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World Journal of Clinical Cases 2019年第10期7卷 1133-1141页

作者： Tomaz Velnar Peter Spazzapan Zoran Rodi natasa kos Roman Bosnjak Department of Neurosurgery University Medical Centre LjubljanaLjubljana 1000Slovenia AMEU-ECM Maribor Ljubljana 1000Slovenia Department of Neurophysiology University Medical Centre LjubljanaLjubljana 1000Slovenia Medical Rehabilitation Unit University Medical Centre LjubljanaLjubljana 1000Slovenia

BACKGROUND Spasticity affects a large number of children,mainly in the setting of cerebral palsy,however,only a few paediatric neurosurgeons deal with this problem.This is mainly due to the fact that until 1979,when Fasano has published the first series of selective dorsal rhizotomy(SDR),neurosurgeons were able to provide such children only a modest help.The therapy of spasticity has made a great progress since then.Today,peroral drugs,intramuscular and intrathecal medicines are available,that may limit the effects of the disease.In addition,surgical treatment is gaining importance,appearing in the form of deep brain stimulation,peripheral nerve procedures and SDR.All these options offer the affected children good opportunities of improving the quality of life.CASE SUMMARY A 15-year old boy is presented that was surgically treated for spasticity as a result of cerebral palsy.Laminotomy at L1 level was performed and L1 to S1 nerve roots were isolated and divided in smaller fascicles.Then,the SDR was made.CONCLUSION We describe a patient report and surgical technique of SDR that was performed in Slovenia for the first time.

关键词： Cerebral palsy Spasticity Selective dorsal rhizotomy Operation Case report

Incorporating physiological knowledge into correlative species distribution models minimizes bias introduced by the choice of calibration area

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Marine Life Science & Technology 2024年第2期6卷 349-362页

作者： Zhixin Zhang Jinxin Zhou Jorge García Molinos Stefano Mammola Ákos Bede‑Fazekas Xiao Feng Daisuke Kitazawa Jorge Assis Tianlong Qiu Qiang Lin CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Marine Biodiversity and Ecological Evolution Research Center South China Sea Institute of OceanologyGuangzhou 510301China Global Ocean and Climate Research Center South China Sea Institute of OceanologyGuangzhou 510301China Institute of Industrial Science The University of Tokyo5-1-5 KashiwanohaKashiwaChiba 277-8574Japan Arctic Research Center Hokkaido UniversitySapporoHokkaido 001-0021Japan Finnish Museum of Natural History University of HelsinkiHelsinkiFinland Molecular Ecology Group(MEG) Water Research Institute(IRSA)National Research Council of Italy(CNR)28922 Verbania PallanzaItaly National Biodiversity Future Center(NBFC) PalermoItaly Institute of Ecology and Botany HUN-REN Centre for Ecological ResearchVácrátótHungary Department of Environmental and Landscape Geography ELTE Eötvös Loránd UniversityBudapestHungary Department of Biology University of North CarolinaChapel HillNC 27599USA Centre of Marine Sciences University of AlgarveCampus de GambelasFaroPortugal CAS Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Correlative species distribution models(SDMs)are important tools to estimate species’geographic distribution across space and time,but their reliability heavily relies on the availability and quality of occurrence data.Estimations can be biased when occurrences do not fully represent the environmental requirement of a species.We tested to what extent species’physiological knowledge might influence SDM estimations.Focusing on the Japanese sea cucumber Apostichopus japonicus within the coastal ocean of East Asia,we compiled a comprehensive dataset of occurrence records.We then explored the importance of incorporating physiological knowledge into SDMs by calibrating two types of correlative SDMs:a naïve model that solely depends on environmental correlates,and a physiologically informed model that further incorporates physiological information as priors.We further tested the models’sensitivity to calibration area choices by fitting them with different buffered areas around known presences.Compared with naïve models,the physiologically informed models successfully captured the negative influence of high temperature on A.japonicus and were less sensitive to the choice of calibration area.The naïve models resulted in more optimistic prediction of the changes of potential distributions under climate change(i.e.,larger range expansion and less contraction)than the physiologically informed models.Our findings highlight benefits from incorporating physiological information into correlative SDMs,namely mitigating the uncertainties associated with the choice of calibration area.Given these promising features,we encourage future SDM studies to consider species physi-ological information where available.

