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Oncogenic BRAF^(V600E) induces microglial proliferation through extracellular signal-regulated kinase and neuronal death through c-Jun N-terminal kinase

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Neural Regeneration Research 2023年第7期18卷 1613-1622页

作者： Qing Ye Pranay Srivastava nasser Al-Kuwari Xiqun Chen Department of Neurology Massachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA Department of Neurology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Aligning Science Across Parkinson’s(ASAP)Collaborative Research Network Chevy ChaseMDUSA

Activating V600E in v-Raf murine sarcoma viral oncogene homolog B(BRAF)is a common driver mutation in cancers of multiple tissue origins,including melanoma and ***^(V600E) has also been implicated in *** present study aims to characterize BRAF^(V600E) during cell death and proliferation of three major cell types of the central nervous system:neurons,astrocytes,and *** primary cultures(primary cortical mixed culture)and cell lines of glial cells(BV2)and neurons(SH-SY5Y)were ***^(V600E) and BRAF^(WT) expression was mediated by lentivirus or *** of downstream effectors(extracellular signal-regulated kinase 1/2 and JNK1/2)were achieved by *** astrocytes and microglia,BRAF^(V600E) induces cell proliferation,and the proliferative effect in microglia is mediated by activated extracellular signal-regulated kinase,but not c-Jun N-terminal *** medium from BRAF^(V600E)-expressing microglia induced neuronal *** neuronal cells,BRAF^(V600E) directly induces neuronal death,through c-Jun N-terminal kinase but not extracellular signal-regulated *** further show that BRAF-related genes are enriched in pathways in patients with Parkinson’s *** study identifies distinct consequences mediated by distinct downstream effectors in dividing glial cells and in neurons following the same BRAF mutational activation and a causal link between BRAF-activated microglia and neuronal cell death that does not require physical *** provides insight into a possibly important role of BRAF in neurodegeneration as a result of either dysregulated BRAF in neurons or its impact on glial cells.

关键词： astrocytes cell death cell proliferation inflammation microglia mutation neurons v-Raf murine sarcoma viral oncogene homolog B(BRAF)

Comparative studies on numerical sensitivity of different scenarios of enhanced oil recovery by water-alternating-gas(CO_(2))injection

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Petroleum Research 2023年第4期8卷 505-513页

作者： Saddam Mohammed Mohammed nasser Achinta Bera Vivek Ramalingam School of Energy Technology Pandit Deendayal Energy UniversityGandhinagarGujarat382007India

Enhanced oil recovery by CO_(2) injection technology(CO_(2)-EOR)plays a crucial role in enhancing oil production and the permanent sequestration of anthropogenic CO_(2) in depleted oil ***,the availability of CO_(2) in oil field locations and its mobility in contrast with reservoir fluids are prime challenges in CO_(2)-*** cost of CO_(2) and its availability at the oil fields has prompted investigations on efficient injection of CO_(2) at the fields to achieve the best sweep efficiency *** strategies such as water-alternating-gas(WAG),simultaneous vertical and horizontal WAG,simultaneous water injection into the aquifer and vertical WAG,water and gas injection simultaneously but separately(SS-WAG),and water and gas injection simultaneously but not separately(SNS-WAG)play a significant role,as well as the purity of CO_(2).In this work,the significance of the above criteria was investigated indi-vidually and in *** coupled sequence of injection rate,soaking time,WAG ratio,and purity of injected CO_(2) for enhancement of oil production were delineated.A realistic reservoir simulation model conceptualizing the CO_(2)-EOR system with five spot injection patterns was developed by the company *** history-matched model that was developed was used to investigate the sensitivity of the coupled effects to the criteria listed above on oil *** investigations quantitatively emphasized that purity and soaking time of CO_(2) have an inverse effect in the oil production rate and that SNS-WAG resulted in a better oil production rate than SS-WAG.

