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Non-escaping frost tolerant QTL linked genetic loci at reproductive stage in six wheat DH populations

The Crop Journal 2022年第1期10卷 147-165页

作者： Jingjuan Zhang MD Shahidul Islam Yun Zhao Masood Anwar Zaid Alhabbar Maoyun She Rongchang Yang Angela Juhasz Guixiang Tang Jiansheng Chen Hang Liu Yanjie Jiang Shengnan Zhai Xin Hu Junkang Rong Yingquan Zhang Yebo Qin Qier Liu Zitong Yu Yujuan Zhang Sadegh Balotf Mirza Dowla Sonia Afrin Nandita Roy Md Resad Mallik Md Atik Us Saieed Shanjida Rahman Nigarin Sultana Sarah Al-Sheikh Ahmed Chris Florides Kefei Chen Darshan Sharma nathan height Ben Biddulph Meiqin Lu Jorge EMayer Wujun Ma Australian-China Joint Centre for Wheat Improvement Western Australian State Agriculture Biotechnology CentreFood Futures InstituteMurdoch UniversitySouth StreetMurdochWA 6150Australia College of Agriculture&Food Zhejiang Agriculture&Forestry UniversityLin’an 311314ZhejiangChina SAGI West Faculty of Science and EngineeringCurtin UniversityBentleyWA 6102Australia Department of Primary Industries and Regional Development Western Australia3 Baron-Hay CourtSouth PerthWA 6151Australia Australian Grain Technologies 12656 Newell HighwayLocked Bag 1100NarrabriNSW 2390Australia Ag RD&IP Consult P/L NerangQLD 4211Australia

Reproductive stage frost poses a major constraint for wheat production in countries such as ***,little progress has been made in identifying key genes to overcome the *** the present study,a severe frost event hit two large-scale field trials consisting of six doubled haploid(DH)wheat populations at reproductive stage(young microspore stage)in Western Australia,leading to the identification of 30 robust frost QTL on 17 *** major 18 QTL with the phenotype variation over 9.5%were located on 13 chromosomes including 2 A,2 B,2 D,3 A,4 A,4 B,4 D,5 A,5 D,6 D,7 A,7 B and7 *** frost QTL were closely linked to the QTL of anthesis,maturity,Zadok stages as well as linked to anthesis related *** of those,six QTL were repetitively detected on the homologous regions on 2 B,4 B,4 D,5 A,5 D,7 A in more than two *** showed that the frost damage is associated with alleles of Vrn-A1 a,Vrn-D1 a,Rht-B1 b,Rht-D1 b,and the high copy number of ***,anthesis QTL and anthesis related genes of Vrn-B1 a and Ta FT3-1 B on chromosomes 5 B and 1 B did not lead to frost damage,indicating that these early-flowering phenotype related genes are compatible with frost tolerance and thus can be utilised in *** results also indicate that wild-type alleles Rht-B1 a and Rht-D1 a can be used when breeding for frost-tolerant varieties without delaying flowering time.

关键词： Anthesis-related genes Wheat DH populations Reproductive stage Non-escaping frost tolerance QTL

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nvestigating the role of exiting vehicles and turn indicator usage in gap acceptance at single-lane roundabouts

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 8-16页

作者： nathan P. BELZ Civil and Environmental Engineering University of Alaska - Fairbanks Fairbanks AK 99775-5960 USA

Roundabouts are becoming a preferred form of intersection control type due to their safety and capacity benefits. Yield control at roundabout entries inherently reduces fuel consumption and emissions when compared to other conventional intersection types. However, these benefits can be limited by poor driver behavior and judgment when entering the roundabout. This research addresses the nature of gap distributions and use of turn indicators by exiting vehicles at three single-lane roundabouts in Vermont, New York, and Alaska. Presented here is a comparison of vehicle headways measured at two different locations in each roundabout. Rejected headways are analyzed in the context of priority abstaining events when entering drivers yield to vehicles exiting on the same leg of the roundabout suggesting that ＂true＂ critical gaps are being overestimated. Results indicate that exiting vehicles, particularly those that do not use their turn indicators when departing from the major-stream of traffic have an influence on the entry decision of drivers on the same approach. This behavior is of particular concern for intersection efficiency （i.e., delay） and sustainability （i.e., excess fuel consumption and emissions）. Results prompt the consideration of more consistent guidance on and enforcement of turn indicator use during roundabout negotiations.

