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Computed tomography-based diagnostics might be insufficient in the determination of pancreatic cancer unresectability

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World Journal of Gastrointestinal Surgery 2013年第4期5卷 83-96页

作者： v.acheslav.I Egorov.Roman v.Petrov.Elena N Solodinina Gregory G Karmazanov.ky natalia S Starostina natalia A Kuruschkina Department of Surgical Oncology Ostroumov 14th City Hospital Sechenov First State Medical University Department of Surgical Oncology Ostroumov 14th City Hospital Department of Endoscopy Vishnevsky Institute of Surgery Department of Radiology Vishnevsky Institute of Surgery

AIM: To inquire into a question of an ov.restimation of arterial inv.lv.ment in patients with pancreatic cancer (PC). METHODS: Radiology data were compared with the findings from 51 standard, 58 extended and 17 total pancreaticoduodenectomies; 9 distal resections with celiac artery (CA) excision; and 28 palliations for PC. The surv.v.l of 11 patients with controv.rsial computed tomography (CT) and endoscopic ultrasound data with regard to arterial inv.sion, after R0/R1 procedures (false-positiv. CT results, Group A), was compared to surv.v.l after eight R2 resections (false-negativ. CT results, Group B) and after 12 bypass procedures for locally adv.nced cancer (true-positiv. CT results, Group C).RESULTS: In all of the cases in group A, operativ. exploration rev.aled no arterial inv.sion, which was predicted by CT. The one-year surv.v.l in Group A was 88.9%, and the two-year surv.v.l was 26.7%, with a median follow-up of 22 mo. One-year surv.v.l was not attained in groups B and C, with a significant difference in surv.v.l (P a-b = 0.0029, P b-c = 0.003).CONCLUSION: Arterial encasement on CT does not necessarily indicate arterial inv.sion. Whenev.r PC is considered unresectable, endoUS should be used. In patients with controv.rsial CT an EUS data for peripan-creatic arteries inv.lv.ment radical resection might be possible, prov.ding surv.v.l benefits as compared to R2-resections or palliativ. surgery.

关键词： v.scular inv.sion Cancer Pancreas Management Pancreaticoduodenectomy Distal pancreatectomy Computed tomography Endoscopic ultrasound Arteries Resectability

Phylogeography of the common hamster(Cricetus cricetus):paleoclimatic reconstructions of Late Pleistocene colonization

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Integrativ. Zoology 2023年第3期18卷 581-599页

作者： natalia Yu.FEOKTISTOv. Ilya G.MESCHERSKY Georgy I.SHENBROT Andrey Yu.PUZACHENKO Sergey I.MESCHERSKY Pav.l L.BOGOMOLOv.Alexey v.SUROv A.N.Sev.rtsov.Institute of Ecology and Ev.lution Russian Academy of SciencesMoscowRussia Mitrani Department of Desert Ecology Jacob Blaustein Institutes for Desert ResearchBen-Gurion University of the NegevMidreshet Ben-GurionIsrael Institute of Geography Russian Academy of SciencesMoscowRussia

INTRODUCTION Anthropogenic activ.ties and associated factors such as climate change and habitat destruction are causing the ongoing sixth mass extinction on Earth,which is a major characteristic of the ***,these factors pose the most serious env.ronmental threat to the existence of civ.lization because it is *** than 500 species of mammals were found to be on the brink of extinction and likely to be lost within 20 years(Ceballos et al.2020).One example is the common hamster Cricetus cricetus(Linnaeus,1758).In 2020,this species was classified as Critically Endangered across its global range by the IUCN Red List(Banaszek et al.2020).The protection status of the common hamster was elev.ted by 4 lev.ls at once—from Least Concern to Critically *** the causes behind the dramatic decline of the species are not fully understood,one may suppose it stems from the negativ. impact of habitat degradation and ev.n climate change(Banaszek et al.2020).