关键词： Water-alternating-gas Enhanced oil recovery Sensitivityanalysis Modelingand simulation Simultaneouslybut not separately water-alternating-gas(SS-WAG) Simultaneously pressure maintenance and WAG

In vitro Evaluation of Seed Germination in Twelve Alfalfa Cultivars under Salt Stress

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Phyton-International Journal of Experimental Botany 2023年第1期92卷 111-120页

作者： Walid Soufan Yaser Hassan Dewir nasser A.Al-Suhaibani Plant Production Department College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia

Alfalfa(Medicago sativa L.),when exposed to abiotic stress such as salinity,suffers significant losses in yield and *** present study evaluated the salinity tolerance of 12 alfalfa cultivars in vitro using five concentrations of sodium chloride(NaCl),ranging from 0 to 250 mmol L^(−1).The results obtained in the current study revealed that the Saudi cultivars,Kasimi and Hassawi,and the German cultivar(Berlin)had the highest salinity tolerance in terms of germination percentage(GP),corrected germination rate index(CGRI),days to reach 50%germination(GT_(50)),and ability to form cotyledonary and true *** mmol L^(−1) NaCl,the Saudi cultivar Kasimi cultivar showed GP,CGRI,and GT_(50) of 55.20%,123.15,and 3.77 days,***,the German cultivar(Berlin)showed GP,CGRI,and GT_(50) of 50.06%,86.61,and 5.17 days,*** findings might reveal a pivotal aspect in salt tolerance in *** results will help to select salt-tolerant alfalfa cultivars that could thrive in arid and semi-arid areas with salinity problems.

关键词： Medicago sativa L. salinity germination screening salt tolerance

Damped Mathieu Equation with a Modulation Property of the Homotopy Perturbation Method

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Sound & Vibration 2022年第1期56卷 21-36页

作者： Yusry O.El-Dib nasser S.Elgazery Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt

In this article,the main objective is to employ the homotopy perturbation method(HPM)as an alternative to classical perturbation methods for solving nonlinear equations having periodic *** a simple example,the nonlinear damping Mathieu equation has been *** this investigation,two nonlinear solvability conditions are *** of them was imposed in the first-order homotopy perturbation and used to study the stability behavior at resonance and non-resonance *** next level of the perturbation approaches another solvability condition and is applied to obtain the unknowns become clear in the solution for the firstorder solvability *** approach assumed here is so significant for solving many parametric nonlinear equations that arise within the engineering and nonlinear science.

关键词： Damped Mathieu Equation parametric nonlinear oscillator resonance instability homotopy perturbation method(HPM)

CO_(2)utilization in syngas conversion to dimethyl ether and aromatics:Roles and challenges of zeolites-based catalysts

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Journal of Energy Chemistry 2023年第4期79卷 418-449页

作者： Ali A.Al-Qadri Galal A.nasser Haruna Adamu Oki Muraza Tawfik A.Saleh Department of Chemical Engineering King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Interdisciplinary Research Center for Hydrogen and Energy Storage(IRC-HES) King Fahd University of Petroleum&MineralsDhahran 31261Saudi Arabia Department of Environmental Management Technology and Department of ChemistryAbubakar Tafawa Balewa UniversityBauchiNigeria Department of Chemistry King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

Several studies have proven a strong correlation between global warming and CO_(2)***,38 billion tons of CO_(2)are approximately emitted into the *** CO_(2)via chemical conversion to clean fuels and value-added aromatics can substantially contribute to controlling the *** the thermodynamic and environmental limitations of hydrogenation of CO_(2)alone to value-added aromatics and fuels,CO_(2)utilization has currently emerged as a promising and practical approach for the production of fuels and aromatics with simultaneous utilization of both CO and CO_(2)*** such,the approach is economically ***_(2)could be converted directly to fuels by the hydrogenation process or as a part of a syngas *** ether(DME)is a clean fuel with a higher energy density,which could be used as a substituent for several fuels such as *** the same vein,value-added aromatics such as benzene,toluene,and xylene(BTX)can be produced from a similar ***,we report a review that collects the most recent studies for the conversion of CO_(2)to DME and aromatics via zeolite-based bifunctional *** highlighted the main routes for producing DME and aromatics,as well as thoroughly discussed the conducted studies on CO_(2)hydrogenation and CO_(2)-rich syngas utilized as feedstock for conversion to DME and *** CO_(2)hydrogenation mostly occurs through the methanol-mediated reaction route but is most often limited by low selectivity and catalyst deactivation,particularly in the utilization of CO_(2)alone for the reduction *** review takes an overview of the progress made so far and concluded by identifying the roles and challenges of zeolite-based catalysts for CO_(2)utilization and conversion to DME and ***,despite the incredible growth the field received in the last couple of years,however,many research challenges and opportunities associated with this process are still abou

