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Impact of phytoconstituents on oral health practices:a post COVID-19 observation

Food Science and Human Wellness 2024年第5期13卷 2386-2400页

作者： Harsh Kumar Reena Singh Daljeet Singh Dhanjal Chirag Chopra natália cruz-martins Gheyath K.Nasrallah Amin F.Majdalawieh Sivakumar Manickam Shahida Anusha Siddiqui Dinesh Kumar Indu Sharma Varun Sharma School of Bioengineering&Food Technology Shoolini University of Biotechnology and Management SciencesSolan 173229India School of Bioengineering and Biosciences Lovely Professional UniversityPunjab 144402India Faculty of Medicine University of PortoPorto 4200-319Portugal Institute for Research and Innovation in Health(i3S) University of PortoPorto 4200-135Portugal Institute of Research and Advanced Training in Health Sciences and Technologies(CESPU) RuaCentral de GandraGandra 4585-116Portugal TOXRUN-Toxicology Research Unit University Institute of Health SciencesCESPUCRLGandra 4585-116Portugal Biomedical Research Center Qatar UniversityDoha 2713Qatar Department of Biomedical Science College of Health SciencesQatar UniversityDoha 2713Qatar Department of Biology Chemistryand Environmental SciencesCollege of Arts and SciencesAmerican University of SharjahSharjah 26666United Arab Emirates Petroleum and Chemical Engineering Faculty of EngineeringUniversiti Teknologi BruneiBandar Seri Begawan BE1410Brunei Campus Straubing for Biotechnology and Sustainability Technical University of MunichStraubing 94315Germany Genetic Heritage Group New York UniversityAbu Dhabi 129188United Arab Emirates Bioinformatics Division NMC Genetics India Pvt.Ltd.Gurugram 122001India

Appropriate oral hygiene significantly reduces the possibility of oral ***,dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral ***,herbal compounds have gained interest in maintaining oral *** of burdock root(Arctium),noni fruit(Morinda citrifolia),and neem leaf(Azadirachta indica)are now used as intracanal medicaments in endodontics and *** amboinicus species and other plants produces essential oil likeβ-caryophyllene,p-cymene,andγ-terpinene can exhibit antibacterial activity;highlighting phytoconstituents plays a vital role in oral *** COVID-19 pandemic highlighted the importance of hygiene and sanitization,to curb *** cavity is among the gateways for virus entry into *** is a potential reservoir of SARS-CoV-2,and there is an increased risk of infection if there is any fissure in the *** enables entry of virus into the vascular system through gingival or periodontal pocket,possibly reaching lung periphery then to lung vessels by interacting with endothelial surface receptors triggering pulmonary vasoconstriction and lung damage due to endothelial *** review aims to draw attention to the possible route of SARS-CoV-2 infection via the oral cavity and the importance of oral hygiene against COVID-19.

关键词： COVID-19 SARS-CoV-2 Oral Hygiene Microbiota Phytochemicals

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Urban development and industrialization impacts on semiaquatic bugs diversity: A case study in eastern Amazonian streams

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Water Biology and Security 2022年第4期1卷 43-50页

作者： Erlane Jose Cunha Gabriel martins cruz Ana Paula Justino Faria John Nascimento De Oliveira Leandro Juen Programa de Pos-graduaçao em Ecologia Universidade Federal do Para e Embrapa Amazonia OrientalRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-graduaçao em Zoologia Universidade Federal do Para/Museu Paraense Emílio GoeldiRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Laboratorio de Ecologia e Conservaçao Universidade Federal do Para/Rua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-Graduaçao em Agricultura e Ambiente Laboratorio de Ciencias Ambientais e BiodiversidadeUniversidade Estadual do MaranhaoSao LuísBrazil Hydro Alunorte Rodovia PA–481km 12Distrito de MurucupiCEP68447-000BarcarenaParaBrazil