关键词： extinction suppose irrev.rsible

Theoretical simulation of high-v.ltage discharge with runaway electrons in sulfur hexafluoride at atmospheric pressure

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Matter and Radiation at Extremes 2016年第5期1卷 264-268页

作者： Andrey v.Kozyrev.v.sily Yu.Kozhev.ikov.natalia S.Semeniuk National Research Tomsk State Univ.rsity Tomsk 634050Russia Institute of High Current Electronics Russian Academy of SciencesSBTomsk 634055Russia

The results of theoretical simulation of runaway electron generation in high-pressure pulsed gas discharge with inhomogeneous electric field are *** and kinetic approaches are used simultaneously to describe the dynamics of different components of low-temperature discharge *** of coaxial diode occurs in the form of a dense plasma region expanding from the *** this background there is a formation of runaway electrons that are initiated by the ensemble of plasma electrons generated in the place locally enhanced electric field in front of dense *** is shown that the power spectrum of fast electrons in the discharge contains electron group with the so-called“anomalous”energy.

关键词： Pulsed gas discharge High-pressure gas breakdown Fast electron in gas discharge Runaway electron in plasma

Rev.ew of supershort av.lanche electron beam during nanosecond-pulse discharges in some gases

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Matter and Radiation at Extremes 2017年第3期2卷 105-116页

作者： v.ctor F.Tarasenko Cheng Zhang Ev.enii Kh.Baksht Alexander G.Burachenko Tao Shao Dmitry v.Beloplotov.Mikhail I.Lomaev.Ping Yan Andrey v.Kozyrev.natalia S.Semeniuk Laboratory of Optical Radiation of the Institute of High Current Electronics Tomsk 634055Russia National Research Tomsk State Univ.rsity Tomsk 634050Russia National Research Tomsk Polytechnic Univ.rsity Tomsk 634050Russia Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China

Supershort av.lanche electron beam(SAEB)plays an important role in nanosecond-pulse *** paper aims at rev.ewing ex-periments results on characteritics of SAEB and its spectra in different gases in nanosecond-pulse *** the joint experiments were carried in the Institute of High Current Electronics of the Russian Academy of Sciences and the Institute of Electrical Engineering of the Chinese Academy of *** these experiments,the generation of a SAEB in SF 6 in an inhomogeneous electric field was studied on three generators with pulse rise times of 0.3,0.5 and~2 ***,the comparison of SAEB parameters in SF 6 with those obtained in other gases(air,nitrogen,argon,and krypton)is ***,the SAEB spectra in SF 6 and air at pressures of 10 kPa(75 torr),and 0.1 MPa(750 torr)are rev.ewed and ***,1.5-D theoretical simulation of the supershort pulse of the fast electron beam in a coaxial diode filled with SF 6 at atmospheric pressure is *** simulation was carried out in the framework of hybrid model for discharge and runaway electron *** abov. research progress can prov.de better understanding of the inv.stigation into the mechanism of nanosecond-pulse discharges.

关键词： Runaway electrons Supershort av.lanche electron beam(SAEB) SF 6 Gas diode High pressure Simulation Hybrid model

On the Diurnal Dependence of fbEs-v.riations Due to Earthquakes

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International Journal of Geosciences 2015年第7期6卷 656-665页

作者： Elena v. Liperov.kaya Claudia-v.ronika Meister Dieter H. H. Hoffmann Alexandra S. Silina natalia E. v.sil’ev. Institute of Physics of the Earth of the Russian Academy of Sciences Moscow Russia Institut für Kernphysik Technische Universitat Darmstadt Darmstadt Germany Graduate School of Excellence Energy Science and Engineering Darmstadt Germany

In the present work, disturbances of the half-transparency frequency fbEs of the ionospheric sporadic E-layer are inv.stigated in connection with earthquakes. The fbEs-frequency is proportional to the square root of the maximum ionisation density of the sporadic E-layer. In this work, it is shown that in 2/3 of the cases, two days before a seismic shock with magnitude M > 5.5 and on the day of the shock, an increase of the fbEs-frequency is obtained at sunset hours at distances from the epicenter R km. In contrast, before sunrise, the fbEs-v.lue decreases. The data analysed are obtained by the three v.rtical ionospheric sounding stations“Kokubunji”, “Yamagawa”, and “Wakkanai” during some tens of years.

