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Mastabol induced acute cholestasis: A case report

World Journal of Hepatology 2013年第3期5卷 133-136页

作者： Brett M Hymel David W Victor luis Alvarez nathan J Shores luis A Balart Department of Gastroenterology Louisiana State University School of Medicine Department of Gastroenterology and Hepatology Tulane University School of Medicine

A 26-year-old male presented with three weeks of jaundice after the self-initiation of the injectable anabolic steroid, Mastabol [Dromastanolone Di-Propionate (17 beta-Hydroxy-2alpha-methyl-5alpha-androstan-3one propionate)]. He reported dark urine, light stools, and pruritus. He denied abdominal pain, intravenous drug use, intranasal cocaine, blood transfusions, newly placed tattoos, or sexually transmitted diseases. He used alcohol sparingly. Physical exam revealed jaundice with deep scleral icterus. The liver was palpable 2 cm below the right costal margin with no ascites. The peak bilirubin was 23.6 mg/dl, alkaline phosphatase was 441 units/l, and aspartate aminotransferase/alanine aminotransferase were 70 units/l and 117 units/l respectively. A working diagnosis of acute intrahepatic cholestasis was made. liver biopsy revealed a centrilobular insult with neutrophilic infiltrates and Ito cell hyperplasia consistent with acute drug induced cholestasis. The patient' s clinical symptoms resolved and his liver enzymes, bilirubin, and alkaline phosphatase normalized. Anabolic steroids with 17 alpha carbon substitutions have been associated with a bland variety of cholestatic injury with little hepatocellular injury. Cholestasis, under these circumstances, may be secondary to the binding of drugs to canalicular membrane transporters, accumulation of toxic bile acids from canalicular pump failure, or genetic defects in canalicular transport proteins. Mastabol is an injectable, 17 beta hydroxyl compound with no alpha alkyl groups at the 17 carbon position. As such, it has been reported to have little potential toxic effects on the liver. This is the first known reported case of Mastabolinduced cholestatic liver injury. It highlights the need for physicians to consider such widely available substances when faced with hepatic injury of unclear etiology.

关键词： Cholestatic Mastabol Hepatic Anabolic Steroids

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临床实践指南应当包含治疗负担

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中国医院院长 2019年第3期15卷 22-22,24,26页

作者： Claudia C Dobler nathan Harb Catherine A Maguire Carol l Armour Courtney Coleman M Hassan Murad 邓璇(翻译) 莫云凌(校) Evidence Based Practice Center Robert D and Patricia E Kern Center for the Science of Health Care Delivery Mayo Clinic Rochester MN USA Woolcock Institute of Medical Research University of Sydney Sydney NSW Australia South Western Sydney Clinical School University of New South Wales NSW Sydney Australia

Claudia Dobler和同事们认为,指南中明确增加有关治疗负担的内容能够改善治疗决策。医疗方案的实施需要花费大量时间和精力,给慢性病患者带来巨大负担。然而,临床实践指南高度重视的是得到某些临床结果(如呼吸急促减少或存活率增加),传... 详细信息

Claudia Dobler和同事们认为,指南中明确增加有关治疗负担的内容能够改善治疗决策。医疗方案的实施需要花费大量时间和精力,给慢性病患者带来巨大负担。然而,临床实践指南高度重视的是得到某些临床结果(如呼吸急促减少或存活率增加),传统指南的建议也是从同样角度提出的。最近的指南会考虑患者的价值观以及指南建议行为的可接受性和可行性,但对治疗负担没有明确规定。这使患者很难根据自己的价值观和能力对治疗作出明智的决定。

关键词：临床实践指南慢性阻塞性肺疾病肺康复急性加重治疗建议慢性病患者工作量

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Evaluation of fermentation conditions triggering increased antibacterial activity from a near-shore marine intertidal environment-associated Streptomyces species

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Synthetic and Systems Biotechnology 2017年第1期2卷 28-38页

作者： A.l.English A.Boufridi R.J.Quinn D.I.Kurtboke Genecology Research Centre and Faculty of Science HealthEducation and EngineeringUniversity of the Sunshine CoastMaroochydore DCQLD4558Australia Eskitis Institute for Drug Discovery Griffith UniversityNathanQLD4111Australia

