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Biomedical and Environmental Sciences 2024年第9期37卷 1086-1090页

作者： Igor Mokrousov Tatiana Vinogradova Marine Dogonadze Maria Vitovskaya natalia zabolotnykh Sergei Chekrygin Anna Vyazovaya Laboratory of Molecular Epidemiology and Evolutionary Genetics St.Petersburg Pasteur InstituteSt.Petersburg197101Russia Henan International Joint Laboratory of Children’s Infectious Diseases Children’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s Hospital Zhengzhou Children’s HospitalZhengzhou 450012HenanChina St.Petersburg Research Institute of Phthisiopulmonology St.PetersburgRussia Resource Center Bio-bank Center Research Park of St.Petersburg State UniversitySt.PetersburgRussia

Despite well-known limitations,mice remain useful as model animals to study tuberculosis(TB)pathogenesis,the basic immune response,the extent of lung pathology as well as efficacy of new drugs against Mycobacterium tuberculosis[1,2].There are four routes of tuberculosis infection in mice:aerosol generation and exposition,intravenous injection,intranasal administration,and subcutaneous administration[3].

关键词： tuberculosis drugs injection

Composite Biomaterials Based on Poly(L-Lactic Acid)and Functionalized Cellulose Nanocrystals

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Journal of Renewable Materials 2020年第4期8卷 383-395页

作者： Mariia Stepanova Ilia Averianov Olga Solomakha natalia zabolotnykh Iosif Gofman Mikhail Serdobintsev Tatiana Vinogradova Viktor Korzhikov-Vlakh Evgenia Korzhikova-Vlakh Institute of Macromolecular Compounds Russian Academy of SciencesSt.Petersburg199004Russia St.Petersburg Research Institute of Phthisiopulmonology St.Petersburg194064Russia Institute of Chemistry Saint-Petersburg State UniversitySt.Petersburg199034Russia

The biocomposite films were prepared from poly(L-lactic acid)and cellulose *** improve interfacial compatibility of hydrophilic cellulose nanocrystals with hydrophobic matrix polymer as well as to provide the osteoconductive properties,cellulose was functionalized with poly(glutamic acid).The modified cellulose nanocrystals were better distributed and less aggregated within the matrix,which was testified by scanning electron,optical and polarized light *** to mechanical tests,composites filled with nanocrystals modified with PGlu demonstrated higher values of Young’s modulus,elongation at break and tensile *** of composite materials in model buffer solutions for 30 weeks followed with staining of Ca^(2+)deposits with Alizarin Red S assay testified better mineralization of materials containing PGlu-modified cellulose nanocrystals as *** the result of in vivo experiment,the developed composite materials showed less level of inflammation in comparison with pure polymer matrix and composites filled with non-functionalized cellulose nanocrystals.

关键词： Biomaterials polymer composites biodegradable and biocompatible polymers poly(L-lactic acid) cellulose nanocrystals modification

Proteostasis failure:at the intersection between aging and Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3221-3222页

作者： natalia Poblete Claudio Hetz Center for Geroscience Brain Health and MetabolismSantiagoChile Biomedical Neuroscience Institute Faculty of MedicineUniversity of ChileSantiagoChile Program of Cellular and Molecular Biology Institute of Biomedical SciencesFaculty of MedicineUniversity of ChileSantiagoChile Buck Institute for Research on Aging NovatoCAUSA

Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of *** we have gained important insights into the pathogenic mechanisms of AD,only palliative care is available to *** is characterized by the abnormal deposition of protein aggregates in the brain formed by amyloid β and hyper-phosphorylated,Tau in addition to neuroinflammation.

关键词： Alzheimer amyloid stasis

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： natalia Kulesskaya Kira M.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

The comparison of design airflow rates with dynamic and steady-state displacement models in varied dynamic conditions

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Building Simulation 2021年第4期14卷 1201-1219页

作者： natalia Lastovets Risto Kosonen Juha Jokisalo Department of Mechanical Engineering Aalto UniversityEspooFinland College of Urban Construction Nanjing Tech UniversityNanjingChina

A temperature-based method is usually applied in displacement ventilation (DV) design when overheating is the primary indoor climate concern. Different steady-state models have been developed and implemented to calculate airflow rate in rooms with DV. However, in practical applications, the performance of DV depends on potentially dynamic parameters, such as strength, type and location of heat gains and changing heat gain schedule. In addition, thermal mass affects dynamically changing room air temperature. The selected steady-state and dynamic models were validated with the experimental results of a lecture room and an orchestra rehearsal room. Among the presented models, dynamic DV model demonstrated a capability to take into account the combination of dynamic parameters in typical applications of DV. The design airflow rate is calculated for the case studies of dynamic DV design in the modelled lecture room in both dynamic and steady-state conditions. In dynamic conditions of heavy construction in 2–4 hours occupancy periods, the actual airflow rate required could be 50% lower than the airflow rate calculated with the steady-state models. The difference between steady-state and dynamic multi-nodal model is most significant with heavyweight construction and short occupancy period (17%–28%). In cases with light construction, the dynamic DV model provides roughly the same airflow rates for four-hour occupancy period than the Mund’s model calculates. The dynamic model can significantly decrease the design airflow rate of DV, which can result in a reduction of investment costs and electrical consumption of fans.