关键词： Bayesian approach Climate change Habitat suitability Physiological knowledge Species distribution model

Functional Gait Assessment scale in the rehabilitation of patients after vestibular tumor surgery in an acute hospital

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World Journal of Clinical Oncology 2020年第11期11卷 945-958页

作者： natasa kos Marusa Brcar Tomaz Velnar Department of Medical Rehabilitation University Medical Centre LjubljanaLjubljana 1000Slovenia Department of Neurosurgery University Medical Centre LjubljanaLjubljana 1000Slovenia

BACKGROUND Patients in the acute phase of rehabilitation after vestibular tumor surgery are dysfunctional in basic daily activities.Balance,gait impairments,and falls are prevalent with vestibular loss.AIM To determine the degree of balance disorders after vestibular tumor surgery,the susceptibility to falls and to assess motor tasks using the Functional Gait Assessment(FGA)scale for functional gait,as part of the vestibular rehabilitation program during hospital stay.METHODS Patients who achieved a score higher than 25 points on the Mini-Mental State Examination and higher than 8 points on the Barthel index were included in the study.They were evaluated with the Berg Balance Scale the second day after surgery,during their hospital stay,at discharge,and three months after surgery.Throughout their hospitalization,patients took part in the vestibular rehabilitation program,focusing on multiple motor tasks included in the FGA.RESULTS All patients progressed clinically and statistically significant differences in functional activities of daily living were observed during hospitalization,before discharge to the home environment(median=11;P=0.0059)and three months after vestibular tumor surgery(median=8;P=0.0058).After discharge from hospital,four patients were at risk of falls,and two patients were at risk at three months.CONCLUSION Our study showed a positive effect of the use of FGA tasks as part of a rehabilitation program on functional activities of daily living in patients after vestibular tumor surgery.Nevertheless,we suggest further research to include a larger sample and a control group to overcome the deficiencies of our study.

关键词： Vestibular tumor Surgery Assessment Balance Gait

Food contaminants and potential risk of diabetes development:A narrative review

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World Journal of Diabetes 2023年第6期14卷 705-723页

作者： Maja Milanovic natasa Milosevic natasa Milic Milica Medic Stojanoska Edward Petri Jelena Markovic Filipovic Department of Pharmacy Faculty of MedicineUniversity of Novi SadNovi Sad 21000Serbia Faculty of Medicine Clinic for EndocrinologyDiabetes and Metabolic DiseasesUniversity Clinical Center of VojvodinaUniversity of Novi SadNovi Sad 21000Serbia Department of Biology and Ecology Faculty of SciencesUniversity of Novi SadNovi Sad 21000Serbia

The number of people diagnosed with diabetes continues to increase,especially among younger populations.Apart from genetic predisposition and lifestyle,there is increasing scientific and public concern that environmental agents may also contribute to diabetes.Food contamination by chemical substances that originate from packaging materials,or are the result of chemical reactions during food processing,is generally recognized as a worldwide problem with potential health hazards.Phthalates,bisphenol A(BPA)and acrylamide(AA)have been the focus of attention in recent years,due to the numerous adverse health effects associated with their exposure.This paper summarizes the available data about the association between phthalates,BPA and AA exposure and diabetes.Although their mechanism of action has not been fully clarified,in vitro,in vivo and epidemiological studies have made significant progress toward identifying the potential roles of phthalates,BPA and AA in diabetes development and progression.These chemicals interfere with multiple signaling pathways involved in glucose and lipid homeostasis and can aggravate the symptoms of diabetes.Especially concerning are the effects of exposure during early stages and the gestational period.Well-designed prospective studies are needed in order to better establish prevention strategies against the harmful effects of these food contaminants.

