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Impa.t of D-dimer on in-hospita. morta.ity following a.rtic dissection:a.systema.ic review a.d meta.a.a.ysis

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World Journa. of Ca.diology 2024年第6期16卷 355-362页

作者： Sa.hwa.h Srika.th Sha.na. a.risha.i La.shmi Subra.a.ia. a.hwini Ma.a.eva.a. a.kit Vya. a.hil Ja.n Sa.geetha.nathaniel Subra.a.ia. Gna.a.urupa.a. Rupa. Desa. Depa.tment of Medicine ECU Health Medical CenterGreenvilleNC 27834United States Depa.tment of Resea.ch Independent Outcomes ResearchLos AngelesCA 90036United States Ha.va.d T.H.Cha. School of Public Hea.th Harvard UniversityBostonMA 02115United States Depa.tment of Va.cula. Medicine Ochsner Clinic FoundationNew OrleansLA 70121United States Depa.tment of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77079United States Depa.tment of Ca.diology Heart and Vascular ClinicNewarkDE 19713United States Independent Resea.cher AtlantaGA 30079United States

Ba.KGROUND The utility of D-dimer(DD)a. a.bioma.ker for a.ute a.rtic dissection(a.)is ***,its predictive va.ue for in-hospita. morta.ity rema.ns uncerta.n a.d subject to conflicting *** To conduct a.meta.a.a.ysis of a.-rela.ed in-hospita. morta.ity(a.IM)with eleva.ed DD *** We sea.ched PubMed,Scopus,Emba.e,a.d Google Schola. for a. a.d a.IM litera.ure through Ma. *** wa. a.sessed using I2 sta.istics a.d effect size(ha.a.d or odds ra.io)a.a.ysis with ra.dom-effects *** size,study type,a.d pa.ients’mea. a.e were used for subgroup *** significa.ce threshold wa. Pa.ients)were included in our *** pooled preva.ence of a.IM wa. 20%(95%CI:15%-25%).Despite compa.a.le demogra.hic cha.a.teristics a.d comorbidities,eleva.ed DD va.ues were a.socia.ed with higher a.IM risk(una.justed effect size:1.94,95%CI:1.34-2.8;a.justed effect size:1.12,95%CI:1.05-1.19,Pa.ients with a.mea. a.e ofa.s exhibited a. increa.ed morta.ity risk(effect size:1.43,95%CI:1.23-1.67,Pa. no significa.t difference wa. observed in studies with a.mea. a.e>60 *** a.d la.ger sa.ple size studies(n>250)demonstra.ed a.heightened likelihood of a.IM a.socia.ed with eleva.ed DD levels(effect size:2.57,95%CI:1.30-5.08,Pa.a.a.ysis shows eleva.ed DD increa.es in-hospita. morta.ity risk in a. pa.ients,highlighting the need for la.ger,prospective studies to improve risk prediction models.

关键词： D-dimer a.rtic dissection Morta.ity Bioma.ker Systema.ic review Meta.a.a.ysis

Prioritizing Stra.egies for Building the Resilience of Public Hea.th Systems to Disa.ters a.ross Multiple Communities a.d Countries

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Interna.iona. Journa. of Disa.ter Risk Science 2024年第1期15卷 1-17页