关键词： Clean fuel DME Aromatics Bifunctional catalyst CO_(2)mitigation

Intelligent Student Mental Health Assessment Model on Learning Management System

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Computer Systems Science & Engineering 2023年第2期44卷 1853-1868页

作者： nasser Ali Aljarallah Ashit Kumar Dutta Majed Alsanea Abdul Rahaman Wahab Sait AlMaarefa University Ad DiriyahRiyadh13713Kingdom of Saudi Arabia Department of Business Administration Majmaah UniversityAlMajmaah11952Kingdom of Saudi Arabia Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityAd DiriyahRiyadh13713Kingdom of Saudi Arabia Department of Computing Arabeast CollegesRiyadh11583Kingdom of Saudi Arabia Department of Archives and Communication King Faisal UniversityAl AhsaHofuf31982Kingdom of Saudi Arabia

A learning management system(LMS)is a software or web based application,commonly utilized for planning,designing,and assessing a particular learning ***,the LMS offers a method of creating and delivering content to the instructor,monitoring students’involvement,and validating their *** mental health issues become common among studies in higher education globally,it is needed to properly determine it to improve mental *** article develops a new seven spot lady bird feature selection with opti-mal sparse autoencoder(SSLBFS-OSAE)model to assess students’mental health on *** major aim of the SSLBFS-OSAE model is to determine the proper health status of the students with respect to depression,anxiety,and stress(DAS).The SSLBFS-OSAE model involves a new SSLBFS model to elect a useful set of *** addition,OSAE model is applied for the classiﬁcation of mental health conditions and the performance can be improved by the use of cuckoo search optimization(CSO)based parameter tuning *** design of CSO algorithm for optimally tuning the SAE parameters results in enhanced classiﬁca-tion *** examining the improved classiﬁer results of the SSLBFS-OSAE model,a comprehensive results analysis is done and the obtained values highlighted the supremacy of the SSLBFS model over its recent methods interms of different measures.

关键词： Learning management system mental health assessment intelligent models machine learning feature selection performance assessment

Optimal Resource Allocation in Fog Computing for Healthcare Applications

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Computers, Materials & Continua 2022年第6期71卷 6147-6163页

作者： Salman Khan Ibrar Ali Shah nasser Tairan Habib Shah Muhammad Faisal Nadeem Department of Computer Software Engineering University of Engineering and TechnologyMardan23200Pakistan Department of Computer Science College of Computer ScienceKing Khalid UniversityAbhaK.S.A Informatics Complex H-8Islamabad44000Pakistan

In recent years,the significant growth in the Internet of Things(IoT)technology has brought a lot of attention to information and communication *** IoT paradigms like the Internet of Vehicle Things(IoVT)and the Internet of Health Things(IoHT)create massive volumes of data every day which consume a lot of bandwidth and ***,to process such large volumes of data,the existing cloud computing platforms offer limited resources due to their distance from IoT ***,cloudcomputing systems produce intolerable latency problems for latency-sensitive real-time ***,a newparadigm called fog computingmakes use of computing nodes in the form of mobile devices,which utilize and process the real-time IoT devices data in orders of *** paper proposes workload-aware efficient resource allocation and load balancing in the fog-computing environment for the *** proposed algorithmic framework consists of the following components:task sequencing,dynamic resource allocation,and load *** consider electrocardiography(ECG)sensors for patient’s critical tasks to achieve maximum load balancing among fog nodes and to measure the performance of end-to-end delay,energy,network consumption and average *** proposed algorithm has been evaluated using the iFogSim tool,and results with the existing approach have been *** experimental results exhibit that the proposed technique achieves a 45%decrease in delay,37%reduction in energy consumption,and 25%decrease in network bandwidth consumption compared to the existing studies.