关键词： roundabouts exiting vehicles turn indicator use headways

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Spectral square moments of a resonance sum for Maass forms

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Frontiers of Mathematics in China 2017年第5期12卷 1183-1200页

作者： nathan SALAZAR Yangbo YE Department of Mathematics The University of Iowa Iowa City Iowa 52242-1419 USA

Let f be a Maass cusp form for Г0（N） with Fourier coefficients 1 k2. λf（n） and Laplace eigenvalue 1/4 ＋k2 For real α≠0 and β 〉 0, consider the sum Sx（f; α,β） = ∑n λf（n）e（αnβ）φ（n/X）, where φ is a smooth function of compact support. We prove bounds for the second spectral moment of Sx （f;α, β）, with the eigenvalue tending towards infinity. When the eigenvalue is sufficiently large, we obtain an average bound for this sum in terms of X. This implies that if f has its eigenvalue beyond X1/2＋ε, the standard resonance main term for Sx（f; ±2√q 1/2）, q ∈Z＋, cannot appear in general. The method is adopted from proofs of subconvexity bounds for Rankin-Selberg L-functions for GL（2） × GL（2）. It contains in particular a proof of an asymptotic expansion of a well-known oscillatory integral with an enlarged range of Kε≤ L≤ K1-ε. The same bounds can be proved in a similar way for holomorphie cusp forms.

关键词： Cusp form Maass form Fourier coefficient of cusp form Kuznetsovtrace formula resonance sum first derivative test weighted stationary phase

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Grain boundary effects in high-temperature liquid-metal dealloying: a multi-phase field study

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npj Computational Materials 2023年第1期9卷 1039-1049页

作者： nathan Bieberdorf Mark Asta Laurent Capolungo Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Materials Science and Technology Division Los Alamos National LaboratoryLos AlamosNM 87545USA

A multi-phase field model is employed to study the microstructural evolution of an alloy undergoing liquid dealloying,specifically considering the role of grain boundaries.A semi-implicit time-stepping algorithm using spectral methods is implemented,which enables simulating large 2D and 3D domains over long time scales while still maintaining a realistic interfacial *** reveal a mechanism of coupled grain–boundary migration to maintain equilibrium contact angles with the topologically complex solid–liquid interface,which locally accelerates diffusion-coupled growth of a liquid channel into the *** mechanism asymmetrically disrupts the ligament connectivity of the dealloyed structure in qualitative agreement with published experimental *** grain boundary migration-assisted corrosion channels form even for precursors with small amounts of the dissolving alloy species,below the parting *** activation of this grain boundary dealloying mechanism depends strongly on grain boundary mobility.

关键词： alloying grain alloy

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MicroRNA deregulation and cancer and medicinal plants as microRNA regulator

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Asian Pacific Journal of Tropical Biomedicine 2020年第2期10卷 47-53页

作者： nathan Shanmugapriya Sreenivasan Sasidharan Institute for Research in Molecular Medicine Universiti Sains Malaysia11800 GelugorPulau PinangMalaysia

MircroRNAs(mi RNAs)are short non-coding RNAs with a length of approximately 20-22 nucleotides,which interact with their target mRNAs at 3’-untranslated region by partial *** miRNAm-RNA interaction leads to induction of mRNA degradation and eventually translational ***,mi RNAs play an important role in virtually all cellular processes,especially differentiation,proliferation,migration,and *** deregulation of miRNAs may lead to serious diseases including *** is mounting evidence demonstrating the participation of mi RNA regulation during *** this review,we discuss an updated miRNA biogenesis,mechanisms involved in their deregulation,and their role in cancer *** review also summarizes updated information on potential medicinal plants which regulate miRNA expression as a promising molecular miRNA therapeutic approach for cancers.

关键词： MiRNA Biogenesis Cancer Medicinal plants

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Serrated neoplasia of the colorectum

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World Journal of Gastroenterology 2007年第28期13卷 3792-3798页

作者： nathan T Harvey Andrew Ruszkiewicz Division of Tissue Pathology Institute of Medical and Veterinary ScienceFrome RdAdelaideAustralia

Serrated polyps of the colorectum form a group of related lesions which include aberrant crypt foci (ACF), conventional hyperplastic polyps, mixed (admixed) polyps, serrated adenomas and sessile serrated adenomas. In recent years the molecular differences between these morphologically similar lesions have been highlighted, and their differing biological potential has been realised. In particular, the sessile serrated adenoma has become recognised as the precursor lesion to a group of sporadic colorectal carcinomas characterised by morphological and molecular features distinct from conventional adenomas. These recent findings have challenged the long held paradigm that all colorectal carcinomas arise via the traditional adenoma-carcinoma sequence. In addition, they present a major challenge for the early detection and management of colorectal cancer, which is no longer regarded as a homogeneous entity.