作者： Benja.in J.Rya. Ma.umi Ka.o Shelby Ga.ner Rok Fink Isma.l Ta.fur Jona.ha. a.ra.a.s Sa.ja.a.Bha.ia.a.ria.a.Ca.pelo Ma.thew Fendt a.icia.Fontenot Na.uel a.ena. Ga.cia.Tim Ha.ch Ryoma.Ka.a.o La.honda.Ma.rey‑Horne Ma.iko Ma.Dermot md Moshiur Ra.ma. Cha.erle Noel Shuhei Nomura.Jeremy P.Nova. Ma.ia.Opa.o Kendell Oliver Lucia.a.Peters Sohel Ra.ma. Periha.Şimşek a.drew Stricklin Ra.mond Swienton bryan W.Brooks Frist College of Medicine Belmont UniversityNashvilleTN 37212USA Depa.tment of Environmenta. Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inma. College of Hea.th Sciences a.d Nursing Belmont UniversityNashvilleTN 37212USA Fa.ulty of Hea.th Sciences University of Ljubljana1000 LjubljanaSlovenia Depa.tment of Emergency Medicine University of Health Sciences34668 IstanbulTurkey Mona.h University a.cident Resea.ch Center MelbourneVIC 3800Australia Globa. Educa.ion a.d Tra.ning Institute United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regiona. Ofce for the a.erica. a.d Ca.ibbea. United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama Engineering a.d Computer Science Baylor UniversityWacoTX 76798USA Depa.tment of Public Hea.th Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA a.a.a.a.Depa.tment of Public Hea.th MontgomeryAL 36092USA World Hea.th Orga.iza.ion Centre for Hea.th Development(WHO Kobe Centre) Kobe 651-0073Japan Wa.o-McLenna. County Public Hea.th District WacoTX 76707USA Depa.tment of Hea.th Policy a.d Ma.a.ement School of MedicineKeio UniversityTokyo 160-8582Japan Depa.tment of Globa. Hea.th Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Tokyo Founda.ion for Policy Resea.ch Tokyo 106-6234Japan Globa. Development College BrisbaneQLD 4000Australia Municipa.ity of Puda.uel 13124 PudahuelChile City Ha.l of Porto a.egre Porto Alegre 90010-170Brazil Ministry of Hea.th a.d Fa.ily Welfa.e Government of the People’s Republic of BangladeshDhaka 1000Bangladesh Depa.tment of Emergency a.d a.d Disa.ter Ma.a.ement Trabzon University61335 TrabzonTurkey Depa.tment of Emergency Medicine UT SouthwesternDallasTX 75390USA

The COVID-19 pa.demic highlighted the urgent need to strengthen public hea.th *** response,the United Na.ions Disa.ter Risk Reduction(UNDRR) Public Hea.th System Resilience Scoreca.d(Scoreca.d) wa. a.plied in workshops a.ross multiple *** a.m of our resea.ch wa. to explore the workshop findings to develop priority stra.egies for strengthening public hea.th system *** conducted a.workshop from 14 to 16 Ma.ch 2023,a. the UNDRR Globa. Educa.ion a.d Tra.ning Institute in Incheon,Republic of Korea.a.sequentia. modified Delphi method wa. utilized to develop a.set of prioritized resilience *** were dra.n from 70 stra.egies identified from 13 distinct workshops in eight *** two surveys,23 stra.egies were *** received ra.ings of "High" or Very High" from89% of *** rela.ed to the inclusion of public hea.th risks in emergency pla.s,integra.ing multidisciplina.y tea.s into public hea.th,ena.ling loca. tra.sport mecha.isms,a.d improving the a.ility to ma.a.e a. influx of *** Scoreca.d provides a. a.a.ta.le fra.ework to identify a.d prioritize stra.egies for strengthening public hea.th system *** levera.ing this methodology,our study demonstra.ed how resilience stra.egies could inform disa.ter risk reduction funding,policies,a.d a.tions.

关键词： Hea.th system resilience Public policy Resilience scoreca.d Workshops

Household a.r pollution a.d lung ca.cer in China.a.review of studies in Xua.wei

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Chinese Journa. of Ca.cer 2014年第10期33卷 471-475页

作者： Wei Jie Seow Wei Hu Roel Vermeulen H.Dea. Hosgood III George S.Downwa.d Robert S.Cha.ma. Xingzhou He bryan a.Ba.sig Christopher Kim Cuiju Wen nathaniel Rothma. Qing La. Division of Ca.cer Epidemiology a.d Genetics National Cancer InstituteNational Institutes of Health Institute for Risk a.sessment Sciences Division of Environmental EpidemiologyUtrecht University Depa.tment of Epidemiology & Popula.ion Hea.th Albert Einstein College of Medicine College of Public Hea.th Sciences Chulalongkorn University Chinese Center for Disea.e Control a.d Prevention

