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Detection of t(9;22) Chromosome Translocation Using Deep Residual Neural Network

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Journal of Computer and Communications 2019年第12期7卷 102-111页

作者： Jiahe Yan Emily Tucci nathaniel Jaffe Trinity-Pawling School Pawling NY USA

Karyotype analysis has significant clinical importance. Effectively detecting the exact abnormity of chromosomes will contribute to the diagnosis of certain diseases. In this paper, I presented a convenient and reliable system that was capable of detecting t(9;22) chromosome translocation, a specific chromosomal abnormity in CML patients. The functions of this system were based on deep learning algorithms, and I created a classification system using ResNet. The model could effectively detect t(9;22) translocation based on images of chromosomes 9 and 22. This model achieves a 97.5% accuracy on the validation set.

关键词： Karyotype t(9 22) Chromosomal Translocation ResNet Deep Learning

Can bedside needle arthroscopy of the ankle be an accurate option for intra-articular delivery of injectable agents?

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World Journal of Orthopedics 2022年第1期13卷 78-86页

作者： Tobias Stornebrink Sjoerd A S Stufkens nathaniel P Mercer John G Kennedy Gino M M J Kerkhoffs Department of Orthopedic Surgery Amsterdam UMCUniversity of AmsterdamAmsterdam Movement SciencesAmsterdam 1105AZNetherlands Academic Center for Evidence based Sports Medicine Amsterdam 1105AZNetherlands Amsterdam Collaboration for Health and Safety in Sports International Olympic Committee Research Center Amsterdam UMCAmsterdam 1105AZNetherlands Department of Orthopedic Surgery NYU Langone HealthNew YorkNY 10010United States

BACKGROUND Bedside needle arthroscopy of the ankle under local anesthesia has been proposed for intra-articular delivery of injectable *** and tolerability of this approach in the clinical setting–including patients with end-stage ankle pathology and/or a history of prior surgery–is not *** To assess clinical accuracy and tolerability of bedside needle arthroscopy as a delivery system for injectable agents into the tibiotalar *** This was a prospective study that included adult patients who were scheduled for an injection with hyaluronic acid to the tibiotalar *** our center,these injections are used as a last resort prior to extensive *** primary outcome was injection accuracy,which was defined as injecting through the arthroscopic cannula with intra-articular positioning confirmed by a clear arthroscopic view of the joint *** outcome measures included a patientreported numeric rating scale(NRS,0-10)of pain during the procedure and willingness of patients to return for the same *** of ankle pain at rest and during walking was collected at baseline and at 2-wk *** were monitored from inclusion up to a 2-wk control *** We performed 24 ***(46%)participants were male,and mean age was 46.8±14.5 *** was the indication for injection in 20(83%)cases,of which 8(33%)patients suffered from osteoarthritis Kellgren-Lawrence grade IV,and 10(42%)patients from Kellgren-Lawrence grade *** osteochondral defect was the indication for injection in 4(17%)cases.A history of ankle surgery was present in 14(58%)participants and a history of multiple ankle surgeries in 11(46%)*** was possible to confirm accuracy in 21(88%)*** 3(12%)participants where needle arthroscopy did not reach a clear view of the joint space all suffered from Kellgren-Lawrence grade IV *** during the procedure was reported with a median of 1[i

关键词： Ankle arthroscopy NanoScope Needle arthroscopy Injections Proof of concept Patient experience

The Diffusion of Geographic Information Systems Knowledge and Technology in Nigeria： An Exploration

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Journal of Earth Science and Engineering 2013年第1期3卷 50-56页

作者： Raimi Abidemi Asiyanbola nathaniel Olugbade Adeoye Department of Geography and Regional Planning Olabisi Onabanjo University Ago-Iwoye 120005 Ogun State Nigeria Department of Geography Obafemi Awolowo University lle-lfe 220005 Osun State Nigeria

The paper examined the state of GIS （geographic information systems） knowledge and adoption in Nigeria, identified factors affecting its implementation and finally discussed methods of enhancing its use in Nigeria. Administrative records of some institutions and information obtained from published articles in journals and text books were used for the study. Records indicate that GIS is relatively young in Nigeria and in terms of development, it is at its youthful stage. The adoption and use of GIS is low at both Federal and State Government levels. However, factors such as, lack of political will, shortage of experts to train the professionals, lack of standardization of digital data, database development and management problems, institutional constraints, security implications of digital maps and poor funding have been inhibiting full adoption, implementation and use of GIS in Nigeria. There is the need to develop a GIS vision in the country and government should formulate policy and create enabling environment for the adoption and implementation of the new technology.

关键词： GIS knowledge adoption institutions constraints Nigeria.

