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Genotyping-by-sequencing application on diploid rose and a resulting high-density SNP-based consensus map

Horticulture Research 2018年第1期5卷 668-681页

作者： Muqing Yan David H.Byrne Patricia e.Klein Jizhou Yang Qianni Dong natalie Anderson Department of Horticultural Sciences Texas A&M UniversityCollege StationTX77843USA Institute for Plant Genomics and Biotechnology Texas A&M UniversityCollege StationTX77843USA Department of Computer Science San Francisco State UniversitySan FranciscoCA94132USA Monsanto Company 700 Chesterfield Parkway WestChesterfieldMO63017USA

Roses,which have been cultivated for at least 5000 years,are one of the most important ornamental crops in the *** of the interspecific nature and high heterozygosity in commercial roses,the genetic resources available for rose are *** effectively identify markers associated with QTL controlling important traits,such as disease resistance,abundant markers along the genome and careful phenotyping are *** genotyping by sequencing technology and the strawberry genome(Fragaria vesca v2.0.a1)as a reference,we generated thousands of informative single nucleotide polymorphism(SNP)*** SNPs along with known bridge simple sequence repeat(SSR)markers allowed us to create the first high-density integrated consensus map for diploid *** maps were first created for populations J06-20-14-3×“Little Chief”(J14-3×LC),J06-20-14-3×“Vineyard Song”(J14-3×VS)and“Old Blush”×“Red Fairy”(OB×RF)and these maps were linked with 824 SNPs and 13 SSR bridge *** anchor SSR markers were used to determine the numbering of the rose linkage *** diploid consensus map has seven linkage groups(LGs),a total length of 892.2 cM,and an average distance of 0.25 cM between 3527 *** combining three individual populations,the marker density and the reliability of the marker order in the consensus map was improved over a single population *** synteny between the strawberry and diploid rose genomes was *** consensus map will serve as the tool for the discovery of marker–trait associations in rose breeding using pedigree-based *** high level of conservation observed between the strawberry and rose genomes will help further comparative studies within the Rosaceae family and may aid in the identification of candidate genes within QTL regions.

关键词： breeding crops linkage

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Method for hull-less barley transformation and manipulation of grain mixed-linkage beta-glucan

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Journal of Integrative Plant Biology 2018年第5期60卷 382-396页

作者： Wai Li Lim Helen M. Collins Rohan R. Singh natalie A. J. Kibble Kuok Yap Jillian Taylor Geoffrey B. Fincher Rachel A. Burton ARC Centre of excellence in Plant Cell Walls School of Agriculture Food and Wine University of Adelaide Waite Campus Glen Osmond SouthAustralia 5064 Australia Institute for Molecular Bioscience The University of Queensland，4072，Australia

Hull-less barley is increasingly offering scope for breeding grains with improved characteristics for human nutrition; however, recalcitrance of hull-less cultivars to transformation has limited the use of these varieties. To overcome this limitation, we sought to develop an effective transformation system for hull-less barley using the cultivar Torrens. Torrens yielded a transformation efficiency of 1.8%, using a modified Agrobacterium transformation method. This method was used to over-express genes encoding synthases for the important dietary fiber component, 0,3;1,4）-β-glucan （mixed-linkage glucan）, primarily present in starchy endosperm cell walls. Over-expression of the HvCslF6 gene, driven by an endosperm-specific promoter, produced lines where mixed-linkage glucan content increased on average by 45%, peaking at 70% in some lines, with smaller increases in transgenic HvCsIH1 grain. Transgenic HvCslF6 lines displayed alterations where grain had a darker color, were more easily crushed than wild type and were smaller. This was associated with an enlarged cavity in the central endosperm and changes in cell morphology, including aleurone and sub-aleurone cells. This work provides proof-of-concept evidence that mixed-linkage glucan content in hull-less barley grain can be increased by over-expression of the HvCslF6 gene, but also indicates that hull-less cultivars may be more sensitive to attempts to modify cell wall composition.