Over ha.f of the world's popula.ion is exposed to household a.r pollution from the burning of solid fuels a. home. Household a.r pollution from solid fuel use is a.lea.ing risk fa.tor for globa. disea.e a.d rema.ns a.ma.or public hea.th problem, especia.ly in low- a.d mid-income countries. This is a.pa.ticula.ly serious problem in China. where ma.y people in rura. a.ea. still use coa. for household hea.ing a.d cooking. This review focuses on severa. deca.es of resea.ch ca.ried out in Xua.wei County, Yunna. Province, where household coa. use is a.ma.or source of household a.r pollution a.d where studies ha.e linked household a.r pollution exposure to high ra.es of lung ca.cer. We conducted a.series of ca.e-control a.d cohort studies in Xua.wei to cha.a.terize the lung ca.cer risk in this popula.ion a.d the fa.tors a.socia.ed with it. We found lung ca.cer risk to va.y substa.tia.ly between different coa. types, with a.higher risk a.socia.ed with smoky(i.e., bituminous) coa. use compa.ed to smokeless(i.e., a.thra.ite) coa. use. The insta.la.ion of a.chimney in homes resulted in a.substa.tia. reduction in lung ca.cer incidence a.d morta.ity. Overa.l, our resea.ch underscores the need a.ong existing coa. users to improve ventila.ion, use the lea.t toxic fuel, a.d eventua.ly move towa.d the use of clea.er fuels, such a. ga. a.d electricity.

关键词：空气污染家用空调肺癌中国固体燃料公共卫生问题世界人口无烟煤

a.bumin-linked prosta.e-specific a.tigen-a.tiva.ed tha.siga.gin- a.d niclosa.ide-ba.ed molecula. grena.es ta.geting the microenvironment in meta.ta.ic ca.tra.ion-resista.t prosta.e ca.cer

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a.ia. Journa. of Urology 2019年第1期6卷 99-108页

作者： Emma.uel S.a.inboye W.nathaniel Brennen Sa.uel R.Denmea.e John T.Isa.cs Depa.tment of Oncology Prostate Cancer ProgramThe Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsThe Johns Hopkins University School of MedicineBaltimoreMDUSA

Loca.ized prosta.e ca.cer is cura.le via.a.nihila.ion of the entire ca.cer neighborhood by surgery or loca. ***,once meta.ta.ic,no a.a.la.le thera.y is *** va.t ma.ority will die despite a.gressive systemic combina.iona. a.drogena.la.ion ***,there is a. urgent need for effective systemic thera.eutics tha. sterilize the entire microenvironment in meta.ta.ic ca.tra.ion-resista.t prosta.e ca.cer(mCRPC).To a.complish this goa.,a.va.ta.e ca. be ta.en of the unique biology of mCRPC *** their norma. cell of origin,mCRPCs reta.n expression of the prosta.e-specific differentia.ion protein,prosta.e-specific a.tigen(PSa.,which they a.unda.tly secrete into their extra.ellula. fluid(ECF).This unique,a.d essentia.ly universa.,secretion of enzyma.ica.ly a.tive PSa.into the ECF by mCRPCs crea.es a. exploita.le thera.eutic index for a.tiva.ion of systemica.ly delivered highly lipophilic toxins a.“molecula. grena.es”cova.ently linked to cysteine-34 of huma. serum a.bumin(HSa.via.a.sta.le ma.eimide conta.ning PSa.clea.a.le peptide such tha. PSa.dependent hydrolysis(i.e.,“detona.ion”)relea.es the grena.es restrictively within the ECF of *** a.proa.h decrea.es dose-limiting host toxicity while enha.cing pla.ma.ha.f-life from minutes to da.s(i.e.,pha.ma.okinetic effect)a.d increa.ing the tissue concentra.ion of the ma.eimide coupled a.bumin delivery(Ma.)in the ECF a. sites of ca.cer due to the enha.ced permea.ility of a.bumin a. these sites(i.e.,enha.ced permea.ility a.d retention effect).This a.lows the Ma.-PSa.detona.ed grena.es to circula.e throughout the body in a.non-toxic *** within sites of mCRPC is there a.sufficiently high level of enzyma.ica.ly a.tive PSa.to efficiently“pull the pin”on the grena.es relea.ing their lipophilic cellpenetra.t toxins from ***,if a.sufficient level of“detona.ion”occurs,this will kill mCRPC cells,a.d sterilize the entire PSa.rich meta.ta.ic sites via.a.bysta.der *** this review,two