A near-shore marine intertidal environment-associated Streptomyces isolate(USC-633)from the Sunshine Coast Region of Queensland,Australia,cultivated under a range of chemically defined and complex media to determine optimal parameters resulting in the secretion of diverse array of secondary metabolites with antimicrobial properties against various antibiotic resistant *** extraction,fractioning and re-testing of active metabolites resulted in persistent antibacterial activity against Escherichia coli(Migula)(ATCC 13706)and subsequent Nuclear Magnetic Resonance(NMR)analysis of the active fractions confirmed the induction of metabolites different than the ones in fractions which did not display activity against the same bacterial *** findings again confirmed the value of One StraineMany Compounds(OSMAC)approach that tests a wide range of growth parameters to trigger bioactive compound secretion increasing the likelihood of finding novel therapeutic *** isolate was found to be adaptable to both marine and terrestrial conditions corresponding to its original nearshore marine intertidal *** variations in its morphology,sporulation and diffusible pigment production were observed when different growth media were used.

关键词： Marine streptomycetes Marine biodiscovery Fermentation media Antibiotics Marine natural products Pigments

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A Comprehensive Transcriptome Assembly of Pigeonpea （Cajanus cajan l.） using Sanger and Second-Generation Sequencing Platforms

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Molecular Plant 2012年第5期5卷 1020-1028页

作者： Himabindu Kudapa Arvind K. Bharti Steven B. Cannon Andrew D. Farmer Benjamin Mulaosmanovi Robin Kramer Abhishek Bohra nathan T. Weeks John A. Crow Reetu Tuteja Trushar Shah Sutapa Dutta Deepak K. Gupta Archana Singh Kishor Gaikwad Tilak R. Sharma Gregory D. May Nagendra K. Singh Rajeev K. Varshney International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Patancheru 502324 india National Center for Genome Resources (NCGR) Santa Fe NM 87505 USA United States Department of Agriculture-Agricultural Research Service (USDA-ARS) Corn Insects and Crop Genetics Research Unit Ames IA USA National Research Centre on Plant Biotechnology (NRCPB) Indian Agricultural Research Institute New Delhi 110 012 India Department of Agronomy Iowa State University Amens IA USA CGIAR Generation Challenge Programme (GCP) c/o ClMMYT 06600 Mexico DF Mexico

A comprehensive transcriptome assembly for pigeonpea has been developed by analyzing 128.9 million short Illumina GA IIx single end reads, 2.19 million single end FlX/454 reads, and 18 353 Sanger expressed sequenced tags from more than 16 genotypes. The resultant transcriptome assembly, referred to as CcTA v2, comprised 21 434 transcript as- sembly contigs （TACs） with an N50 of 1510 bp, the largest one being -8 kb. Of the 21 434 TACs, 16 622 （77.5%） could be mapped on to the soybean genome build 1.0.9 under fairly stringent alignment parameters. Based on knowledge of intron junctions, 10 009 primer pairs were designed from 5033 TACs for amplifying intron spanning regions （ISRs）. By using in silico mapping of BAC-end-derived SSR loci of pigeonpea on the soybean genome as a reference, putative mapping posi- tions at the chromosome level were predicted for 6284 ISR markers, covering all 11 pigeonpea chromosomes. A subset of 128 ISR markers were analyzed on a set of eight genotypes. While 116 markers were validated, 70 markers showed one to three alleles, with an average of 0.16 polymorphism information content （PIC） value. In summary, the CcTA v2 transcript assembly and ISR markers will serve as a useful resource to accelerate genetic research and breeding applications in pigeonpea.

关键词： Cajanus cajan (l.) second-generation sequencing transcriptome assembly intron spanning region (ISR)markers.

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风生紊流导致微囊藻群体破碎和形态变化

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湖泊科学 2021年第2期33卷 349-365页

作者：朱伟陈怀民肖曼 lürling Miquel 李明河海大学环境学院浅水湖泊综合治理与资源开发教育部重点实验室南京210098 格里菲斯大学澳大利亚河流研究所澳大利亚昆士兰州4111 瓦格宁根大学环境科学系水生态及水质管理组荷兰瓦格宁根6700AA 西北农林科技大学资源环境学院杨凌712100

微囊藻群体大小和形态决定其垂向迁移能力,从而影响着水华的形成.为了探讨湖泊中风生紊流对微囊藻群体大小和形态的影响,本研究于2012年8月26日至9月7日在太湖梅梁湾的围隔内进行了12 d的昼夜不间断的高频采样(采样间隔每2小时一次).研... 详细信息