Landscape changes have caused the decline of biodiversity and affected the integrity of aquatic *** this study,we assessed the influence of industrialization associated with urban development on aquatic environments and the biodiversity of semiaquatic bugs(Gerromorpha)at different scales(water quality,habitat,and landscape).Using the simple buffer method,we evaluated nine streams assessing water quality variables,habitat structure,and linear features(radius¼300 m,length¼600 m)for the percentage of land use and land *** results found that species composition of Gerromorpha was mainly affected by primary forest cover,habitat integrity,leaves substrate,and water temperature(29%explanation),and the species richness was mostly influenced by the habitat integrity index(HII)and phosphorus *** model that best explained the variation in species richness showed a positive relationship with phosphorus concentrations and HII(43%variation).Therefore,our results show that those human activities are the main factors altering aquatic biodiversity from local to regional ***,the retention of riparian forests–even in urban and industrialized areas–can maintain the diversity of semiaquatic insect species by providing suitable environments for the habitat,feeding,and reproductive requirements of these aquatic ***,our results also show that the management of riparian vegetation in urban areas and industrial complexes promotes aquatic biodiversity conservation in regions under development in the Amazon.

关键词： Aquatic insects Biodiversity conservation Gerromorpha Stream conservation Land use

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Grid-Connected PV Solar Energy Converter with Active and Reactive Power Control

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Journal of Energy and Power Engineering 2014年第2期8卷 331-342页

作者： Roberto F. Coelho Artur Pagnoncelli Galbiatti Denizar cruz martins INEP Power Electronics Institute Federal University of Santa Catarina Florian6polis (SC) 88040-970 Brazil

This work proposes a 12 kW three-phase grid-connected single stage PWM DC-AC converter destined to process the energy provided by a photovoltaic array composed of 57 KC200GT PV modules with high power factor for any solar radiation. The PWM inverter modeling and the control strategy, using dqO transformation, are proposed in order to also allow the system operation as an active power filter, capable to compensate harmonic components and react power generated by the non-linear loads connected to the mains grid. An input voltage clamping technique is proposed to impose the photovoltaic operation on the maximum power point. Simulation and experimental results are presented to validate the proposed methodology for grid connected photovoltaic generation system.

关键词： Active and reactive power dqO transformation grid-connected PV systems three-phase DC-AC PWM converter.

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Evaluation of parasitemia by qPCR in patients with chronic Chagas disease treated with benznidazole

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Asian Pacific Journal of Tropical Medicine 2023年第12期16卷 565-572页

作者： Tycha Bianca Sabaini Pavan Eros Antônio de Almeida Rodrigo Gonçalves de Lima Jamiro da Silva Wanderley Luiz Cláudio martins Sandra Cecília Botelho Costa Gláucia Elisete Barbosa Marcon Departamento de Clínica Médica Faculdade de Ciências MédicasUniversidade Estadual de Campinas(Unicamp)CampinasSão PauloBrasil Fundação Oswaldo cruz Fiocruz Mato Grosso do SulCampo GrandeMSBrasil

Objective:To evaluate parasitemia by qPCR in patients undergoing etiological treatment and followed in a Brazilian reference ***:Parasite load was quantified by qPCR in 32 participants with chronic Chagas disease who were treated with *** analyses were performed before and after the treatment and parasite loads were compared prior and 12/18 months post the ***:Thirty-two participants were recruited and treated with benznidazole,and 20 were *** events(AE)were observed in 22 out of 29 participants that had safety data(76%),and dermatological alterations were the most frequently observed *** the 20 participants analyzed,13 and 7 completed 12 and 18 months follow-up after the treatment,respectively.12 Months after the final treatment,Trypanosoma cruzi was detectable in 3 patients by qPCR;18 months after the final treatment,Trypanosoma cruzi was detectable per qPCR in 4 of the 7 ***,between 12 and 18 months,7 participants of the 20 initial follow-up cases showed positive qPCR,indicating treatment ***:qPCR can be used as an alternative method for evaluating the effectiveness of the etiological treatment of CD,and can be applied to analyze early therapeutic *** study showed that benznidazole therapy had limited effectiveness in treating chronic CD patients,thus emphasizing the importance of conducting continued research for developing more effective therapies and diagnosis for CD.

