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参连汤预防大白兔缺血性室性心律失常的试验研究

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临床心血管病杂志 2010年第12期26卷 946-948页

作者：刘鹰唐耀平刘钢周烨玲闭肇龙 bryan nathan 广西中医学院附属瑞康医院心电科南宁530011 美国德州大学休斯敦分子医学研究所广西中医学院附属瑞康医院制剂室广西中医学院附属瑞康医院检验科

目的:研究参连汤在大白兔心肌缺血时防治T波电交替(T wave alternans,TWA)的离子基础。方法:建立大白兔左冠状动脉前降支结扎造成急性心肌梗死模型,测定假手术组、模型组、参连汤大剂量组、参连汤中剂量组以及参连汤小剂量组TWA、恶性... 详细信息

目的:研究参连汤在大白兔心肌缺血时防治T波电交替(T wave alternans,TWA)的离子基础。方法:建立大白兔左冠状动脉前降支结扎造成急性心肌梗死模型,测定假手术组、模型组、参连汤大剂量组、参连汤中剂量组以及参连汤小剂量组TWA、恶性室性心律失常和心性猝死的发生率,测定Ca2+浓度以及ATP酶活性。结果:参连汤各组动物的各种ATP酶活性升高,TWA的发生率减少,恶性室性心律失常减少,实验动物死亡率明显降低。同时我们还发现使用中大剂量参连汤疗效显著,明显优于低剂量组,尽管低剂量组也有效。结论:参连汤能有效控制TWA的发生发展,显著减少了恶性室性心律失常,疗效与剂量有关。

关键词：心肌梗死参连汤心律失常 ATP酶钙超载

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E-DNA scaffold sensors and the reagentless, single- step, measurement of HIV-diagnostic antibodies in human serum

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Microsystems & Nanoengineering 2020年第1期6卷 1141-1148页

作者： Claudio Parolo Ava s.Greenwood nathan E.Ogden Di Kang Chase Hawes Gabriel Ortega Netzahualcoyotl Arroyo-Curras Kevin W.Plaxco Department of Chemistry and Biochemistry University of CaliforniaSanta BarbaraSanta BarbaraCAUSA Department of Materials University of CaliforniaSanta BarbaraSanta BarbaraCAUSA Department of Pharmacology and Molecular sciences Johns Hopkins School of MedicineBaltimoreMD 21205USA Interdepartmental Program in Biomolecular science and Engineering University of CaliforniaSanta BarbaraSanta BarbaraCA 93106USA

The multiplexed,point-of-care measurement of specific antibodies could improve the speed with which diseases are diagnosed and their treatment *** this end,we are developing E-DNA scaffold sensors,which consist of a rigid,nucleic acid“scaffold”attached on one end to an electrode and presenting both a redox reporter and an epitope on the *** the absence of antibody,the reporter efficiently transfers electrons when interrogated ***-induced steric hindrance limits movement,reducing electron transfer in a manner that is both easily measured and quantitatively related to target *** we have used monoclonal antibodies to explore the analytical performance of E-DNA sensors,showing that they support the rapid,single-step,quantitative detection of multiple antibodies in small volume ***,in contrast,we employ authentic human samples to better explore the platform’s clinical ***,we developed E-DNA sensors targeting three HIV-specific antibodies and then compared the analytical and clinical performance of these against those of gold standard serological *** so we find that,although the multistep amplification of an ELIsA leads to a lower detection limits,the clinical sensitivity of ELIsAs,E-DNA sensors and lateral-flow dipsticks are indistinguishable across our test *** thus appears that,by merging the quantitation and multiplexing of ELIsAs with the convenience and speed of dipsticks,E-DNA scaffold sensors could significantly improve on current serological practice.

关键词： antibodies attached initiated

Efficient and interpretable graph network representation for angle-dependent properties applied to optical spectroscopy

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npj Computational Materials 2022年第1期8卷 1434-1442页

作者： Tim Hsu Tuan Anh Pham nathan Keilbart stephen Weitzner James Chapman Penghao Xiao s.Roger Qiu Xiao Chen Brandon C.Wood Center for Applied scientific Computing Lawrence Livermore National LaboratoryLivermoreCAUSA Materials science Division Lawrence Livermore National LaboratoryLivermoreCAUSA Department of Physics and Atmospheric science Dalhousie UniversityHalifaxNSCanada

