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World Journal of Gastroenterology 2014年第38期20卷 13911-13919页

作者： Márcia Sanae Mizuno Amanda Rabello Crisma primavera Borelli Bárbara Tavares schfer Mariana póvoa Silveira patricia Castelucci Department of Anatomy/Biomedical Science Institute University of S?o Paulo Faculty of pharmaceutical Sciences University of S?o Paulo Department of Surgery Faculty of Veterinary Medicine and Animal ScienceUniversity of S?o Paulo

AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese ***:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were *** tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the p2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric *** neurons were labeled using an NADH-diaphorase histochemical staining ***:The analysis demonstrated that the p2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the *** density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(ppnation of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and ***:Obesity may exert its effects by promoting a decrease in p2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons.

关键词： Obesity p2X2 receptor Myenteric neurons Chemical coding

Treatment of Aged Skin with a pH 4 Skin Care product Normalizes Increased Skin Surface pH and Improves Barrier Function: Results of a pilot Study

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Journal of Cosmetics, Dermatological Sciences and Applications 2011年第3期1卷 50-58页

作者： Jürgen Blaak Rainer Wohlfart Nanna Y. schürer 不详

The physiological skin surface pH is just below 5. With age the skin surface pH increases up to 6. An increased pH correlates with reduced barrier integrity/cohesion. The present pilot study assesses possible normalization of an increased skin surface pH of the elderly and improvement of barrier function via application of ≈pH 4.0 skin care products. Baseline skin surface pH was determined in elderly (80+ years old;n = 15) compared to middle aged adults (31 - 50 years old;n = 15). The effect of o/w emulsions at pH-values of 3.5, 4.0, 4.5 and 5.5 on the skin surface pH was determined in both groups. Further, the effect of a 4-week treatment with a pH 4.0 skin care product on the skin surface pH, skin hydration and barrier integrity was assessed. Thirteen elderly females were involved in this home-in-use test. Increased baseline skin surface pH of the elderly normalizes to the physiological pH of 4.5 - 5.0 over 7 hours after single application of o/w-emulsions with a given pH of 3.5 or 4.0. A 4 week treatment employing the pH 4.0 skin care product improves the epidermal barrier integrity of the elderly significantly (p = 0.005). Reduction of the increased baseline skin surface pH of the elderly is accompanied by improved epidermal barrier integrity. Skin care products for the elderly have to be adjusted in the pH range of 3.5 to 4.0.

关键词： Skin Aging Skin Care Skin Surface pH Epidermal Barrier Function

The archaeogenomic validation of Saint Ladislaus'relic provides insights into theárpád dynasty's genealogy

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Journal of Genetics and Genomics 2023年第1期50卷 58-61页

作者： Gergely I.B.Varga Lilla Alida Kristóf Kitti Maár Luca Kis Oszkár schütz Orsolya Váradi Bence Kovács Alexandra Gînguță Balázs Tihanyi péter L.Nagy Zoltán Maróti Emil Nyerki Tibor Török Endre Neparáczki Department of Archaeogenetics Institute of Hungarian ResearchH-1014 BudapestHungary Doctoral school of History University of SzegedSzegedHungary Department of Genetics University of SzegedH-6726 SzegedHungary Department of Biological Anthropology University of SzegedH-6726 SzegedHungary Department of Molecular Biology and Biotechnology Faculty of Biology and GeologyBabes-Bolyai University400006 Cluj-NapocaRomania praxis Genomics LLC AtlantaUSA Department of pediatrics and pediatric Health Center University of SzegedH-6725 SzegedHungary

The house of Arp ad ruled Hungary for more than four centuries,establishing dynastical relationships with numerous European nobleand ruling houses,and giving many Catholic saints and blesseds to the Catholic *** were one of the significant dynasties of Medieval Europe(Krist o and Makk,1996).The knight-king Saint Ladislaus I(c.1040-1095,reign:1077-1095)is one of the most outstanding kings of this *** addition to the hand relic(the Holy Right)of King Saint Stephanus I(c.975-1038,reign:1000/1001-1038),the skull relic in the Saint Ladislaus’Herma(Fig.1A-1C)preserved in the Cathedral of Gy or,is one of the most important relics for Hungarians(Klaniczai,2000).