关键词： Acrylamide Bisphenol A Phthalates Endocrine disrupting chemicals β-cell Diabetes

Diabetes mellitus type 2 as an underlying,comorbid or consequent state of mental disorders

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World Journal of Diabetes 2023年第5期14卷 481-493页

作者： Milica M Borovcanin Katarina Vesic Ivica Petrovic Ivan P Jovanovic natasa R Mijailovic Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Neurology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pathophysiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Center for Molecular Medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

Somatic disturbances that occur in parallel with psychiatric diseases are a major challenge in clinical practice.Various factors contribute to the development of mental and somatic disorders.Type 2 diabetes mellitus(T2DM)is a significant health burden worldwide,and the prevalence of diabetes in adults is increasing.The comorbidity of diabetes and mental disorders is very common.By sharing a bidirectional link,both T2DM and mental disorders influence each other in various manners,but the exact mechanisms underlying this link are not yet elucidated.The potential mechanisms of both mental disorders and T2DM are related to immune and inflammatory system dysfunction,oxidative stress,endothelial dysfunction,and metabolic disturbances.Moreover,diabetes is also a risk factor for cognitive dysfunction that can range from subtle diabetesassociated cognitive decline to pre-dementia and dementia.A complex relationship between the gut and the brain also represents a new therapeutic approach since gut-brain signalling pathways regulate food intake and hepatic glucose production.The aim of this minireview is to summarize and present the latest data on mutual pathogenic pathways in these disorders,emphasizing their complexity and interweaving.We also focused on the cognitive performances and changes in neurodegenerative disorders.The importance of implementing integrated approaches in treating both of these states is highlighted,along with the need for individual therapeutic strategies.

关键词： Diabetes mellitus type 2 Mental disorders Neuroinflammation Neurodegeneration Cognition

Responsibility of States in implementing the Green Model rather than the Traditional Model of Development

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学术界 2017年第3期 266-274页

作者： natasa Maric Embassy of Bosnia Herzegovina in the People's Republic of China

Green Development strategy is officially no longer a pending question in China's development process however the transition from the Traditional Model to the implementation of Green Model Development is slow and presents a challenge to State's Responsibility in managing ways of life. We seek to analyze: "Why visible changes come slow despite a firm policy?"Short-term and long-term Green Development strategies of implementation are difficult to coordinate and may cause a crumbling transition. It is in State's responsibility to ensure"slow but steady"transition,with a low risk of collateral damage and a transition compatible with inequalities that still exist between rural and urban areas. Green Development Model implementation has three major features,sustainable development,state responsibility and time.

关键词：责任传统绿色发展战略可持续发展管理能力生活方式心理状态 COM

Presence and role of stem cells in ovarian cancer

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World Journal of Stem Cells 2019年第7期11卷 383-397页

作者： natasa Kenda Suster Irma Virant-Klun Department of Gynecology Division of Obstetrics and GynecologyUniversity Medical Centre LjubljanaLjubljana 1000Slovenia Department of Human Reproduction Division of Obstetrics and GynecologyUniversity Medical Centre LjubljanaLjubljana 1000Slovenia

Ovarian cancer is the deadliest gynecological malignancy.It is typically diagnosed at advanced stages of the disease,with metastatic sites disseminated widely within the abdominal cavity.Ovarian cancer treatment is challenging due to high disease recurrence and further complicated pursuant to acquired chemoresistance.Cancer stem cell(CSC)theory proposes that both tumor development and progression are driven by undifferentiated stem cells capable of self-renewal and tumor-initiation.The most recent evidence revealed that CSCs in terms of ovarian cancer are not only responsible for primary tumor growth,metastasis and relapse of disease,but also for the development of chemoresistance.As the elimination of this cell population is critical for increasing treatment success,a deeper understanding of ovarian CSCs pathobiology,including epithelial-mesenchymal transition,signaling pathways and tumor microenvironment,is needed.Finally,before introducing new therapeutic agents for ovarian cancer,targeting CSCs,accurate identification of different ovarian stem cell subpopulations,including the very small embryoniclike stem cells suggested as progenitors,is necessary.To these ends,reliable markers of ovarian CSCs should be identified.In this review,we present the current knowledge and a critical discussion concerning ovarian CSCs and their clinical role.