Graph neural networks are attractive for learning properties of atomic structures thanks to their intuitive graph encoding of atoms and ***,conventional encoding does not include angular information,which is critical for describing atomic arrangements in disordered *** this work,we extend the recently proposed ALIGNN(Atomistic Line Graph Neural Network)encoding,which incorporates bond angles,to also include dihedral angles(ALIGNN-d).This simple extension leads to a memory-efficient graph representation that captures the complete geometry of atomic ***-d is applied to predict the infrared optical response of dynamically disordered Cu(II)aqua complexes,leveraging the intrinsic interpretability to elucidate the relative contributions of individual structural *** and dihedral angles are found to be critical contributors to the fine structure of the absorption response,with distortions that represent transitions between more common geometries exhibiting the strongest absorption *** directions for further development of ALIGNN-d are discussed.

关键词： representation disordered absorption

Advances in active fire detection using a multi-temporal method for next-generation geostationary satellite data

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International Journal of Digital Earth 2019年第9期12卷 1030-1045页

作者： bryan Hally Luke Wallace Karin Reinke simon Jones Andrew skidmore school of science RMIT UniversityMelbourneAustralia Bushfire and Natural Hazards Cooperative Research Centre MelbourneAustralia Faculty for Geo-Information science and Earth Observation(ITC) University of TwenteEnschedeNetherlands Department of Environmental science Macquarie UniversitySydneyAustralia

A vital component of fire detection from remote sensors is the accurateestimation of the background temperature of an area in fire’s absence,assisting in identification and attribution of fire activity. Newgeostationary sensors increase the data available to describebackground temperature in the temporal domain. Broad area methodsto extract the expected diurnal cycle of a pixel using this temporally richdata have shown potential for use in fire detection. This paper describesan application of a method for priming diurnal temperature fitting ofimagery from the Advanced Himawari Imager. The BAT method is usedto provide training data for temperature fitting of target pixels, to whichthresholds are applied to detect thermal anomalies in 4 μm imageryover part of Australia. Results show the method detects positive thermalanomalies with respect to the diurnal model in up to 99% of caseswhere fires are also detected by Low Earth Orbiting (LEO) satellite activefire products. In absence of LEO active fire detection, but where aburned area product recorded fire-induced change, this method alsodetected anomalous activity in up to 75% of cases. Potentialimprovements in detection time of up to 6 h over LEO products are alsodemonstrated.

关键词： Fire detection diurnal variation geostationary sensors broad area training advanced himawari imager

Numerical modeling of the effects of roughness on flow and eddy formation in fractures

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第1期9卷 105-115页

作者： scott Briggs bryan W. Karney Brent E. sleep University of Toronto Toronto M5S 1A4 Canada

The effect of roughness on flow in fractures was investigated using lattice Boltzmann method(LBM).simulations were conducted for both statistically generated hypothetical fractures and a natural dolomite fracture. The effect of increasing roughness on effective hydraulic aperture, Izbash and Forchheimer parameters with increasing Reynolds number(Re) ranging from 0.01 to 500 was examined. The growth of complex flow features, such as eddies arising near the fracture surface, was directly associated with changes in surface roughness. Rapid eddy growth above Re values of 1, followed by less rapid growth at higher Re values, suggested a three-zone nonlinear model for flow in rough fractures. This three-zone model, relating effective hydraulic conductivity to Re, was also found to be appropriate for the simulation of water flow in the natural dolomite fracture. Increasing fracture roughness led to greater eddy volumes and lower effective hydraulic conductivities for the same Re values.

关键词： Hydrogeology Fracture flow Fracture roughness Computational fluid dynamics Lattice Boltzmann method(LBM)

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Fish assemblages in protected seagrass habitats:Assessing fish abundance and diversity in no-take marine reserves and fished areas

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Aquaculture and Fisheries 2020年第5期5卷 213-223页

作者： Rhiannon s.Kiggins nathan A.Knott Tristan New Andrew R.Davis Centre for sustainable Ecosystem solutions and school of Biological sciences University of WollongongWollongongNSW2522Australia Fisheries Research NSW Department of Primary IndustriesPO Box 89HuskissonNSW2540Australia

