Composite Biomaterials Based on Poly(L-Lactic Acid)and Functionalized Cellulose Nanocrystals

作     者：Mariia Stepanova Ilia Averianov Olga Solomakha Natalia Zabolotnykh Iosif Gofman Mikhail Serdobintsev Tatiana Vinogradova Viktor Korzhikov-Vlakh Evgenia Korzhikova-Vlakh 

作者机构：Institute of Macromolecular CompoundsRussian Academy of SciencesSt.Petersburg199004Russia St.Petersburg Research Institute of PhthisiopulmonologySt.Petersburg194064Russia Institute of ChemistrySaint-Petersburg State UniversitySt.Petersburg199034Russia 

出 版 物：《Journal of Renewable Materials》 (可再生材料杂志（英文）)

年 卷 期：2020年第8卷第4期

页      面：383-395页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 08[工学] 0706[理学-大气科学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：funded by the Russian Ministry of Education and Science(state contract no.14.W03.31.0014 MegaGrant) 

主　　题：Biomaterials polymer composites biodegradable and biocompatible polymers poly(L-lactic acid) cellulose nanocrystals modification 

摘      要：The biocomposite films were prepared from poly(L-lactic acid)and cellulose *** improve interfacial compatibility of hydrophilic cellulose nanocrystals with hydrophobic matrix polymer as well as to provide the osteoconductive properties,cellulose was functionalized with poly(glutamic acid).The modified cellulose nanocrystals were better distributed and less aggregated within the matrix,which was testified by scanning electron,optical and polarized light *** to mechanical tests,composites filled with nanocrystals modified with PGlu demonstrated higher values of Young’s modulus,elongation at break and tensile *** of composite materials in model buffer solutions for 30 weeks followed with staining of Ca^(2+)deposits with Alizarin Red S assay testified better mineralization of materials containing PGlu-modified cellulose nanocrystals as *** the result of in vivo experiment,the developed composite materials showed less level of inflammation in comparison with pure polymer matrix and composites filled with non-functionalized cellulose nanocrystals.