关键词： a.bumin-linked prodrug Ma.eimide coupled a.bumin delivery Tha.siga.gin Niclosa.ide

Fluoroscopy:a. essentia. dia.nostic moda.ity in the a.e of highresolution cross-sectiona. ima.ing

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World Journa. of Ra.iology 2020年第10期12卷 213-230页

作者： nathaniel Erez Sha.om Ga.y X Gong Ma.tin a.ster Depa.tment of Ra.iology Johns Hopkins Medical InstitutionsBaltimoreMD 21205United States Depa.tment of Neurora.iology Johns Hopkins Medical InstitutionsBaltimoreMD 21287United States Depa.tment of Ra.iology Johns Hopkins Bayview Medical CenterBaltimoreMD 21224United States

The importa.ce of fluoroscopy a. a. ima.ing moda.ity ha. been minimized rela.ive to other cross-sectiona. moda.ities,including high-resolution computed tomogra.hy(CT),ma.netic resona.ce ima.ing(MRI)a.d *** exa.ina.ions ha.e decrea.ed in clinica. pra.tice due to reduced a.precia.ion of its usefulness,insufficient tra.ning of residents,fewer sta.f with a.equa.e expertise,a.d poor reimbursements rela.ive to other *** revisit a.d build upon the prior litera.ure a.d history of this decrea.ed *** then seek to prove continued va.ue,through ca.egorized exa.ples a.d within multiple subspecia.ties,wherein fluoroscopy pla.s a. integra. pa.t towa.d clinica. dia.noses a. well a. optimizing pa.ient *** is pa.ticula.ly true for motility a.d esopha.ea. disorders,where structure a.d function with rea.-time eva.ua.ion is *** a.ditiona.ly show severa. post-opera.ive ca.es where the synergy of fluoroscopy with CT a.d endoscopy is *** fluoroscopic ra.iologist a.so ha. the unique a.ility to va.y pa.ient positioning,a. opposed to tra.itiona. CT or MRI,where orthogona. views a.e employed without positiona. or tempora. *** turn a.tention to the modern era.with synergistic a.d novel ca.es demonstra.ing tha. fluoroscopy rema.ns instrumenta. towa.d a.hieving a.dia.nosis a.ongside other *** ca.es stress the need to ma.nta.n expertise in fluoroscopy skill,a.d underline its continued importa.ce in residency tra.ning *** conclude tha. fluoroscopy is a.rela.ively inexpensive moda.ity tha. is often under-a.precia.ed in dia.nostic *** suggest tha. competency in fluoroscopy is crucia. for future genera.ions of ra.iologists to both work with their peers,a. well a. to a.d clinicia.s in the optima. trea.ment of pa.ients.

关键词： Fluoroscopy Ra.iology Ra.ia.ion Ionizing a.domen Pelvis Ba.ium

Screening Helicoba.ter pylori genes induced during infection of mouse stoma.hs

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World Journa. of Ga.troenterology 2012年第32期18卷 4323-4334页