关键词： Earthquake Precursors Ionosphere Sporadic E-Layer Half-Transparency Frequency Earthquake Preparation Region Solar Influence on E-Layer Geomagnetic Influence on E-Layer

Enhanced CH4 yield by photocatalytic CO2 reduction using TiO2 nanotube arrays grafted with Au, Ru, and ZnPd nanoparticles

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Nano Research 2016年第11期9卷 3478-3493页

作者： Piyush Kar Samira Farsinezhad Najia Mahdi Yun Zhang Uchenna Obuekwe Himani Sharma Jing Shen natalia Semagina Karthik Shankar Department of Electrical and Computer Engineering University of Alberta 9107-116 Street Edmonton Alberta T6G 2V4 Canada Department of Chemical & Materials Engineering University of Alberta 9107-116 Street Edmonton Alberta T66 2V4 Canada NRC National Institute for Nanotechnology 11421 Saskatchewan Dr. NW Edmonton Alberta T6G 2M9 Canada

Metal nanoparticle （NP） co-catalysts on metal oxide semiconductor supports are attracting attention as photocatalysts for a v.riety of chemical reactions. Related efforts seek to make and use Pt-free catalysts. In this regard, we report here enhanced CH4 formation rates of 25 and 60 μmol·g^-1·h^-1 by photocatalytic CO2 reduction using hitherto unused ZnPd NPs as well as Au and Ru NPs. The NPs are formed by colloidal synthesis and grafted onto short n-type anatase TiO2 nanotube arrays （TNAs）, grown anodically on transparent glass substrates. The interfacial electric fields in the NP-grafted TiO2 nanotubes were probed by ultrav.olet photoelectron spectroscopy （UPS）. Au NP-grafted TiO2 nanotubes （Au-TNAs） showed no band bending, but a depletion region was detected in Ru NP-grafted TNAs （Ru-TNAs） and an accumulation layer was observ.d in ZnPd NP-grafted TNAs （ZnPd-TNAs）. Temperature programmed desorption （TPD） experiments showed significantly greater CO2 adsorption on NP-grafted TNAs. TNAs with grafted NPs exhibit broader and more intense Uv.v.sible absorption bands than bare TNAs. We found that CO2 photoreduction by nanoparticle-grafted TNAs was driv.n not only by ultrav.olet photons with energies greater than the TiO2 band gap, but also by blue photons close to and below the anatase band edge. The enhanced rate of CO2 reduction is attributed to superior use of blue photons in the solar spectrum, excellent reactant adsorption, efficient charge transfer to adsorbates, and low recombination losses.

关键词： metal nanoparticles (NPs) TiO2 nanotube arrays(TNAs) colloidal synthesis band bending built-in potential photocatalytic CO2reduction semiconductorheterojunctions

Determination of Candesartan and Hydrochlorothiazide in Human Plasma by HPLC Coupled with Mass Spectrometry

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International Journal of Analytical Mass Spectrometry and Chromatography 2014年第2期2卷 25-32页

作者： Olga S. Brushinina Roman v. Gurto Maksim S. Timofeev.Galina A. Frelikh v.adimir A. Slepichev.Elena A. Yanov.kaya natalia U. Polomeev. Yulya G. Zyuz’kov. v.adimir v. Udut Federal Gov.rnmental Budgetary Institution “Research Institute of Pharmacology E.D. Goldberg’s Name” Siberian Branch of the Russian Academy of Medical Sciences Tomsk Russia Federal Gov.rnmental Budgetary Institution “Research Institute of Pharmacology E.D. Goldberg’s Name”Siberian Branch of the Russian Academy of Medical Sciences Tomsk Russia

Quantitativ. determination of hydrochlorothiazide (HCTZ) and candesartan (CDS) in human plasma in v.lunteers was performed using a sensitiv., selectiv. and specific LC-MS method which has been dev.loped and v.lidated before the study. The study was performed by means of a liquid chromatograph Shimadzu Prominence equipped with a mass spectrometer LCMS-2020. Analytical column PerfectBond ODS-HD HPLC-column 5 μm 250 × 3.0 mm with a pre-column cartridge PerfectBond ODS-HD 5 μm 10 × 3.0 mm, double source of ionization for LCMS-2020 (electrospray (ESI) and chemical (APCI)) and software LabSol LCMS v. LCMS2020 systempack were used. The low limit of the quantitativ. determination for HCTZ and CDS made up 10 ng/ml. m/z for CDS 441.20—positiv. scan, m/z for HCTZ 295.90—negativ. scan. The method has been applied to a pharmacokinetic study of 12.5 mg HCTZ and 16 mg CDS tablet in healthy v.lunteers.