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亚洲城市进一步发展和扩张的规划和管理

建筑学报 2006年第9期 13-16页

作者： nathaniel von Einsiedel 城市合作基金会

引言亚太地区的城市化是当今世界面临的一个主要问题.如何应对这一城市化浪潮,不仅仅会对该地区,而且将对全世界的未来发展产生重大影响.我们在未来几年采取的措施,将会对未来的发展产生重大的杠杆效应和深远的影响.因此,现在就应该制... 详细信息

引言亚太地区的城市化是当今世界面临的一个主要问题.如何应对这一城市化浪潮,不仅仅会对该地区,而且将对全世界的未来发展产生重大影响.我们在未来几年采取的措施,将会对未来的发展产生重大的杠杆效应和深远的影响.因此,现在就应该制定适当的政策和方法,同时随着环境的改变不断作出更正,以引导那些关键参与者共同塑造亚洲的都市区域,这一点很重要.本文考察了亚太地区在城市化进程中遇到的一些关键挑战和问题,并为一些关键问题,特别是未来城市发展和扩张以及市内老城区的重注生机给出了一些政策提示.此外,本文还就这些问题的解决,提出了一些工具和方法建议.

关键词：城市化亚洲管理规划扩张亚太地区杠杆效应都市区

Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer

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Asian Journal of Urology 2019年第1期6卷 99-108页

作者： Emmanuel S.Akinboye W.nathaniel Brennen Samuel R.Denmeade John T.Isaacs Department of Oncology Prostate Cancer ProgramThe Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsThe Johns Hopkins University School of MedicineBaltimoreMDUSA

Localized prostate cancer is curable via annihilation of the entire cancer neighborhood by surgery or local ***,once metastatic,no available therapy is *** vast majority will die despite aggressive systemic combinational androgenablation ***,there is an urgent need for effective systemic therapeutics that sterilize the entire microenvironment in metastatic castration-resistant prostate cancer(mCRPC).To accomplish this goal,advantage can be taken of the unique biology of mCRPC *** their normal cell of origin,mCRPCs retain expression of the prostate-specific differentiation protein,prostate-specific antigen(PSA),which they abundantly secrete into their extracellular fluid(ECF).This unique,and essentially universal,secretion of enzymatically active PSA into the ECF by mCRPCs creates an exploitable therapeutic index for activation of systemically delivered highly lipophilic toxins as“molecular grenades”covalently linked to cysteine-34 of human serum albumin(HSA)via a stable maleimide containing PSA cleavable peptide such that PSA-dependent hydrolysis(i.e.,“detonation”)releases the grenades restrictively within the ECF of *** approach decreases dose-limiting host toxicity while enhancing plasma half-life from minutes to days(i.e.,pharmacokinetic effect)and increasing the tissue concentration of the maleimide coupled albumin delivery(MAD)in the ECF at sites of cancer due to the enhanced permeability of albumin at these sites(i.e.,enhanced permeability and retention effect).This allows the MAD-PSA detonated grenades to circulate throughout the body in a non-toxic *** within sites of mCRPC is there a sufficiently high level of enzymatically active PSA to efficiently“pull the pin”on the grenades releasing their lipophilic cellpenetrant toxins from ***,if a sufficient level of“detonation”occurs,this will kill mCRPC cells,and sterilize the entire PSA-rich metastatic sites via a bystander *** this review,two

关键词： Albumin-linked prodrug Maleimide coupled albumin delivery Thapsigargin Niclosamide

Five years of fecal microbiota transplantation-an update of the Israeli experience

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World Journal of Gastroenterology 2018年第47期24卷 5403-5414页

作者： Sharon A Greenberg Ilan Youngster nathaniel A Cohen Dan M Livovsky Jacob Strahilevitz Eran Israeli Ehud Melzer Kalman Paz Naomi Fliss-Isakov Nitsan Maharshak Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Centeraffiliated with the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv 6423906Israel Bacteriotherapy Clinic Tel Aviv Sourasky Medical Centeraffiliated with the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv 6423906Israel Assaf Harofe Medical Center Zerifin 70300Israel Digestive Diseases Institute Shaare Zedek Medical CenterJerusalem 91031Israel Department of Clinical Microbiology and Infectious Diseases Hadassah-Hebrew UniversityJerusalem 91120Israel Department of Gastroenterology and Liver Diseases Hadassah-Hebrew UniversityJerusalem 91120Israel Gastrointestinal and Liver Diseases Institute Kaplan Medical CenterRehovot 76100Israel