关键词： Tobias I. Baskin University of Massachusetts USA

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Inverse Methods in Global Biogeochemical Cycles, Volume 114

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丛书名： Geophysical monograph

2000年

作者： Prasad Kasibhatla Martin Heimann Peter Rayner natalie Mahowald Ronald G. Prinn Dana e. Hartley

ISBN: (数字)9781118664452

ISBN: (纸本)9780875900971

Published by the American Geophysical Union as part of the Geophysical Monograph Series, Volume 114. Our understanding of biogeochemical cycles is directly related to the research and analyses we bring to them, and to our critical sense of the methods we use. Of primary importance here are the theories behind, and our use of, inverse methods and data assimilation techniques across a multidisciplinary context that includes atmosphere-biosphere and atmosphere-ocean interactions, atmospheric chemistry, physical oceanography, and ocean biogeochemistry. Certainly, researchers in many earth system science disciplines, whether novice or expert, will benefit from the breadth and depth we have brought to the topics discussed in this monograph. At the same time, we have provided readers with a unique opportunity to enhance their research acumen and their understanding of ways and means. Toward this end, this monograph consists of a tutorial section with problem sets for use by readers who wish to test and enhance their knowledge, and a research section that showcases some of the latest scientific results from use of the aforementioned methods in a variety of earth science disciplines.

关键词： Biogeochemical cycles

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Males at High Risk for Breast Cancer: Who Are They and How Should We Screen Them?

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Surgical Science 2014年第7期5卷 320-331页

作者： natalie Swergold Vijayashree Murthy Ronald S. Chamberlain Department of Surgery Saint Barnabas Medical Center Livingston USA Saint George’s University School of Medicine Grenada West Indies

Background: It is estimated that 2240 males in the United States will develop invasive breast cancer (BC) in 2013, resulting in 410 deaths. Overall, male breast cancers (MBCs) are diagnosed with larger tumor size, more frequent lymphatic invasion, and advanced tumor stage compared to their female counterparts. Several risk factors have been elucidated for the development of MBC, and this paper aims to critically review the existing literature on at-risk populations and provide screening recommendations. Methods: A comprehensive search for all published studies on populations at risk for MBC using PubMed, eBSCOhost, and Google Scholar was performed (1982- 2013). The search focused specifically on genetic and epidemiologic risk factors, and screening for MBC. Keywords searched included “male breast cancer risk factors”, “male breast cancer epidemiology”, and “male breast cancer genetics”. A total of 34 studies involving 4,865,819 patients were identified. Results: Five studies (N = 327,667) focused primarily on family history of breast cancer as a risk factor for MBC. 15% - 20% of men with BC have a family history of breast or ovarian cancer, and a family history of BC among first-degree relatives confers a 2-to 3-fold increase in MBC risk (odds ratio = 3.3). Seventeen studies (N = 5451) analyzed associations between several heritable genes and MBC. Lifetime MBC risk among BRCA1 mutation carriers is 1% - 5%, while MBC risk in BRCA2 mutation carriers is higher and varies between 4% - 40%. Less clear associations between MBC and PALB2, Androgen Receptor gene, CYP17, and CHeK2 mutations have also been documented. Five studies (N = 16,667) have addressed occupational risk factors for MBC. An 8-fold increase in MBC is reported in males working in the cosmetic cream manufacturing, and the motor vehicle industries. A meta-analysis of 18 trials also identified electromagnetic field exposure as a potential MBC risk, though causation remains undocumented. eleven studies (N = 4,

关键词： Male Breast Cancer Risk Factors Carcinoma of the Male Breast Breast Carcinoma

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The Dangers of Nuclear Proliferation for energy Production ——Are the Benefits Really Worth the Risks?

The Dangers of Nuclear Proliferation for Energy Production ...