关键词： Serrated adenoma Serrated neoplasia Serrated adenocarcinoma Hyperplastic polyps Microsatellite instability

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Evaluation on the Two Filling Functions for the Recovery of Forest Information in Mountainous Shadows on Landsat ETM + Image

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Journal of Mountain Science 2011年第3期8卷 414-426页

作者： SHAHTAHMASSEBI Amir reza MOORE nathan Institute of Agriculture Remote Sensing and Information Technology Zhejiang University Key Laboratory of Agricultural Remote Sensing and Information System of Zhejiang Province Department of Geography Michigan State University

In general,topographic shadow may reduce performance of forest mapping over mountainous regions in remotely sensed *** this paper,information in shadow was synthesized by using two filling techniques,namely,roifill and imfill,in order to improve the accuracy of forest mapping over mountainous *** two methods were applied to Landsat Enhanced Thematic Mapper (ETM +) multispectral image from Dong Yang County,Zhejiang Province,*** performance of these methods was compared with two conventional techniques,including cosine correction and multisource *** results showed that by applying filling approaches,average overall accuracy of classification was improved by 14 ***,through conventional methods this value increased only by 9 *** results also revealed that estimated forest area on the basis of shadow-corrected images by 'roifill' technique was much closer to the survey data compared to traditional *** from this finding,our finding indicated that topographic shadow was an accentuated problem in medium resolution images such as Landsat ETM+ over mountainous regions.

关键词： Shadow Imfill: Roifill: Landsat ETM+

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LEUNIG_HOMOLOG and LEUNIG Regulate Seed Mucilage Extrusion in Arabidopsis

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Journal of Integrative Plant Biology 2011年第5期53卷 399-408页

作者： Minh Bui nathan Lim Paja Sijacic Department of Cell Biology and Molecular Genetics University of MarylandCollege ParkMaryland 20742USA

LEUNIG （LUG） and LEUNIG_HOMOLOG （LUH） encode two closely related Arabidopsis proteins, belonging to the Gro/TLE family of transcriptional co-repressors. These two genes were previously shown to exhibit partially overlapping functions in embryo and flower development. In this report, the role of both LUH and LUG on seed mucilage extrusion was examined. Seed mucilage extrusion occurs after the seeds are imbibed, serving as functional aid in seed hydration, germination, and dispersal. While luh-1 mutants exhibited strong defects in seed mucilage extrusion, lug-3 mutants exhibited a minor phenotype in mucilage extrusion. Further characterization indicates that luh-1 does not exhibit any obvious defect in seed epidermal cell differentiation, mucilage synthesis, or mucilage deposition, suggesting a specific role of LUH in mucilage extrusion. This seed mucilage phenotype of luh-1 is identical to that of mucilage modified 2 （mum2） mutants. MUM2 encodes a β-galactosidase required for the modification of the mucilage. Quantitative reverse transcription polymerase chain reaction of RNA extracted from siliques detected a slight decrease of MUM2 mRNA in the luh-1 mutant compared to the wild type. Together, LUH and possibly LUG may specifically regulate mucilage extrusion by promoting the expression of genes required for mucilage maturation.

关键词： Genes Extrusion Mucilages Adhesives Transcription Exhibitions Lymphocytes Defects Phenotypes Dispersants

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Non-HFE haemochromatosis

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World Journal of Gastroenterology 2007年第35期13卷 4690-4698页

作者： Daniel F Wallace V nathan Subramaniam Membrane Transport Laboratory The Queensland Institute of Medical ResearchBrisbaneQueenslandAustralia

Non-HFE hereditary haemochromatosis （HH） refers to a genetically heterogeneous group of iron overload disorders that are unlinked to mutations in the HFE gene. The four main types of non-HFE HH are caused by mutations in the hemojuvelin, hepcidin, transferrin receptor 2 and ferroportin genes. Juvenile haemochromatosis is an autosomal recessive disorder and can be caused by mutations in either hemojuvelin or hepcidin. Ar~ adult onset form of HH similar to HFE-HH is caused by homozygosity for mutations in transferrin receptor 2. The autosomal dominant iron overload disorder ferroportin disease is caused by mutations in the iron exporter ferroportin. The clinical characteristics and molecular basis of the various types of non-HFE haemochromatosis are reviewed. The study of these disorders and the molecules involved has been invaluable in improving our understanding of the mechanisms involved in the regulation of iron metabolism.

关键词： Haemochromatosis Iron overload Non-HFE Juvenile haemochromatosis Hemojuvelin Hepcidin Transferrin receptor 2 Ferroportin

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Role of the NLRP3 inflammasome in neurodegenerative diseases and therapeutic implications

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Neural Regeneration Research 2020年第7期15卷 1249-1250页

作者： Yanhui Duan nathan Kelley Yuan He Department of Biochemistry Microbiology and Immunology Wayne State University School of Medicine

Neurodegenerative diseases are a group of neuronal disorders caused by progressive neuronal cell death in different regions of the human ***'s disease(AD)and Parkinson's disease(PD)are the most common types of neurodegenerative diseases that affect millions of people *** is no cure available for either *** of the pathological hallmarks of neurodegenerative diseases is the abnormal protein aggregation in the central nervous system.

关键词： NLRP3 diseases degenerative

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