Marine reserves are an important management tool for conserving local biodiversity and protecting fragile ecosystems such as seagrass that provide significant ecological functions and services to people and the marine *** humans placing ever-growing pressure on seagrass habitats,marine reserves also provide an important reference from which changes to seagrass and their ecological assemblages may be *** eight years of protection of seagrass beds(Posidonia australis)in no-take marine reserves(sanctuary Zones)within the Jervis Bay Marine Park(New south Wales,Australia;zoned in 2002),we aimed to assess what changes may have occurred and assess continuing change through time in fish assemblages within these seagrass *** baited remote underwater videos(BRUVs),we sampled seagrass fish assemblages at three locations in no-take zones and five locations in fished zones three times from 2010 to ***,we observed a total of 2615 individuals from 40 fish species drawn from 24 *** detected no differences in total fish abundance,diversity,or assemblage composition between management zones,although we observed a significant increase in Haletta semifasciata,a locally targeted fish species,in no-take marine reserves compared with fished *** assemblages in seagrass varied greatly amongst times and *** species varied in relative abundance greatly over months and years,whilst others had consistently greater relative abundances at specific *** discuss the potential utility of marine reserves covering seagrass habitats and the value of baseline data from which future changes to seagrass fish populations may be measured.

关键词： Baited remote underwater video BRUV Jervis Bay Marine Park JBMP Booderee National Park sanctuary zone Haletta semifasciata Blue Weed Whiting

First principles insights into oxide/polymer composites: srTiO_(3) /polyaniline/graphene

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Journal of Materials science & Technology 2023年第35期166卷 250-260页

作者： nathan D.Wood Joshua s.Tse Jonathan M.skelton David J.Cooke Lisa J.Gillie stephen C.Parker Marco Molinari Department of Chemical sciences School of Applied SciencesUniversity of HuddersfieldHuddersfield HD13DHUK Department of Chemistry University of ManchesterManchester M139PLUK Department of Chemistry University of BathBath BA27AYUK

A detailed computational investigation,based on density functional theory,of the interaction of polyani-line(PANI)and graphene nanoribbons(GNRs)with srTiO_(3) is *** adsorption of PANI in var-ious oxidation states and co-adsorption with GNRs is found to be thermodynamically ***-sorbed PANI introduces N and C 2p states into the srTiO_(3) bandgap,while co-adsorption of PANI and GNRs leads to a bridging of the gap and semi-metallic behaviour,thus rendering the electrical properties highly sensitive to the loading of the GNRs/PANI in the *** the lattice dynamics of the composites predicts a 68-88%reduction in the lattice thermal conductivity due to reduced phonon group *** together,these findings provide insight into the growing number of experimental studies highlighting the enhanced thermoelectric performance of oxide-polymer composites and indicate co-adsorption with graphene as a facile direction for future research.

关键词： Polymer/inorganic composites Polyaniline/strontium titanate/graphene nanoribbon composites PANI/GNR/srTiO_(3)composites Thermoelectric composites Electrical transport Thermal conductivity1 Introduction

Bridge Maintenance Robotic Arm:Mechanical Technique to Reduce the Nozzle Force of a sandblastine Rig

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武汉理工大学学报 2006年第S1期28卷 12-18页

作者： nathan Kirchner Gavin Paul Centre for Autonomous systems Kevin Kirby Suite Building 2Level 6University of Technology Sydney Broadway 2007 NSW. Australia

This paper describes a mechanical technique to reduce the nozzle reaction force of a sandblasting rig. A theoretical evaluation of the magnitudes and direction of action of typical sandblasting nozzle forces has been conducted and a technique for exploiting available energy in order to reduce the magnitude of the forces at the nozzle has been *** results from a variety of tests in different configurations have confirmed the theoretically determined force magnitude’s accuracy and shown that forces of up to 106N can be present in typical sandblasting operations. The results have also shown that an up to 77% reduction of force at the nozzle can be achieved by applying the developed mechanicaltechnique.

关键词： sandblasting nozzle force maintenance robot mechanical advantage

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singapore’s economicdevelopment:pro-or anti-Washington Consensus?

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Economic and Political studies 2018年第1期6卷 30-52页

作者： nathan Peng sock-Yong Phang school of social sciences Singapore Management UniversitySingapore school of Economics Singapore Management UniversitySingapore

singapore's remarkable economic development in the past five decades since independence has attracted much policy *** article first provides a brief overview of singapore's economic *** second part discusses singapore's development strategies that are aligned with the Washington Consensus:globalisation,conservative fiscal and monetary policies,investments in education and *** also discusses the policies adopted to further enhance the outcomes of such *** third part focusses on policies that are inconsistent with the prescriptions of the Washington Consensus:the visible hand of government direction of industry,the important role of state owned enterprises,as well as growth-enhancing social *** concludes with the present challenges facing the city-state.

关键词： Washington Consensus economic development policies politicaleconomy singapore trade liberalisation financial liberalisation governance institutions