微囊藻群体大小和形态决定其垂向迁移能力,从而影响着水华的形成.为了探讨湖泊中风生紊流对微囊藻群体大小和形态的影响,本研究于2012年8月26日至9月7日在太湖梅梁湾的围隔内进行了12 d的昼夜不间断的高频采样(采样间隔每2小时一次).研究期间,水面微囊藻密度呈现4次周期性消涨,藻密度变化范围为4×10^(4)~2671×10^(4)cells/m l.而整个水柱中的藻密度变化范围仅为3×10^(4)~18×10^(4)cells/m l.皮尔逊相关性分析表明微囊藻的原位生长速率与表面藻密度呈负相关而与风速呈正相关.强风速使微囊藻在水柱中均匀分散,增强了透光性,促进了微囊藻的生长.微囊藻群体粒径随着风速的增大逐渐减小,反之亦然.其中值粒径(D50)变化范围为66.2~768.0μm.在此期间微囊藻群体形态主要以鱼害微囊藻、不规则的惠氏微囊藻、球状的惠氏微囊藻和铜绿微囊藻群体形态为主,其占比也呈现出波动状态.皮尔逊相关分析结果显示微囊藻群体大小与风速呈负相关,说明湖泊中风生紊流会影响微囊藻群体大小.当紊流强度为2.33×10^(-5)m^(2)/s3时,微囊藻群体会发生破碎现象,该紊流强度相当于5 m/s的风在30 m深的水库或湖泊中所产生的紊流强度.微囊藻群体被风生紊流破碎后最大粒径与该风速下紊流的最小涡旋尺度相近,表明紊流的最小涡旋尺度决定了微囊藻所能形成群体的最终大小.监测期间,整水柱中不同群体形态的微囊藻占比发生了明显变化,在监测初期以鱼害微囊藻群体形态为主,随后不规则的惠氏微囊藻和铜绿微囊藻群体形态的比例不断增加,最后鱼害微囊藻群体形态又占据主导地位.球状的惠氏微囊藻群体形态在整个监测期中的比例随时间的增加而逐渐降低.不同群体形态微囊藻之间比例的大幅变化无法用微囊藻生长演替来解释.而皮尔逊相关分析结果显示鱼害微囊藻与惠氏微囊藻(不规则的和球状的惠氏微囊藻之和)群体形态之间存在负相关,且惠氏微囊藻与铜绿微囊藻群体形态呈负相关.但在今后研究中需进一步关注在微囊藻群体形态的动态变化过程中细胞大小、胶被、产毒特性和基因序列等特征,从而验证不同种微囊藻群体是否存在形态转换这一猜想.总而言之,普通强度的风生紊流能够破碎微囊藻群体,而气候变化导致的内陆湖泊周边风速下降会促使微囊藻形成更大的群体,从而有利于水华的形成.

关键词：微囊藻水华紊流群体粒径形态太湖

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Distribution of Plasmodium *** in asymptomatic carriers in perennial and low seasonal malaria transmission settings in West Africa

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Infectious Diseases of Poverty 2018年第1期7卷 374-386页

作者： Constant G.N.Gbalegba Hampate Ba Kigbafori D.Silue Ousmane Ba Emmanuel Tia Mouhamadou Chouaibou nathan T.Y.Tian-Bi Gre goire Y.Yapi Brama Kone Jurg Utzinger Benjamin G.Koudou Unite de Formation et de Recherche Sciences de la Nature Universite Nangui Abrogoua02 B.P.801Abidjan 02Cote d’Ivoire Centre Suisse de Recherches Scientifiques en Cote d’Ivoire 01 B.P.1303Abidjan 01Cote d’Ivoire. laboratoire de Parasitologie–Mycologie Institut National de Recherches en Sante PubliqueB.P.695NouakchottMauritania Unite de Formation et de Recherche Biosciences Universite Felix Houphouët-Boigny22 B.P.582Abidjan 22Cote d’Ivoire Centre d’Entomologie Me dicale et Veterinaire Universite Alassane Ouattara27 B.P.529Abidjan 27Cote d’Ivoire UniversitePe le foro Gon Coulibaly B.P.1328KorhogoCote d’Ivoire Swiss Tropical and Public Health Institute P.O.BoxCH-4002 BaselSwitzerland University of Basel P.O.BoxCH-4003 BaselSwitzerland Centre for Neglected Tropical Diseases Liverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK

countries in West Africa remain a hotspot for malaria with all age groups at *** carriers of Plasmodium *** important sources of infections for malaria vectors and thus contribute to the anchoring of the disease in favourable eco-epidemiological *** objective of this study was to assess the asymptomatic malaria case rates in Korhogo and Kaedi,two urban areas in northern Côte d’Ivoire and southern Mauritania,***:Cross-sectional surveys were carried out during the rainy season in 2014 and the dry season in 2015 in both *** each season,728 households were randomly selected and a household-based questionnaire was implemented to collect demographic and epidemiological data,including of malaria preventive methods used in ***-prick blood samples were obtained for biological examination using microscopy and rapid diagnostic tests(RDTs).Results:Overall,2672 households and 15858 consenting participants were *** *** was confirmed in 12.4%(n=832)and 0.3%(n=22)of the assessed individuals in Korhogo and Kaedi,*** Korhogo,the prevalence of asymptomatic malaria was 10.5%(95%CI:9.7-11.2)as determined by microscopy and 9.3%(95%CI:8.6-10.0%)when assessed by *** Kaedi,asymptomatic malaria prevalence was 0.2%(95%CI:0.1-0.4%)according to microscopy,while all RDTs performed were negative(n=8372).In Korhogo,asymptomatic malaria infection was significantly associated with age and season,with higher risk within the 5-14 years-old,and during the rainy *** Kaedi,the risk of asymptomatic malaria infection was associated with season only(higher during the dry season;crude OR(cOR):6.37,95%CI:1.87-21.63).*** was the predominant species identified in both study sites representing 99.2%(n=825)in Korhogo and 59.1%(n=13)in *** were observed only in Korhogo and only during the rainy season at 1.3%(95%CI:0.7-2.4%).Conclusions:Our findings show a low prevalence of c

关键词： Plasmodium spp. Asymptomatic carriers Urban area Rapid diagnostic tests Microscopy Côte d’Ivoire Mauritania Korhogo Kaedi

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Environmental and spatial contributions to seedling and adult tree assembly across tropical,subtropical and subalpine elevational gradients

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Journal of Plant Ecology 2019年第1期12卷 103-112页

作者： Xiaoyang Song Min Cao Roger l.Kitching Yong Tang Zhenhua Sun Akihiro Nakamura Melinda J.laidlaw Jie Yang Key laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China University of Chinese Academy of Sciences Beijing 100049China Griffith School of Environment and Environmental Futures Research Institute Griffith UniversityNathanBrisbane QLD 4111Australia Department of Science Information Technology and InnovationQueensland HerbariumToowongQueensland 4066Australia

Aims Quantifying the relative importance of the mechanisms that drive community assembly in forests is a crucial issue in community *** present study aims to understand the ways in which niche-based and spatially based processes influence community assembly in areas in different climatic conditions and how these processes change during the transition from seedling to *** In this study,we investigated how taxonomic and phylogenetic beta diversity in seedling and adult stages of forest trees change across three elevational transects in tropical,subtropical and subalpine for-ests in Southwest China,and the relationships of these changes to the environment and inter-site *** quantified the relative contribution of environmental conditions and spatial distribution to taxonomic and phylogenetic beta diversity of both seedling and adult life stages along each elevational *** also quantified the taxonomic and phylogenetic similarity between seedlings and adult trees along *** Findings Taxonomic and phylogenetic beta diversity of both seedlings and adult trees increased with an increase in both environmental distance and spatial distance in all three *** both taxonomic and phylo-genetic levels,the effects of environmental filtering and spatial dispos-ition varied between life stages and among forest *** similarity between seedlings and adult trees increased with elevation,although the taxonomic similarity did not show clear elevational *** results suggest that the relative contribution of niche-based and space-based processes to taxonomic and phylogenetic assem-blages varies across major plant life stages and among forest *** findings also highlight the importance of ontogenetic stages for fully understanding community assembly of long-lived tree species.