AIM To evaluate and describe the efficacy of fecal microbiota transplantation(FMT) for Clostridium difficile infection(CDI) in a national Israeli *** All patients who received FMT for recurrent(recurrence within 8 wk of the previous treatment) or refractory CDI from 2013 through 2017 in all the five medical centers in Israel currently performing FMT were included. Stool donors were screened according to the Israeli Ministry of Health guidelines. Clinical and laboratory data of patients were collected from patients' medical files, and they included indications for FMT, risk factors for CDI and disease severity. Primary outcome was FMT success(at least 2 mo free of CDI-related diarrhea post-FMT). Secondary outcomes included initial response to FMT(cessation of diarrhea within 7 d) and recurrence at 6 *** There were 111 FMTs for CDI, with a median age of 70 years [interquartile range(IQR): 53-82], and 42%(47) males. Fifty patients(45%) were treated via the lower gastrointestinal(LGI, represented only by colonoscopy) route, 37(33%) via capsules, and 24(22%) via the upper gastrointestinal(UGI) route. The overall success rate was 87.4%(97 patients), with no significant difference between routes of administration(P = 0.338). In the univariant analysis, FMT success correlated with milder disease(P = 0.01), ambulatory setting(P < 0.05) and lower Charlson comorbidity score(P < 0.05). In the multivariant analysis, only severe CDI [odd ratio(OR) = 0.14, P < 0.05] and inpatient FMT(OR = 0.19, P < 0.05) were each independently inversely related to FMT success. There were 35(32%) patients younger than 60 years of age, and 14(40%) of them had a background of inflammatory bowel *** FMT is a safe and effective treatment for CDI, with capsules emerging as a successful and well-tolerated route. Severe CDI is less likely to respond to FMT.

关键词： Clostridium difficile infection Capsules Israel Fecal microbiota transplantation

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红字 5

16 YEARS IN THE MINES

丛书名：书虫·牛津英汉双语读物

2014年

作者： (美)nathaniel Hawthorne

本书讲述的是一出发生在北美殖民时期的恋爱悲剧。通过女人公海丝特·白兰的悲惨遭遇，反映了清教徒殖民统治的黑暗、残酷和教会的虚伪、凶恶。

ISBN: (纸本)9787513544726;9787894205636

本书讲述的是一出发生在北美殖民时期的恋爱悲剧。通过女人公海丝特·白兰的悲惨遭遇，反映了清教徒殖民统治的黑暗、残酷和教会的虚伪、凶恶。

关键词：长篇小说英语汉语

来源：畅想之星图书光盘版（南... 评论

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The World of Chinese 2021年第6期 50-58页

作者：陈年喜 nathaniel J.GAN

My name is Chen Nianxi,and Fm from Danfeng county,Shaanxi province.I worked 16 years as a blaster in the mines,and I’ve been a writer for almost 20 years as *** life has been like the wind and rain,always in flux.

关键词： has always province.

Systematic review and meta-analysis of esophageal cancer in Africa:Epidemiology, risk factors, management and outcomes

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World Journal of Gastroenterology 2019年第31期25卷 4512-4533页

作者： Akwi W Asombang nathaniel Chishinga Alick Nkhoma Jackson Chipaila Bright Nsokolo Martha Manda-Mapalo Joao Filipe G Montiero Lewis Banda Kulwinder S Dua Division of Gastroenterology/Hepatology Warren Alpert Medical School of Brown UniversityProvidenceRI 02903United States Department for HIV Elimination Fulton County GovernmentAtlantaGA 30303United States Department of Gastroenterology Royal Stoke University HospitalUniversity Hospitals of North Midlands NHS TrustStaffordshire ST4 6QGUnited Kingdom Department of Surgery University Teaching Hospital-Adult HospitalLusaka 10101Zambia Department of Medicine Levy Mwanawasa University Teaching HospitalTropical Gastroenterology and Nutrition Group(TROPGAN)Lusaka 10101Zambia Department of Medicine The University of New MexicoAlbuquerqueNM 87106United States Department of Medicine Brown UniversityProvidenceRI 02903United States Hematology/Oncology Cancer Disease HospitalLusaka 10101Zambia Department of Medicine and Pediatrics Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Esophageal cancer(EC)is associated with a poor prognosis,particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this *** To provide further understanding of EC in the context of the unique cultural and genetic diversity,and socio-economic challenges faced on the African *** We performed a systematic review of studies from Africa to obtain data on epidemiology,risk factors,management and outcomes of EC.A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer,and the Cancer in Sub-Saharan *** searched EMBASE,PubMed,Web of Science,and Cochrane Central from inception to March 2019 and reviewed the list of articles *** effects metaanalyses were used to assess heterogeneity between studies and to obtain odds ratio(OR)of the associations between EC and risk factors;and incidence rate ratios for EC between sexes with their respective 95%confidence intervals(CI).RESULTS The incidence of EC is higher in males than females,except in North Africa where it is similar for both *** highest age-standardized rate is from Malawi(30.3 and 19.4 cases/year/100000 population for males and females,respectively)followed by Kenya(28.7 cases/year/100000 population for both sexes).The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years ***-analysis shows a strong association with tobacco(OR 3.15,95%CI:2.83-3.50).There was significant heterogeneity between studies on alcohol consumption(OR 2.28,95%CI:1.94-2.65)and on low socioeconomic status(OR 139,95%CI:1.25-1.54)as risk factors,but these could also contribute to increasing the incidence of *** best treatment outcomes were with esophagectomy with survival rates of 76.6%at 3 years,and chemo-radiotherapy with an overall combined survival time of 267.50 *** Africa has high incidence and mortality rates of EC,with preventable and nonmodifiable ris

关键词： Esophageal cancer in Africa Esophageal squamous cell carcinoma Cancer in Africa Systematic review