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作者： natalie Jordaan （周星星）山东大学

学位级别：硕士

在一国的决策过程中,成本与收益是一项关键的考量因素。然而,这种决策过程是不适用于所有情况的。各国当局为各自的国家和人口已经很长一段时间一直在评估（主要是经济上的）核能源的成本和效益,特别在工业化程度较高的国家。然而,一个... 详细信息

在一国的决策过程中,成本与收益是一项关键的考量因素。然而,这种决策过程是不适用于所有情况的。各国当局为各自的国家和人口已经很长一段时间一直在评估（主要是经济上的）核能源的成本和效益,特别在工业化程度较高的国家。然而,一个更合适的方式来处理核能源问题是衡量其风险和其所带来的利益。代价和风险最大的区别是代价是可预料的;风险不是。而且,在我们所谈的题目上,代价主要的是以经济的形式来计量的;风险是指核能源带来的危险,无数人的生命和环境损失,以及一个相当大的经济损失状态。讨论代价的时候,我们通常是衡量其利益和成本;如此,在讨论风险时,我们拿有可能性比较大的预计来做衡量;问题是：预计的利益值得吗?或者风险太大了吗?然而,在核电的情况下,好处是显而易见的：能源生产。虽然可能承担的风险（即潜在的成本）不应该超出一个明确的实实在在的利益,本文认为,在某些情况下,风险太大了。本论文要讨论的问题到底是： a)如果人们所有关于防止核武器扩散重要性的关注是为了人类安全而不扩散核武器,那么出于同样原因,足够的关注也应该给予防止核能源扩散。 b)核能源当前扩散与推广情况是因为其他能源的缺乏。尽管已经开发的替代能源是采之不尽用之不完的并且对环境有着较小的影响（比如：使用风,水和太阳能）当前世界对取代国家核能源生产并单一依靠天然替代能源计划的落实与实施的观点是,首先,不稳妥,其次,在经济上不可行。然而,事实似乎是相反,此论点在文章的第二部分进行讨论。本论文试图承认不扩散核武器的重要性并找出背后的理论依据,但其重点是在防扩散核能的论点。通过历史事件证明,原子意外都是通过核能源项目而发生的,一样可以像使用核武器那样给人类安全带来隐忠,但至今为止此问题还没有像扩散核武器那样引起足够的重视和考虑并解决这些问题。案例将来自真实历史事件并用其数据来证明核能事故的危险。其次,本文还将讨论美,世界最大的工业国家之一,核能政策以及以21世纪高科技能源发电技术所提供的替代品。本论文还会包括了Doyne Farmer的研究意见,来讨论是否像美国这样的国家可以完全不依靠核能源。如果美国能够做到这一点,那么也许从社会经济和产业化能力完全与美国不同的国家也是有可能做到的。其它经济巨头国家,如德国和中国,在此也会以论点的方式来进行讨论。因此,可行性核能源的未来替代品是我的第三个研究问题。

关键词：核能源成本效益不扩散核武器核能政策风险度量

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Familial Alzheimer's disease modelling using induced pluripotent stem cell technology

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World Journal of Stem Cells 2014年第2期6卷 239-247页

作者： Lisa Mohamet natalie J Miazga Christopher M Ward Stem Cell Biology Group Core Technology FacilityFaculty of Human and Medical SciencesThe University of Manchester

Alzheimer’s disease(AD)is a progressive neurodegenerative disease in which patients exhibit gradual loss of memory that impairs their ability to learn or carry out daily *** of AD is difficult,particularly in early stages of the disease,and largely consists of cognitive assessments,with only one in four patients being correctly *** of novel therapeutics for the treatment of AD has proved to be a lengthy,costly and relatively unproductive process with attrition rates of>90%.As a result,there are no cures for AD and few treatment options available for ***,there is a pressing need for drug discovery platforms that can accurately and reproducibly mimic the AD phenotype and be amenable to high content screening ***,we discuss the use of induced pluripotent stem cells(iPSCs),which can be derived from adult cells,as a method of recapitulation of AD phenotype in *** assess their potential use in high content screening assays and the barriers that exist to realising their full potential in predictive efficacy,toxicology and disease *** present,a number of limitations need to be addressed before the use of iPSC technology can be fully realised in AD therapeutic ***,whilst the use of AD-derived iPSCs in drug discovery remains a fledgling field,it is one with immense potential that is likely to reach fruition within the next few years.

