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Gymnema montanum improves endothelial function via inhibition of endoplasmic reticulum stress by activating Nrf2 signaling

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Asian Pacific Journal of Tropical Biomedicine 2020年第8期10卷 379-386页

作者： Dornadula Sireesh natarajan suganya Suvro Chatterjee Kunka Mohanram Ramkumar SRM Research Institute SRM Institute of Science and TechnologyKattankulathur-603203Tamil NaduIndia Department of Biotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur-603203Tamil NaduIndia Vascular Biology Lab AU-KBC Research CentreAnna UniversityChromepetChennai-600044Tamil NaduIndia

Objective:To investigate the effects of Gymnema montanum leaf extract against endoplasmic reticulum(ER)stress-induced toxicity in endothelial ***:The immortalized endothelial hybrid cell,***926 was treated with different concentrations of Gymnema montanum leaf extract(0–100μg/mL)and the ER stress inducer,*** cytotoxicity was assessed by MTT as well as lactate dehydrogenase and malondialdehyde levels were *** levels of ER stress markers,GRP78 and CHOP were analysed by Western blot *** Gymnema montanum leaf extract-mediated activation of nuclear factor erythroid 2-related factor 2(Nrf2)was assessed by cell-based luciferase enzyme fragment complementation assay and antioxidant responsive element driven luciferase reporter *** levels of phosphoproteins of the MAPK pathway were analyzed using the Bioplex ***:A dose-dependent cytoprotective effect of Gymnema montanum leaf extract was observed in tunicamycin-induced *** montanum leaf extract significantly reduced lactate dehydrogenase activity and malondialdehyde levels in ER stress-induced endothelial *** also suppressed ER stress markers dose dependently and inhibited the phosphorylation of JNK,ERK,MEK and p38 MAPK in tunicamycin-induced endothelial ***,Gymnema montanum leaf extract increased the expression of Nrf2 and its downstream targets in endothelial ***:Gymnema montanum leaf extract attenuates ER stress by increasing the expression of Nrf2 and its downstream genes.

关键词： ER stress Gymnema montanum Nrf2 Endothelial cells

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In vitro evaluation of free radical scavenging activity of Codariocalyx motorius root extract

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Asian Pacific Journal of Tropical Medicine 2013年第3期6卷 188-194页

作者： Uma Chidambaram Vanitha Pachamuthu suganya natarajan Bhakkiyalakshmi Elango Suriyanarayanan Kunga Mohan Ramkumar Department of Biotechnology School of BioengineeringSRM UniversityKattankulathur-603 203TamilnaduIndia Department of Water and Health JSS UniversityMysore-570015KarnatakaIndia

Objective:To determine the phenolic content in Codariocalyx motorius root extract and to evaluate its antioxidant properties using various in vitro assay ***:The antioxidant activity was evaluated based on scavenging of 1,1—diphenyl—2—picrylhydrazyl,hydroxyl radicals,superoxide anions,nitric oxide,hydrogen peroxide,peroxvnilrile,reducing power and by inhibition oi lipid peroxidation which was estimated in terms of thiohurhituric acid reactive ***:The root extract of the Codariocalyx motorius(***) exhibited potent total antioxidant activity that increased with increasing amount of extract concentration,which was compared with standard drug such as *** *** at different *** different concentrations of the extracts showed inhibition on lipid *** addition,the extracts had effective reducing power,free radical scavenging, super oxide anion scavenging,nitric oxide scavenging,lipid peroxidation,and total phenolic content depending on *** correlation between total phenolic contents and scavenging potential of different reactive oxygen species(r^2=0.83 1 -0.978) indicated the polyphenols as the main ***:Codariocalyx motorius(***) root possess the highly active antioxidant substance which can be used for the treatment of oxidative stress-related diseases.

关键词： Codariocalyx motorius Antioxidant activity Medicinal plants Polyphenols

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