关键词： displacement ventilation design airflow rate temperature gradient dynamic model simplified building energy models

Revisiting non-linear Thomson scattering with metamaterials

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National Science Review 2024年第1期11卷 71-72页

作者： natalia M.Litchinitser Department of Electrical and Computer Engineering Duke University

Non-linear optics is a branch of optics that studies the intriguing and sometimes unexpected ways in which light and matter interact at high intensities, when the polarization density does not respond linearly to the electric field of the light. The pursuit of the perfect non-linear optical material has been ongoing ever since the pioneering experiment on second harmonic generation carried out by Franken in 1961 [1]. Indeed,

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Distribution and diversity of microbial communities in meromictic soda Lake Doroninskoe(Transbaikalia,Russia) during winter

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Chinese Journal of Oceanology and Limnology 2015年第6期33卷 1378-1390页

作者： Evgeniya MATYUGINA natalia BELKOVA Institute of Natural Resources Ecology and CryologySiberian Branch of the Russian Academy of Sciences Limnological Institute Siberian Branch of the Russian Academy of Sciences Irkutsk State University

Meromictic soda and saline lakes are unique ecosystems characterized by the stability of physical,chemical and biological parameters,and they are distributed all over the *** located in regions with average annual negative air temperature are of particular interest because of the presence of two periods with intensive and dynamic processes:the so-called biological summer and the long ice season with the biological *** Lake Doroninskoe is located in Eastern Transbaikalia(51°14′N,112°14′E) in the permafrost zone in an extreme continental climate,and is covered by ice for seven months per *** structure and diversity of the microbial communities throughout the water column of the lake was studied by 16 S r RNA gene amplicon *** species with specific functions were found to dominate at different *** flexible bacteria with a capacity to switch between anoxygenic photosynthesis and aerobic chemotrophic metabolism dominate in soda Lake Doroninskoe.

关键词： bacterial diversity soda lake meromixis Lake Doroninskoe 16S rRNA genes high-throughput amplicon sequencing

Diffuse matter and cosmogony of stellar systems in researches by ***

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Research in Astronomy and Astrophysics 2018年第8期18卷 89-96页

作者： natalia Ivanovna Bondar Crimean Astrophysical Observatory RAS Nauchny298409Russia

The main topic of long-term researches by G.A. Shajn is the nature of diffuse matter, its dis- tribution in the Galaxy and extragalactic systems, interaction with the interstellar medium and hot stars, and the formation of emission and reflection nebulae and stars. Based on the analysis of experimental data, mainly photographic observations of nebulae in the Milky Way and extragalactic systems, he made conclusions and suggested well-founded hypotheses on a wide range of considered problems, including those related to cosmogony. The structure of nebulae, and their masses and sizes give reasons behind the conclusion that most of them are formed not in the process of ejection of matter from the stars, but rather they are objects which are born and evolve, and quite often are comprised of giant conglomerates of gas, dust and stars. The distribution of OB-type stars and nebulae in spiral branches points to their genetic relation and the fundamental role of the interstellar medium as the source of their formation. The structural features of nebulae are determined by the action of magnetohydrodynamic forces. Magnetic fields in a galaxy control the motion of diffuse gas-dust matter and ensure the maintenance of its spiral structure. These ideas continue being developed in modern directions of astrophysics.

关键词： galaxy interstellar matter diffuse nebulae cosmogony

TRP channels in prostate cancer： the good, the bad and the ugly？

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Asian Journal of Andrology 2011年第5期13卷 673-676页

作者： Dimitra Gkika natalia Prevarskaya llnserm U1003 Equipe labellisee par la Ligue Nationale contre le cancer Villeneuve d＇Ascq France Universite des Sciences et Technologies de Lille （USTL） Villeneuve d＇Ascq France

During the last decade, transient receptor potential （TRP） channels emerge as key proteins in central mechanisms of the carcinogenesis such as cell proliferation, apoptosis and migration. Initial studies showed that expression profile of some TRP channels, notably TRP melastatin 8 （TRPM8）, TRP vanilloid 6 （TRPV6）,TRP canonical （TRPC6） and TRPV2, is changing during the development and the progression of prostate cancer towards the hormone-refractory stages. The link between the change in expression levels and the functional role of these channels in prostate cancer is step by step being elucidated. These recent advances are here described and discussed.

关键词： ion channel lysophospholipids migration neuroendocrine prostate cancer PSA transient receptor potential (TRP)channels TRP channels TRPM8 TRPV6 TRPV2

On the Local Solvability and Stability for the Inverse Spectral Problem of the Generalized Dirichlet–Regge Problem

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Acta Mathematica Sinica,English Series 2022年第7期38卷 1229-1240页

作者： Xiao Chuan XU natalia Pavlovna BONDARENKO School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044P.R.China Department of Applied Mathematics and Physics Samara National Research UniversityMoskovskoye Shosse 34Samara 443086Russia Department of Mechanics and Mathematics Saratov State UniversityAstrakhanskaya 83Saratov 410012Russia

For the generalized Dirichlet–Regge problem with complex coefficients,we prove the local solvability and stability for the inverse spectral problem,which indicates an improved result of the previous work([Journal of ... 详细信息

关键词： Dirichlet-Regge problem inverse spectral problem local solvability stability reconstruction algorithm