关键词： Trypanosoma cruzi Chagas disease Antitrypanosomal therapy Benznidazole qPCR Therapeutic failure

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Sagittal abdominal diameter as a marker of visceral obesity in older primary care patients

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Journal of Geriatric Cardiology 2020年第5期17卷 279-283页

作者： Maria Auxiliadora Nogueira Saad Antonio José Lagoeiro Jorge Diane Xavier deávila Wolney de Andrade martins Márcia Maria Sales dos Santos Luciana Thurler Tedeschi Ismar Lima Cavalcanti Maria Luiza Garcia Rosa Rubens Antunes da cruz Filho Fluminense Federal University NiteróiRio de Janeiro StateBrazil

Background Longevity,combined with a higher prevalence of obesity,particularly visceral obesity,has been associated with an increased risk of cardiovascular *** resistance(IR)is an important link between visceral obesity and cardiovascular *** important association has been found between sagittal abdominal diameter,visceral obesity and *** objective of this study is to evaluate sagittal abdominal diameter as a marker of visceral obesity and correlate it with IR in older primary health care *** A cross-sectional study was performed with 389 patients over 60 years of age(70.6±6.9),of whom 74%were *** clinical,anthropometric and metabolic profiles were assessed and their fasting serum insulin level was used to calculate the homeostasis model assessment insulin resistance(HOMA-IR).Sagittal abdominal diameter was measured in the supine position at the midpoint between the iliac crest and the last rib with abdominal *** Sagittal abdominal diameter was significantly correlated with anthropometric measures of general and visceral obesity and with HOMA-IR in both *** was no change in the association between sagittal abdominal diameter and HOMA-IR after adjusting for age,sex,diabetes and *** It is feasible to use sagittal abdominal diameter in older primary care patients as a tool to evaluate visceral obesity,which is an indicator of cardiovascular risk.

关键词： Cardiovascular risk Insulin resistance Primary health care Sagittal abdominal diameter

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COVID-19 in dialysis units: A comprehensive review

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World Journal of Virology 2021年第5期10卷 264-274页

作者： Gabriel martins Nogueira Moises Santana Oliveira Ana Flavia Moura Constanca Margarida Sampaio cruz JoseA Moura-Neto Department of Medicine Bahiana School of Medicine and Public HealthSalvador 40290-000Brazil Department of Internal Medicine Bahiana School of Medicine and Public HealthSalvador 40290-000Brazil Department of Internal Medicine Hospital Santo AntônioSalvador 40415-006Brazil

The coronavirus disease 2019(COVID-19)pandemic has been challenging for healthcare professionals *** of the populations affected by the pandemic are patients on renal replacement therapy,as kidney disease is an independent risk factor for severe COVID-19 and maintenance dialysis(a lifesustaining therapy)cannot be interrupted in the vast majority of *** the past months,several authors and medical societies have published recommendations and guidelines on the management of this *** article is a comprehensive review regarding the measures to prevent,contain and deal with a COVID-19 pandemic in the dialysis *** recapitulate the epidemiology and pathophysiology of COVID-19 in kidney dysfunction and present the main recommendations concerning the screening of healthcare personnel,dialysis patients and visitors as well as measures to improve the safety of the dialysis facilities’*** addition to preventive measures,this article briefly describes actions directed towards management of an outbreak of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)within a dialysis facility,the management of complications in dialysis patients with COVID-19 and overall data regarding the management of children with kidney disease.