关键词： Ovarian cancer Cancer stem cells Very small embryonic-like stem cells Epithelial-mesenchymal transition

Swimming pool heating technology:A state-of-the-art review

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Building Simulation 2021年第3期14卷 421-440页

作者： Yantong Li natasa Word Gongsheng Huang Xin Li Department of Architecture and Civil Engineering City University of Hong KongTat Chee AvenueKowloonHong KongChina Department of Energy and Process Engineering Norwegian University of Science and TechnologyTrondheimNorway

A large amount of heat is needed to maintain the thermal comfort of both indoor and outdoor swimming pools in cold seasons.This motivates the development of various heating technologies aiming to reduce energy use,as well as operating and investment costs.Although their development can be traced back to the 1960s,a comprehensive review of these technologies is lacking.Therefore,this paper presents a comprehensive review of the development of heating technologies for swimming pools.This review firstly introduces available heat transfer models that can be used to calculate or predict heat loss and heat gain for swimming pools.Then,different passive and active technologies are summarized.The active heating technologies used for indoor swimming pools include solar collector,heat pump,waste heat recovery,geothermal energy,and congregation technologies.The active heating technologies used for outdoor swimming pools include solar collector,heat pump,PCM storage,geothermal energy,biomass heater,and waste heat recovery technologies.A discussion is presented on the practical and possible heating techniques for swimming pool applications.Finally,through the reviewed literature,future research opportunities are identified,to guide researchers to investigate swimming pool heating systems with suitable and relevant technologies.

关键词： swimming pool heating supply solar energy heat pump phase change material

TG-interacting Factor(TGIF) Downregulates SOX3 Gene Expression in the NT2/D1 Cell Line

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Journal of Genetics and Genomics 2012年第1期39卷 19-27页

作者： Marija Mojsin Jelena Popovic natasa Kovacevic Grujicic Milena Stevanovic Laboratory for Human Molecular Genetics Institute of Molecular Genetics and Genetic EngineeringUniversity of BelgradeVojvode Stepe 444aPO Box 2311010 BelgradeSerbia

SOX3 is a member of the Sox gene family implicated in brain formation and cognitive function. It is considered to be one of the earliest neural markers in vertebrates, playing a role in specifying neuronal fate. Recently, we have established the first link between TALE （three- amino-acid loop extension） proteins, PBX1 （pre-B-cell leukemia homeobox 1） and MEIS1 （myeloid ecotropic viral integration site 1 homologue）, and the expression of the human SOX3 gene. Here we present the evidence that TGIF （TG-interacting factor） is an additional TALE superfamily member involved in the regulation of human SOX3 gene expression in NT2/D1 cells by direct interaction with the consensus binding site that is conserved in primate orthologue promoters. Functional analysis demonstrated that mutation of the TGIF binding site resulted in the activation of SOX3 promoter. TGIF overexpression downregulates SOX3 promoter activity and decreases endogenous SOX3 protein expression in both uninduced and retinoic acid （RA）-induced NT2/D1 ceils. Up to now, this is the first transcription factor identified as a negative regulator of SOX3 gene expression. The obtained results further underscore the significance of TALE proteins as important transcriptional regulators of SOX3 gene expression.

关键词： NT2/D1 cells TGIF Retinoic acid SOX3

Analysis of the CAG repeat number in exon 1 of the androgen receptor gene in Slovene men with idiopathic azoospermia and oligoasthenoteratozoospermia

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Asian Journal of Andrology 2007年第2期9卷 280-282页

作者： Borut Peterlin Branko Zorn natasa Teran Tanja Kunej Division of Medical Genetics University Medical Centre Ljubljana Liubljana 1000 Slovenia Andrology Centre Department of Obstetrics and Gynecology University Medical Centre Ljubljana Ljubljana 1000 Slovenia Biotechnical Faculty University of Ljubljana Ljubljana 1000 Slovenia

Dear Sir, I am Borut Peterlin, from Division of Medical Genetics, Department of Obstetrics and Gynaecology, University Medical Center, Ljubljana, Slovenia. We write to you to discuss if the number of CAG repeats in the androgen receptor （AR） gene is associated with male infertility in a group of 190 Slovene infertile men compared to 137 men with proven fertility.

关键词： Analysis CAG repeat number gene Slovene men idiopathic azoospermia oligoasthenoteratozoospermia