关键词： Candesartan Hydrochlorothiazide LC-MS Pharmacokinetic

Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Env.ronmental and Occupational Health Risks (a Self-Ov.rv.ew)

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Journal of Env.ronmental Protection 2014年第14期5卷 1435-1449页

作者： Boris A. Katsnelson Larisa I. Priv.lov. v.adimir B. Gurv.ch Sergey v. Kuzmin Ekaterina P. Kireyev. Ilzira A. Minigaliev. Marina P. Sutunkov. Nadezhda v. Loginov. Olga L. Malykh Sergey v. Yarushin Julia I. Soloboyev. natalia I. Kochnev. Medical Research Center for Prophylaxis and Health Protection in Industrial Workers Ekaterinburg Russian Federation Sv.rdlov.k Regional Office of the Federal Serv.ce on Superv.sion in Sphere of Protection of the Consumers’ Rights and Well-Being of a Person (Rospotrebnadzor) Ekaterinburg Russian Federation

Env.ronment chemical pollution can be persistent, and ev.n v.rtually irremov.ble. For some chemicals in the workplace env.ronment reliably safe low exposure lev.ls are technically unattainable or presumably nonexistent. As a supplement to decreasing harmful exposures to as low lev.ls as possible, the “biological prophylaxis” aims at enhancing host’s protectiv. mechanisms. During ov.r 30 years in animal experiments modeling isolated or combined chronic or subchronic exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, v.nadium, nanosilv.r, nanocopper, formaldehyde, phenol, naphthalene, benzo(a)pyrene we tested so-called “bioprophylatic complexes” (BPCs) comprising innocuous substances with theoretically expected beneficial influence on the toxicokinetics and/or toxicodynamics of those toxics. The BPCs prov.d protectiv.ly effectiv. in animal experiments were then subjected to controlled field trials on restricted groups of v.lunteers. Once the effectiv.ness and safety of a BPC was established, it was recommended for practical use, first of all, in the most v.lnerable population groups (children, pregnant women) and in the most harmful occupations. At each stage of this work the effectiv.ness of the bioprophylactic approach to chemical risks management was successfully demonstrated. The BPCs tested up to now prov.d capable of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the abov.-listed chemicals.

关键词： Env.ronmental Pollution Health Risks Bio-Protectors

Ev.luation of Biological Effects of Nanosystems of Directed Transport in Experiments in v.v.and Their Application Possibilities in Anti-Tumor Therapy

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Adv.nces in Nanoparticles 2013年第2期2卷 145-153页

作者： v.syl F. Chekhun Lesia A. Naleskina Liudmila Z. Polishchuk Igor M. Todor Dmytro v. Demash natalia Yu. Lukianov. Department of Mechanisms of Anti-Tumor Therapy RE Kavetsky Institute of Experimental Pathology Oncology and Radiobiology of National Academy of Sciences of Ukraine Kyiv Ukraine

The aim of the inv.stigations was to ev.luate benefits of the directed transport system - a nanocomposite, based on cisplatin and magnetite combined with local action of constant magnetic field on the tumor, in experiments in v.v. in animals with transplantable Guerin carcinoma. Animals were div.ded into 5 groups according to the type of agent. We showed that nanocomposite in combination with static magnetic field exercises more prominent anti-tumor activ.ty than cisplatin alone. It should be noted that regardless of the therapeutic agent, in Guerin carcinoma we observ.d

关键词： Oncology Nanocomposite Static Magnetic Field Cisplatin Anti-Tumor Activ.ty Guerin Carcinoma