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Review of cost and surgical time implications using virtual patient specific planning and patient specific implants in midface reconstruction

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Plastic and Aesthetic Research 2022年第1期9卷 614-627页

作者： Michael Lawless Brian Swendseid natalia von windheim Kyle VanKoevering Nolan Seim Matthew Old Department of Otolaryngology-Head and Neck Surgery The Ohio State University Comprehensive Cancer CenterThe Ohio State UniversityColumbusOH 43212USA Center for Design and Manufacturing Excellence The Ohio State University College of EngineeringThe Ohio State UniversityColumbusOH 43212USA

Aim:Summarize the available data on midfacial virtual patient specific planning and patient specific implants,highlighting the financial costs and savings,and additionally emphasize the potential cost implications of transitioning to“in-house”virtual 3D modeling and ***:Review of current ***:Current literature suggests cost benefits of virtual patient specific planning and patient specific implants in the form of improved ischemia time,better boney apposition between flaps,and reduced patient *** reduction of complications includes a reduction in blood loss and time spent in the intensive care unit from flap *** boney apposition results in a higher likelihood of boney union and a further reduction in failure and *** benefits of virtual patient specific planning and patient specific implants are shown in the form of improved reconstructive surgeon mental ***-house production of 3D models and presurgical planning provides additional cost benefits for providers as they can produce viable models at a fraction of the price of that which is produced by industrial *** can also construct and use models in an expedient manner compared to industrial models,allowing for the opportunity to be utilized in more acute *** foundation of developing an in-house workflow is adequate funding,resources,and clinical *** also must focus on appropriate quality and safety measures,as well as appropriate workflow development for adequate production of ***:Virtual patient specific planning and patient specific implants show benefits in midfacial reconstructive outcomes,resulting in realized financial and temporal gains for both patient and *** gains may be enhanced by moving to in-house planning and printing.

关键词： Virtual patient specific planning midface maxillofacial reconstruction head and neck cost 3D-printing

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In situ high-pressure nuclear magnetic resonance crystallography in one and two dimensions

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Matter and Radiation at Extremes 2021年第6期6卷 94-103页

作者： Thomas Meier Alena Aslandukova Florian Trybel Dominique Laniel Takayuki Ishii Saiana Khandarkhaeva natalia Dubrovinskaia Leonid Dubrovinsky Center for High Pressure Science and Technology Advanced Research BeijingChina Bayerisches Geoinstitut University of BayreuthBayreuthGermany Department of Physics Chemistry and Biology(IFM)Linkoping UniversitySE-58183 LinkopingSweden Material Physics and Technology at Extreme Conditions Laboratory of CrystallographyUniversity of BayreuthBayreuthGermany

Recent developments in in situ nuclear magnetic resonance(NMR)spectroscopy under extreme conditions have led to the observation of a wide variety of physical phenomena that are not accessible with standard high-pressure experimental ***,inherent di-or quadrupolar line broadening in diamond anvil cell(DAC)-based NMR experiments often limits detailed investigation of local atomic structures,especially if different phases or local environments ***,we describe our progress in the development of high-resolutionNMRexperiments in DACs using one-and two-dimensional homonuclear decoupling experiments at pressures up to the megabar *** this technique,spectral resolutions of the order of 1 ppm and below have been achieved,enabling high-pressure structural *** examples are presented that demonstrate the wide applicability of this method for extreme conditions research.

关键词： NMR extreme dimensions

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A cop1 spa Mutant Deficient in COP1 and SPA Proteins Reveals Partial Co-Action of COP1 and SPA during Arabidopsis Post-Embryonic Development and Photomorphogenesis

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Molecular Plant 2015年第3期8卷 479-481页

作者： natalia Ordonez-Herrera Petra Fackendahl Xu Yu Sabine Schaefer Csaba Koncz Ute Hoecker Botanical Institute and Cluster of Excellence on Plant Sciences (CEPLAS) Biocenter University of Cologne Zülpicher Strasse 47b 50674 Cologne Germany Max Planck Institute for Plant Breeding Research Carl-von-Linné Weg 10 50829 Cologne Germany Institute of Plant Biology Biological Research Center of Hungarian Academy of Sciences Temesvari krt. 62 H-6726 Szeged Hungary

Dear Editor,The Arabidopsis CONSTITUTIVELY PHOTOMORPHOGENIC1/ SUPPRESSOR OF PHYA-105 （COP1/SPA） complex is a key repressor of light signaling that inhibits light responses in dark- ness. It acts as an E3 ubiquitin ligase, which ubiquitinates posi- tively acting light-signaling intermediates, mainly transcription factors, thereby targeting them for proteolytic degradation by the 26S proteasome. In the light, photoreceptors directly interact with the COP1/SPA complex, leading to its inactivation, which subsequently allows the target transcription factors to accumu- late and initiate vast reprogramming of gene expression （Huang et al., 2014）.