关键词： COVID-19 SARS-CoV-2 Renal dialysis Renal replacement therapy Hemodialysis units,Hospital

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Streptococcus pneumoniae and Herpes Simplex Virus-1 Central Nervous System Co-Infection

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Advances in Infectious Diseases 2023年第1期13卷 47-53页

作者： António martins Cláudio Silva Fernando Silva Lúcia Ribeiro António José cruz Filipa Ceia Lurdes Santos Infectious Diseases Department Centro Hospitalar Universitário de São João Porto Portugal Nephrology and Infectious Diseases R&D i3S-Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal

Co-infections of the central nervous system (CNS) caused by bacterial and viral pathogens are considered to be rare. Herpes simplex virus type-1 (HSV-1) reactivation following Streptococcus pneumoniae infection is well described but most cases are related to oral or cutaneous lesions or in respiratory samples. HSV-1 CNS reactivation after Streptococcus pneumoniae meningitis is a very rare event and may have significant morbidity and mortality. In this case report, we describe a 71-year-old female patient that presented with a history of abdominal pain and confusion/disorientation that had tonic-clonic seizures while in the Emergency Department. The diagnostic work-up confirmed CNS co-infection caused by Streptococcus pneumoniae and HSV-1. Of note, beyond age, the patient had no known risk factors for both entities and recovered fully after antibiotic and antiviral therapy. This case underlines that clinicians must be aware of CNS co-infection despite being a rare diagnosis. This should be suspected particularly in patients who present an unusual clinical course of CNS infection.

关键词： Streptococcus pneumoniae Herpes Simplex Virus Type 1 Central Nervous System Co-Infection

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Antithrombotic treatment in chronic heart failure and sinus rhythm: Systematic review

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World Journal of Meta-Analysis 2015年第1期3卷 36-42页

作者： Daniel Caldeira Inês cruz Rita Calé Cristina martins Helder Pereira Joaquim J Ferreira Fausto J Pinto Joo Costa Cardiology Department Hospital Garcia de Orta Clinical Pharmacology Unit Instituto de Medicina Molecular Laboratory of Clinical Pharmacology Faculty of MedicineUniversity of Lisbon Cardiology Department CCUL CAML Faculty of Medicine Evidence Based Medicine Centre Faculty of Medicine University of Lisbon Portuguese Collaborating Centre of the Cochrane Iberoamerican Network Faculty of Medicine University of Lisbon

AIM: To assess the efficacy and safety of antithrombotic drugs(antiplatelet or anticoagulant drugs) compared to no antithrombotic treatment or placebo in patients with heart failure(HF) and sinus rhythm. METHODS: We searched Medline and Cochrane Library for randomized controlled trials evaluating antithrombotic treatment and no antithrombotic treatment in patients with HF and sinus rhythm. Risk ratio(RR) and 95%CIs were estimated performing meta-analysis with random effects method. RESULTS: Two studies met the inclusion criteria: Heart failure Long-term Antithrombotic Study and Warfarin/Aspirin Study in Heart failure, with 336 patients and mean follow-up 1.8-2.25 years. Stroke risk was not reduced by acetylsalicylic acid(RR = 1.18, 95%CI: 0.17-8.15), oral anticoagulation(RR = 0.30, 95%CI: 0.03-2.65) or overall antithrombotic drugs(RR = 0.52, 95%CI: 0.10-2.74). Acetylsalicylic acid showed a significant increased risk of worsening HF(RR = 1.78, 95%CI: 1.08-2.92), while oral anticoagulation had no impact in this outcome(RR = 1.03, 95%CI: 0.61-1.75). Overall antithrombotic drugs showed a significant risk increase of major bleeding(RR = 6.99, 95%CI: 0.89-54.64). CONCLUSION: Best available evidence does not support the routine use of antithrombotic drugs in patients with HF and sinus rhythm. These drugs, particularly oral anti-coagulation has the hazard of increase significantly major bleeding risk.