关键词： Human induced pluripotent stem cells Alzheimer’ s disease Neurodegenerative diseases High-throughput screening assays Cholinergic neurons Drug discovery Stratified medicine

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The Plastid envelope CHLOROPLAST MANGANeSe TRANSPORTeR1 Is essential for Manganese Homeostasis in Arabidopsis

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Molecular Plant 2018年第7期11卷 955-969页

作者： Marion eisenhut natalie Hoecker Sidsel Birkelund Schmidt Rubek Merina Basgaran Samantha Flachbart Peter Jahns Tabea eser Stefan Geimer Seren Husted Andreas P.M. Weber Dario Leister Anja Schneider Biochemie der Pflanzen Cluster of Excellence on Plant Science (CEPLAS) Heinrich-Heine-University Di3sseldorf 40225 Desseldorf Germany Molekularbiologie der Pflanzen (Botanik) Department Biologie I Ludwig-Maximilians-University Mernchen 82152 Martinsried Germany Department of Plant and environmental Sciences and Copenhagen Plant Science Centre (CPSC) Faculty of Science University of Copenhagen 1871 Frederiksberg Denmark Zellbiologie/elektronenmikroskopie NW I/B1 Universit&t Bayreuth 95447 Bayreuth Germany These authors contributed equally to this article.

The transition metal manganese （Mn） is indispensable for photoautotrophic growth since photosystem II （PSII） employs an inorganic Mn4CaOs cluster for water splitting. Here, we show that the Arabidopsis membrane protein CHLOROPLAST MANGANeSe TRANSPORTeR1 （CMT1） is involved in chloroplast Mn homeostasis. CMT1 is the closest homolog of the previously characterized thylakoid Mn transporter PHOTOSYNTHeSIS-AFFeCTeD MUTANT71 （PAM71）. In contrast to PAM71, CMT1 resides at the chloro- plast envelope and is ubiquitously expressed. Nonetheless, like PAM71, the expression of CMT1 can also alleviate the Mn-sensitive phenotype of yeast mutant qomrl. The cmtl mutant is severely suppressed in growth, chloroplast ultrastructure, and PSII activity owing to a decrease in the amounts of pigments and thylakoid membrane proteins. The importance of CMT1 for chloroplast Mn homeostasis is demonstratedby the significant reduction in chloroplast Mn concentrations in cmtl-1, which exhibited reduced Mn binding in PSII complexes. Moreover, CMT1 expression is downregulated in Mn-surplus conditions. The pam71 cmtl-ldouble mutant resembles the cmtl-f single mutant rather than pare71 in most respects. Taken together, our results suggest that CMT1 mediates Mn2 uptake into the chloroplast stroma, and that CMT1 and PAM71 function sequentially in Mn delivery to PSII across the chloroplast envelope and the thylakoid membrane.

关键词： manganese transporter envelope chloroplast photosynthesis Arabidopsis

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Recent developments on Opuntia spp.,their bioactive composition,nutritional values,and health effects

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Food Bioscience 2022年第3期47卷 46-66页