关键词： Fog computing internet of health things resource management

Long-term complications of the transmeatal approach (Open Transcanal) in cochlear implants: A follow-up study

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Journal of Otology 2023年第1期18卷 33-37页

作者： Hesham Saleh Almofada nasser KAlmutairi Michael Steven Timms King Faisal Specialist Hospital and Research Center RiyadhSaudi Arabia Al Faisal University College of MedicineSaudi Arabia Saudi German Hospital DubaiUnited Arab Emirates

Objective: Multiple alternative approaches of cochlear implant surgery have been described, such as the suprameatal approach, transcanal approach, transmeatal approach and middle cranial fossa ***(open trnascanal) approach has not been adapted since first described in the clinical *** aimed to assess the long-term complications of the transmeatal approach in a series of 131 patients at our center between 2004 and ***: This study was a retrospective case series of all patients who underwent cochlear implants with the transmeatal(open transcanal) approach from May 2004 to December 2008 at King Faisal Specialist and Research Hospital(Riyadh, Saudi Arabia), which were conducted by the same ***: Complications were observed often with various combinations-recurrent otitis externa, posterior tympanic membrane perforation, electrode extrusion, cholesteatoma, and chronic mastoiditis. The overall long-term complication rate was 16%(21/131). The gap between the implantation and the diagnosis of a complication ranged from <1 year to 11 years. Major complications were as follows:cholesteatoma in 5(3.8%) patients, extrusion of the electrode in 5(3.8%) patients, and tympanic membrane perforation or deep retractions in 5(3.8%) patients. Minor complications were as follows: recurrent mastoiditis with/without concomitant temporary facial nerve palsy in 4(3%) patients, recurrent otitis externa infections in 7(5%) patients, and weakness of the posterior canal wall in 1 ***: The transmeatal approach posed an high rate of complications on long-term follow-up such as cholestetoma formation, extrusion of electrode or perielectrode reaction formation to tympanic membrane and external auditory canal.

关键词： Cochlear implant Transmeatal approach Open transcanal approach Surgical complication

Determinants of overweight and obesity and preventive strategies in Pacific countries: a systematic review

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Global Health Journal 2022年第3期6卷 122-128页

作者： Tanebu Julia Tong Masoud Mohammadnezhad nasser Salem Alqahtani Ministry of Health and Medical Services Tarawa 487Kiribati Faculty of Health Studies School of Nursing and Healthcare LeadershipUniversity of BradfordBradfordWest Yorkshire BD71DPUnited Kingdom Department of Clinical Nutrition Northern Border UniversityArar 1321Saudi Arabia

Objective:This study aimed to explore more on contributing factors and prevention of overweight and obesity among Pacific ***:Using Cochrane library guideline,four electronic databases,PubMed,Embase,Scopus and CINAHL,were systematically searched from 2010 to *** strategy included key concepts,free text terms,and database-controlled vocabulary terms to identify articles on determinants and preventative strategies of overweight and obesity in the Pacific countries.A data extraction sheet was developed to extract relevant information required for analysis and theme development for this ***:A total of 22 articles were summarized and *** of overweight and obesity identified two themes:environmental related factors 13.6%(3/22)and sociocultural related factors 27.3%(6/22).The preventative strategies of overweight and obesity was categorized into behavioural change 22.7%(5/22),school-related 18.2%(4/22),and policies 50%(11/22).The quality assessment of articles showed“Good”68.2%(15/22),and“Fair”31.8%(7/22).Conclusion:This study highlighted two contributing,non-medication factors affecting overweight and obesity are both environmental and socio-cultural *** and obesity preventative strategies identified in the Pacific context considered behavioural change,knowledge enhancement,and policy *** research should aim at exploring the current preventative strategies in-depth,to appreciate the most feasible and recommended preventative approach within the Pacific society.

关键词： Determinants Preventative strategies Overweight Obesity Pacific Systematic review