关键词： COP1 SPA 蛋白质拟南芥光形态建成胚胎发育突变体 26S蛋白酶体

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Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture

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Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： Jean-Daniel Malcor Emma J.Hunter natalia Davidenko Daniel V.Bax Ruth Cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUVECs),by inhibiting cell–collagen ***,we have improved crucial HUVEC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUVEC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

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Regeneration of Nothofagus dombeyi(Mirb.)Ø*** little to moderately disturbed southern beech forests in the Andes of Patagonia(Argentina)

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Forest Ecosystems 2023年第4期10卷 472-482页

作者： Stefan Zerbe Stefanie T.Storz Georg Leitinger natalia Zoe Joelson JoséBava Steffi Heinrichs Christoph Leuschner Gabriel Loguercio Alois Simon María F.Urretavizcaya Helge Walentowski Faculty of Agricultural Environmental and Food SciencesFree University of Bozen-BolzanoBolzanoItaly Department of Ecology University of InnsbruckInnsbruckAustria Faculty of Resource Management HAWK University of Applied Sciences and ArtsGöttingenGermany Department of Plant Ecology and Ecosystem Research Albrecht-von-Haller-Institute for Plant SciencesUniversity of GöttingenGöttingenGermany Centro de Investigación y Extensión Forestal Andino Patagónico(CIEFAP) EsquelArgentina Department of Forest Planning Tyrol Forest AdministrationOffice of the Tyrolean GovernmentInnsbruckAustria

Natural forests and stands subjected to little to moderate human impact are continuously declining worldwide and with these,their biodiversity and ecosystem *** Nothofagus forests in the south of the South American continent are in a pristine state or only moderately impacted by *** grazing by livestock,in the past and still today often practiced in a non-sustainable way is,however,increasingly under discussion to meet current environmental and socio-economic ***,we investigate the regeneration of Nothofagus dombeyi,a keystone species of the Patagonian Andes,in secondary forests in Argentinian northern Patagonia,particularly addressing the role of disturbance through grazing by livestock at various *** test the hypothesis that the regeneration of this tree species is favored by grazing impact and,thus,disturbance of the herb layer and soil *** support of our hypothesis,Nothofagus dombeyi regeneration was significantly higher in terms of individuals and height classes in moderately grazed *** analysis shows significant positive effects of moderate grazing pressure,herb layer cover,and the occurrence of bare soil on the regeneration of Nothofagus *** results show that an integration of livestock grazing and forest regeneration is possible and that agroforestry systems can be an adequate management option for stakeholders in the region.A grazing management can also be part of a forest fire prevention ***,the regeneration success and grazing pressure should be continuously monitored.

关键词： Agroforestry Disturbance Fire management Forest grazing Forest management Plant traits

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阿尔泰山地区全新世植被和气候变化（英文）

阿尔泰山地区全新世植被和气候变化（英文）

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中国古生物学会第十二次全国会员代表大会暨第29届学术年会

作者：黄小忠彭卫 natalia Rudaya Eric C.Grimm 陈雪梅曹现勇张军潘小多刘思丝陈春珠陈发虎 Key Laboratory of Western China's Environmental System(Ministry of Education) College of Earth and Environmental SciencesLanzhou University Kazan State University Alfred Wegener Institute Helmholtz Center for Polar and Marine Research Department of Periglacial Research Institute of Earth and Environmental Science University of Potsdam Department of Earth Sciences University of Minnesota Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Institute of Tibetan Plateau Research Chinese Academy of Sciences School of Geographic Science Nantong University

A comprehensive understanding of the regional vegetation responses to long-term climate change will help forecast earth system *** on a new well-dated pollen dataset from Kanas Lake and a review of published pollen records from in and around the Altai Mountains,the regional vegetation dynamics and forcing mechanisms are *** the Altai Mountains,the forest optimum occurred during 10-7 ka for the upper forest zone and a tree line decline and/or ecological shifts were caused by climatic cooling from around 7 *** the lower forest zone,the forest reached an optimum in the middle Holocene,and then increased openness of the forest,possibly caused by both climatic cooling and human activities,occurred in the late *** the lower basins or plains around the Altai Mountains,the development of proto-grassland or forest benefited from increasing humidity in the middle to late *** Points:A new pollen data set from a large deep lake was used to interpret the regional vegetation and climate of the southern Altai *** vegetation showed different long-term responses to climate change in and around the Altai *** dynamics and their impact on geophysical processes should be incorporated into coupled vegetation-climate models.

关键词： Altai Mountains Kanas Lake Holocene vegetation climate change

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