作者： Davor Daniloski Nathan M.D'Cunha Hollie Speer Andrew J.McKune natalie Alexopoulos Demosthenes B.Panagiotakos Anka T.Petkoska Nenad Naumovski Victoria University Advanced Food Systems Research UnitInstitute for Sustainable Industries and Liveable Cities and College of Health and BiomedicineMelbourneVictoria8001Australia Teagasc Food Research Centre Food Chemistry and Technology DepartmentMooreparkFermoyP61 C996CorkIreland University of Canberra Faculty of HealthSchool of Rehabilitation and Exercise SciencesBruceAustralian Capital Territory2617Australia University of Canberra Functional Foods and Nutrition Research (FFNR) LaboratoryNgunnawal CountryBruceAustralian Capital Territory2617Australia University of Canberra Research Institute for Sport and Exercise (UC-RISE)BruceAustralian Capital Territory2617Australia University of KwaZulu-Natal Discipline of BiokineticsExercise and Leisure SciencesSchool of Health ScienceDurbanKwaZulu-Natal4000South Africa Chiron Organic Health WedderburnVictoria3518Australia Harokopio University Discipline of Nutrition and DieteticsSchool of Health Science and EducationAthens17676Greece St.Clement of Ohrid University of Bitola Faculty of Technology and Technical SciencesDimitar Vlahov4000VelesNorth Macedonia

Opuntia is a plant that grows in wild,arid,and semi-arid regions,and it is a renowned food source that is presently *** chemical composition and properties of the Opuntia genus have attracted research and commercial interest as its species are rich in phytochemicals,nutrients,and bioactive *** of these constituents have revealed anti-inflammatory,antioxidant,antibacterial,anti-cancer,anti-atherosclerotic,antidiabetic,neurological,and gut protective *** review provides an extensive and up-to-date evidence synthesis of the nutrients in the Opuntia genus,its phytochemical composition,health benefits,the influence of the processing technologies on its bioactive components,and the potential for functional food product *** to its high nutritional value,Opuntia genus has the potential to contribute to improving food security and contribute to the food industry as food additive or ***,Opuntia products can be utilized as food substitutes as part of a well-balanced diet and may potentially have pharmacological *** Opuntia genus is also used as animal feed,a source of nutraceuticals,an addition to edible packaging materials,wastewater treatment,and land rehabilitation in arid *** is a rich source of minerals,essential amino acids,and vitamins,and is high in antioxidants,making it a promising candidate for the management of non-communicable *** potential health-promoting effects of Opuntia consumption remain relatively unexplored,and further research human trials are required to unravel its mechanisms of action.

关键词： Opuntia Functional food Bioactive compounds Non-communicable diseases Health benefits

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成长与探索:职业养成理论与课业规划

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中国职业技术教育 2011年第18期27卷 84-91页

作者：陈贤旭 natalie R.Kosine 长沙职业技术学院湖南浏阳410300 路易斯维尔大学教育与心理咨询系

苏泊尔的职业养成理论认为,人的一生本质上是成长与探索的过程,是以自己的兴趣和能力获取知识以应对职业需求的过程。中学生实际上都处于职业养成的探索阶段。本文探索了此阶段中学生应该做出的课程选择及其深远影响,并对促进职业养成... 详细信息

苏泊尔的职业养成理论认为,人的一生本质上是成长与探索的过程,是以自己的兴趣和能力获取知识以应对职业需求的过程。中学生实际上都处于职业养成的探索阶段。本文探索了此阶段中学生应该做出的课程选择及其深远影响,并对促进职业养成的相关理论及其有效干预进行了评价。

关键词：职业养成课业规划

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Future needs for informed consent in stem cell clinical trials in neurodegenerative diseases

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Neural Regeneration Research 2016年第1期11卷 83-85页

作者： natalie Hellmers Yaa Obeng-Aduasare Inmaculada de Melo-Martín Claire Henchcliffe Weill Cornell Parkinson’s Disease and Movement Disorders Institute Department of Neurology Weill Cornell Medical College Division of Medical ethics Department of Medicine Weill Cornell Medical College

Translation of recent advances in stem cell research into clinical trials for restorative therapies for human disease is accelerating dramatically,with a strong focus upon neurodegenerative disorders such as Parkinson... 详细信息

关键词： consent informed amyotrophic restorative Huntington likely advances accelerating comprehension intracerebral

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