关键词： relic provides insights into the The archaeogenomic validation of Saint Ladislaus d dynasty’s genealogy

北京市pM2.5对DNA的氧化性损伤规律分析

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中国环境科学 2013年第10期33卷 1863-1868页

作者：胡颖邵龙义 schaefer K 王静 Suppan p 王建英中国矿业大学(北京)地球科学与测绘工程学院北京100083 Institute of Meteorology and Climate Research Atmospheric Environmental Research(IMK-IFU)at the Karlsruhe Institute of Technology(KIT)82467 Garrnisch-PartenkirchenGermany

运用质粒DNA损伤评价法,在北京市2010年6月至2011年6月全年的大气pM2.5样品中,选取每月的2个样品(包括正常和雾霾天气),共24个样品进行实验,分析其氧化性损伤能力的变化规律及其与采样条件的相互关系.结果表明,北京市大气颗粒物全样的... 详细信息

运用质粒DNA损伤评价法,在北京市2010年6月至2011年6月全年的大气pM2.5样品中,选取每月的2个样品(包括正常和雾霾天气),共24个样品进行实验,分析其氧化性损伤能力的变化规律及其与采样条件的相互关系.结果表明,北京市大气颗粒物全样的氧化性损伤能力等于或略大于相应的水溶组分,说明颗粒物氧化性损伤能力多来自于水溶组分,大气颗粒物对DNA损伤率呈现在50,100,150,200 g/mL剂量水平下依次递增的规律,即随剂量的增加而增加;雾霾天气下DNA损伤率出现高值;4月和6月的DNA损伤率在全年中较高.其他月份正常天气条件下损伤率均较低,在200 g/mL剂量下损伤率基本低于50%;损伤率与环境平均温度和湿度呈正相关,与平均大气压强和日平均风速呈负相关,相关性大小顺序为:环境平均温度>平均大气压强>平均湿度>日平均风速.

关键词： pM2 5 质粒DNA 北京市

STUDY ON TOTAL SEDIMENT TRANSpORT BY FLOW

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Journal of Hydrodynamics 2001年第2期13卷 86-90页

作者： Gao, X.p. sch. of Civil Eng. Tianjin Univ. Tianjin 300072 China

Total sediment transport under the action of flow includes generally three forms of sediment transport, suspended load, density current and bed load. How to realize simultaneously these three forms of sediment movement in an identical physical model was studied in this paper. For the suspended load, fall and pickup similarities were used to design sediment gradation, and similarities of sediment-carrying capacity and scouring and depositing time were be insured. For the density current its occurrence condition should be similar, and similarities of sediment concentration and depositing time were insured. For the bed load, sediment gradation was designed by the similarity of incipient motion, and similarities of sediment discharge and scouring and depositing time were satisfied. And a physical model test was conducted.

关键词： Flow of fluids Mathematical models

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一种沉淀法白炭黑对硅橡胶的补强作用

橡胶参考资料 1981年第7期 1-10页

作者： p.Vondráek M.schtz 雷育民

新型沉淀法白炭黑silica FK 160和气相法白炭黑Aerosil 130,Aerosil 200和Aer-osil R 972在热硫化硅橡胶中的对比研究表明,这种沉淀法炭黑在硅橡胶中的性能同用有机氯硅烷反应改性的（钝化的）气相法白炭黑（Aerosil R 972）在某种意义... 详细信息

新型沉淀法白炭黑silica FK 160和气相法白炭黑Aerosil 130,Aerosil 200和Aer-osil R 972在热硫化硅橡胶中的对比研究表明,这种沉淀法炭黑在硅橡胶中的性能同用有机氯硅烷反应改性的（钝化的）气相法白炭黑（Aerosil R 972）在某种意义上非常相似。Silica FK 160补强的硫化胶的热稳定性比用气相法白炭黑更好。分别用沉淀法白炭黑和气相法白炭黑补强的模压硫化胶在机械性能方面的差异可以借助于添加一种工艺助剂来消除。在未硫化胶料和在硫化胶中,Silica FK 160表明它的表面活性都比较低。用NH3改性的硫化胶膨胀试验法获得的结果支持了这个结论。从实用观点出发,可以得出结论,Silica FK 160是硅橡胶的一种良好的二氧化硅补强填料,“皱折硬化”趋势小,模型硫化胶具有良好的机械性能和卓越的耐热性。

关键词：硅橡胶电工橡胶沉淀法白炭黑补强作用

22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses

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World Journal of Gastroenterology 2016年第39期22卷 8820-8830页

作者： William Sterlacci Athanasios D Sioulas Lothar Veits pervin G?nüllü Guido schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer Institute of pathology Clinic of Bayreuth Department of Interdisciplinary Endoscopy University Hospital Hamburg-Eppendorf Department of Biochemistry and Molecular Biology University of Athens Institute of pathology Institute of pathology University Hospital Hamburg-Eppendorf

AIM To compare the aspiration needle(AN) and core biopsy needle(pC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal *** Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G pC(Echo Tip pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the pC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and *** Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and pC reached similar overall results for diagnostic accuracy(AN: 88.9 vs pC: 96.1, p = 0.25), specimen adequacy(AN: 96.4% vs pC: 91.1%, p = 0.38), mean number of passes(AN: 1.5 vs pC: 1.7, p = 0.14), mean cellularity score(AN: 1.7 vs pC: 1.1, p = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the pC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs pC: 1.0, p = 0.034); no other differences were of statistical *** Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle.