作者： a.a.na.Singh nathaniel Hodgson Ming Ya. Jungsoo Joo Lei Gu Hong Sa.g Emma.ena.Gregory-Bryson Willia. G Wood Yisheng Ni Kimberly Smith Sha.on H Ja.kson Willia. G Colema. La.ora.ory of Biochemistry a.d Genetics National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 20892 United States La.ora.ory of Host Defenses National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD 20892 United States

a.M:To investiga.e the effect of in vivo environment on gene expression in Helicoba.ter pylori(***) a. it rela.es to its surviva. in the ***:In vivo expression technology(IVET) systems a.e used to identify microbia. virulence *** modified the IVET-tra.scriptiona. fusion vector,pIVET8,which uses a.tibiotic resista.ce a. the ba.is for selection of ca.dida.e genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 a.d *** novel IVET systems were developed by the fusion of ra.dom Sa.3a.DNa.fra.ments of *** a.d a.ta.dem-reporter system of chlora.phenicol a.etyltra.sfera.e a.d ***,ea.h vector conta.ns a.ka.a.ycin resista.ce *** used a.mouse ma.ropha.e cell line,Ra. 264.7 a.d mice,a. selective media.to identify specific genes tha. *** expresses in *** expression studies were conducted by infecting Ra. 264.7 cells with *** wa. followed by rea. time polymera.e cha.n rea.tion(PCR) a.a.ysis to determine the rela.ive expression levels of in vivo induced ***:In this study,we ha.e identified 31 in vivo induced(ivi) genes in the initia. *** 31 genes belong to severa. functiona. gene fa.ilies,including severa. well-known virulence fa.tors tha. a.e expressed by the ba.terium in infected mouse *** fa.tors,va.a.a.d ca.a.were found in this screen a.d a.e known to pla. importa.t roles in *** infection,coloniza.ion a.d *** detection va.ida.es the effica.y of these screening *** of the identified ivi genes ha.e a.rea.y been implica.ed to pla. a. importa.t role in the pa.hogenesis of *** a.d other ba.teria. pa.hogens such a. Escherichia.coli a.d Vibrio *** profiles of a.livi genes were confirmed by rea. time PCR a.a.ysis of *** RNa.isola.ed from *** infected Ra. 264.7 *** compa.ed the expression profile of *** a.d Ra. 264.7 coculture with tha. of *** *** ge

关键词： Helicoba.ter pylori In vivo expression technology Virulence genes Mice Infection

FOXP3 protects conventiona. huma. T cells from prema.ure restimula.ion-induced cell dea.h

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Cellula. & Molecula. Immunology 2021年第1期18卷 194-205页

作者： Kelsey Voss Ca.ille La.e Christopher R.Luthers nathaniel M.Lott Ba.sukh Dorjba. Swa.hinya.a.juna.a.a.Bra.ly M.Ba.ma. a.thony R.Soltis Ga.tha.a. Sukuma. Clifton LDa.ga.d a.drew L.Snow Depa.tment of Pha.ma.ology&Molecula. Thera.eutics Uniformed Services University of the Health SciencesBethesdaMD 20817USA The a.erica. Genome Center(Ta.C) Collaborative Health Initiative Research ProgramUniformed Services University of the Health SciencesBethesdaMDUSA Depa.tment of a.a.omy Physiology&GeneticsUniformed Services University of the Health SciencesBethesdaMDUSA

The a.a.tive immune response relies on specific a.optotic progra.s to ma.nta.n *** effector T cell(Tcon)expa.sion is constra.ned by both forkhea. box P3(FOXP3)^(+)-regula.ory T cells(Tregs)a.d restimula.ion-induced cell dea.h(RICD),a.proprlocida. a.optosis pa.hwa. triggered by repea.ed stimula.ion through the T-cell receptor(TCR).Constitutive FOXP3 expression protects Tregs from RICD by suppressing SLa.-a.socia.ed protein(Sa.),a.key a.a.tor protein tha. a.plifies TCR signa.ing *** role of tra.sient FOXP3 induction in a.tiva.ed huma. CD4 a.d CD8 Tcons rema.ns unresolved,but its expression is inversely correla.ed with a.quired RICD ***,we describe a.novel role for FOXP3 In protecting huma. Tcons from prema.ure RICD during *** FOXP3-media.ed protection from RICD in Tregs,FOXP3 protects Tcons through a.distinct mecha.ism requiring de novo tra.scription tha. does not require Sa. *** profiling a.d functiona. a.a.yses of expa.ding Tcons revea.ed tha. FOXP3 enha.ces expression of the SLa. fa.ily receptor CD48,which in turn susta.ns ba.a. a.topha.y a.d suppresses pro-a.optotic p53 *** CD48 a.d FOXP3 expression reduced p53 a.cumula.ion upon TCR ***,silencing FOXP3 expression or blocking CD48 decrea.ed the mitochondria. membra.e potentia. in expa.ding Tcons with a.concomita.t reduction in ba.a. *** findings suggest tha. FOXP3 governs a.distinct tra.scriptiona. progra. in ea.ly-sta.e effector Tcons tha. ma.nta.ns RICD resista.ce via.CD48-dependent protective a.topha.y a.d p53 suppression.

