assessments like flow cytometry,which are vital for confirming the efficacy of the isolated *** discuss the advantages and drawbacks of using autologous vs allogeneic SVF sources,touching upon immunocompatibility and logistical considerations,as well as the variability inherent in donor-derived *** choices,the selection between hypo-dermic needles vs liposuction cannulas,and the role of adipose tissue lysers in achieving cellular dissociation are evaluated for their impact on SVF *** protocols are also analyzed for their part in ensuring the integrity of the *** necessity for standardized MSC isolation protocols is highlighted,promoting reproducibility and successful clinical *** encourage ongoing research to deepen the understanding of MSC biology and therapeutic action,aiming to further the field of regenerative *** review concludes with a call for rigorous research,interdisciplinary collaboration,and strict adherence to ethical and regulatory standards to safeguard patient safety and optimize treatment outcomes with MSCs.

关键词： Mesenchymal stromal cells Stromal vascular fraction Adipose tissue Autologous stromal vascular fraction Stromal vascular fraction isolation

Modeling measles transmission in adults and children:Implications to vaccination for eradication

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Infectious Disease Modelling 2024年第4期9卷 1007-1026页

作者： Anjana Pokharel Khagendra Adhikari Ramesh Gautam Kedar Nath Uprety naveen K.Vaidya Padma Kanya Multiple Campus Tribhuvan UniversityKathmanduNepal Mathematical Biology Research Center KathmanduNepal Amrit Campus Tribhuvan UniversityKathmanduNepal Ratna Rajya Laxmi Campus Tribhuvan UniversityKathmanduNepal Central Department of Mathematics Tribhuvan UniversityKathmanduNepal Department of Mathematics and Statistics San Diego State UniversitySan DiegoCAUSA Computational Science Research Center San Diego State UniversitySan DiegoCAUSA Viral Information Institute San Diego State UniversitySan DiegoCAUSA

Despite the availability of successful vaccines,measles outbreaks have occurred frequently in recent years,presumably due to the lack of proper vaccination ***,measles cases in adult groups,albeit small in number,indicate that the previously neglected adult group may need to be brought into vaccine coverage to achieve WHO's goal of measles eradication from the *** this study,we develop a novel transmission dynamics model to describe measles cases in adults and children to evaluate the role of adult infection in persistent measles cases and vaccination programs for *** of our model,validated by measles cases from outbreaks in Nepal,provides the vaccination reproduction number(conditions for measles eradication or persistence)and the role of contact network *** results highlight that while children are primary targets for measles outbreaks,a small number of infections in adults may act as a reservoir for measles,causing obstacles to ***,our model analysis shows that while impactful controls can be achieved by children-focused vaccines,a combined adult-child vaccination program may help assert eradication of the disease.

关键词： Measles eradication Measles reservoir Adult-child vaccination Adults and children groups Nepal

Advancing orthopaedic trauma care through WhatsApp:An analysis of clinical and non-clinical applications,challenges,and future directions

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World Journal of Orthopedics 2024年第6期15卷 529-538页

作者： Ravi Saini Madhan Jeyaraman naveen Jeyaraman Vijay Kumar Jain Swaminathan Ramasubramanian Karthikeyan P Iyengar Department of Orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr Ram Manohar Lohia HospitalNew Delhi 110001India Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Trauma and Orthopaedics Southport and Ormskirk HospitalsMersey and West Lancashire Teaching NHS TrustSouthport PR86PNUnited Kingdom

The integration of WhatsApp,a widely-used instant messaging application(IMA),into the realm of orthopaedics and trauma surgery has emerged as a significant development in recent *** paper explores the multifaceted role of WhatsApp in orthopaedics,focusing on its clinical and non-clinical applications,advantages,disadvantages,and future *** study synthesizes findings from various research papers,emphasizing the growing reliance on mobile technology in ***’s role in orthopaedics is notable for its ease of use,real-time communication,and ***,it facilitates triage,teleconsultation,diagnosis,treatment,patient advice,and post-operative ***-clinically,it supports telemedicine,teleradiology,virtual frac-ture clinics,research,and education in orthopaedic *** application has proven beneficial in enhancing communication among healthcare teams,providing quick responses,and motivating junior *** use in educational settings has been shown to improve learner’s understanding and patient ***,the use of WhatsApp in orthopaedics is not without *** include the potential spread of misleading information,privacy concerns,and issues with image quality affecting diagnosis and treatment *** paper acknowledges the importance of maintaining professional boundaries and the need for oversight measures to ensure content *** forward,the potential of WhatsApp and similar IMAs in orthopaedics lies in their ability to streamline data collection and retrieval,improve doctor-patient communication,and address challenges like bureaucratic red tape and limited *** paper suggests that future orthopaedic practice,particularly in emergency departments,will increasingly rely on such technologies for efficient patient *** shift,however,must be approached with an understanding of the ethical,legal,and practical implications of integrating social media and mobile

关键词： Social media WhatsApp Orthopaedics Trauma Research

Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman naveen Jeyaraman Tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan Saurabh Kumar Jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United *** Both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and B *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

Gut microbiome:A revolution in typeⅡdiabetes mellitus

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World Journal of Diabetes 2024年第9期15卷 1874-1888页

作者： Madhan Jeyaraman Tejaswin Mariappan naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Gabriel Silva Santos Lucas Furtado da Fonseca JoséFábio Lana Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Community Medicine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

TypeⅡdiabetes mellitus(T2DM)has experienced a dramatic increase globally across countries of various income levels over the past three *** persistent prevalence of T2DM is attributed to a complex interplay of genetic and environmental *** numerous pharmaceutical therapies have been developed,there remains an urgent need for innovative treatment approaches that offer effectiveness without significant adverse *** this context,the exploration of the gut microbiome presents a promising *** has increasingly shown that the gut microbiome of individuals with T2DM exhibits distinct differences compared to healthy individuals,suggesting its potential role in the disease’s pathogenesis and *** emerging field offers diverse applications,particularly in modifying the gut environment through the administration of prebiotics,probiotics,and fecal microbiome *** interventions aim to restore a healthy microbiome balance,which could potentially alleviate or even reverse the metabolic dysfunctions associated with *** current results from clinical trials have not yet shown dramatic effects on diabetes management,the groundwork has been laid for deeper *** and future clinical trials are critical to advancing our understanding of the microbiome’s impact on *** further elucidating the mechanisms through which microbiome alterations influence insulin resistance and glucose metabolism,researchers can develop more targeted *** potential to harness the gut microbiome in developing new therapeutic strategies offers a compelling prospect to transform the treatment landscape of T2DM,potentially reducing the disease’s burden significantly with approaches that are less reliant on traditional pharmaceuticals and more focused on holistic,systemic health improvements.

关键词： TypeⅡdiabetes Gut microbiome Probiotics Prebiotics Fecal microbiota transplantation