关键词： Endoscopic ultrasound Cytology Fine needle aspiration Abdominal tumors Core biopsy needle

INORGANIC THIN-FILM SENSOR MEMBRANES WITH pLD-pREpARED CHALCOGENIDE GLASSES: CHALLENGES AND IMpLEMENTATION

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INORGANIC THIN-FILM SENSOR MEMBRANES WITH PLD-PREPARED CHALC...

大豆粗蛋白对新生羔羊空肠粘膜生长发育的影响

第二届国际传感器科学研讨会

作者： Joachim p.KLOOCK Yulia G.MOURZINA Yuri ERMOLENKO Theodor DOLL Jrgen schUBERT Michael J.schNING University of Applied Sciences Aachen （Division Jlich） Laboratory for Chemical Sensors and Biosensors52428 Jlich Germany Research Centre Jlich Institute of Thin Films and Interfaces52425 JlichGermany Research Centre Jlich Institute of Thin Films and Interfaces52425 JlichGermany St.petersburg State University Faculty of Chemistry199034 St.PetersburgRussia St.petersburg State University Faculty of Chemistry199034 St.PetersburgRussia Institute of Microtechnology Mainz 55129 MainzGermany Research Centre Jlich Institute of Thin Films and Interfaces52425 JlichGermany University of Applied Sciences Aachen （Division Jlich） Laboratory for Chemical Sensors and Biosensors52428 JlichGermany Research Centre JlichInstitute of Thin Films and Interfaces52425 JlichGermany

＜正＞ Intensive investigations in the field of ion-selective electrodes on the basis of chalcogenide glass materials are carried out during the last two decades. Different chalcogenide glasses for the detection of heavy metals in aqueous media were presented. The advantage of chalcogenide glasses are the high chemical stability of these vitreous materials in comparison to their crystalline counterpart [1-2]. For modem and miniaturised sensor devices, however, it is necessary to prepare the sensitive material in a fast and cost-effective way. This especially becomes very interesting in terms of multi-sensor systems for the simultaneous measurement of

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营养学报 2008年第3期30卷 290-293页

作者：何军 schnhusen U. Voigt J. 沈赞明南京农业大学农业部动物生理生化重点开放实验室 Research Institut efor the Biology of Farm Animals D-181196Germany

目的研究大豆粗蛋白(soybean protein,Sp)取代部分乳源蛋白对新生羔羊空肠粘膜生长发育的影响,为大豆代乳品的合理利用和开发提供依据。方法17只7日龄羔羊随机分为Sp组(n=8)和CS组(n=9),人工哺乳。Sp组用大豆粗蛋白取代30%乳源蛋白;CS... 详细信息

目的研究大豆粗蛋白(soybean protein,Sp)取代部分乳源蛋白对新生羔羊空肠粘膜生长发育的影响,为大豆代乳品的合理利用和开发提供依据。方法17只7日龄羔羊随机分为Sp组(n=8)和CS组(n=9),人工哺乳。Sp组用大豆粗蛋白取代30%乳源蛋白;CS组用与大豆蛋白等氮的酪蛋白取代,作为对照。每日哺乳2次,1W适应期。饲喂4W后宰杀取空肠组织样,扫描电镜观察空肠绒毛形态;以玻片刮取空肠各段粘膜用于蛋白质、RNA/DNA含量及碱性磷酸酶(ALp)含量测定。结果Sp和CS两组羔羊采食量和体增重没有差别。Sp组羔羊空肠绒毛明显萎缩;前段(127.2±4.6vs143.6±7.3mg/g粘膜,p=0.07)和中段(111.2±6.3vs132.7±8.5mg/g,p=0.06)粘膜总蛋白含量有降低的趋势;前段粘膜RNA/DNA(1.40±0.10vs1.68±0.08)及蛋白质/DNA(41.3±3.2vs51.5±2.8)比率均显著低于CS组(pp含量均显著下降(p<0.05)。结论短期以大豆蛋白取代30%的乳源蛋白饲喂新生羔羊,延缓空肠粘膜生长和发育,但未影响摄食和体增重。

关键词：大豆蛋白酪蛋白空肠粘膜碱性磷酸酶羔羊