关键词： Heart failure Sinus rhythm Platelet aggregation inhibitors Anticoagulants

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Application of Automatic Mass Balance in Metal Accounting of Iron Ore Plant

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Journal of Environmental Science and Engineering(A) 2013年第2期2卷 127-134页

作者： Rodrigo Cesar de Miranda Marco Aurelio Soares martins Hugo Montalvao Gontijo Plinio cruz Gianeli Bruna Torres Negreiros Cordeiro Andrade Process Engineering CEMI Process Technology and Engineering Belo Horizonte 30112-000 Minas Gerais Brazil Operational Management CEMI Process Technology and Engineering Belo Horizonte 30112-000 Minas Gerais Brazil Automation and Control CEMI Process Technology and Engineering Belo Horizonte 30112-000 Minas Gerais Brazil

The purpose of this work is to present state of the art mass balances closing strategies in ore treatment plants to report metal accounting in a reliable manner. The current methodology is based on usage of an expert system which seizes and filters the plant data, analyses situations of equipment stops and mostly instruments failures. It is still possible to internally create a strategy to check the data of an instrument failure. The system is coupled to software with a Lagrangian model of mass balance closure that receives the pre-treated data. Thus, the data goes through filtering and reconciling processes to generate a reliable mass balance of the ore treatment plant. This made it possible to obtain a system that is able to tell the real productivity of an ore plant through reliable mass balances. Residence times on equipment are critical to the balance, thus, they require good logic to eliminate errors due to the characteristics of non-steady state. Among the next challenges is the inclusion of a soft sensor as a replacement of an instrument required for mass balance closure.

关键词： Mass balance data reconciliation metal accounting expert system

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Mesenchymal Stem Cells Express Low Levels of Cardiomyogenic Genes and Show Limited Plasticity towards Cardiomyogenic Phenotype

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Journal of Life Sciences 2013年第9期7卷 950-964页

作者： Juliana Lott de Carvalho Danilo Roman Campos Maira Souza Oliveira Jader Santos cruz nathalia martins Breyner Dawidson Assis Gomes Alfredo Miranda de Goes Department of Biochemistry and Immunology Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte 30123-970 Minas Gerais Brazil Department of Pharmacology Columbia University Presbyterian Hospital New York 10032 United States Department of Clinic and Surgery College of Veterinary Medicine Federal University of Minas Gerais Belo Horizonte 30123-970 Minas Gerais Brazil Institut national de Recherche Agronomique Paris 75338 France

Mesenchymal stem cell differentiation towards osteogenic, chondrogenic and adipogenic lineages have been extensively described and reproduced in the literature. In contrast, cardiomyogenic differentiation still remains largely controversial. In this study the authors aim to shed new light into this unclear phenomenon and test whether BMMSC （bone marrow mesenchymal stem cells） and ATMSC （adipose tissue derived mesenchymal stem cells） are able to differentiate into functional cardiomyocytes, investigating two differentiation protocols. AT and BMMSC behaved differently when cultured in differentiation media and presented lower levels of proliferation and alkaline phosphatase production, expression of cardiomyocyte-specific transcription factors such as GATA-4, Nkx2-5 and proteins such as ct and 13 Myosin Heavy Chains. Furthermore, MSC started to express higher levels of Connexin-43 and c~ sarcomeric actinin protein. Unfortunately, though, MSC did not present cardiomyocyte-like electrophysiological properties. In order to analyze a possible explanation for such limited plasticity, the authors decided to address the issue using a quantitative approach. Gene expression was quantified by Real time PCR, and, for the first time, the authors show that a possible explanation for limited plasticity of MSC is that even though differentiated cells presented differential gene expression, the levels of key cardiomyogenic genes did not reach expression levels presented by adult cardiomyocytes, nor were maintained along differentiation, reaching peaks at 4 days of stimulation, and decaying thereafter.

关键词： Mesenchymal stem cells cardiomyogenic differentiation limited plasticity in vitro differentiation

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