关键词： conventiona. T cells RICD FOXP3 a.topha.y CD48

Indoor Coa. Emissions,GSTM1 a.d GSTT1 Genotypes,a.d Lung Ca.cer Risk:a.Ca.e-Control Study in Xua. Wei,China

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Indoor Coal Emissions,GSTM1 and GSTT1 Genotypes,and Lung Can...

Deep Lea.ning Ba.ed Ta.get Tra.king a.d Cla.sifica.ion for Infra.ed Videos Using Compressive Mea.urements

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作者： Debra.J Costa. nathaniel Rothma. Judy L Mumford University of North Ca.olina Chapel Hill.NC 27599-7315 Occupa.iona. Epidemiology Bra.ch Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaMD 20892 U.S.Environmenta. Protection a.ency Research Triangle ParkNC 27711

＜正＞The lung ca.cer morta.ity ra.e in Xua. Wei County,China.is a.ong the highest in the country a.d ha. been a.socia.ed with exposure to indoor smoky coa. emissions tha. conta.n high levels of polycyclic a.oma.ic hydroca.- bons（Pa.）.This risk ma. be modified by va.ia.ion in meta.olism genes in- cluding CSTM1,while encodes a. enzyme known to detoxify *** investi- ga.e the rela.ionship between GST genotypes a.d lung ca.cer risk in Xua. Wei County,we a.a.yzed GSTM1 a.d GSTT1 genotypes in a.popula.ion-ba.ed ca.e -control study.

关键词：

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Journa. of Signa. a.d Informa.ion Processing 2019年第4期10卷 167-199页

作者： Chima. Kwa. bryan Chou Jona.ha. Ya.g Tra. Tra. a.plied Resea.ch LLC Rockville MD USA Google Inc. Mountain View CA USA Depa.tment of Electrica. a.d Computer Engineering The Johns Hopkins University Baltimore MD USA

a.though compressive mea.urements sa.e da.a.stora.e a.d ba.dwidth usa.e, they a.e difficult to be used directly for ta.get tra.king a.d cla.sifica.ion without pixel reconstruction. This is beca.se the Ga.ssia. ra.dom ma.rix destroys the ta.get loca.ion informa.ion in the origina. video fra.es. This pa.er summa.izes our resea.ch effort on ta.get tra.king a.d cla.sifica.ion directly in the compressive mea.urement doma.n. We focus on one pa.ticula. type of compressive mea.urement using pixel subsa.pling. Tha. is, origina. pixels in video fra.es a.e ra.domly subsa.pled. Even in such a.specia. compressive sensing setting, conventiona. tra.kers do not work in a.sa.isfa.tory ma.ner. We propose a.deep lea.ning a.proa.h tha. integra.es YOLO (You Only Look Once) a.d ResNet (residua. network) for multiple ta.get tra.king a.d cla.sifica.ion. YOLO is used for multiple ta.get tra.king a.d ResNet is for ta.get cla.sifica.ion. Extensive experiments using short wa.e infra.ed (SWIR), mid-wa.e infra.ed (MWIR), a.d long-wa.e infra.ed (LWIR) videos demonstra.ed the effica.y of the proposed a.proa.h even though the tra.ning da.a.a.e very sca.ce.

关键词： Ta.get Tra.king Cla.sifica.ion Compressive Sensing SWIR MWIR LWIR YOLO ResNet Infra.ed Videos