关键词： beta diversity dispersal limitation environmental filtering phylogeny

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Different environmental factors drive tree species diversity along elevation gradients in three climatic zones in Yunnan,southern China

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Plant Diversity 2021年第6期43卷 433-443页

作者： Xiaoyang Song Min Cao Jieqiong li Roger l.Kitching Akihiro Nakamura Melinda J.laidlaw Yong Tang Zhenhua Sun Wenfu Zhang Jie Yang CAS Key laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of Sciences666303YunnanChina Center of Conservation Biology Core Botanical GardensChinese Academy of SciencesMengla666303China School of Environmental&Natural Sciences Griffith UniversityNathan QLD4111BrisbaneAustralia Department of Environment and Science Queensland HerbariumToowongAustralia

Elevational patterns of tree diversity are well studied ***,few studies have examined how seedlings respond to elevational gradients and whether their responses vary across climatic *** this study,we established three elevational transects in tropical,subtropical and subalpine mountain forests in Yunnan Province,southern China,to examine the responses of tree species and their seedlings to elevational *** each transect,we calculated species diversity indices and composition of both adult trees and seedlings at different *** both adult trees and seedlings,we found that species diversity decreased with increasing elevation in both tropical and subalpine *** composition showed significant elevational separation within all three *** species had specific elevational preferences,but abundant tree species that occurred at specific elevations tended to have very limited recruitment in the *** results highlight that the major factors that determine elevational distributions of tree species vary across climatic ***,we found that the contribution of air temperature to tree species composition increased from tropical to subalpine transects,whereas the contribution of soil moisture decreased across these transects.

关键词： Air temperature Climate zones Montane forest Soil moisture Seedling Tree species distribution

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行体外循环冠状动脉搭桥术的低风险患者中早期神经认知功能缺陷的预测因素

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 34-35页

作者： Boodhwani M. Rubens F.D. Wozny D. H.J. nathan 刘少伟 H341 40 Ruskin Street Ottawa Ont. K1Y 4W7 CanadaDr

背景:即使是在心脏手术的低风险患者中,术后认知功能缺陷(POCD)也是病死原因之一,且经常发生。神经认知功能缺陷的预测因素可用于确定潜在的、可干预的危险因素,以及可能需要采取替代性血运重建策略的高风险患者。方法和结果:448例接受... 详细信息

背景:即使是在心脏手术的低风险患者中,术后认知功能缺陷(POCD)也是病死原因之一,且经常发生。神经认知功能缺陷的预测因素可用于确定潜在的、可干预的危险因素,以及可能需要采取替代性血运重建策略的高风险患者。方法和结果:448例接受冠状动脉手术[冠状动脉搭桥术(CABG)]的患者分别在术前和术后进行标准化神经认知功能测试,作为两项评估冠状动脉手术中适度低温后果的随机试验中的一部分。

关键词：冠状动脉搭桥术神经认知血运重建病死原因随机试验插管时间肌酐水平多变量重症监护停留时

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Endocannabinoid system: A newer molecular target for the treatment of alcohol-related behaviors

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World Journal of Pharmacology 2012年第3期1卷 44-49页

作者： Basalingappa l Hungund K Yaragudri Vinod Division of Analytical Psychopharmacology New York State Psychiatric Institute New York NY 10032 United States Department of Psychiatry College of Physicians and Surgeons Columbia University New York NY 10032 United States Division of Analytical Psychopharmacology Nathan Kline S. Institute for Psychiatric Research Orangeburg NY 10962 United States Department of Child and Adolescent Psychiatry New York University Medical Center New York NY 10016 United States

The cannabinoid （CB） receptors, endocannabinoids （eCB） and their synthesizing and catabolizing enzymes and the proteins involved in their transport, constitute what is now recognized as the eCB system. The eCBs are a class of lipids that have been identifed as retro-grade messengers and produce their effects via presyn-aptic CB receptors. The major function of the eCBs has been suggested to be that of modulating the release of several neurotransmitters implicated in a number of biological functions that include reward and reinforce-ment. There is now significant evidence to suggest that the eCB system plays an important role in the development of alcohol tolerance, dependence and relapse. Recent studies suggest that the pharmacological manipulation of the eCB system has the potential not only to block the direct reinforcing properties of alcohol but also alleviate behavioral abnormalities associated with relapse. There is also accumulating evidence that points to the possible utility of the eCB system targeted drugs in the treatment of alcoholism-related behavioral disorders. The agents that block CB1 receptor function or inhibit the synthesis of eCBs are attractive candidate drugs that need to be explored. Further understanding of the role of the eCB system in molecular mechanism/s that underlies alcoholism-related behaviors should lead to a better treatment of this devastating disorder.

关键词： Endocannabinoids CB1 receptor Alcohol Tolerance Dependence

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